ライフサイエンスコーパス: polyadenylation factor

1 polyadenylation factors of CPF (cleavage and polyadenylation factor).

2 racts with FY, a highly conserved eukaryotic polyadenylation factor.

3 K1) identified PTI1, a potential 3' cleavage/polyadenylation factor.

4 this pattern with that of known splicing and polyadenylation factors.

5 cleavage complex (HCC) consisting of several polyadenylation factors.

6 the function of SSUP-72 and several nuclear polyadenylation factors.

7 and can be co-immunoprecipitated with other polyadenylation factors.

8 ed with gene 3' ends to recruit cleavage and polyadenylation factors.

9 hree distinct hubs involving the Arabidopsis polyadenylation factors.

10 sequence signals in pre-mRNA and a group of polyadenylation factors.

11 S4 forms a complex in vivo with FY and other polyadenylation factors.

12 ently requires a poly(A) signal and cleavage/polyadenylation factors.

13 -containing RNA binding protein, kinetoplast polyadenylation factor 3 (KPAF3), and demonstrate its ro

14 slinking patterns of multiple elongation and polyadenylation factors across transcribed genes.

15 Ser-2 carboxyl-terminal phosphorylation, and polyadenylation factor additions to RNA polymerase II.

16 Knockdown of polyadenylation factors also prevented nuclear localisat

17 in immunoprecipitation experiments show that polyadenylation factors and Rat1 localize to snoRNA gene

18 ivities of either generic or tissue-specific polyadenylation factors and/or splicing factors.

19 independently of THO, Sub2, or cleavage and polyadenylation factors, and enhances mRNA export via TR

20 sing of EBV pol RNA by cellular cleavage and polyadenylation factors appears to be compensated for an

21 The same polyadenylation factors are associated with the endogeno

22 Polyadenylation factors are co-transcriptionally recruit

23 This is supported by the finding that polyadenylation factors are required for inflammation in

24 Our identification of two key polyadenylation factors as SUMO targets and of the role

25 , our results implicate CstF64, an essential polyadenylation factor, as a master regulator of 3'-UTR

26 e U7 snRNP, and suggest that in animal cells polyadenylation factors assemble into two alternative co

27 These findings suggest that polyadenylation factors can be recruited to an RNA 3'-pr

28 sable for Yra1 recruitment, but the cleavage/polyadenylation factor, CF1A, is required.

29 Polyadenylation factor CLP1 is essential for mRNA 3'-end

30 eraction of Srb5/Med18 with the cleavage and polyadenylation factor complex, however, could be detect

31 multiple components of the CPF (cleavage and polyadenylation factor) complex involved in messenger RN

32 The primary structure of the human CstF-64 polyadenylation factor contains 12 nearly identical repe

33 sion of FIP1L1, one of the core cleavage and polyadenylation factors, correlated with the degree of A

34 on the roles played by general cleavage and polyadenylation factors (CPA factors).

35 cture, but which do not bind the CPE-binding polyadenylation factor CPEB, failed to induce unmasking.

36 o very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which

37 to RNA 3' end processing by the cleavage and polyadenylation factor (CPF or CPSF).

38 revisiae Pta1 is a component of the cleavage/polyadenylation factor (CPF) 3'-end processing complex a

39 hat Ssu72, a component of the yeast cleavage/polyadenylation factor (CPF) complex, is a CTD phosphata

40 e low-abundance subunits of the cleavage and polyadenylation factor (CPF) complex.

41 ity factor (CPSF) in humans, or cleavage and polyadenylation factor (CPF) in yeast, coordinates these

42 when both PABPs are absent, the cleavage and polyadenylation factor (CPF) limits pA tail synthesis.

43 factor Ssu72 is a component of the cleavage/polyadenylation factor (CPF) of Saccharomyces cerevisiae

44 y loss-of-function mutations in cleavage and polyadenylation factor (CPF) subunits and termination fa

45 per se is lethal in the absence of cleavage-polyadenylation factor (CPF) subunits Ppn1 and Swd22 and

46 ho1 de-repression by IP8 depends on cleavage-polyadenylation factor (CPF) subunits, termination facto

47 e show that Clp1 interacts with the Cleavage-Polyadenylation Factor (CPF) through its N-terminal and

48 tase Glc7 associates with the yeast cleavage/polyadenylation factor (CPF), but the role of Glc7 in 3'

49 Yth1, a subunit of yeast Cleavage Polyadenylation Factor (CPF), contains five CCCH zinc fi

50 y the 1-megadalton multiprotein cleavage and polyadenylation factor (CPF).

51 Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein com

52 Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein comp

53 olytic cleavage is catalyzed by the cleavage/polyadenylation factor CPSF-73.

54 th morpholino technology or silencing of the polyadenylation factor CPSF1 caused a splice switch that

55 c post-mortem controls were analysed for the polyadenylation factor CPSF4 and inflammatory markers.

56 ng a truncated form of the mRNA cleavage and polyadenylation factor CPSF6, the completion of HIV-1 ve

57 Furthermore, the polyadenylation factor CPSF73 is not effectively recruit

58 mRNA cap methyltransferase and the Hrp1/CFIB polyadenylation factor cross-link to both promoter and c

59 In a complementary pattern, polyadenylation factors crosslink strongly at the 3' end

60 equences or the Rna14 protein causes loss of polyadenylation factor crosslinking and read-through of

61 The mRNA polyadenylation factor CstF interacts with the BRCA1-ass

62 quences are recognized by the heterotrimeric polyadenylation factor CstF, although how, and indeed if

63 We next show that the polyadenylation factor CstF, plays a direct role in the

64 ELL2 and the polyadenylation factor CstF-64 tracked together with RNA

65 n to identify factors that interact with the polyadenylation factor CstF-64, we uncovered an interact

66 including an association of PAF1-C with the polyadenylation factor CstF.

