ライフサイエンスコーパス: polyether

1 esis of lasalocid A, an ionophore antibiotic polyether.

2 complete removal of external K by 18-Crown-6 polyether.

3 ecognition sites being part of a macrocyclic polyether.

4 ibitor, and the programmable construction of polyethers.

5 d Lewis acids as catalysts to produce cyclic polyethers.

6 branched, hyperbranched, and dendrimer like polyethers.

7 ohexanediamine (TMCDA), and 2,2'-bipyridine; polyethers 12-crown-4, 15-crown-5, 18-crown-6, and digly

8 lted in conversion to the hexafunctionalized polyether 15.

9 ment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a

10 Ligand 9 is the most active polyether analogue in rodents and is also very effective

11 arboxylic acid [(S)-4'-(HO)-DADFT-PE, 11], a polyether analogue, along with its ethyl and isopropyl e

12 Both polyether analogues in subcutaneous (sc) versus oral (po

13 This compelled a closer look at additional polyether analogues, the subject of this work.

14 The parent polyether and its isopropyl and ethyl esters were all sh

15 d for molecular weight (MW) determination of polyether and polyester polyurethane (PUR) soft blocks.

16 of surfactants consisting of perfluorinated polyether and polyethylene glycol (PFPE-PEG).

17 Full-arch impressions were taken using polyether and polyvinylsiloxane.

18 ngs in the case of both the free macrocyclic polyether and the [2]catenane have led to a deeper funda

19 r electrolyte composed of strongly solvating polyether and weakly solvating fluorohydrocarbon pendant

20 packed Ni-zeolite to produce 20 macrocyclic polyethers and 11 examples of broad macrolactones with w

21 sing approximately 50 potentially hemilabile polyethers and amino ethers.

22 until his retirement to synthesis of cyclic polyethers and evaluation of their metal ion complexatio

23 We leveraged this reactivity to degrade polyethers and poly(vinyl ethers) in the presence of pol

24 an electrocatalytic oxidative degradation of polyethers and poly(vinyl ethers) via electrochemically

25 alysis, revealing that substructure R-O-R in polyethers and polysaccharides positively influenced bio

26 hesis of all-cis polyesters, polycarbonates, polyethers and polysulfites.

27 the macroporogen and a variety of aliphatic polyethers and triblock copolymeric surfactants as porog

28 to O-containing aromatic compounds, complex polyether- and ester-containing alkyl molecules of prebi

29 mistry present in the C13-C21 portion of the polyether antibiotic semduramycin (1).

30 Lasalocid acid A is a natural product polyether antibiotic used in veterinary medicine to prev

31 rase (RNAP) by sorangicin (Sor), a macrolide polyether antibiotic.

32 ases responsible for the biosynthesis of the polyether antibiotics nanchangmycin (1) and salinomycin

33 find that it acts by a mechanism similar to polyether antibiotics, which are structurally highly div

34 Based on similarities to polyether anticancer agents we have further examined TDA

35 Ionophore antibiotics (IPAs) are polyether antimicrobials widely used in the livestock in

36 Three DADFT polyethers are evaluated: (S)-4,5-dihydro-2-[2-hydroxy-4

37 reochemically defined flexible cyclic ethers/polyethers as high affinity P2-ligands.

38 ioxynaphthalene (DNP)-containing macrocyclic polyethers as pi-electron donor rings have been synthesi

39 ncorporating 34- and 36-membered macrocyclic polyethers as recognition modules in the construction of

40 sin, principles underlying the initiation of polyether assemblies are proposed.

41 ne droplets in Fomblin Y 06/6 perfluorinated polyether at capillary numbers up to 0.81 and with a dro

42 a polymeric hydrocarbon and a perfluorinated polyether) at a common junction leads to molecular frust

43 The polyether axle accelerates the shuttling by ~70% compare

44 a tetra-amide macrocycle interlocked onto a polyether axle.

45 g homopolymers based on a highly hydrophilic polyether backbone-the first of its kind-through a one-s

46 s to synthesize amorphous silicon-containing polyether-based electrolytes with varying substituent bu

47 de, and we extended this method to degrade a polyether-based polyurethane in a green solvent.

48 thus establish a general model of haptophyte polyether biosynthetic logic.

49 trol mechanism and electronics, and flexible polyether block amide-coated silicone sheath housing the

50 egy to provide well-defined polyacrylamido-b-polyether block copolymers by a one-pot combination of p

51 urfactant composed of perfluoropolyether and polyether blocks.

