ライフサイエンスコーパス: polygenic risk score

1 be identified by use of our newly developed polygenic risk score.

2 tes family history, and genome-wide diabetes polygenic risk score.

3 gh pathways other than cognition-related and polygenic risk score.

4 h cognition-related pathways not captured by polygenic risk score.

5 artery disease have been leveraged to create polygenic risk scores.

6 anels could be clinically more relevant than polygenic risk scores.

7 l inform the development of subtype-specific polygenic risk scores.

8 the accumulation of AD genetic risk through polygenic risk scores.

9 e genetic risk variants can be combined into polygenic risk scores.

10 tudies, single nucleotide polymorphisms, and polygenic risk scores.

11 an ~57% increase in the predictive power of polygenic risk scores.

12 ions of a key module are associated with the polygenic risk scores.

13 pairment and used these results to construct polygenic risk scores.

14 nic risk score], and high [quintile 5 of the polygenic risk score]).

15 Twenty percent had high polygenic risk scores, 60% had intermediate risk scores,

16 y complex traits, the non-transferability of polygenic risk scores across populations suggests the pr

17 east one copy of the APOE e4 allele and b) a polygenic risk score (AD-PRS) estimated from AD-GWAS.

18 roader polygenic architecture, estimated via polygenic risk scoring (AD-PRS).

19 The schizophrenia polygenic risk scores also predicted social and behaviou

20 Polygenic risk score analyses showed prognostication of

21 Polygenic risk score analyses showed that the combined e

22 attempt in these independent samples through polygenic risk score analysis (t = 4.02, p = 5.75 x 10(-

23 Polygenic risk score analysis did not support a higher b

24 Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzh

25 Phenome-wide polygenic risk score analysis in an independent biobank

26 OPS), as well as the association between the polygenic risk score and coronary artery calcification (

27 Polygenic risk score and D:A:D score contributed to CKD.

28 We then compared the contribution of AF polygenic risk score and LOF variants to AF risk.

29 much lower but still varied according to the polygenic risk score and the healthy lifestyle score (me

30 absolute risk of CRC varied according to the polygenic risk score and the healthy lifestyle score (me

31 d with an increased PTSD risk and had higher polygenic risk scores and a greater methylation compared

32 risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped

33 further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN po

34 regions that were associated with increased polygenic risk scores and enriched risk gene expression

35 ssociation analysis, (v) meta-analysis, (vi) polygenic risk scoring and (vii) replication analysis.

36 genome-wide association testing, followed by polygenic risk scoring and phenome-wide screening, to id

37 rait meta-analysis, Mendelian randomization, polygenic risk score, and functional analysis.

38 Linkage disequilibrium score regression, polygenic risk scoring, and two-sample Mendelian randomi

39 sk score], intermediate [quintile 2-4 of the polygenic risk score], and high [quintile 5 of the polyg

40 This analysis was followed by a polygenic risk score approach to test for associations b

41 e identified multiple disease-associated and polygenic risk score-associated differentially methylate

42 ody mass index) subscores, and a genome-wide polygenic risk score based on 1.1 million variants.

43 sceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic vari

44 We show for height how polygenic risk scores based on summary statistics from a

45 iet, physical activity, and body fatness), a polygenic risk score (based on 90 single-nucleotide poly

46 The estrogen receptor-positive polygenic risk score built from 89 known susceptibility

47 In addition, we divided polygenic risk score by biological pathways and tested t

48 by meta-analysis with an independent cohort, polygenic risk score calculation, and cross-phenotype an

49 P-chip heritability estimates of 7.29%, with polygenic risk scoring capturing 4.4% of the variance in

50 A polygenic risk score comprising 93 single-nucleotide pol

51 Polygenic risk scores comprising millions of single-nucl

52 esearch should validate our findings using a polygenic risk score constructed from historical data.

53 ared genetic etiology and whether Tourette's polygenic risk scores correlate with worst-ever tic seve

54 ADHD polygenic risk scores correlated positively with ED symp

55 formed in FOURIER to determine whether a VTE polygenic risk score could identify high-risk patients w

56 The polygenic risk score derived from 112 single-nucleotide

57 For each participant, we calculated a polygenic risk score derived from up to 57 common DNA se

58 We used polygenic risk scores derived from a patient discovery s

59 he performance of several different vitiligo polygenic risk scores derived from GWAS data.

