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1 nteracted with those who were already highly polarized.
2 tend our current model of PCP signaling from polarizing a field of epithelial cells to conferring new
3 show that secreted Wnts regulate PCP through polarizing a specific subset of PCP proteins.
4   Both Clec9A and Xcr1 targeting induced Th1-polarized Ab responses, although the Th1 polarization of
5 on of chiral MBA cations leads to circularly polarized absorption from the inorganic Sn-I sublattice,
6  to internal sites, which was facilitated by polarized absorption-emission overlap among the parallel
7 our findings show that CP is dispensable for polarized actin growth and motility in situations where
8 aces in the absence of CP, we produce robust polarized actin growth and motility.
9  were defective at producing the dominant DC-polarizing agent IFN-gamma.
10  rational design concepts for more efficient polarizing agents (PAs).
11                  Structurally distinct T(H)2-polarizing agonists varied in their ability to replace O
12           CAFs moving toward Gln presented a polarized Akt2 distribution that was modulated by the Gl
13 or controlling the G(1)->S transition in the polarized alpha-proteobacterium Caulobacter crescentus,
14 t with previous studies, we found that IL-33 polarized alternatively activated macrophages (AAMPhi) i
15 radients with an atomic force microscope tip polarizes an ultrathin film of an archetypal dielectric
16  vasculature and to directionally spread, to polarize and to govern haptotactic migration along gradi
17                                   PM ARF6 is polarized and colocalized with RPH3A, RAB21, PIP5K1C90,
18 e fluid flow and cellular motility using the polarized and coordinated beating of hundreds of motile
19                                          The polarized and differentiated cells were infected with a
20  Here, we demonstrate that human CAR-T cells polarized and expanded under a Th9-culture condition (T9
21 giocytes in the channel of the device became polarized and formed mature tight junctions, that the pe
22                            AMOT130 is highly polarized and present only at the apical side of polariz
23                       They are intrinsically polarized, and when compared to their nonspecially activ
24 e have inferred the formation of a partially polarized antiferroelectric state, with inclusions of st
25 ic network with reduced reactive gliosis and polarized aquaporin-4 (AQP4) distribution.
26                                            A polarized architecture is central to both epithelial str
27                                Are voters as polarized as political leaders when it comes to their pr
28 lic adhesion protein Crumbs regulates planar-polarized assembly of actomyosin cables at tissue bounda
29 osin II activator Rho-kinase (Rok) is planar polarized at the tissue boundary of the Drosophila embry
30 the result of a mixed population of distinct polarized ATMs.
31 rtex beam lasing can be switched to linearly polarized beam lasing, or vice versa, with switching tim
32  vitro model of the human placental barrier (polarized BeWo monolayers) using flow cytometry.
33                 Finally, we show that AAMPhi polarized by IL-33-stimulated mast cells attenuated the
34            Furthermore, we found that AAMPhi polarized by IL-33-stimulated mast cells could suppress
35 raising the question if ctenophore cells are polarized by mechanisms involving Par proteins.
36  of weak H bonds that occur between a highly polarized C-H group and an electron-rich oxygen atom, ha
37 yosin IIB drove CD59 uptake in both HeLa and polarized Caco2 intestinal epithelial cells.
38 se of the ketone, 2-phenoxyacetophenone, the polarized carbonyl pai system apparently binds directly
39  promote dendrite development and facilitate polarized cargo trafficking; however, the mechanism that
40  dendritic cell activation that primes a Tc1-polarized CD8(+) T cell response to bolster tumor reject
41     Duodenum Intestine-Chip demonstrates the polarized cell architecture, intestinal barrier function
42  axial tissues driven by PSM compression and polarized cell intercalation pushes the caudal progenito
43 20 mechanotrafficking mechanism required for polarized cell migration and stem cell-driven tissue rep
44 ed cell invasiveness, in part, by disrupting polarized cell motility under confinement and cell chemo
45 rting stable polarization, yields a robustly polarized cell state.
46                     During distinct modes of polarized cell wall deposition, such as in the tip growt
47 ate intracellular sorting observed in highly polarized cells such as neurons.
