ライフサイエンスコーパス: polyanion

1 a-tryptase, and the beta-tryptase-activating polyanion.

2 copurified lipid molecules, and a synthetic polyanion.

3 dependent on the net charge and size of the polyanion.

4 s intimate that NTHi P5 is associated with a polyanion.

5 10.3, and consistent with the inclusion of a polyanion.

6 e delta-isomer of the Keggin polyoxometalate polyanion.

7 ess and overall polarity of the triphosphate polyanion.

8 tively charged Tau is condensed by cytosolic polyanions.

9 filtration chromatography in the absence of polyanions.

10 hexakisphosphate is supplemented with other polyanions.

11 occupied ER from the nucleus compared to the polyanions.

12 an autocatalytic process requiring accessory polyanions.

13 of cell wall (dltA) and cell membrane (mprF) polyanions.

14 viously observed structural stabilization by polyanions.

15 direct binding of PEDF to glycosaminoglycans/polyanions.

16 to interact with various glycosaminoglycans/polyanions.

17 nhibited by divalent cation-chelators and by polyanions.

18 in 4-sulfate and dermatan sulfate as the GAG polyanions.

19 the presence of PF4 or DNA and polyphosphate polyanions.

20 roteins, prions bind nucleic acids and other polyanions.

21 ) is used as the recognition element for the polyanions.

22 line-earth, and rare-earth elements, and Sb4 polyanions.

23 concentration and the charge density of the polyanions.

24 ring anti-HIV activities with those of other polyanions.

25 conformational changes when complexing with polyanions.

26 oxidative damage, and host surface-specific polyanions.

27 s a slow reaction that can be accelerated by polyanions.

28 immunogenic complexes with heparin and other polyanions.

29 reduced activity and decreased activation by polyanions.

30 ies in the absence of nucleic acids or other polyanions.

31 W9O34)2].35H2O (Na101-V2, sodium salt of the polyanion 1-V2), was synthesized, thoroughly characteriz

32 301S tau is sensitive to a greater number of polyanions (28/37) than WT tau (21/37).

33 igated the interaction between five cellular polyanions (actin, tubulin, heparin, heparan sulfate, an

34 Polyanions activate IDE toward some substrates, yet an e

35 ey residue required for maximal activity and polyanion activation, although other cysteines affect po

36 residue also reduced activity and decreased polyanion activation.

37 states of the dimer that affect activity and polyanion activation.

38 DE toward some substrates, yet an endogenous polyanion activator has not yet been identified.

39 Polyanions also interfere with substrate ubiquitylation.

40 ized silica gel particles were coated with a polyanion and a polycation bearing thymine chromophores.

41 tor H where previous reports have identified polyanion and C3b-binding sites.

42 tocatalytic method composed of decatungstate polyanion and disulfide cocatalysts, which enable the in

43 existence of positional correlations between polyanion and polycation charges has not been confirmed

44 ed a monomer Mr of 163,000 in the absence of polyanions and a Mr of 607,000, corresponding to a tetra

45 f listing PABPs by the number of interacting polyanions and a string search for author surnames.

46 of the abundance and stability of cytosolic polyanions and an underestimation of crucial intracellul

47 Herein, locations of binding sites for polyanions and C3b are reexamined rigorously by overexpr

48 the TFIIIB-DNA complex and its resistance to polyanions and high salt.

49 the complex and dynamic interactions between polyanions and Lipoplex, and the use of QP modeling to d

50 roved stability in the presence of competing polyanions and nuclease protection in serum relative to

51 were assembled by sequentially chemisorbing polyanions and polycations on miniature (5 x 10(-4) cm2)

52 can be used to deposit alternating layers of polyanions and polycations on the surface surrounding th

53 Over a thousand combinations of polyanions and polycations were tested to search for new

54 Coulomb repulsions between the fragments of polyanions and their attractions to polycations, is even

55 interactions with surface-associated C3b or polyanions and thereby diminish the ability of fH to reg

56 ment in the detection limits toward heparin (polyanion) and protamine (polycation) of at least 1 orde

57 oltage-dependent anion channel (VDAC), Konig polyanion, and 4,4'-diisothiocyanatostilbene-2,2'-disulf

58 types of molecule, including carbohydrates, polyanions, and lipids.