60 Tests were performed to determine whether polygenic risk scores derived from potentially related t

61 The polygenic risk score did not significantly improve calib

62 In models including both alcohol and the AF polygenic risk score, each remained associated with AF.

63 as micro-ribonucleic acid (miRNA) genetics, polygenic risk scores, environmental pollutants, and som

64 We created a novel expression-based polygenic risk score (ePRS) reflecting variations in the

65 ulation-specific variants, fine-mapping, and polygenic risk score estimation.

66 ur bipolar disorder sample, which shows that polygenic risk scores explain a higher proportion of the

67 In contrast, the AF polygenic risk score explained 4.7% of the variance in A

68 In total, polygenic risk score explained 8.07% [confidence interva

69 (7.05-21.6; P=1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the vari

70 benign breast disease, mammographic density, polygenic risk score, family history of breast cancer, a

71 A polygenic risk score for AF was estimated using the LDpr

72 urrence after ablation using a comprehensive polygenic risk score for AF.

73 We constructed a polygenic risk score for aortic valve area, which in a s

74 men; and as a continuous variable) and an AF polygenic risk score for association with incident AF.

75 wins with genome-wide data, we constructed a polygenic risk score for BMI (PRSBMI) using almost 1 mil

76 rs with obesity, we calculated a genome-wide polygenic risk score for BMI (PRSBMI).

77 to optimize the predictive performance of a polygenic risk score for CAD based on summary statistics

78 The addition of a polygenic risk score for CAD to pooled cohort equations

79 Polygenic risk score for CAD, pooled cohort equations, a

80 d for sex, age, family socioeconomic status, polygenic risk score for cognitive function, adolescent/

81 We used a polygenic risk score for cutaneous melanoma to compare f

82 A polygenic risk score for dementia with low (lowest quint

83 d significantly negatively correlated with a polygenic risk score for educational attainment.

84 We therefore tested whether a polygenic risk score for heel quantitative ultrasound sp

85 We further show that a polygenic risk score for hypertension associates with pr

86 ment and apathy were associated with reduced polygenic risk score for intelligence.

87 Polygenic risk score for major depression was associated

88 A higher polygenic risk score for obesity significantly correlate

89 A polygenic risk score for SCAD was associated with (1) hi

90 any substance use disorder diagnosis and the polygenic risk score for schizophrenia (mega-analysis ps

91 We investigated whether a high polygenic risk score for schizophrenia (PGRS-SCZ) is ass

92 A polygenic risk score for SOS was trained and selected in

93 We developed a genome-wide polygenic risk score for venous thromboembolism that ide

94 To test the association of a polygenic risk score for waist-to-hip ratio (WHR) adjust

95 A polygenic risk score for WHR adjusted for BMI, a measure

96 hat could allow selection of those with high polygenic risk scores for clinical trials and precision

97 m (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in

98 linkage disequilibrium score regression and polygenic risk scores for depressive symptoms, schizophr

99 ed published summary statistics to calculate polygenic risk scores for eight well-studied phenotypes.

100 Finally, we tested how polygenic risk scores for HIV-1 acquisition influence bl

101 brain regions and highlights the utility of polygenic risk scores for identifying molecular pathways

102 Polygenic risk scores for major depression were signific

103 We used polygenic risk scores for major depressive disorder (MDD

104 Polygenic risk scores for prostate cancer were higher in

105 Polygenic risk scores for psychiatric disorders, particu

106 To do this, polygenic risk scores for schizophrenia derived from a l

107 lso significantly positively correlated with polygenic risk scores for schizophrenia, alcohol use dis

108 Whole-genome polygenic risk scores for the development of Alzheimer's

109 t updates to the role of genetic testing and polygenic risk scores for the prediction of stroke and c

110 Our work indicates a potential use of polygenic risk scoring for the prediction of adult telom

111 d in increased trans-ancestry portability of polygenic risk scores from Europeans to East Asians acro

112 in the general population by 1) constructing polygenic risk scores from large genome-wide association

113 low-density lipoprotein cholesterol (LDL-C) polygenic risk score further increased CVD risk in patie

114 Polygenic risk scores had reduced performance when trans

115 monogenic FH and superimposed elevated LDL-C polygenic risk scores have the greatest risk of prematur

116 A polygenic risk score identified patients who were at >2-

117 Analyses of polygenic risk scores identified pleiotropy with neurops

118 relationships between gmCBF with APOE and AD polygenic risk score in a young cohort (N = 75; aged: 19

119 Our results suggest that the use of a polygenic risk score in fracture risk screening could de

120 (PGx) markers, blood antigen serotyping, and polygenic risk scores in 100 individuals (50 with cardio

121 g by testing the association between partner polygenic risk scores in 34,987 couple pairs from the UK

122 from the meta-analysis, we constructed five polygenic risk scores in a range of thresholds (p=5 x 10

123 The incremental value of polygenic risk scores in addition to well-established ri

124 ew opportunities for developing and applying polygenic risk scores in the clinic, to systematically e

125 iderations relevant to the implementation of polygenic risk scores in the health care setting.

