ライフサイエンスコーパス: polygenic

1 100, suggesting LOAD is more oligogenic than polygenic.

2 include testing to identify those with high polygenic AAA risk, once the cost of genotyping becomes

3 lation, we further supported the evidence of polygenic adaptation at height-associated loci among the

4 (p = 0.0082), consistent with a signature of polygenic adaptation driven primarily by the Sardinian p

5 stion whether height loci exhibit signals of polygenic adaptation in any human population.

6 is one of the earliest putative examples of polygenic adaptation in humans.

7 , the data generated in this study suggest a polygenic adaptation of SHB to the southern climate, and

8 We found that HIV-1 acquisition is polygenic and heritable, with SNP heritability estimates

9 Their genetic architectures are highly polygenic and overlapping, which is supported by heterog

10 r findings suggest that handedness is highly polygenic and that the genetic variants that predispose

11 atterns of inheritance are consistent with a polygenic architecture of many contributing risk loci.

12 plant preferences, a finding that supports a polygenic architecture of species boundaries.

13 relationships to other autoimmune diseases, polygenic architecture of vitiligo risk, vitiligo trigge

14 nce of specific genetic markers and a highly polygenic architecture that overlaps with that of schizo

15 id- and human-scale evidence underscored the polygenic architecture underlying DILI vulnerability at

16 onstrate that AD risk is shaped by a broader polygenic architecture, estimated via polygenic risk sco

17 such as psychiatric disorders have a complex polygenic architecture, making the identification of a s

18 h gene flow as previously suggested, whereas polygenic architectures can promote rapid and stable spe

19 t determined by a single gene, but rather is polygenic, arising from the action and interaction of mu

20 es a molecular mechanism contributing to the polygenic autoimmune diseases of systemic lupus erythema

21 bstantial gradients in disease risk based on polygenic background - the probability of disease by age

22 study 80,928 individuals to examine whether polygenic background can modify penetrance of disease in

23 We propose that accounting for polygenic background is likely to increase accuracy of r

24 se findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic r

25 Single-marker and polygenic cell deconvolution establish that this relatio

26 A polygenic component for AVSD in DS has not been examined

27 This discovery indicates that a polygenic component operates in VEO-IBD pathogenesis.

28 quences of heterogenous mutations in complex polygenic conditions is challenging.

29 pproximately 1%, suggesting at least a small polygenic contribution to DS-associated AVSD.

30 This work highlights the impact of polygenic contributions to brain function beyond APOE, w

31 Polygenic contributions to LDL-C explain some of the het

32 ly produced vitamin D metabolites were under polygenic control in African calves.

33 We hypothesized that a polygenic discovery approach using LV mass measurements

34 te feasibility of multiplex base editing for polygenic disease modeling in primate zygotes.

35 putational and experimental neurogenetics of polygenic disease risk.

36 RA is a polygenic disease with 106 known genome-wide significant

37 Compound heterozygous recessive or polygenic diseases could be addressed through gene corre

38 Common polygenic diseases result from compounded risk contribut

39 Like other polygenic diseases, a significant proportion of estimate

40 Schizophrenia is a highly polygenic disorder with important contributions from bot

41 Autoinflammatory diseases are monogenic and polygenic disorders due to dysregulation of the innate i

42 etic factors often play an important role in polygenic disorders.

43 omologous (allelic) counterparts, increasing polygenic drive for blood-cell proliferation traits.

44 e but also for how we estimate sex-dependent polygenic effects for clinical use.

45 tions for Alzheimer's disease, sex-dependent polygenic effects have not been demonstrated.

46 tion have reconstructed how, when, and where polygenic evolution of phenotypic plasticity proceeded f

47 Both monogenic and polygenic factors contribute to AF risk in the general p

48 chiatric disorders, established their highly polygenic genetic architecture, and identified hundreds

49 Complications associated with the polygenic haploinsufficiency make 22qDS symptoms particu

50 lative to sex-mismatched scores, sex-matched polygenic hazard scores showed significantly stronger as

51 k scores, showed lower predictive power than polygenic hazard scores with no evidence for sex differe

52 We also found the trajectory of polygenic height scores between the Sardinian and the Br

53 ern and western Europe [CEU] on the basis of polygenic height scores, p = 3.89 x 10(-4)).