48  redistributed from the front to the back of polarized cells where they triggered intracellular cAMP/
49 e microtubule density at the leading edge of polarized cells, suggesting that tubulin binding may pla
50  SMAD signaling only from the apical side of polarized cells, while basolateral BMP-SMAD signaling is
51  pathogenic transcriptional programs in Th17-polarized cells, while it enhances antiinflammatory gene
52 MOT function are interlinked in apical-basal polarized cells.
53 rized and present only at the apical side of polarized cells.
54 udied form of intercellular communication in polarized cells.
55 s while planar cell polarity (PCP) signaling polarizes cells with respect to this axis, but how these
56 , which is enhanced by the ferroelectrically polarized charges in the multipiezo material.
57    These results support the conclusion that polarized cholangiocytes release distinct sEV pools to m
58 ongress since 1979 and examine the impact of polarized coalitions on the effectiveness of passing bil
59 e steady states (three homogeneous and three polarized) coexist for a fixed set of parameters, each o
60 perties of these 3R domains, featuring layer-polarized conduction-band states caused by lack of both
61 nd social media encourage the propagation of polarized conflict.
62 ase transition from a normal metal to a spin-polarized correlated state.
63                        The discovery of spin-polarized correlated states in electric-field-tunable TD
64 phore archetype, FeNHCPZn, features a highly polarized CT state having a profoundly extended (3)MLCT
65 uctive materials to magnetic fields and spin-polarized currents is essential for magnetic sensors and
66 esults in suboptimal up-regulation of T cell-polarizing cytokines during cDC1 maturation.
67          Platelets did not modulate the Th-1-polarizing cytokines IL-12 and IL-18.
68 IFN-alpha) can suppress production of T-cell polarizing cytokines or induce inhibitory antigen-presen
69 d blood from healthy donors and submitted to polarizing cytokines, with and without spermidine treatm
70                                            A polarized cytoskeletal organization is typical for muscl
71     This is fully supported by a recent spin-polarized density functional theory study.
72 quantized Landau fan structure features spin-polarized Dirac dispersion with a large Chern gap.
73 ears, which possess intriguing gapless, spin-polarized Dirac states with linear dispersion only on th
74  generate action potentials and regulate the polarized distribution of proteins, lipids, and organell
75 illin-binding protein 3 (PBP3/FtsI) initiate polarized division, but the process arrests at an early
76      Consistent with their distinct roles in polarized division, peptidoglycan organization is differ
77 ding protein 2 (PBP2) are unable to initiate polarized division, while cells treated with inhibitors
78 fest themselves as an interlinked network of polarized domain walls in a non-polar background matrix.
79 se 1 (TMK1) is critical for the formation of polarized domains at the plasma membrane (PM) during the
80 dback that reinforces these nanodomains into polarized domains.
81             CD56-knockout (KO) cells fail to polarize during immunological synapse (IS) formation and
82                                Significantly polarized dysregulation zones specific to cancer types a
83     These results indicate that spermidine's polarizing effect requires an intact autophagic machiner
84 ntional enantiopure chemical reagent by spin-polarized electrons that provide the chiral bias for ena
85                Throughout the NPC, we find a polarized electrostatic potential and a diffuse thermore
86  polarized luminescence (CPL) spectra show a polarized emission band with dissymmetry factors |g(lum)
87 cally (I(VV)(t)) and horizontally (I(VH)(t)) polarized emission for time-resolved fluorescence anisot
88 ignificantly strong transverse magnetic (TM) polarized emission is recorded, which is ~4 times strong
89                                      Using a polarized endocervical cell culture system, we determine
90                           When we cocultured polarized endocervical cells with HIV-1-infected lymphoc
91 y of allocentric strategies in geometrically polarized environments.
92  of nonpolar pluripotent stem cells into the polarized epiblast epithelium.
93 al cells lining bile ducts, were cultured as polarized epithelia in a Transwell system as a model wit
94 docytosis and specific to the apical side of polarized epithelial and endothelial cells.
95 retinal pigment epithelium (RPE) is a highly polarized epithelial cell type maintained at a senescenc
96                                              Polarized epithelial cells execute distinct signaling ag
97  in the embryonic cortex must maintain their polarized epithelial structure as they undergo both earl
98 nesis, including apical midbody migration in polarizing epithelial cells of the gut, pharynx and sens
99 gative feedback loop, the signals oppositely polarize, establishing sharp boundaries and consequently
100 hibition of Rac signaling causes the cell to polarize even when initially overstimulated.
