ライフサイエンスコーパス: polo-like kinase 1

1 rder oligomers upon phosphorylation by PLK1 (Polo-like kinase 1).

2 lation of RAD51 by the key mitotic regulator Polo-like kinase 1.

3 al that is controlled by phosphorylation via Polo-like kinase 1.

4 nase 2 (Mst2) and Nek2A but does not involve polo-like kinase 1.

5 pericentriolar material proteins, including Polo-like kinase 1.

6 and a subsequent delay in the activation of polo-like kinase 1.

7 the CDH1 targets such as Aurora kinase A and Polo-like kinase 1.

8 For Polo-like kinase 1, 2, and 3, and their homologs, the en

9 Phosphorylated BLM interacts with polo-like kinase 1, a mitotic kinase that binds to phosp

10 P16 is also required for deubiquitination of Polo-like kinase 1, a mitotic master kinase, and the sub

11 we found that Chk2 coimmunoprecipitates with Polo-like kinase 1, a regulator of chromosome segregatio

12 bitors, small-molecule inhibitors (e.g., for Polo-like kinase 1 and aminopeptidase), inhibitors of mu

13 ociated with decreased protein levels of the Polo-like kinase 1 and Aurora B kinase, which phosphoryl

14 chromosome arms occurs under the control of Polo-like kinase 1 and Aurora B, while Shugoshin is thou

15 ition of two cell cycle-regulating proteins, polo-like kinase 1 and Aurora kinase A.

16 Nek6, as well as its upstream activators polo-like kinase 1 and Aurora-A, targeted Hsp72 to the p

17 lex dynamics are linked to the cell cycle by Polo-like kinase 1 and govern the movement of PAR protei

18 eport on a combination approach co-targeting polo-like kinase 1 and MEK in NRAS-mutant melanomas.

19 Our results show that dual inhibition of polo-like kinase 1 and RhoA/Rho kinase (ROCK) leads to t

20 Moreover, by cotargeting polo-like kinase 1 and vascular endothelial growth facto

21 egulators that control PCM assembly in vivo, Polo-like kinase-1 and SPD-2/Cep192.

22 mplementary regulators of cytokinesis: Plk1 (polo-like kinase 1) and Ect2 (epithelial cell-transforma

23 ammed to upregulate the mitotic kinase Plk1 (Polo-like kinase 1) and other M-phase cell-cycle protein

24 ALPNIDPPTVER) from CWPHs (P-4.3) identified Polo like kinase 1 as a potential target, which strongly

25 Here we identified PLK1 (Polo-like kinase 1) as a novel interaction partner of JL

26 ition, to inhibit the Gravin binding partner polo-like kinase 1 at spindle poles.

27 E), leading to impaired cytokinesis, loss of Polo-like kinase-1 at the midbody, and the accumulation

28 directed the disassembly of Shugoshins in a polo-like kinase 1-augmented manner, aiding centromere r

29 nd found frequent overexpression of securin, polo-like kinase 1, aurora A, and Skp2 in malignant tumo

30 els of the mitotic regulatory genes encoding polo-like kinase 1, aurora B kinase, and survivin, all o

31 ascular endothelial growth factor receptors, Polo-like kinase 1, Aurora B kinase, laminin alpha4 (Lam

32 r regions of several oncogenes such as PLK1 (Polo-like kinase 1), C-MYC, serine-threonine kinase BUB1

33 In this study, we have found that Plk1 (polo-like kinase 1) can phosphorylate MyoGEF, thereby re

34 nt CSF release, and is rapidly degraded in a Polo-like kinase 1-dependent manner in response to calci

35 Complexes assembled through a Polo-like kinase 1-dependent mechanism during extended m

36 Greatwall, and is mediated by Cdk-, but not Polo-like kinase 1-dependent phosphorylation.

37 Moreover, the inhibition of Polo-like-kinase 1 eliminates Yoda1-induced centriole di

38 a melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell d

39 Plk1 (Polo-like kinase 1) has been documented as a critical re

40 Polo-like kinase 1-interacting checkpoint helicase (PICH

41 We identified Polo-like kinase 1-interacting checkpoint helicase (PICH

42 Plk1 (Polo-like kinase 1) is a critical regulator of cell cycl

43 PLK1 (polo-like kinase 1) is a key mitotic kinase and a therap

44 PLK1, polo-like kinase 1, is a central player regulating mitos

45 y of Kindlin-1 to bind integrins but also on Polo-like kinase 1-mediated Kindlin-1 phosphorylation.