54 de assays, has confirmed the contribution of polygenic inheritance involving common alleles of small

55 d synapse function and underscoring a highly polygenic inheritance pattern that may be another import

56 tions that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes.

57 ithium, compared to those patients with high polygenic load [lowest vs highest PGS quartiles, multi-e

58 Family members had significantly higher mean polygenic load for cutaneous melanoma than unrelated cas

59 The CAD risk associated with a high polygenic load for lipid-increasing variants was proport

60 Bipolar patients with a low polygenic load for MD were more likely to respond well t

61 First, we show that, whereas the polygenic load for neuroticism is associated with the ge

62 ritabilities from PolyFun + SuSiE to perform polygenic localization, constructing minimal sets of com

63 on a total of 18 chromosomes, reflecting the polygenic nature of growth.

64 The highly polygenic nature of quantitative traits and most common

65 We then analyzed the polygenic nature of SLE statistically.

66 genetic studies have confirmed the complex, polygenic nature of the risk architecture of bipolar dis

67 the role of genetic regulation of leptin in polygenic obesity remains poorly understood.

68 Twenty-three subjects with monogenic or polygenic obesity underwent hyperinsulinemic-euglycemic

69 age multiple cells and tissues, and follow a polygenic or omnigenic model depicting numerous genes co

70 on associations with intelligence indicating polygenic overlap.

71 ciations with SCZ and vice versa, indicating polygenic overlap.

72 ype analysis identified a complex pattern of polygenic pleiotropy between CC and other immune-mediate

73 Despite the emerging importance of polygenic predictions for Alzheimer's disease, sex-depen

74 Secondary analyses using polygenic predictors confirmed a significant association

75 We test 26 polygenic predictors using tens of thousands of genetic

76 with increased risk of AF across a range of polygenic predisposition to AF and adds to inherited and

77 ssed the association between alcohol intake, polygenic predisposition to AF, and incident AF in the U

78 We show that polygenic predisposition to PR interval duration is an e

79 hol intake or body mass index interacts with polygenic predisposition.

80 s encompassing >4,500 genes, suggests highly polygenic properties of gene dosage with respect to auti

81 High polygenic risk (top 20% of PRS) conferred 1.9-fold odds

82 re highly heritable and arise from a complex polygenic risk architecture.

83 but we argue that the advent of genome-wide polygenic risk assessment now makes an empirical evaluat

84 onnectome-wide associations of schizophrenia polygenic risk at the systems level and suggest that dis

85 imary prevention patients (n = 33,251), high polygenic risk did not correspond with increased recomme

86 es may be related to shared environmental or polygenic risk factors rather than MITF(E318K).

87 higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia

88 enotyped cohort, we delineate a pathway from polygenic risk for ADHD to hyperactive-impulsive symptom

89 We found that polygenic risk for ADHD was associated with symptoms of

90 By studying a cohort of 362 youth, we ask if polygenic risk for ADHD, combined with baseline neural a

91 agnostically specific and were not found for polygenic risk for ASD or schizophrenia.

92 son comorbidity index and is associated with polygenic risk for coronary heart disease and type 2 dia

93 vidence for these observations, GWAS-derived polygenic risk for depression was enriched for genes exp

94 Attachment style may moderate polygenic risk for PTSD symptoms, and a novel locus impl

95 Higher polygenic risk for schizophrenia associated with a great

96 ame connectivity was adversely influenced by polygenic risk for schizophrenia in healthy subjects.

97 rgic function and the expression profiles of polygenic risk for schizophrenia.

98 rd connectivity, and delusional thinking and polygenic risk for schizophrenia.