101 independent resistance, which is due to spin polarized even at zero fields, preserves under magnetic
102 uorescence decays acquired with a vertically polarized excitation and vertically (I(VV)(t)) and horiz
103  to spin-galvanic effect of the ionized spin-polarized excitons, where spin polarization occurs in th
104 can derive from chemically induced local and polarized expansion of the pectin nanofilaments without
105 slowly migrating epithelial MCF10A cells and polarizing, fast-migrating, neutrophil-like HL60 cells.
106 aces, and aligned nanomaterials used to make polarized films cannot be easily reconfigured once align
107           Wild-type mesoderm cells have long polarized filopodia-like protrusions, which are absent i
108 ecules follow 1D pathways and exhibit highly polarized fluorescence, consistent with their orientatio
109 14SB and its derivatives rather than ff94 or polarized force fields provided the most accurate scorin
110 ractions at the tissue scale to drive global polarized forces and tissue elongation.
111                   To do this, they undergo a polarized form of cytokinesis at the apical membrane tha
112  To convert these immature crypts into fully polarized, functional units with a basal stem cell niche
113                 Here, we investigate whether polarized furrowing and abscission in mouse NSCs are reg
114 ti-inflammatory TAMs (also referred to as M2-polarized) generally suppress antitumor immune responses
115 to magnetic fields suggests evidence of spin-polarized ground states, in stark contrast to magic-angl
116 bers to the food are faster in more ordered, polarized groups.
117 ified novel Pak1 substrates that function in polarized growth and cytokinesis.
118 ng of FgMsb3 to the HAD and this affects the polarized growth and pathogenicity of the fungus.
119                       Protein kinases direct polarized growth by regulating the cytoskeleton in time
120               Interestingly, Fgfrb-dependent polarized growth is observed in polyp but not embryonic
121  transport of secretory vesicles to sites of polarized growth.
122        We also provide proof-of-concept that polarized HLCs can be used for pharmacokinetic and drug-
123                                 We show that polarized HLCs secrete cargo directionally: Albumin, ure
124  uses transwell filters to generate columnar polarized HLCs with clearly defined basolateral and apic
125 ed disease symptoms upon transfer of T cells polarized in high-NaCl conditions.
126 e reveals that this bound state is spin-down polarized, in lock with a negative orbital magnetization
127 sing either linearly polarized or circularly polarized incident light.
128                                 The linearly polarized, inelastically scattered light rotates by ~40
129 rties of this versatile DC population in Th1-polarized infection settings.
130 ed with nonatopic T-helper type 1 (Th1) cell polarized inflammation that correlates with pulmonary fu
131                                     However, polarized infrared imaging under scattering based on 2D
132   Importantly, explant organization requires polarized inheritance of maternal factors from dorsal-ma
133 yl-2-amino-1,3,4-nonanetriol] (OCH), a T(H)2-polarizing iNKT cell agonist, before they received alpha
134 e basal side of follicle cells, emerges from polarized intercellular filopodia that radiate from basa
135 coffee and measured their transport across a polarized intestinal epithelium.
136                                  Macrophages polarize into functionally distinct subtypes while respo
137 r cells to produce retinoic acid (RA), which polarizes intratumoral monocyte differentiation toward T
138 pha-MoO(3) is reported by modeling far-field polarized IR reflectance spectra acquired on a single th
139 entee ballots has emerged as an increasingly polarized issue.
140 round deeper epithelialized cells and extend polarized lamellipodia to migrate apposed to the overlyi
141 achieved by the generation of persistent and polarized lamellipodia.
142 y key roles in the propagation of circularly polarized light and display optical properties with prom
143                    Water sorption isotherms, polarized light and scanning electron micrographs showed
144 ng electron bunches, is not just valid for p-polarized light and thin foil targets, but generally des
145 s stronger than the transverse electric (TE) polarized light at 295 nm.