52 Treatment of polyether bridged bis(diphenylacetylenes) with a source

53 ue of the polymer products-polycarbonates or polyether carbonates-it could provide an economic stimul

54 oxylic acids (PFECAs) and a chloro-perfluoro-polyether carboxylic acid (ClPFPECA) [k(SO4)(*-) = (0.85

55 which are separated from each other along a polyether chain carrying 2,6-diisopropylphenyl stoppers

56 These findings suggest that polyether chain length has a profound effect on ICE, tis

57 two chelating IL systems (one with a pendent polyether chain with three ether oxygens, MPEG3PyrTFSI,

58 oxypyridine unit attached to either end of a polyether chain, mixed with a transition metal ion (e.g.

59 yridyl complexes of Co decorated with 350-Da polyether chains (Co(350)(2+)) form molten phases of nuc

60 Chelating ionic liquids (ILs), in which polyether chains are pendent from the organic pyrrolidin

61 Quantitative analysis revealed that the polyether chains can displace both TFSI(-) and BH4(-) fr

62 ing aggregated bilirubin cores within mobile polyether chains.

63 and free states of borohydride, TFSI(-), and polyether COC groups.

64 rrence of a trifurcated hydrogen bond at the polyether compartment of the macrobicycle, account for t

65 The majority of reported polyether complexes contain lead(ii) and thallium(i) but

66 in regard to the chemical properties of the polyether complexes is highlighted.

67 ations by macrocyclic and diazamacrobicyclic polyethers, composed of ordered arrays of hard oxygen (a

68 Veterinary ionophore antibiotics (IPAs) are polyether compounds used extensively in the livestock in

69 Ionophore antibiotics (IPAs) are polyether compounds used in broiler feed to promote grow

70 rganoplatinum square and a {2+2} macrocyclic polyether containing two 1,5-dioxynaphthalene (DNP) and

71 An electron-rich macrocyclic polyether containing two TTF units of different constitu

72 opper(I) catalysts having multiple sites for polyether coordination, intramolecular oxonium ylide for

73 redox flow battery tests at neutral pH, the polyethers cycle well with no observable interference fr

74 bed that contain duplex DNA as the anion and polyether-decorated transition metal complexes based on

75 cules were linked to the core of a family of polyether dendrimers, which caused the hexamer to be for

76 Some of the SAMs prepared with new acyclic polyether derivatives are able to detect potassium catio

77 Acyclic polyether derivatives can also self-assemble on gold to

78 ocrystallisation of regio- and stereoregular polyethers derived from d- and l-xylose, leading to enha

79 The eight spirotricyclic polyethers differ in the size of the rings containing th

80 oly(2-butenediol), an unsaturated telechelic polyether diol with molecular weights between 400 and 46

81 The resulting polyether displays predictable end groups, molar mass, a

82 ectional approach and finally coupled to the polyether domain by an allyl/alkenyl Stille reaction und

83 We show that like polyether drugs, TDA collapses the proton motive force b

84 mechanism for epoxide selection by ionophore polyether epoxide hydrolases.

85 nomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family

86 )-poly(butylene terephthalate) (PEOT/PBT), a polyether-ester multiblock copolymer to direct different

87 bridizing 3D-printed carbon fiber-reinforced polyether ether ketone (CF-PEEK) with perforated aluminu

88 implant material included titanium (n = 12), polyether ether ketone (PEEK) (n = 3), porous polyethyle

89 ted to a section of a relatively inexpensive polyether ether ketone (PEEK) HPLC column.

90 commercial probe head to a newly designed SP polyether ether ketone (PEEK) probe head.

91 a domestic microwave oven with the aid of a polyether ether ketone (PEEK) vise.

92 e consisting of lithium-exchanged sulfonated polyether ether ketone embedded with polyhedral oligosil

93 ination of the metal content in a sulfonated polyether ether ketone in the form of an indium(III) sal

94 fabricated from high-grade plastics such as polyether ether ketone or lower-grade plastics like poly

95 The polyether fatty acid, okadaic acid has been shown previo

96 he foundation for the production of designer polyethers for drug development.

97 zyme intermediates, whereas tandem cyclic PK polyether formation of furans and pyrans can be initiate

98 y nucleophilic attack, and in the subsequent polyether formation process, it promotes the reaction of

99 l phenoxides with halobenzenes as models for polyether formation.

100 introduction of either a hydroxyl group or a polyether fragment onto the aromatic ring resulted in or

101 ed coordination and interlocking of diolefin polyether fragments around the cyclic polymer backbone u

102 de, providing a short and versatile route to polyether fragments.

103 ature trans-anti-trans 7,7,6-fused tricyclic polyether framework was constructed in a single bromoniu

104 synthesis of oxepanes and oxepane-containing polyethers from di- and trisubstituted epoxides.

105 Macrocyclic polyether fullerenes are a new class of ionophores, whic

106 lubricated with Fomblin RT15 perfluorinated polyether grease in order to ensure compatibility with t

107 t the first total synthesis of marine ladder polyether gymnocin B (1) based on a two-phase strategy.