99 neurodevelopmental processes associated with polygenic risk for SCZ and ASD across the allelic freque

100 reatments for PTSD for individuals with high polygenic risk for this disorder.

101 mune vitiligo is a complex disease involving polygenic risk from at least 50 loci previously identifi

102 Schizophrenia polygenic risk is plausibly manifested by complex transc

103 may be countered, at least in part, by a low polygenic risk potentially representing other innate mec

104 ty was measured using a previously described polygenic risk score (N=929 single-nucleotide polymorphi

105 t gastric cancer across the quintiles of the polygenic risk score (p(trend)<0.0001).

106 Finally, we perform phenome-wide polygenic risk score (PRS) analyses on 67 complex traits

107 We performed polygenic risk score (PRS) analyses to investigate share

108 s interactions between an established 77-SNP polygenic risk score (PRS) and non-genetic risk factors

109 A polygenic risk score (PRS) based on a GWAS of risk-toler

110 A polygenic risk score (PRS) derived from genome-wide asso

111 We built a 201-variant polygenic risk score (PRS) for CAD and tested for intera

112 To determine the incremental value of polygenic risk score (PRS) for coronary artery disease,

113 In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effec

114 A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individu

115 ized sequence kernel association testing and polygenic risk score (PRS) methods to examine rare and c

116 sk by using summarized GWAS results to build polygenic risk score (PRS) models in three PTC study gro

117 In addition, a polygenic risk score (PRS) of 188 prostate cancer varian

118 The authors sought to assess polygenic risk score (PRS) prediction of subsequent psyc

119 , we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of

120 A polygenic risk score (PRS) was strongly associated with

121 history of breast cancer (N = 49,674) and a polygenic risk score (PRS, N = 9,365).

122 Polygenic risk score analyses showed that the combined e

123 attempt in these independent samples through polygenic risk score analysis (t = 4.02, p = 5.75 x 10(-

124 Phenome-wide polygenic risk score analysis in an independent biobank

125 We then compared the contribution of AF polygenic risk score and LOF variants to AF risk.

126 absolute risk of CRC varied according to the polygenic risk score and the healthy lifestyle score (me

127 This analysis was followed by a polygenic risk score approach to test for associations b

128 ody mass index) subscores, and a genome-wide polygenic risk score based on 1.1 million variants.

129 by meta-analysis with an independent cohort, polygenic risk score calculation, and cross-phenotype an

130 esearch should validate our findings using a polygenic risk score constructed from historical data.

131 formed in FOURIER to determine whether a VTE polygenic risk score could identify high-risk patients w

132 The polygenic risk score derived from 112 single-nucleotide

133 In contrast, the AF polygenic risk score explained 4.7% of the variance in A

134 A polygenic risk score for AF was estimated using the LDpr

135 urrence after ablation using a comprehensive polygenic risk score for AF.

136 We constructed a polygenic risk score for aortic valve area, which in a s

137 men; and as a continuous variable) and an AF polygenic risk score for association with incident AF.

138 wins with genome-wide data, we constructed a polygenic risk score for BMI (PRSBMI) using almost 1 mil

139 to optimize the predictive performance of a polygenic risk score for CAD based on summary statistics

140 Polygenic risk score for CAD, pooled cohort equations, a

141 d for sex, age, family socioeconomic status, polygenic risk score for cognitive function, adolescent/

142 We therefore tested whether a polygenic risk score for heel quantitative ultrasound sp

143 We further show that a polygenic risk score for hypertension associates with pr

144 ment and apathy were associated with reduced polygenic risk score for intelligence.

145 Polygenic risk score for major depression was associated

146 A higher polygenic risk score for obesity significantly correlate

147 A polygenic risk score for SCAD was associated with (1) hi

148 A polygenic risk score identified patients who were at >2-

149 Our results suggest that the use of a polygenic risk score in fracture risk screening could de

150 g individuals in the highest 0.44% of the AF polygenic risk score only 9.3% had AF.