146 e of a sample to the direction of circularly polarized light can be used to infer conformation handed
147         Our findings suggest that circularly polarized light can guide cellular development for biome
148 ic catalysts, chiral sensors, and circularly polarized light emitters will require a greater control
149              In desert locusts, the angle of polarized light in the zenith above the animal and the d
150 spin angular momentum components of linearly polarized light interacting with an Archimedean coupling
151                     The model predicted that polarized light modifies the appearance of MS leading to
152 We show that shining mid-infrared circularly polarized light on 1T-TiSe(2) while cooling it below the
153         The biological effects of circularly polarized light on living cells are considered to be neg
154 rded central-complex neurons to the angle of polarized light presented from up to 33 positions in the
155 enon generated with depolarized and linearly polarized light were consistent with the model simulatio
156 ed skylight can be converted to elliptically polarized light with efficiency up to 53% by single scat
157 ction strength between matter and circularly polarized light with opposite helicity.
158 and thus provide light modulation only for p-polarized light.
159 re designed to selectively transmit radially-polarized light.
160 ons using optical helicity, i.e., circularly polarized light.
161 e nanoparticle assemblies exert a circularly-polarized-light-dependent force on the cytoskeleton, and
162                                              Polarized localization of plasma membrane (PM) phosphati
163 oes not justify the presence of transversely polarized Love waves, nevertheless widely observed.
164 thesis of magnetically responsive Circularly Polarized Luminescence (CPL) complexes displaying except
165                                   Circularly polarized luminescence (CPL) spectra show a polarized em
166 CD, and its emission counterpart, circularly polarized luminescence, CPL, provide tools for studying
167 ar copper(I) complexes exhibiting circularly polarized luminescence.
168 and micropatterns with tailorable circularly polarized luminescence.
169 ly, septins copurify and accumulate near the polarized lytic granules at the CS, where they regulate
170                              These nanocells polarize M1 macrophages and activate NK cells concurrent
171 ent and the maintenance of the alternatively polarized macrophage phenotype.
172                        Environmental signals polarize macrophages to either a proinflammatory (M1) st
173    CXADR was specifically associated with M1-polarized macrophages and foam cells and was experimenta
174         It has long been known that in vitro polarized macrophages differ in morphology.
175 ha-dependent, with TNFalpha produced by IL-4-polarized macrophages triggering MDA-MB-231 cell apoptos
176 th FR-beta expression occurring mainly in M1-polarized macrophages.
177 ncrease in a subset of tumor-infiltrating M2-polarized macrophages.
178 LD-mediated actions of Resolvin-D5 (RvD5) in polarizing macrophages (M1-like toward M2-like) was foun
179 eaction triggered by an exogenous circularly polarized magnetic field (MF) to enhance ferroptosis-lik
180 lses can drive transitions between optically polarized magnetic sublevels of the two-exciton states,
181 asy-plane AFMs with two orthogonal, linearly polarized magnon eigenmodes own unique advantages for lo
182 e specific cytokines and present antigens to polarize mainly naive CD8(+) or CD4(+) T cells, respecti
183 st time interference with BMP signaling in a polarized manner and identifies AMOT130 as a novel BMP s
184         Using spectroscopic imaging and spin-polarized measurements with a scanning tunneling microsc
185 lium dicyanamide) provides the requisite and polarizing medium to realize the detection at "room temp
186 nating current (ac) waveform to electrically polarize microelectrodes.
187            Axons contain arrays of uniformly polarized microtubules with plus-ends facing the tips of
188                              Next-generation polarized mid-infrared imaging systems generally require
189 aflagellar transport (IFT) 20 (Ift20) during polarized migration of epidermal cells.
190 -triggered mitochondrial fission, preventing polarized mitochondrial calcium increase and plasma memb
191 ing tips of cell filaments, likely marking a polarized molecular address.
192                    Analysis of the ventrally polarized molecular landscape identified endothelin 1 as
193                   To migrate, cells assume a polarized morphology, extending forward with a leading e
194 he CSF flow is generated locally by caudally-polarized motile cilia along the ventral wall of the cen
195 mono- and polysynaptic circuits may underlie polarized motor reflexes evoked by local gut stimulation
196                     Calcium wave induces the polarized movement of the surrounding cells toward the e
197 n vitro when cells were co-cultured with IL4-polarized MPhi.
198 ons stimulated cellular differentiation into polarized mucin-secreting and multiciliated cells, recap
199  ubiquitination profiles are different among polarized murine macrophage subsets.