59 PrP binds to polyanions, and RNAs were shown to promote the conversio

60 protein-protein interactions, recognition of polyanions, and the role of HK and Zn2+ in contact syste

61 oantibodies including anti-platelet factor 4/polyanion (anti-PF4/P), anti-phospholipid, anti-phosphat

62 ptamers has the potential to induce anti-PF4/polyanion antibodies and a prothrombotic diathesis.

63 We determined the frequency of anti-PF4/polyanion antibodies in healthy vaccinees and assessed w

64 81 participants tested positive for anti-PF4/polyanion antibodies postvaccination (All: 6.8% [95% con

65 Presented are serial anti-PF4/polyanion antibody, platelet, and D-dimer measurements i

66 nvironmental cofactors such as metal ions or polyanions are observed in association with regions of s

67 Yet the counterions for these polycations or polyanions are often ignored, even though they are imper

68 r of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3

69 This polyanion, as the dimethylammonium salt, shows a thermal

70 imited attention due in part to their strong polyanion association, which impedes intracellular polya

71 rubin oxidase from Myrothecium verrucaria, a polyanion at pH >4.1, and the polycationic redox copolym

72 result from a failure of FH to interact with polyanions at cell surfaces in the kidney.

73 both polycations at levels >/=10 mug/mL and polyanions at levels of >/=40 mug/mL by changing the dir

74 nal change resulting in the shielding of the polyanion backbone; this was monitored by a change in th

75 of [K(crypt-222)](+) salts of novel Bi-rich polyanions [Bi@Ga(8)(Bi(2))(6)](q-) (q = 3, 5; in 1), (G

76 ntents exceed that of the largest homoatomic polyanion, Bi(11)(3-).

77 These polyanions bind to the film not only electrostatically b

78 a and the amino acids of PF4 contributing to polyanion binding are highly conserved, our results furt

79 pressed fragment encompassing the C-terminal polyanion binding site (complement control protein domai

80 activation, although other cysteines affect polyanion binding to a lesser extent.

81 wed the conformer specificity of the protein-polyanion binding to be monitored.

82 rstanding of the structural requirements for polyanion binding to dengue virus envelope protein has b

83 nanostructures can exhibit enantioselective polyanion binding.

84 he interactions between polyanions (PAs) and polyanion-binding proteins (PABPs) have been found to pl

85 We demonstrate that a large number of polyanion-binding proteins exist that contain multiple p

86 ature of cellular interiors, we propose that polyanion-binding proteins interact with a wide variety

87 InsPs and PtdInsPs interact with the polyanion-binding site located on an inner chamber wall

88 theory simulations, we found that Ga(F,X)(n) polyanions boost Li(+)-ion transport by weakening Li(+)-

89 nmodified Tau that is condensed by cytosolic polyanions but negatively charged, hyperphosphorylated T

90 molecular weight dextran sulfate and heparin polyanions, but also was produced by beta-tryptase tetra

91 e cations that are attracted to nucleic acid polyanions, but have also showed that anions are exclude

92 platelet factor 4 (PF4) and heparin or other polyanions, but the risk of thrombosis extends beyond ex

93 ain value and that the substitution of PO(4) polyanions by SiO(4) also enhances the ionic conductivit

94 These longer polyanions can also induce PF4 dimer assembly when bound

95 Heparin and other polyanions can neutralize histones but challenges with d

96 Here we show that interaction with polyanions causes self-association forming tetramers of

97 is primarily electrostatic, because DNA-like polyanion chains (e.g. heparin and polyglutamate) can me

98 ls to deliver messenger RNA (mRNA) and other polyanions (circRNA, saRNA, pDNA, CRISPR-Cas, reprogramm

99 mmetric polyelectrolyte mixtures: polycation-polyanion complexation and polyion pair-pair condensatio

100 IgG/PF4/polyanion complexes directly activate platelets via Fc g

101 nce of antibodies to platelet factor 4 (PF4)-polyanion complexes using a clinically validated immunoa

102 sed by immunoglobulin G directed against PF4/polyanion complexes.