151 can subjects in either cohort, nor did an AD polygenic risk score or genetic skin pigment score expla

152 r meta-GWAS hit replication rates and poorer polygenic risk score predictive performance in survivor

153 A polygenic risk score predicts disease with up to 90% acc

154 Polygenic risk score profiling revealed improved predict

155 Polygenic risk score quantifying the risk across multipl

156 summarizes clinical CKD risk factors, and a polygenic risk score that summarizes genetic information

157 anding of EoE and provides a framework for a polygenic risk score to be validated in future studies.

158 ng a risk threshold of 7.5%, addition of the polygenic risk score to pooled cohort equations resulted

159 risk threshold of 7.5%, the addition of the polygenic risk score to the pooled cohort equations did

160 When this polygenic risk score was applied to the CKB cohort, we f

161 redictive accuracy of a previously validated polygenic risk score was assessed among 4847 adults of w

162 this analysis of 2 cohorts of US adults, the polygenic risk score was associated with incident corona

163 The polygenic risk score was significantly associated with 1

164 The genetic extended model included a polygenic risk score with 313 single nucleotide polymorp

165 rait meta-analysis, Mendelian randomization, polygenic risk score, and functional analysis.

166 CAD discrimination for polygenic risk score, pooled cohort equations, and both

167 d to evaluate the predictive accuracy of the polygenic risk score, pooled cohort equations, and both

168 enotype identified by these four models are: polygenic risk score, sex, age, and education.

169 These have been combined into a vitiligo polygenic risk score, which has allowed various aspects

170 nic risk score], and high [quintile 5 of the polygenic risk score]).

171 sk score], intermediate [quintile 2-4 of the polygenic risk score], and high [quintile 5 of the polyg

172 fied by genetic risk (low [quintile 1 of the polygenic risk score], intermediate [quintile 2-4 of the

173 (GWAS) on delta age, combined into distinct polygenic risk scores (PRS(cis-eQTL) and PRS(GWAS)), and

174 as to evaluate the associations between ADHD polygenic risk scores (PRS) and a broad range of childho

175 study, we explore the association between MS polygenic risk scores (PRS) and brain imaging outcomes f

176 Polygenic risk scores (PRS) for breast cancer have poten

177 Polygenic risk scores (PRS) for coronary artery disease

178 Recent studies indicate high polygenic risk scores (PRS) for coronary artery disease

179 Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and s

180 Polygenic risk scores (PRS) for the 22 risk factors were

181 ifferent approaches to generating predictive polygenic risk scores (PRS) from genome-wide association

182 Polygenic risk scores (PRS) may soon be used to predict

183 Polygenic risk scores (PRS) provide a personalized genet

184 ts at the 99th risk percentile of underlying polygenic risk scores (PRS), compared to average risk, r

185 tologies, for association with schizophrenia polygenic risk scores (PRSs) and with diagnosis, and als

186 Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medi

187 While polygenic risk scores (PRSs) are poised to be translated

188 e we developed an alternative approach using polygenic risk scores (PRSs) based on genome-wide associ

189 Previous research has shown that polygenic risk scores (PRSs) can be used to stratify wom

190 There is growing evidence that polygenic risk scores (PRSs) can identify individuals wi

191 n The Netherlands (2002-2006), we calculated polygenic risk scores (PRSs) for ASD and attention-defic

192 SUA in 6,881 Korean individuals, calculated polygenic risk scores (PRSs) for common variants, and va

193 Because polygenic risk scores (PRSs) for coronary heart disease

194 Polygenic risk scores (PRSs) for major depression, bipol

195 stream mechanistic investigation or yielding polygenic risk scores (PRSs) for prognostication.