200 a germband epithelium, which displays planar-polarized myosin II and experiences anisotropic forces f
201     However, another major role of IL6 is to polarize naive CD4(+) T cells from Tregs to Th17 cells.
202 endritic cells (DCs) to investigate how they polarize naive CD4(+) T(H) cells.
203 kin to selectively suppress their ability to polarize naive OVA-TCR transgenic CD4(+) T cells into IF
204 ized skin were examined for their ability to polarize naive OVA-TCR transgenic CD4(+) T cells.
205                                          The polarized nature of spacer adaptation revealed the histo
206 ty all reduce Ena/VASP's ability to maintain polarized network growth in the absence of CP.
207                         The development of a polarized neuron relies on the selective transport of pr
208  differentiation of neuronal stem cells into polarized neurons is a well-coordinated process which ha
209 py, differential scanning calorimetry (DSC), polarized optical microscopy, ion chromatography, and in
210 er of the irradiation spot by the circularly polarized optical vortex pulse.
211           Differential scanning calorimetry, polarizing optical microscopy and X-ray diffraction prov
212  accordingly assessed, using either linearly polarized or circularly polarized incident light.
213 ward using photoexcited QDs to strongly spin polarize organic radicals having long spin relaxation ti
214 c astral microtubule organization drives the polarized orientation of the S. cerevisiae mitotic spind
215                                     Spindles polarized, pairs of daughter cells oriented between the
216                                          The polarized partitioning of proteins in cells underlies as
217        Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/
218 imum obtained adhesion force of a positively polarized PDA-modified AFM-SECM probe was 6.2 +/- 2.2 nN
219                                         Spin-polarized periodic density functional theory (DFT) and n
220 f ectodermal epithelial cells and are planar polarized perpendicular to the oral-aboral axis of the a
221 red phase and quasiparticle breakdown in the polarized phase at high transverse field.
222                                              Polarized photoluminescence (PL) reveals that AB stackin
223 nto neurons can be accelerated by circularly polarized photons when DNA-bridged chiral assemblies of
224 o create a two-dimensional Fermi gas of spin-polarized potassium-rubidium (KRb) polar molecules, in w
225              We showed that hRV infection of polarized primary human airway epithelial cells resulted
226 less (i.e., 2.6 +/- 1.1 nN) for a negatively polarized probe at a hydrophilic OH-terminated gold surf
227                 Our systematic magnetization-polarized probe reveals that this bound state is spin-do
228  in terms of an interference of two linearly polarized, propagating magnons in analogy to the birefri
229                                              Polarized Raman measurements of single Si(2)Te(3) nanopl
230 plane optical anisotropy is demonstrated via polarized Raman spectroscopy and second-harmonic generat
231 noclinic structure, as recently suggested by polarized Raman spectroscopy investigations in thin (8-3
232                       Detailed time-resolved polarized reflectance spectroscopy is used to investigat
233                                  Using cross-polarized reflectance spectroscopy we show that the stro
234                                              Polarized reflection measurements at different temperatu
235 tes a wide array of distinct homogeneous and polarized regulatory phenotypes that arise for fixed mod
236                              Transfection of polarized RPE (porcine primary cells, iPSC-RPE) that end
237  Crystallographic evidence suggests that the polarized [Ru-Cl] bond of the catalyst interacts with th
238                             Here we use spin-polarized scanning tunneling microscopy/spectroscopy (ST
239                             Here, using spin-polarized scanning tunneling microscopy/spectroscopy (ST
240                                       Highly polarized secretion at a growing pollen tube tip require
241      Activation of the model resulted in the polarized secretion of CXCL10, IL-8 and CCL-20 by IEC an
242 s study, we show in various Th1- and/or Th17-polarized settings of acute and chronic bacterial infect
243                          In contrast, in Th2-polarized settings such as house dust mite-induced aller
244 nswell system as a model with which to study polarized sEV communication.
245 ial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression pr
246 l connection that targets the Par complex to polarized sites on the cell membrane.
247                                     Linearly polarized skylight can be converted to elliptically pola
248 in-sorting adaptor AP-1B, which mediates the polarized sorting of Toll-like receptor 3 (TLR3) towards
249 ed light beams including high-order linearly polarized spatial fibre modes, cylindrical vector (CV) b
250 ith the ferromagnetic electrode but from the polarized spin that crosses the interface between the su
251 undergo pollen mitosis I (PMI) and arrest at polarized stage with a single central vacuole.