103 gh levels of antibodies to platelet factor 4-polyanion complexes; however, they had had no previous e

104 Exploring polyanion compounds with high theoretical capacity such

105 be detected in heparin at only 2-mg/mL total polyanion concentration with a linear response (R(2) = 0

106 These contain the largest known discrete polyanion consisting only of main-group elements.

107 High charge-density polyanion contaminants and impurities in heparin can be

108 Current polyanion delivery relies heavily on cationic amines, wh

109 fects of the polyene antibiotic MS-8209, the polyanion dextran sulfate 500 (DS500), and Congo red wer

110 ling evidence that factor XIa binding to the polyanions, dextran sulfate and heparin, results in inhi

111 Here, by using polycation- and polyanion-directed intrafibrillar mineralization, we cha

112 r PrP(Sc) propagation, RNA and several other polyanions do not promote the propagation of mouse and v

113 chemoresistance gene survivin and two model polyanion drugs (suramin, heparin).

114 e contributions of three mechanisms by which polyanion drugs reduced the gene silencing activity of L

115 the concentrations used, excluding a general polyanion effect.

116 Accordingly, low-titer positive PF4/polyanion EIA results should be interpreted with caution

117 reference range, <0.50), and none of the PF4/polyanion EIA+ samples induced platelet activation in th

118 n healthy vaccinees and assessed whether PF4/polyanion EIA+ sera exhibit platelet-activating properti

119 We conclude that positive PF4/polyanion EIAs can occur after severe acute respiratory

120 atients that tested strongly positive in PF4-polyanion ELISA but were not platelet-activating.

121 honey with essential oils nanoemulsions as a polyanion) employing the Layer-by-Layer assembly techniq

122 strongly positive in platelet factor 4 (PF4)/polyanion enzyme immunoassays (EIAs), and serum-induced

123 cination who tested strongly positive by PF4/polyanion enzyme-immunoassays and negative/weakly positi

124 Technically simple platelet factor 4 (PF4)-polyanion enzyme-linked immunosorbent assays (ELISAs) ar

125 cts, but the mechanisms by which this simple polyanion exerts its effects remain unclear.

126 ored with an additive of inorganic Se(8)(2-) polyanion, fabricating the designed topologies.

127 ough an assembly of cubic octameric Q(3) (8) polyanions formed through cross-linking and polymerizati

128 We find that polyanions from many different structural classes can pr

129 the membrane to cause the extraction of the polyanions from the sample into the membrane and potenti

130 = 4.97-5.30 A) and feature a two-dimensional polyanion [GaEH](2-) that corresponds to a corrugated he

131 Polyanions [GaEH](2-) are electron precise, and the hydr

132 We find that water-soluble polyanions generally accelerate the polymerization.

133 eases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids.

134 ned by the choice of transition metal and/or polyanion group in the structure.

135 s C, but appears nevertheless facilitated by polyanion (H(2)PO(4)(-)) group reorientation.

136 hat the remarkable properties of Poly P as a polyanion have made it suited for a crucial role in the

137 Polyanions have been reported to induce tau aggregation

138 Interestingly, binding of the polyanion heparin also leads to release of the C terminu

139 asminogen, as addition of excess NaCl or the polyanion heparin did not have any significant effect on

140 cting agents, cyclodextrin and nystatin, and polyanion heparin significantly inhibited virus entry.