126 urements of genetic risk (e.g. schizophrenia polygenic risk scores) in causation models to assess the

127 This scientific commentary refers to 'Polygenic risk score increases schizophrenia liability t

128 The remainder of the polygenic risk score influence (3.93%, CI 2.37-4.48%) re

129 e than a third (2.71%, CI 2.41-3.85%) of the polygenic risk score influence was mediated through cogn

130 disease risk for some disorders by means of polygenic risk scores integrated with classical epidemio

131 fied by genetic risk (low [quintile 1 of the polygenic risk score], intermediate [quintile 2-4 of the

132 The heritability explained by polygenic risk score is the highest for educational atta

133 Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric ge

134 These findings suggest that a polygenic risk score may not enhance risk prediction in

135 Applying the major depressive disorder polygenic risk score (MDD-PRS) derived from the most rec

136 ches, including genomics approaches (such as polygenic risk scores), microbiome profiling and, potent

137 ty was measured using a previously described polygenic risk score (N=929 single-nucleotide polymorphi

138 Second, we created polygenic risk scores of DBP and systolic blood pressure

139 The polygenic risk scores of LV phenotypes were predictive o

140 ion paths, exceeding the direct influence of polygenic risk score on schizophrenia risk (1.43%, CI 0.

141 itive deficit mediates some of the effect of polygenic risk scores on the disorder.

142 g individuals in the highest 0.44% of the AF polygenic risk score only 9.3% had AF.

143 can subjects in either cohort, nor did an AD polygenic risk score or genetic skin pigment score expla

144 s for incident depression were identified by polygenic risk scores or by reported traumatic life even

145 t gastric cancer across the quintiles of the polygenic risk score (p(trend)<0.0001).

146 Polygenic risk scores (PGS) enable rapid estimation of g

147 CAD discrimination for polygenic risk score, pooled cohort equations, and both

148 d to evaluate the predictive accuracy of the polygenic risk score, pooled cohort equations, and both

149 Through genome-wide polygenic-risk-score prediction, more than 6% of the phe

150 r meta-GWAS hit replication rates and poorer polygenic risk score predictive performance in survivor

151 A polygenic risk score predicts disease with up to 90% acc

152 Polygenic risk score profiling revealed improved predict

153 Finally, we perform phenome-wide polygenic risk score (PRS) analyses on 67 complex traits

154 We performed polygenic risk score (PRS) analyses to investigate share

155 ociation analyses were conducted between MDD polygenic risk score (PRS) and AD case-control status in

156 s interactions between an established 77-SNP polygenic risk score (PRS) and non-genetic risk factors

157 investigate the relationship between an IOP polygenic risk score (PRS) and short-term IOP profile.

158 The polygenic risk score (PRS) approach has shown 75 to 84%

159 A polygenic risk score (PRS) based on a GWAS of risk-toler

160 A polygenic risk score (PRS) composed of single nucleotide

161 A polygenic risk score (PRS) composed of these SNPs (RT-in

162 Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive

163 A polygenic risk score (PRS) derived from genome-wide asso

164 A glaucoma polygenic risk score (PRS) enables effective risk strati

165 We built a 201-variant polygenic risk score (PRS) for CAD and tested for intera

166 d with risk for BE or EAC, and constructed a polygenic risk score (PRS) for cases and controls by sum

167 To determine the incremental value of polygenic risk score (PRS) for coronary artery disease,

168 In this study, we developed a polygenic risk score (PRS) for DILI by aggregating effec

169 measure of total susceptibility burden, the polygenic risk score (PRS) for each individual was defin

170 e combined Magnetic Resonance Imaging with a polygenic risk score (PRS) for five psychiatric patholog

171 CNV burden and a polygenic risk score (PRS) for schizophrenia were used t

172 Calculating polygenic risk score (PRS) has become widely used due to

173 ease risk we test the extent to which higher polygenic risk score (PRS) identifies the affected sibli

174 A polygenic risk score (PRS) including 123 known risk vari

175 A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individu

176 Polygenic risk score (PRS) methods based on genome-wide

177 ized sequence kernel association testing and polygenic risk score (PRS) methods to examine rare and c

178 sk by using summarized GWAS results to build polygenic risk score (PRS) models in three PTC study gro

179 In addition, a polygenic risk score (PRS) of 188 prostate cancer varian

180 We constructed one polygenic risk score (PRS) per lipid trait (total choles

181 The authors sought to assess polygenic risk score (PRS) prediction of subsequent psyc

182 , we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of

183 iac arterial beds, and derived a genome-wide polygenic risk score (PRS) to identify a subset of the p

184 A polygenic risk score (PRS) was strongly associated with

185 schizophrenia risk alleles, as indexed by a polygenic risk score (PRS), carried by 139,679 participa

186 e a cumulative estimation of risk known as a polygenic risk score (PRS).