196 Polygenic risk scores (PRSs) have been consistently asso

197 Polygenic risk scores (PRSs) have shown promise in predi

198 To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an ext

199 ividual risk prediction based on genome-wide polygenic risk scores (PRSs) using millions of genetic v

200 o, high psoriasis, and low atopic dermatitis polygenic risk scores (PRSs) were associated with longer

201 Additionally, 3 polygenic risk scores (PRSs) were generated with 97 BMI

202 We derived polygenic risk scores (PRSs) with ~6M variants separatel

203 y complex traits, the non-transferability of polygenic risk scores across populations suggests the pr

204 d with an increased PTSD risk and had higher polygenic risk scores and a greater methylation compared

205 regions that were associated with increased polygenic risk scores and enriched risk gene expression

206 We show for height how polygenic risk scores based on summary statistics from a

207 Polygenic risk scores comprising millions of single-nucl

208 hat could allow selection of those with high polygenic risk scores for clinical trials and precision

209 linkage disequilibrium score regression and polygenic risk scores for depressive symptoms, schizophr

210 Finally, we tested how polygenic risk scores for HIV-1 acquisition influence bl

211 Polygenic risk scores for prostate cancer were higher in

212 Polygenic risk scores for psychiatric disorders, particu

213 d in increased trans-ancestry portability of polygenic risk scores from Europeans to East Asians acro

214 in the general population by 1) constructing polygenic risk scores from large genome-wide association

215 The incremental value of polygenic risk scores in addition to well-established ri

216 ew opportunities for developing and applying polygenic risk scores in the clinic, to systematically e

217 iderations relevant to the implementation of polygenic risk scores in the health care setting.

218 Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric ge

219 s for incident depression were identified by polygenic risk scores or by reported traumatic life even

220 The utility of polygenic risk scores to stratify coronary artery diseas

221 Polygenic risk scores were used to assess the collective

222 as micro-ribonucleic acid (miRNA) genetics, polygenic risk scores, environmental pollutants, and som

223 Models without using hazard weights, i.e. polygenic risk scores, showed lower predictive power tha

224 and, although it generates highly predictive polygenic risk scores, the predictive power can be expla

225 The odds ratios of polygenic risk scores, which included 330 variants, for

226 pairment and used these results to construct polygenic risk scores.

227 roader polygenic architecture, estimated via polygenic risk scoring (AD-PRS).

228 genome-wide association testing, followed by polygenic risk scoring and phenome-wide screening, to id

229 , clinicians will have an opportunity to use polygenic risk to predict perioperative complications.

230 years, probability of cirrhosis with extreme polygenic risk was 13.7%, 20.1%, and 48.2% among individ

231 cceptable range and in the highest decile of polygenic risk was 2.33% (95% CI, 2.07-2.59), compared w

232 ilarly, probability among those with extreme polygenic risk was 6.5%, 10.3%, and 19.5% among individu

233 The impact of extreme polygenic risk was substantially more pronounced in thos

234 vailable, schizophrenia and bipolar disorder polygenic risk were significantly overtransmitted to pro

235 We conclude that some measures of polygenic risk, cognition, and neuroimaging show signifi

236 acceptable range and in the lowest decile of polygenic risk.

237 explored the interplay between monogenic and polygenic risk.

238 Additionally, an elevated LDL-C polygenic score (>=80th percentile) was associated with

239 A body mass index (BMI) genome-wide polygenic score (BMIGPS) was generated by summing BMI-in

240 model the association between a genome-wide polygenic score (GPS) for BMI and BMI, while generalized

241 A polygenic score (PGS) or polygenic risk score (PRS) is a

242 ), gene and gene set-enrichment testing, and polygenic score analyses, as well as single-nucleotide p

243 ncluding genome-wide association studies and polygenic score analyses.

244 n with esketamine efficacy identified in the polygenic score analysis was from the genetic loading fo

245 ing score for 213 samples, incorporating the polygenic score derived from it into a predictive model

246 000 traits showed multiple links between the polygenic score for aortic valve disease and key health-

247 f socioeconomic status (SES) and genome-wide polygenic score for BMI to explaining variation in BMI.