141 pulations when either nonspecific DNA or the polyanion heparin was used.

142 ts competition by high concentrations of the polyanion heparin.

143 e residues of FH19-20, and competed with the polyanions heparin and DNA.

144 Further, an analogous polyanion (heparin)-sensitive electrode is used to estim

145 stries, including chalcogenides, oxides, and polyanions, highlighting merits and challenges of each c

146 ably layered with four biologically relevant polyanions: hyaluronate (HA), poly-L-aspartate (PLD), po

147 ion and manipulation of this highly reactive polyanion in water is controlled exclusively by its coun

148 There are dozens of polyanions in living systems, and it is not clear which

149 host was observed to strongly bind aromatic polyanions in water, including the fluorescent dye molec

150 These polyanions include heparan sulfate (HS), a glycosaminogl

151 receptors (SR-AI/II) recognize a variety of polyanions including bacterial cell wall products such a

152 nomenon by studying the ability of different polyanions, including DNA, ATP, heparin, and heparan sul

153 stingly, capsid reassembly can be induced by polyanions, including oligonucleotides, poly-glutamic ac

154 High molecular weight polyanions increased degradation of these anaphylatoxins

155 tween VP22.C1 and divalent cations and model polyanions indicate that Mg(2+), Zn(2+), oligonucleotide

156 Polyanion-induced amyloid fibrillation has been implicat

157 ation, reduced cell binding, and a defect in polyanion-induced nonfusogenic dissolution.

158 ontrol protein domains 18-20) also exhibited polyanion-induced self-association, suggesting that the

159 of the chemokine platelet factor 4 (PF4) to polyanions induces heparin-induced thrombocytopenia, a p

160 Finally, the identity of the polyanion influences fibril morphology based on electron

161 These observations suggest that sulfated polyanions inhibit the invasion of erythrocytes by meroz

162 ards polyP inhibition, termed macromolecular polyanion inhibitors (MPI), with high binding affinity a

163 s antiviral activity and that it, like other polyanions, inhibits virus attachment.

164 The cellular polyanion inositol hexakisphosphate (IP(6)) binds to a p

165 The cellular polyanion inositol hexakisphosphate (IP6) has recently b

166 c head groups are bound identically by these polyanions, irrespective of chirality.

167 A large-molecular-weight polyanion is found to possess lubricating properties for

168 The exact structure of polyanions is not important for in vitro capsid reassemb

169 des is functionally similar to that of other polyanions, is dependent on RSV G, and does not specific

170 s of all reactant moieties, the [Nb6O19](8-) polyanion, its Cs(+) counterions, and the DMMP substrate

171 ago assay had persistently positive anti-PF4/polyanion levels 100 days' postdiagnosis, whereas 94% of

172 of plasma exchange seemed to reduce anti-PF4/polyanion levels and increase platelet counts in the acu

173 Interaction with cell-surface polyanions like heparin is centrally important in the fu

174 2)K(2)[(MesCu)(2)Ge(4)](NH(3))(7.5) with the polyanion [(MesCu)(2)Ge(4)](4-).

175 However, the effect of polyanion mixing on the ion-transport properties is stil

176 NASICON electrolyte to elucidate the role of polyanion mixing on the Na-ion transport properties.

177 ules in a purified system requires accessory polyanion molecules.

178 stom searches via four menus: protein names, polyanion names, the source species of the proteins and

179 ted with the presence of antibodies to a PF4/polyanion neoepitope and measured by using enzyme-linked

180 Preyssler polyanions of general formula [LnP(5)W(30)O(110)](12-) (

181 y substrate blocks the inhibitory effects of polyanions on activator binding and APC/C activity.

182 ng and inhibitory effects of polycations and polyanions on HIV-1 infection are largely dependent on t

183 potential role for postattachment effects of polyanions on RSV entry.