187 s of ADHD symptomatology are related to ADHD polygenic risk score (PRS).

188 history of breast cancer (N = 49,674) and a polygenic risk score (PRS, N = 9,365).

189 (GWAS) on delta age, combined into distinct polygenic risk scores (PRS(cis-eQTL) and PRS(GWAS)), and

190 ne-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to

191 014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5

192 Polygenic risk scores (PRS) aggregate the effects of man

193 as to evaluate the associations between ADHD polygenic risk scores (PRS) and a broad range of childho

194 study, we explore the association between MS polygenic risk scores (PRS) and brain imaging outcomes f

195 Polygenic risk scores (PRS) are poised to improve biomed

196 Polygenic risk scores (PRS) based on an individual's gen

197 Here, we show polygenic risk scores (PRS) calculated from genome-wide

198 We used data from the UK Biobank to combine polygenic risk scores (PRS) for 13 diseases and 12 morta

199 Polygenic risk scores (PRS) for BD, schizophrenia (SCZ),

200 Polygenic Risk Scores (PRS) for both traits are associat

201 Polygenic risk scores (PRS) for breast cancer have poten

202 Polygenic risk scores (PRS) for coronary artery disease

203 Recent studies indicate high polygenic risk scores (PRS) for coronary artery disease

204 Psychiatric risk alleles were indexed by polygenic risk scores (PRS) for schizophrenia using geno

205 Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and s

206 Polygenic risk scores (PRS) for the 22 risk factors were

207 Using polygenic risk scores (PRS) from a European-ancestry gen

208 ifferent approaches to generating predictive polygenic risk scores (PRS) from genome-wide association

209 Polygenic risk scores (PRS) have been shown to predict b

210 Polygenic risk scores (PRS) have shown promise in predic

211 Polygenic risk scores (PRS) may soon be used to predict

212 Polygenic risk scores (PRS) provide a personalized genet

213 opulations, which limits the use of existing polygenic risk scores (PRS) to identify subpopulations a

214 We also analyzed the impact of polygenic risk scores (PRS), calculated using genetic va

215 ts at the 99th risk percentile of underlying polygenic risk scores (PRS), compared to average risk, r

216 Polygenic risk scores (PRS), which capture the genetic s

217 mple, comparing their predictive accuracy to polygenic risk scores (PRS).

218 e genetic liability of complex disease using polygenic risk scores (PRS).

219 n models and molecular genetic methods, i.e. polygenic risk scores (PRS).

220 stimate associations between 135 SNPs (and a polygenic risk score, PRS) and LCADs among 6345 individu

221 orts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing

222 tologies, for association with schizophrenia polygenic risk scores (PRSs) and with diagnosis, and als

223 Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medi

224 While polygenic risk scores (PRSs) are poised to be translated

225 e we developed an alternative approach using polygenic risk scores (PRSs) based on genome-wide associ

226 The mean polygenic risk scores (PRSs) between study subjects with

227 Previous research has shown that polygenic risk scores (PRSs) can be used to stratify wom

228 There is growing evidence that polygenic risk scores (PRSs) can identify individuals wi

229 ding to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and

230 Polygenic risk scores (PRSs) denoting the sum of an indi

231 The authors investigated the role of polygenic risk scores (PRSs) derived from a TS genome-wi

232 By contrast, polygenic risk scores (PRSs) derived from genome-wide as

233 This study examined the association of polygenic risk scores (PRSs) for a broad depression phen

234 We hypothesized that higher polygenic risk scores (PRSs) for AD would be associated

235 n The Netherlands (2002-2006), we calculated polygenic risk scores (PRSs) for ASD and attention-defic

236 Psychiatric genetic risk was indexed by polygenic risk scores (PRSs) for attention deficit hyper

237 SUA in 6,881 Korean individuals, calculated polygenic risk scores (PRSs) for common variants, and va

238 Because polygenic risk scores (PRSs) for coronary heart disease

239 Polygenic risk scores (PRSs) for major depression, bipol

240 stream mechanistic investigation or yielding polygenic risk scores (PRSs) for prognostication.