108 The polyethers had uniformly higher ICEs than their correspo

109 The redox behavior of the macrocyclic polyether has been investigated by electrochemical techn

110 Anthraquinone-containing cyclic polyether hosts form 1:1 complexes with hydronium ion, p

111 in (DMDFT, 1) hydroxamates and a bis-salicyl polyether hydroxamate are evaluated for their iron-clear

112 tone via polysulfide, addition silicone, and polyether impression materials.

113 Casts obtained from polyether impressions were also scanned using an industr

114 indicating the importance of the macrocyclic polyether in PQT2+ docking.

115 table [2]catenane, composed of a macrocyclic polyether incorporating 1,5-dioxynaphthalene (DNP) and t

116 rupting compounds and identified Monensin, a polyether ionophore antibiotic, as a potent migration su

117 he determination of six antibiotics from the polyether ionophore class (lasalocid, maduramicin, monen

118 e biosynthetic gene cluster (97 kbp) for the polyether ionophore monensin from Streptomyces cinnamone

119 that induce HSC inactivation, including the polyether ionophore nanchangmycin (NCMC).

120 agmentation reactions in the carboxylic acid polyether ionophore nigericin.

121 We discovered that the polyether ionophore salinomycin potently inhibited the f

122 synthesis of three new cyclic derivatives of polyether ionophore, monensin A (MON).

123 These data identify salinomycin and other polyether ionophores as novel potential antiscarring the

124 ion reactions in macrotetrolides, a class of polyether ionophores produced by Streptomyces species, w

125 an potentially identify different classes of polyether ionophores rapidly and selectively.

126 and those adopted in European Community for polyether ionophores.

127 The [2]catenane in which the macrocyclic polyether is mechanically interlocked with the cyclobis(

128 helatase antibody 7G12 was found to bind the polyether jeffamine in addition to its cognate hapten N-

129 Evidence that the natural substrate for the polyether KR(0) domains is, as predicted, a (2R)-2-methy

130 ble seven-membered rings embodied in a large polyether ladder-like scaffold structure, and (iii) dete

131 ligation of K(+) with different macrocyclic polyether ligands (L).

132 ns are complexed by either cyclic or acyclic polyether ligands and which have well-characterized sing

133 th the syntheses of various cyclic ether and polyether ligands have been described.

134 g components, and macrocyclic isophthalamide polyether ligands have been prepared using a general ani

135 ble aspects of the chemistry of complexes of polyether ligands including crown ethers, cryptands, gly

136 ers, cryptands, glycols, glymes, and related polyether ligands with heavier group 13 and 14 elements

137 ric and electronic effects for the different polyether ligands.

138 initrobenzene in the presence of macrocyclic polyether ligands: L(C) (cryptand) and L(E) (crown-ether

139 mbered macrocyclic nucleoside analogues with polyether linkages, including C2-symmetric molecules, ha

140 These were transformed into polyether-linked basket dioxocyclams 4a,b and bis-dioxoc

141 as a flexible linker to produce macrocyclic polyether-linked malonates 5, 6, 8, and 9 under solid-li

142 A polyether macrocycle monomer with two parallel diacetyle

143 All rotaxanes involve the well known polyether macrocycle, benzo[24]crown-8.

144 etates for the construction in high yield of polyether macrocycles having ring sizes greater than 25

145 capable of forming one-to-one complexes with polyether macrocycles that consist of two pi-electron-ri

146 n marked the beginning of research on cyclic polyether macrocyclic compounds.

147 ly, multiple additions to C60 of macrocyclic polyether malonate 5 gave C60 bis-adduct 10 selectively,

148 Structural characterization of the "ladder" polyether marine natural products raised a puzzle that p

149 y metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a maj

150 gurational assignment of this largest of the polyether marine toxin include (i) introduction of p-(me

151 o the highly viscous, semisolid hybrid redox polyether melt, [Co(phenanthroline)(3)](MePEG-SO(3))(2),

152 bout the Co complexes in the semisolid redox polyether melts.

153 ynthesis of two pentacyclic analogues of the polyether monensin A is described.

154 des offer the potential to construct complex polyether natural products expeditiously and in a manner

155 Biosynthesis of some polyether natural products involves a kinetically disfav

156 plications in the biosynthesis of the ladder polyether natural products, such as the brevetoxins and

157 he context of the synthesis of marine ladder polyether natural products.

158 (PbTx-1 to PbTx-10) are potent lipid soluble polyether neurotoxins produced by the marine dinoflagell

159 (PbTx-1 to PbTx-10) are potent lipid-soluble polyether neurotoxins produced by the marine dinoflagell

160 istable [2]catenanes composed of macrocyclic polyethers of different sizes incorporating both electro

161 thetic platform allows libraries of discrete polyether oligomers to be prepared and the impact of var

162 luoroalkyl sulfonic acids (C4-C8), mono- and polyether perfluoroalkyl ether acids, and polyfluoroalky

163 depolymerize an environmentally recalcitrant polyether, poly(ethylene oxide) (PEO), that cannot penet

164 polymers, including aliphatic polyesters and polyethers, poly(alpha-peptoid)s, poly(meth)acrylates, p

165 onally protected two-generation, trifurcated polyether-polyamide dendron.

