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1 may alter Treg cell function contributing to polygenic disease.
2 dering their intrinsically promising role in polygenic disease.
3 Asthma is a complex polygenic disease.
4 Type 1 diabetes is a common polygenic disease.
5 M) reported in 1994 was the first in a human polygenic disease.
6 and may be altered by DNA variants linked to polygenic disease.
7 on the molecular and cellular mechanisms of polygenic disease.
8 y associated with targeting a single gene in polygenic diseases.
9 netic factors and is associated with several polygenic diseases.
10 r both simple monogenic diseases and complex polygenic diseases.
11 rstand the complex nature of these and other polygenic diseases.
12 ajor hopes for the future are application to polygenic diseases.
13 g their applications in complex genomics and polygenic diseases.
14 cidating the genetic underpinnings of common polygenic diseases.
15 urden of human disease lies predominantly in polygenic diseases.
16 the identification of genes associated with polygenic diseases.
17 and may be more broadly applicable to other polygenic diseases.
18 nking variants to functions for other common polygenic diseases.
19 f altering specific variants associated with polygenic diseases.
23 proach can enrich mutations underlying these polygenic diseases among the top of candidate mutations.
25 variance affects disparities in the risk of polygenic diseases and influences the identification of
26 ical evidence, yielding unique insights into polygenic diseases and providing a basis for the develop
27 ymorphisms will enhance the investigation of polygenic diseases and the use of genetics in drug devel
29 irms the complexity of its risk factors as a polygenic disease, and provides causally associated evid
30 sts that dental caries and periodontitis are polygenic diseases, and very large sample sizes and info
31 or schizophrenia, we infer an overwhelmingly polygenic disease architecture in which >/=71% of 1-Mb g
32 If validated, GMAS may imply that common polygenic diseases are related as much to group interact
33 e for single-gene disorders, whereas complex polygenic diseases are typically due to multiple genetic
34 ts in cis-acting enhancers are important for polygenic disease, but their role in Mendelian disease i
35 t predictor of health status in many chronic polygenic diseases, but its role in CF has not been syst
36 Schizophrenia and autism are examples of polygenic diseases caused by a multitude of genetic vari
40 dating the genetic predisposition for common polygenic diseases, especially in determining the functi
41 date-gene approach in association studies of polygenic diseases has often yielded conflicting results
42 alized vitiligo is a common, multifactorial, polygenic disease in which autoimmune loss of melanocyte
43 zed vitiligo is an acquired, multifactorial, polygenic disease in which depigmented spots of skin, ov
44 ing has been performed in a variety of human polygenic diseases, including schizophrenia, bipolar aff
45 ch to the identification of genes underlying polygenic disease is to identify "functional candidates"
46 An important approach to the study of such polygenic diseases is the use of appropriate animal mode
47 enetic extremes of rare monogenic and common polygenic diseases lie diverse oligogenic disorders invo
49 that the discovery of genes associated with polygenic diseases may be limited by the overreliance on
52 = 2.4 x 10(-22)) and are associated with the polygenic diseases osteoporosis (P = 1.8 x 10(-13)) and
57 vastness of genomic variants associated with polygenic disease risk and address recent advances in ho
58 cDRS), an approach that links scRNA-seq with polygenic disease risk at single-cell resolution, indepe
59 ion of the revealed patterns with individual polygenic disease risk for schizophrenia was explored in
60 variants (SNVs) in regulatory DNA linked to polygenic disease risk, the transcription factors (TFs)
66 promising for repositioning drugs for use in polygenic diseases such as PD, and is capable of address
67 roader potential that also includes acquired polygenic diseases, such as congestive heart failure.
68 zheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia c
69 ute to the development of type 2 diabetes, a polygenic disease that is characterized by insulin resis
70 e BioBreeding diabetes-prone (BBDP) rat is a polygenic disease that resembles in many aspects human t
71 understanding of the genetic basis for other polygenic diseases that are also greatly influenced by e
77 monary hypertension is a partially heritable polygenic disease, with related though distinct genetic