241 Polygenic risk scores (PRSs) for schizophrenia were calc

242 Polygenic risk scores (PRSs) have become the standard fo

243 Polygenic risk scores (PRSs) have been applied to many c

244 Polygenic risk scores (PRSs) have been consistently asso

245 Polygenic risk scores (PRSs) have shown promise in predi

246 Polygenic risk scores (PRSs) have successfully summarize

247 To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an ext

248 We constructed polygenic risk scores (PRSs) using external weights and

249 ividual risk prediction based on genome-wide polygenic risk scores (PRSs) using millions of genetic v

250 o, high psoriasis, and low atopic dermatitis polygenic risk scores (PRSs) were associated with longer

251 Additionally, 3 polygenic risk scores (PRSs) were generated with 97 BMI

252 We derived polygenic risk scores (PRSs) with ~6M variants separatel

253 Relationships between Tourette's polygenic risk scores (PRSs), other tic disorders, ascer

254 ted genetic variants used in a prototype QTc-polygenic risk score (QTc-PRS).

255 Polygenic risk score quantifying the risk across multipl

256 enotype identified by these four models are: polygenic risk score, sex, age, and education.

257 At age 7-9 years, schizophrenia polygenic risk scores showed associations with lower per

258 Analyses of polygenic risk scores showed that individuals with a hig

259 Models without using hazard weights, i.e. polygenic risk scores, showed lower predictive power tha

260 EO-IBD patients have, on average, higher IBD polygenic risk scores than population controls (99 patie

261 summarizes clinical CKD risk factors, and a polygenic risk score that summarizes genetic information

262 Polygenic risk scores that provide an overall estimate o

263 y lifestyle factors and family history and a polygenic risk score, the model identified women at high

264 and, although it generates highly predictive polygenic risk scores, the predictive power can be expla

265 In clinical research, the application of polygenic risk scores-the cumulative sum of associated a

266 anding of EoE and provides a framework for a polygenic risk score to be validated in future studies.

267 ng a risk threshold of 7.5%, addition of the polygenic risk score to pooled cohort equations resulted

268 Addition of the polygenic risk score to the pooled cohort equations did

269 risk threshold of 7.5%, the addition of the polygenic risk score to the pooled cohort equations did

270 The utility of polygenic risk scores to stratify coronary artery diseas

271 riking ability of genetics, in the form of a polygenic risk score, to identify those individuals at h

272 Polygenic risk score using variants rs2230288 and rs2291

273 those at high genetic risk (top quintile of polygenic risk score) versus all others (WOSCOPS), as we

274 among participants at the 95th percentile of polygenic risk score was 88.2% (95% CI, 71.8-95.7).

275 When this polygenic risk score was applied to the CKB cohort, we f

276 redictive accuracy of a previously validated polygenic risk score was assessed among 4847 adults of w

277 Each 1-SD increase in the polygenic risk score was associated with 1.32-fold (95%

278 An AF polygenic risk score was associated with AF (hazard rati

279 Polygenic risk score was associated with all subtypes ex

280 this analysis of 2 cohorts of US adults, the polygenic risk score was associated with incident corona

281 The performance of the polygenic risk score was compared with that of the 2013

282 10-5), while the estrogen receptor-negative polygenic risk score was much higher in blacks than in w

283 The polygenic risk score was significantly associated with 1

284 2DS and population-based cohorts showed that polygenic risk score was significantly greater in indivi

285 The calculation of polygenic risk scores was based on genome-wide associati

286 Polygenic risk scoring was used to investigate the genet

287 Polygenic risk score were generated from a published Psy

288 depressive symptoms, we found that higher RA polygenic risk scores were associated with increased str

289 Polygenic risk scores were calculated from summary stati

290 Polygenic risk scores were computed for each individual

291 Polygenic risk scores were constructed based on common g

292 Polygenic risk scores were constructed from the summary

293 No significant association between partner polygenic risk scores were observed.

294 OCD polygenic risk scores were significantly associated with

295 Project, we found that higher schizophrenia polygenic risk scores were significantly correlated with

296 Polygenic risk scores were used to assess the collective

297 These have been combined into a vitiligo polygenic risk score, which has allowed various aspects

298 The odds ratios of polygenic risk scores, which included 330 variants, for

299 The genetic extended model included a polygenic risk score with 313 single nucleotide polymorp

300 We show a significant interaction of the polygenic risk scores with personal life events (0.12% o