166 me, a new class of multifunctional dendritic polyether polyketals containing different ketal linkages

167 Monensin A is a prototypical natural polyether polyketide antibiotic.

168 Polyether polyketides are a structurally diverse group o

169 controlled mainly by the amount of aliphatic polyether porogen.

170 Polyether precursors to the polyradicals are prepared vi

171 Polyarylmethyl polyether precursors to the spin clusters, with linear a

172 Lasalocid A is a canonical natural polyether produced by the soil bacterium Streptomyces la

173 The dinoflagellate-derived polyether prorocentin is a co-metabolite of the archetyp

174 Ethanolamine is applied for polyether PUR degradation.

175 ctivities of five caged crown ethers and two polyether reference compounds in methanol solution.

176 +) rings encircling dumbbells or macrocyclic polyethers, respectively, that contain a BIPY(2+) unit w

177 of diiminoisoindoline with amine-terminated polyethers results in the formation of phthalocrown macr

178 le in that it consists of two separate fused polyether ring assemblies linked by a methylene group.

179 c N-(X)sulfonyl carbamoyl lariat ethers with polyether ring sizes of 12-crown-4, 14-crown-4, 15-crown

180 roup of natural neurotoxins characterized by polyether ring systems that are found in the blooms of r

181 yne/azide handles and fluorine) flanking the polyether scaffold.

182 Our recent work with cyclic and acyclic polyether self-assembled monolayers (SAMs) on gold is pr

183 unterion relaxation is in turn controlled by polyether "solvent" fluctuations, this is a new form of

184 Herein, we report the in situ polyether stereocomplex formation from racemic epoxide m

185 ly resolves a single enantiomeric, isotactic polyether stereoisomer ([mm](P)>=78 %), the isoselective

186 analyses of brevetoxins have shown that the polyether structure invariably has a very high affinity

187 brevis metabolites, though the "interrupted" polyether structure of brevisin is novel and provides fu

188 s leading to a variety of substituted ladder polyether structures.

189 PQT2+ inside a framework (MOF-177) devoid of polyether struts showed negligible uptake of PQT2+, indi

190 rticles (EUOL@AgNPs) incorporated sulfonated polyether sulfone (SPES)/polyethersulfone (PES) electros

191 Polyphenylquinoxaline/polyether-sulfone (PPQ/PES) copolymers are synthesized s

192 ses, the epimerase-active KR(0) domains from polyether synthases lack one or both residues of the con

193 sight into the biogenesis of such fused-ring polyether systems.

194 PEG-SO(3))(2), where MePEG-SO(3) is a MW 350 polyether-tailed sulfonate anion, remarkably accelerates

195 ,5-dihydrofuran) (PDHF), from an unsaturated polyether that contains cyclobutane-fused THF in each re

196 e strategies afford a family of carbohydrate polyethers, the physical and chemical properties of whic

197 of CO(2) incorporation within polyesters and polyethers, thereby allowing access to new polymer chemi

198 lic acid [(S)-4'-(HO)-DADFT, 1] revealed the polyether to be more tolerable, achieving higher concent

199 as paralytic shellfish poisoning toxins and polyether toxins are also discussed, and genetic aspects

200 ns for a hypothetical biosynthesis of marine polyether toxins are discussed.

201 erved on fish are thought to be due to algal polyether toxins, known as the prymnesins, but their lac

202 Their polyketide polyether toxins, the prymnesins, are among the largest

203 ed in the biosynthesis of ladder-type marine polyether toxins.

204 long an isotactic hydroxyl-group-derivatized polyether track by the formation/breakage of ester linka

205 e to the physical diffusion (D(PHYS)) of the polyether-transition metal complex.

206 The one-step synthesis of amino-polyether tri-tert-butyl ester monomer 2, by condensatio

207 Six novel oxasqualenoids (polyether triterpenes) were isolated from the red alga L

208 For this application, a polyether-type Ni-catalyst 37c, readily soluble in the r

209 owing toolbox for epoxide polymerization, a "polyether universe" may be envisaged that in its structu

210 d functional diversity into sequence-defined polyethers, unlocking their potential for real-life appl

211 antitative analysis of a matrix, hydrophilic polyether urethane (HPEU) intravaginal ring (IVR) for su

212 Although 3 was superior to its isomers, this polyether was overshadowed by 15 to an extent in excess

213 th selected proton-based systems: 18-crown-6 polyether with protonated peptides and base-pairing ener

214 lied to the construction of sequence-defined polyethers, with side-arms at precisely defined location