252 leton to break symmetry and achieve a stable polarized state.
253 regulation prevents locking macrophages into polarized states.
254 odulated by the handedness of the circularly polarized subterahertz irradiation.
255 s proposed, which generates a longitudinally-polarized super-resolution focal point.
256           Here we show that a dorsal-ventral polarized supracellular F-actin network, running around
257 evelopment of a chronic T helper cell type 1-polarized systemic immune response accelerated the onset
258                       We discuss examples of polarized systems and detail how polarization is establi
259 ed much faster enabling them to activate and polarize T cells stronger.
260                                           In polarized T cells, HIV-1 structural protein Gag localize
261 orm designed to increase the number of T(h)1-polarized T(fh) cells enhances the magnitude and quality
262  cells in the reactive group skewed toward a polarized T(H)2 effector phenotype, and expression of T(
263                              Compared to IL2-polarized (T1) cells, T9 CAR-T cells secrete IL9 but lit
264 e overall effect is skewing the TAMs from M2-polarized TAMs into the M1-polarized TAMs.
265  the TAMs from M2-polarized TAMs into the M1-polarized TAMs.
266                                          The polarized terminal GeO bond in the germa-acylium ion was
267  expression of AW112010 was high in in vitro-polarized Th1 and Th17 cells but low in Th2 cells, sugge
268 vo but was remarkably distinct from cytokine-polarized Th17 cells.
269 hows that the photoexcited QDs strongly spin polarize the NDI radical anion, which is interpreted in
270 itochondrial fission at the injury site help polarize the repair response.
271 electivity (CISS), whereby helical molecules polarize the spin of electrical current, is an intriguin
272 r nuclear membrane protein nesprin-2G, which polarizes the inner nuclear membrane protein SUN1.
273 otential functionalization and the effect of polarizing the bridging N(2) ligand by employing differe
274 ate of the aldehyde by two effects, that is, polarizing the carbonyl group and increasing the probabi
275 r to recruit macrophages to IRISOE cells and polarize them to protumor M2 TAMs.
276 e isolated macrophages from mice and humans, polarized them ex vivo, and examined their functional in
277 owed that FgPal1 plays a role in maintaining polarized tip growth and coordination between nuclear di
278                      Pollen tubes are highly polarized tip-growing cells that depend on cytosolic pH
279 es/macrophages content reverts to normal and polarize to a M2-like CD206(+) phenotype.
280 types in complex pathological conditions and polarize to a predominant phenotype depending on the dur
281          Here, we show that lung macrophages polarize to a pro-inflammatory, classically activated ph
282 ntacts, others are broadly contractile, some polarize to facilitate migration, and yet others exhibit
283  by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune-suppressive
284 al acted with high selectivity on hair cells polarized to be activated by posterior deflections, as w
285 xonemal dynein motor proteins becomes highly polarized to the distal end of the cilia during cytoplas
286 myces cerevisiae actin cables, which provide polarized tracks for intracellular transport and maintai
287          Deletion of FgMSB3 causes excessive polarized trafficking but blocks the fusion of FgSnc1-as
288 zation, the mechanisms of AIS stability, and polarized trafficking in neurons.
289 imulating factors, secreted by cancer cells, polarize tumor-associated macrophages (TAMs) to a tumori
290 cer cells secrete stimulating factors, which polarize tumor-associated macrophages from an antitumor
291 stitute the formation of cables that undergo polarized turnover and maintain steady-state lengths sim
292  of single redox DMPC liposome collisions at polarized UMEs was investigated under different experime
293 olayer transepithelial resistance, predicted polarized vascular endothelial growth factor (VEGF) secr
294          Rgd3 itself is localized to dynamic polarized vesicles that, while distinct from constitutiv
295 ly heavily on their uniquely distributed and polarized VIF network to enhance their transition from a
296 l self-assembled monolayer film that is spin-polarized, while the other two show that the chiral bias
297 lated mimetic construct is active and highly polarized, while the phospho-mimetic form is not.
298  high temporal resolution as macrophages are polarized with cytokines that drive them into "M1" and "
299 , cells within the vascular wall were planar polarized, with an integrin- and curvature-dependent axi
300 ypes that can be generated in vitro, and the polarized yet updateable group effector commitment often

 
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