46 ond-line setting; new targets include CD105, polo-like kinase-1, phosphatidylinositide 3-kinases (PI3

47 ed with several small-molecule inhibitors of Polo-like Kinase 1 (PLK 1) (e.g., HMN-214 and BI 2536),

48 approach with experiments to understand how Polo-Like Kinase 1 (PLK-1) forms a cytoplasmic gradient

49 Here, we explore the role of Polo-like kinase 1 (PLK-1) in Caenorhabditiselegans oocy

50 Polo-like kinase 1 (PLK-1) is essential for both mitotic

51 human cells and Caenorhabditis elegans, the Polo-like kinase 1 (PLK-1) is recruited to the nuclear p

52 ted by multiple defense mechanisms including polo-like kinase 1 (Plk-1), protein kinase B (Akt-1), an

53 assembly is a stepwise process that involves Polo-like kinase 1 (PLK-1)-dependent and -independent st

54 During cytokinesis, polo-like kinase 1 (PLK1) activates the small GTPase Rho

55 hich coincides with higher cyclin B/CDK1 and Polo-like kinase 1 (PLK1) activities in an S-phase-enric

56 Cells lacking Polo-like kinase 1 (PLK1) activity suffer severe chromos

57 In this study, we show that Polo-like kinase 1 (Plk1) also phosphorylates key factor

58 ing we discover that centrosomal delivery of Polo-like kinase 1 (Plk1) and Aurora A (AurA) inhibitors

59 lysis, we show that two of these regulators, polo-like kinase 1 (Plk1) and Aurora A, are degraded at

60 t in genome instability; (4) upregulation of Polo-like kinase 1 (Plk1) and Aurora kinase A, important

61 Herein, we have identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as t

62 luding pituitary tumour transforming gene 1, Polo-like kinase 1 (PLK1) and Caveolin-2.

63 are associated with induction of the mitotic polo-like kinase 1 (Plk1) and down-regulation of the chr

64 altered network identified a central role of Polo-like kinase 1 (PLK1) and known PLK1 targets.

65 Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regu

66 have identified the serine/threonine kinase Polo-like kinase 1 (PLK1) as a host kinase that phosphor

67 Our previous studies identified polo-like kinase 1 (PLK1) as a major regulator of FoxM1b

68 We identified Polo-like kinase 1 (Plk1) as a parallel activator of cen

69 polo-box domain (PBD) of the mitotic kinase polo-like kinase 1 (Plk1) as a specific phosphoserine (p

70 Here, we identify Polo-like kinase 1 (PLK1) as an interactor and phosphata

71 cal library targeting kinases and identified Polo-like kinase 1 (PLK1) as one of the kinases involved

72 g a library targeting 720 kinases identified Polo-like kinase 1 (PLK1) as one of the top genes whose

73 lyses revealed a consistent up-regulation of polo-like kinase 1 (PLK1) as well as other genes control

74 emonstrate that PrimPol is phosphorylated by Polo-like kinase 1 (PLK1) at a conserved residue between

75 27 Thr186, to generate an anchoring site for polo-like kinase 1 (Plk1) at kinetochores.

76 sociates with Aurora kinase A (Aurora-A) and Polo-like kinase 1 (Plk1) at the centrosomes and spindle

77 Here, we report that in G2 phase polo-like kinase 1 (Plk1) can trigger centrosome separat

78 We demonstrate that Polo-like kinase 1 (Plk1) creates the 3F3/2 phosphoepito

79 We previously reported that polo-like kinase 1 (Plk1) depletion by lentivirus-based

80 e, Parkin is phosphorylated and activated by polo-like kinase 1 (Plk1) during mitosis.

81 s cohesin and how cohesin phosphorylation by polo-like kinase 1 (Plk1) enhances cleavage.

82 inking hyperactive PI3K to mis-regulation of Polo-like kinase 1 (Plk1) expression late in G2.

83 tudy, data revealed that mutant NRAS induced Polo-like kinase 1 (Plk1) expression, and pharmacologic

84 ragment of IKKbeta as substrate and purified Polo-like kinase 1 (Plk1) from HeLa cell extracts by sta

85 hosphatases are primarily required to remove Polo-like kinase 1 (PLK1) from the BUB complex, which ca

86 Polo-like kinase 1 (Plk1) functions as a key regulator o

87 Although polo-like kinase 1 (Plk1) has been implicated in centros

88 Polo-like kinase 1 (Plk1) has been shown to be a crucial

89 Polo-like kinase 1 (PLK1) has important functions in mai

90 We first assay the role of Polo-like kinase 1 (Plk1) in centriole elimination.

91 In this study, we investigated the role of polo-like kinase 1 (PLK1) in Cr(VI)-transformed (CrT) br

92 Although the involvement of polo-like kinase 1 (PLK1) in metabolic reprogramming fro

93 of the G2/M checkpoint and up-regulation of Polo-like kinase 1 (PLK1) in PDX.