248 ized beta-values = -0.178 to 0.302), and the polygenic score for education was associated with cognit

249 Here we used a polygenic score for educational attainment (EduYears-PGS

250 Among these high polygenic score individuals, adherence to a healthy life

251 g carriers of TTN truncating mutations, this polygenic score influences the size and function of the

252 We assessed the influence of an LDL-C polygenic score on levels of LDL-C and risk of ASCVD for

253 gnificant loci and genes were identified and polygenic score prediction of suicide death case-control

254 A polygenic score was tested in Partners HealthCare Bioban

255 We assessed the association between LDL-C polygenic score with LDL-C levels and ASCVD risk using l

256 We constructed a weighted LDL-C polygenic score, composed of 28 single-nucleotide varian

257 est whether such variants, aggregated into a polygenic score, enable genomic risk stratification, and

258 tional outcomes of genotyping arrays include polygenic score, runs of homozygosity (ROH)/heterozygosi

259 Although the polygenic score-based analysis showed a much subtler sig

260 ected in haplotype-based analysis but not in polygenic score-based analysis.

261 artners HealthCare Biobank individuals, high polygenic score-defined as the top quintile of the distr

262 These 12 variants were used to generate a polygenic score.

263 Genome-wide polygenic scores (GPS) integrate information from many c

264 Genome-wide polygenic scores (GPSs) integrate information from many

265 We also calculated polygenic scores (PGSs) based on large-scale GWAS data f

266 nia sample and profiled the subgroups across polygenic scores (PGSs) for schizophrenia, cognition, ed

267 Weighted polygenic scores (PGSs) were computed for major depressi

268 hlight both the complexities of interpreting polygenic scores and underappreciated obstacles to their

269 Consequently, polygenic scores are biased in that they recapitulate en

270 enetics and sociology are increasingly using polygenic scores based on genome-wide association studie

271 Our results suggest that while polygenic scores can be informative for identifying grou

272 predictive validity for cognitive ageing of polygenic scores derived from genome-wide association st

273 Conditional on prior achievement, polygenic scores failed to accurately predict later achi

274 The increasing predictive power of polygenic scores for education has led to their promotio

275 ling records, we investigated how accurately polygenic scores for education predicted pupils' test sc

276 eference point, we also predicted individual polygenic scores for related phenotypes and 13 different

277 s and also highlight the future potential of polygenic scores for risk stratification among individua

278 Polygenic scores for several other psychiatric disorders

279 Polygenic scores of ASD (ASD-PGSs) were generated across

280 We also assessed the performance of polygenic scores over and above phenotypic data that are

281 Polygenic scores provide increasing power to detect patt

282 We construct and validate polygenic scores that explain up to 45% of protein level

283 n this preregistered study, we used fourteen polygenic scores to predict variation in cognitive abili

284 Humans (SUGAR-MGH), we constructed weighted polygenic scores using known genome-wide significant ass

285 Several polygenic scores were associated with the level of cogni

286 Prediction of educational outcomes from polygenic scores were inferior to those from parental so

287 Notably, suicide polygenic scores were significantly predictive across tr

288 the association of these phenotypes with two polygenic scores, derived for schizophrenia and intellig

289 When these results are used to construct polygenic scores, even subtle biases can cumulatively le

290 pean ancestry-based genetic disease risk and polygenic scores, substantiating the need for multi-ethn

291 ne system show evidence of admixture-enabled polygenic selection in Latin American populations.

292 quency between wild and farmed fish indicate polygenic selection on behavioural traits during domesti

293 ched for signatures of selection, indicating polygenic selection.

294 We developed a polygenic single nucleotide polymorphism-based predictor

295 bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associat

296 ur results indicate that growth is a complex polygenic trait governed by carbon and energy partitioni

297 es to understand the genetic architecture of polygenic traits in many different organisms.

298 ntiation among species that have diverged in polygenic traits is genomically widespread and much high

299 eds from standing variation and selection on polygenic traits, both of which may leave faint genomic

300 coefficients, and inference of selection on polygenic traits.