184 The effects of several polyanions on the hydrolysis of the chromogenic substrat

185 investigated the impact of the four surface polyanions on the transfection and uptake of mRNA- and p

186 ysiological ionic strength in the absence of polyanions; only monomeric species are observed, and the

187 er diffusely associated with the RNase P RNA polyanion or required for binding mature tRNA(Asp).

188 that cofactors such as nucleic acids, other polyanions, or lipids are non-obligatory for prion prote

189 Polycation/polyanion pairs are tested for coacervation, and resulti

190 The interactions between polyanions (PAs) and polyanion-binding proteins (PABPs)

191 d on proteolytic digestion of protamine, and polyanions (pentosan polysulfate and heparin) based on t

192 ight also find a role in management of other polyanion PF4-antibody-mediated conditions, including va

193 Polyanion phosphate based Li(3)V(2)(PO(4))(3) material h

194 al and synergistic action of a decatungstate polyanion photocatalyst and cobaloxime co-catalyst to st

195 Blending the weak polyanion poly(acrylic acid), PAA, with the strong polya

196 ion poly(acrylic acid), PAA, with the strong polyanion poly(styrene sulfonate), PSS, to layer alterna

197 vely charged microdomains of the avidin, two polyanions, poly(acrylic acid-co-maleic acid) and poly(a

198 l activity of tPMP was also inhibited by the polyanions polyanetholsulfonic acid and polyaspartic aci

199 electron- electron repulsion present in the polyanion polyradicals.

200 We also find that some polyanions preferentially reduce the lag time of the agg

201 rochemistry, we find that binding of the DNA polyanion promotes a negative shift in [4Fe4S] cluster p

202 c liquid and magnetically oriented rigid-rod polyanion provides widely tunable properties for use in

203 Planar potentiometric polycation and polyanion PSEs are prepared by incorporating tridodecylm

204 tions of the C-terminal domains prevent host polyanion recognition.

205 ion association, which impedes intracellular polyanion release.

206 tion is unlikely since the concentrations of polyanions required for inhibition of small peptide hydr

207 nd succinylated PLL (SPLL) as polycation and polyanion, respectively, we demonstrated layer-by-layer

208 In contrast, at acidic pH addition of a polyanion resurrects enzyme activity.

209 via CCPs 1-4, CCPs 6-8 and CCPs 19-20, with polyanion-rich host surfaces that bear covalently attach

210 cement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g

211 to the rotor phase is indeed uncoupled from polyanion rotations at high temperatures.

212 The polyanion scattering functions exhibit a peak at the inv

213 e-activity relationships, the valency of the polyanion seems to be an important chemical feature such

214 on a reversible pulsed chronopotentiometric polyanion-selective membrane electrode for the detection

215 Lastly, it is shown that plasticizer-free polyanion-sensitive optodes based on an adsorbed layer o

216 Bismuth-rich polyanions show a unique potential in constructing nanos

217 lyphosphate (polyP), a universally conserved polyanion, significantly accelerates alpha-Synuclein fib

218 ot due to binding of either substrate by the polyanions since only a decrease in V(max) without any e

219 A combination of polyanion size and charge allows the Keggin-type polyoxo

220 Here, we show that the presence of polyanions (SO4(2-) and HPO4(2-)) or lipids in the form

221 The polyanion, sodium poly(7-oxanorbornene-2-carboxylate), i

222 Lithium and sodium (Na) mixed polyanion solid electrolytes for all-solid-state batteri

223 ecent studies demonstrating that this simple polyanion stabilizes protein folding intermediates and s

224 , the chemically generated radical anion and polyanion states, Xn-Hex(*-) and Xn-Hex(n(*-)), respecti

225 oncentration without interference from other polyanions such as alginate, gum arabic and starch.

226 mulated in its utilization of UDP-glucose by polyanions such as heparin, the recombinant enzyme was s

227 sociation is stimulated by abundant cellular polyanions such as nucleic acids and polyphosphate.