94 roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1) in primary cilia disassembly.

95 Herein, we show pX activates Polo-like kinase 1 (Plk1) in the G(2) phase, thereby att

96 ever, we identified a site phosphorylated by Polo-like kinase 1 (PLK1) in the GRASP65 N-terminal doma

97 Here we explore the role of Polo-like kinase 1 (PLK1) in the pancreas using a pancre

98 f Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1.

99 efficacy and tolerability of onvansertib, a polo-like kinase 1 (PLK1) inhibitor, in combination with

100 Therefore, we studied the effect of polo-like kinase 1 (Plk1) inhibitors on prostate cancer

101 In a search for Polo-like kinase 1 (Plk1) interaction proteins, we have

102 Polo-like kinase 1 (Plk1) is a conserved serine/threonin

103 Polo-like kinase 1 (Plk1) is a critical regulator in man

104 Polo-like kinase 1 (PLK1) is a key cell cycle regulator

105 Polo-like kinase 1 (Plk1) is a key player in mitosis and

106 Polo-like kinase 1 (Plk1) is a key regulator of cell div

107 Polo-like kinase 1 (Plk1) is a key regulator of progress

108 Polo-like kinase 1 (Plk1) is a mitotic kinase that has b

109 Polo-like Kinase 1 (PLK1) is a serine/threonine protein

110 Polo-like kinase 1 (Plk1) is a serine/threonine-protein

111 Polo-like kinase 1 (Plk1) is a well-established mitotic

112 Polo-like kinase 1 (Plk1) is an attractive target for th

113 Polo-like kinase 1 (PLK1) is an essential cell-cycle reg

114 Polo-like kinase 1 (PLK1) is an evolutionarily conserved

115 Polo-like kinase 1 (Plk1) is an important regulator of t

116 Polo-like kinase 1 (PLK1) is an oncogenic kinase that co

117 The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinic

118 Polo-like kinase 1 (Plk1) is considered an attractive ta

119 Mammalian polo-like kinase 1 (Plk1) is critical for proper mitotic

120 The activity of polo-like kinase 1 (Plk1) is elevated in tissues and cel

121 As a key regulator of mitosis, Polo-like kinase 1 (Plk1) is essential for this attachme

122 The polo-box domain (PBD) of mammalian polo-like kinase 1 (Plk1) is essential in targeting its

123 Polo-like kinase 1 (Plk1) is instrumental for mitotic en

124 Increased abundance of polo-like kinase 1 (PLK1) is observed in various tumor t

125 We found that Polo-like kinase 1 (PLK1) is recruited into mitotic ripo

126 Polo-like kinase 1 (PLK1) is recruited to centrosomes an

127 However, we show here that Polo-like kinase 1 (Plk1) is required for endomitosis, a

128 Polo-like kinase 1 (Plk1) is required for multiple stage

129 Polo-like kinase 1 (Plk1) is required for the generation

130 Phosphorylation of cohesin subunit SA2 by polo-like kinase 1 (Plk1) is required for the removal of

131 We published previously that polo-like kinase 1 (Plk1) is upregulated in E6/E7-expres

132 sociated with an ATR-dependent inhibition of polo-like kinase 1 (Plk1) kinase activity and a decrease

133 veal that GOF mutant Shp2 hyperactivates the Polo-like kinase 1 (Plk1) kinase by enhancing c-Src kina

134 on of Cep55 was accompanied by repression of polo-like kinase 1 (Plk1) levels due to p53 induction.

135 ll, Shrestha et al. (2015) show that mitotic Polo-like kinase 1 (Plk1) links internalization of PCP p

136 Here we provide evidence that a mammalian polo-like kinase 1 (Plk1) localizes to mitotic spindles

137 We show that Prdx5 regulates DDR through (1) polo-like kinase 1 (Plk1) mediated phosphorylation of at

138 ll survival by increasing the active pool of Polo-like kinase 1 (PLK1) molecules.

139 study, we measured the impact of inhibiting polo-like kinase 1 (Plk1) on both dynein populations.