67 , a protein known to form a complex with the polyadenylation factors CstF and CPSF.

68 accumulation of one subunit of an essential polyadenylation factor (CstF-64) is specifically repress

69 Here a polyadenylation factor, CstF-50 (cleavage stimulation fa

70 factor, PC4 (or Sub1 in yeast), and an mRNA polyadenylation factor, CstF-64 (Rna15 in yeast), and pr

71 -PCR profiling identified elevated levels of polyadenylation factor CSTF3 in tumors with APA.

72 ges induced nuclear localisation of NFkB and polyadenylation factors, effects inhibited by cordycepin

73 ey recruit the endonuclease CPSF73 and other polyadenylation factors, forming catalytically active ho

74 stone pre-mRNA processing in the presence of polyadenylation factors from nuclear extracts.

75 The cleavage/polyadenylation factor I (CF I) is one of four factors r

76 ur factors [cleavage factor I (CF I), CF II, polyadenylation factor I (PF I), and poly(A) polymerase

77 n four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1).

78 The interaction of the Fip1 subunit of polyadenylation factor I with the Saccharomyces cerevisi

79 for specific polyadenylation when mixed with polyadenylation factor I, purified poly(A) polymerase, a

80 p1, CF II, and the Fip1 and Yth1 subunits of polyadenylation factor I.

81 s of cleavage factor IA (CFIA), an essential polyadenylation factor in Saccahromyces cerevisiae.

82 pe1 is involved in contact with the cleavage/polyadenylation factor in which Mpe1 resides.

83 The increased expression of polyadenylation factors in OA synovia indicates a new ta

84 nt (PEE), promoting the recruitment of other polyadenylation factors in yeast.

85 tone cleavage complex (HCC), and a subset of polyadenylation factors including the endonuclease CPSF7

86 Given evidence that certain polyadenylation factors, including Rna15p, are necessary

87 ever, also increases the affinity of general polyadenylation factors independently for the C2 poly(A)

88 y pentatricopeptide repeat (PPR) Kinetoplast Polyadenylation Factors (KPAFs).

89 t-translational modifications of splicing or polyadenylation factors, leading to splicing events that

90 lex that exploits Pab1p to link cleavage and polyadenylation factors of CFIA and CFIB (cleavage facto

91 and CFIB (cleavage factors IA and IB) to the polyadenylation factors of CPF (cleavage and polyadenyla

92 physically interacting with the cleavage and polyadenylation factor or cleavage factor 1 (CF1) comple

93 Depletion of cleavage and polyadenylation factors or of histone pre-mRNA processin

94 iated via THO and Sub2 of TREX, cleavage and polyadenylation factors, or Sus1 (that regulates mRNA ex

95 Surprisingly, polyadenylation factors promote RNP coassembly in vivo,

96 4 (PCFS4), an Arabidopsis homologue of yeast polyadenylation factor Protein 1 of Cleavage Factor 1 (P

97 Interestingly, levels of the polyadenylation factor Pta1 are also reduced in kin28 mu

98 While certain cleavage and polyadenylation factors remain Pol II associated, Integr

99 educed in kin28 mutants, while several other polyadenylation factors remain stable.

100 ot inhibited by mutations in 3'-cleavage and polyadenylation factors, Rna14, Rna15 and Pap1, which bl

101 naffected, but cross-linking of the cleavage-polyadenylation factors Rna15 and Pta1 toward the 3' end

102 ired for the recruitment of the cleavage and polyadenylation factor Rna15p.

103 ns even under conditions in which functional polyadenylation factors should be in excess.

104 Genes that encode key polyadenylation factors showed differential expression p

105 p binding protein, SR proteins, cleavage and polyadenylation factors, small nucleolar RNAs, nucleolar

106 CITY FACTOR30 (CPSF30) gene, which encodes a polyadenylation factor subunit homolog.

107 ks between PAP and several other Arabidopsis polyadenylation factor subunit homologs.

108 The N-terminal domain of another Arabidopsis polyadenylation factor subunit, AtFip1(V), dramatically

109 utants are suppressed by loss of function in Polyadenylation factor subunit-2 (PFS-2), a conserved WD

110 eins that are similar to mammalian and yeast polyadenylation factor subunits.

111 of this intronic PAS depends on the nuclear polyadenylation factor SYDN-1, which inhibits the RNA po

112 ghtly interacts with a unique combination of polyadenylation factors: symplekin, CstF64, and all CPSF

113 an effect on the efficiency of binding of a polyadenylation factor to an alternative polyadenylation

114 er, in ctk1Delta strains, the recruitment of polyadenylation factors to 3' regions of genes is disrup

115 unstructured domain which allows the general polyadenylation factors to efficiently assemble on the R

116 tion functions as a mechanism for recruiting polyadenylation factors to HSP genes to enhance the effi

117 ese results suggest that ubH2B helps recruit polyadenylation factors to STAT1-activated genes.

118 e inflammatory transcription factor NFkB and polyadenylation factors (WDR33 and CPSF4).

119 ecause FY has been shown to have homology to polyadenylation factors, we examined polyadenylation sit

120 quence homology search using human and yeast polyadenylation factors, we identified 28 proteins that

121 ases (CCNT2 and HEXIM1); mRNA processing and polyadenylation factors were also highlighted (HNRNPL/F,

122 n; beta(2) microglobulin; and a cleavage and polyadenylation factor) were identified as zinc-modulate

123 yer regulatory mechanisms controlling fungal polyadenylation factors, which have profound implication

124 onucleoprotein particle (snRNP) and cleavage/polyadenylation factors, which, in turn, cooperatively r