228 Polyanions such as nucleoside phosphates or oligomers of

229 ies have shown that the co-administration of polyanions such as poly-L-aspartic acid (PAA) can both r

230 Polyanions such as polyglutamate and double-stranded and

231 flakes, Ti(3) C(2) T(z) and V(2) CT(z) , by polyanions such as polyphosphates, polysilicates or poly

232 issues upon association with C3b and surface polyanions such as sialic acids, heparin, and other glyc

233 ules of cationic platelet factor 4 (PF4) and polyanions such as unfractionated heparin (UFH) that bin

234 ssed on myeloid cells 2 (TREM2), which binds polyanions, such as dextran sulphate and bacterial LPS,

235 A) and poly(dT), as well as non-nucleic acid polyanions, such as heparan sulfate proteoglycan.

236 ich bind platelet factor 4 (PF4) modified by polyanions, such as heparin (H).

237 ve overall charge and is highly soluble; so, polyanions, such as heparin, are typically required to p

238 lease II (EC 3.1.22.1), by glycosaminoglycan polyanions, such as heparin, chondroitin 4-sulfate, and

239 of the gp120 which is known to interact with polyanions, such as phosphorothioate oligodeoxynucleotid

240 It is demonstrated how a polyanion supporting electrolyte in concert with a conju

241 These activities can be inhibited by the polyanion suramin in a rapidly reversible manner.

242 dramatically facilitated by relatively short polyanions (synthetic heparin-mimetic pentasaccharide),

243 ts provide insights into the crucial role of polyanion-tau interactions in modulating tau conformatio

244 Like DNA, SPS is a high-molecular-weight polyanion that is soluble in water but insoluble in alco

245 ure consists of isolated [CuB(4)O(10)](6)(-) polyanions that are bridged by six LiO(4) tetrahedra.

246 sulfate (OSCS) and other high charge-density polyanions that could potentially be used to adulterate

247 tron-accepting molecule inside the solid, a 'polyanion', that fills its available energy states with

248 Moreover, in the presence of a polyanion the fluorophore was far more resistant to quen

249 In the presence of species that bind these polyanions, the activity of the enzyme is regained in an

250 After conversion into polyanions, these four copolymers exhibited activity aga

251 Addition of a polyanion to these monomers at neutral pH fails to conve

252 buffer concentration, etc.) confirm that the polyanion unit (1-V2) itself is the dominant active cata

253 The polyanion unit in 1 is disorder-free.

254 f equimolar charge ratios of polycations and polyanions, we demonstrate that increasing crosslinks be

255 pidly when added to culture media containing polyanions, whereas PC-containing complexes did not.

256 eraction between the thiazolium salt and the polyanion, which spontaneously coacervate together to fo

257 n in host tissues through its recognition of polyanions, which mediate CFH binding to host cell surfa

258 the nucleus in low-salt buffer using various polyanions, which mimic the phosphate backbone of DNA.

259 HBV capsid assembly and integrity depend on polyanions, which probably can help minimize intersubuni

260 ethylphosphonic acid ((M)MPA) product to the polyanions, which ultimately inhibits catalytic turnover

261 covalent AVP-pVIc complexes (AVP-pVIc) as a polyanion with a high negative charge density.

262 ter premixing a catechol-functionalized weak polyanion with a polycation in dimethyl sulphoxide (DMSO

263 vestigated how pentosan polysulfate (PPS), a polyanion with antiprion activity in vitro and in vivo,

264 The generation of gaseous polyanions with a Coulomb barrier has attracted attentio

265 ry DNA/PLL complexes by displacing DNA while polyanions with a longer carboxyl/backbone distance effe

266 Polyanions with a shorter carboxyl/backbone distance ten

267 rin) based on the strong binding reaction of polyanions with protamine.

268 polyiodides or superchaotropic redox-active polyanions within the macrocyclic host matrix.

269 Both mono and polyanion X-ides are discussed and classified with respe