140 c6), a DNA replication initiation factor, by polo-like kinase 1 (Plk1) on the regulation of chromosom

141 urora A on threonine 288, phosphorylation of Polo-like kinase 1 (PLK1) on threonine 210, and phosphor

142 Polo-like kinase 1 (PLK1) participates in the HR process

143 RHINO accumulates in M phase, undergoes Polo-like kinase 1 (PLK1) phosphorylation, and interacts

144 Mammalian polo-like kinase 1 (Plk1) plays a pivotal role during M-

145 Polo-like kinase 1 (Plk1) plays a pivotal role in the re

146 Polo-like kinase 1 (Plk1) plays an important role in cel

147 Polo-like kinase 1 (Plk1) plays essential roles at multi

148 Polo-like kinase 1 (Plk1) plays pivotal roles in mitosis

149 Polo-like kinase 1 (Plk1) plays several roles in mitosis

150 anine nucleotide exchange factor (MyoGEF) by polo-like kinase 1 (Plk1) promotes the localization of M

151 Polo-like kinase 1 (PLK1) protects against genome instab

152 usefulness of this method by monitoring both Polo-like kinase 1 (Plk1) protein abundance in multiple

153 lymphomas exhibit nuclear expression of the polo-like kinase 1 (PLK1) protein, stabilizing MYC (alia

154 Mammalian polo-like kinase 1 (Plk1) rapidly accumulates at centros

155 59 in mitosis, that phosphorylation requires polo-like kinase 1 (PLK1) rather than DNA-PKcs, that SAF

156 Here, we report that the polo-like kinase 1 (PLK1) regulates BMI1 expression, and

157 We further show that polo-like kinase 1 (Plk1) regulates Nek2 phosphorylation

158 he existence of a MYC-protein kinase A (PKA)-polo-like kinase 1 (PLK1) signaling loop in cells.

159 h a G2/M cell cycle arrest via inhibition of polo-like kinase 1 (PLK1) signalling pathway and down-mo

160 iferation of MB by using Volasertib (VSB), a Polo-like kinase 1 (PLK1) specific inhibitor.

161 ously reported the phenotype of depletion of polo-like kinase 1 (Plk1) using RNA interference (RNAi)

162 Polo-like kinase 1 (PLK1) was found to be significantly

163 Polo-like kinase 1 (PLK1), a critical cell cycle regulat

164 on of Pten results in elevated expression of Polo-like kinase 1 (Plk1), a critical regulator of the c

165 One promising target is Polo-like kinase 1 (Plk1), a key regulator of the cell c

166 Our previous study revealed that Polo-like kinase 1 (PLK1), a serine/threonine kinase tha

167 Polo-like kinase 1 (Plk1), a serine/threonine protein ki

168 ay from APC/CCDH1, triggering proteolysis of polo-like kinase 1 (PLK1), a tumor suppressor and multit

169 Polo-like kinase 1 (PLK1), an essential regulator of cel

170 e protein expression of cathepsin E, maspin, polo-like kinase 1 (Plk1), and survivin in patients with

171 odazole-arrested HeLa cells was inhibited by Polo-like kinase 1 (Plk1), as suggested by the effects o

172 Disengagement requires the activity of Polo-like kinase 1 (Plk1), but how Plk1 drives this proc

173 tive PKD1 inhibition when compared with AKT, polo-like kinase 1 (PLK1), CDK activating kinase (CAK),

174 The mitotic kinase, polo-like kinase 1 (PLK1), facilitates the assembly of t

175 showed that Chk1 is a negative regulator of polo-like kinase 1 (Plk1), in either the absence or pres

176 Another serine/threonine kinase, polo-like kinase 1 (Plk1), is an important regulator of

177 se and promotes Aur-A-mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of

178 e we show that two mitotic kinases, Cdk1 and polo-like kinase 1 (Plk1), phosphorylate ECT2 in vitro.

179 Polo-like kinase 1 (Plk1), the best characterized member

180 Polo-like kinase 1 (Plk1), the best characterized Ser/Th

181 ties of Cyclin-dependent kinase 1 (CDK1) and Polo-like kinase 1 (PLK1), transitions through Anaphase-

182 t functions of a pleiotropic mitotic kinase, Polo-like kinase 1 (Plk1), via distinct thresholds of ki

183 hat cell-cycle-related genes, in particular, Polo-like kinase 1 (PLK1), were associated with disease

184 7, which in turn promotes the recruitment of Polo-like kinase 1 (Plk1), which is a critical regulator

185 Here, we report that Polo-like kinase 1 (Plk1), which is vital for cell proli

186 In a search for Polo-like kinase 1 (Plk1)-interacting proteins using a y

187 otein regulator of cytokinesis 1 (PRC1), and polo-like kinase 1 (PLK1).

188 this reduplication requires the activity of Polo-like kinase 1 (Plk1).

189 sion factor recruitment is controlled by the Polo-like kinase 1 (Plk1).

190 ns responsive to activation by overexpressed Polo-like kinase 1 (PLK1).

191 One of these genes is the mitotic kinase Polo-like kinase 1 (Plk1).

192 hat during mitosis, mammalian MYPT1 binds to polo-like kinase 1 (PLK1).

193 lating mitotic regulatory pathways including polo-like kinase 1 (Plk1).

194 y reported that wortmannin potently inhibits Polo-like kinase 1 (Plk1).

195 ntain "phosphorylation consensus motifs" for Polo-like kinase 1 (Plk1).

196 The direct target of the Chfr pathway is Polo-like kinase 1 (Plk1).

197 trate that phosphorylation is carried out by Polo-like kinase 1 (PLK1).

198 profile enriched in mitotic kinases such as polo-like kinase 1 (PLK1).

199 , we identified Numb as a novel substrate of Polo-like kinase 1 (Plk1).

200 sitive to inhibitors of G2/M kinases such as polo-like kinase 1 (PLK1).

201 er fertilization requires phosphorylation by Polo-like kinase 1 (Plk1).

202 which are acutely sensitive to inhibition of Polo-like kinase 1 (Plk1).

203 phorylates NPM1 at Ser-4, a site shared with polo-like kinase 1 (PLK1).

204 iscovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1).

205 controls mitosis, apparently by antagonizing polo-like kinase 1 (PLK1).

206 revealed that the Aurora A kinase (Aurora A)/Polo-like kinase 1 (PLK1)/cyclin-dependent kinase 1 (CDK

207 A gating mechanism dependent on polo-like kinase-1 (PLK1) activity underlies this hetero

208 Reduction of polo-like kinase-1 (Plk1) at kinetochores as cells progr

209 Polo-like kinase-1 (Plk1) is a highly conserved kinase w

210 Polo-like kinase-1 (Plk1) phosphorylates a number of mit

211 Polo-like kinase-1 (PLK1) plays a major role in driving

212 Small-molecule inhibitors for one target, Polo-like kinase-1 (PLK1), are already in clinical trial

213 ort that inhibitors of the mitotic regulator polo-like kinase-1 (Plk1), including the clinically acti

214 including cullin 1, beta-TrCP, Aurora A, and Polo-like kinase-1 (PLK1).

215 ein, we identified cellular serine/threonine Polo-like-kinase 1 (PLK1) as a positive effector of HBV

216 The Xenopus polo-like kinase 1 (Plx1) is essential during mitosis fo

217 Xenopus polo-like kinase 1 (Plx1) is required for activation of

218 protein by polo-like kinase 1/Xenopus laevis polo-like kinase 1 (Plx1) on kinetochores lacking tensio

219 During mitosis the Xenopus polo-like kinase 1 (Plx1) plays key roles in the activat

220 nt kinase 1 activity, cyclin B1 protein, and Polo-like kinase 1 protein turnover remained intact when

221 e and especially cyclin B--Cdc2, but not the polo-like kinase 1, remove cyclin E--Cdk2 from chromatin

222 antly occurs upstream of Aurora A kinase and Polo-like kinase 1, resulting in a failure to remove the

223 we provide evidence that disruption of local polo-like kinase 1 signaling underlies the gamma-tubulin

224 Moreover, the delivery of siRNA targeting polo-like kinase 1 (siPLK1) efficiently silenced PLK1 ex

225 eins securin, cyclin B, aurora A kinase, and polo-like kinase 1, the anaphase promoting complex/cyclo

226 214 coordinates deubiquitination of uH2A and Polo-like kinase 1, thus ensuring proper cell cycle prog

227 otic regulators (such as Aurora B kinase and polo-like kinase 1) was remarkably reduced in Yap-KO mic

228 n-dependent kinase 1 (Cdk1) or Plx1 (Xenopus polo-like kinase 1), whereas depletion of Gwl from extra

229 iole over-elongation is dependent on mitotic Polo-like kinase 1, which we uncover as a novel regulato

230 the phosphorylation of an unknown protein by polo-like kinase 1/Xenopus laevis polo-like kinase 1 (Pl