ライフサイエンスコーパス: polyinosinic-polycytidylic acid

1 stimulation with TLR ligands (Pam3CSK4, LPS, polyinosinic-polycytidylic acid).

2 tion or in adulthood to the immune stimulant polyinosinic-polycytidylic acid.

3 al genes induced by a synthetic viral mimic, polyinosinic-polycytidylic acid.

4 icity induced by TNF, lipopolysaccharide and polyinosinic-polycytidylic acid.

5 n of apoptosis by both transfected PRNAs and polyinosinic-polycytidylic acid.

6 administration of low doses of a TLR ligand, polyinosinic-polycytidylic acid.

7 i such as lipopolysaccharide, IFN-gamma, and polyinosinic-polycytidylic acid.

8 n hematopoietic cells upon inducing Cre with polyinosinic-polycytidylic acid.

9 ize the synthetic MDA5 agonist/(ds)RNA mimic polyinosinic-polycytidylic acid.

10 on with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid.

11 to CD8(+) T cells following activation with polyinosinic-polycytidylic acid.

12 FN-alphabeta-inducing viral infections or by polyinosinic:polycytidylic acid.

13 rat virus following brief pretreatment with polyinosinic:polycytidylic acid.

14 DCs after activation with the TLR3 agonist, polyinosinic:polycytidylic acid.

15 intraperitoneally at gestational day 9 with polyinosinic:polycytidylic acid.

16 kness induced by lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid.

17 by exposing neurospheres to the viral mimic, polyinosinic:polycytidylic acid.

18 EW.1W and Wistar Furth) strains induced with polyinosinic:polycytidylic acid.

19 6 production in response to the viral mimic, polyinosinic:polycytidylic acid.

20 o injections with LPS (a bacterial mimic) or polyinosinic-polycytidylic acid (a viral mimic), M-TRAF3

21 eport in this study that TLR3 stimulation by polyinosinic-polycytidylic acid, a double-stranded RNA a

22 murine DCs in response to the dsRNA agonist polyinosinic-polycytidylic acid, a subset of which were

23 In this study, we describe a model of polyinosinic: polycytidylic acid-accelerated lupus nephr

24 Polyinosinic-polycytidylic acid activated IFN regulatory

25 tranded PRNAs 50 nucleotides long as well as polyinosinic-polycytidylic acid activated the RNA-depend

26 dies markedly diminished the cytotoxicity of polyinosinic-polycytidylic acid-activated natural killer

27 llular immunity as well as an enhancement of polyinosinic-polycytidylic acid activation of TLR3.

28 ls have a deficiency in activation following polyinosinic:polycytidylic acid administration in vivo.

29 We found that polyinosinic:polycytidylic acid, aka poly(I:C), exposure

30 he synthetic analogue of viral nucleic acid, polyinosinic-polycytidylic acid, also induced IL-6-depen

31 response to inflammatory stimuli, including polyinosinic polycytidylic acid and LPS.

32 accination with a peptide subunit mixed with polyinosinic-polycytidylic acid and agonistic anti-CD40

33 ng APC pretreated ex vivo with TLR agonists, polyinosinic-polycytidylic acid and CpG, to prime naive

34 We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus inf

35 The synthetic dsRNA analog polyinosinic-polycytidylic acid and infection with live

36 ase to athymic WAG-rnu/rnu rats treated with polyinosinic: polycytidylic acid and a monoclonal antibo

37 ls readily develop IDDM after treatment with polyinosinic:polycytidylic acid and a cytotoxic anti-RT6

38 of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that dep

39 DDM can readily be induced by treatment with polyinosinic:polycytidylic acid and depletion of RT6+ T-

40 (lsl-)(DTA) bone marrow with the viral mimic polyinosinic:polycytidylic acid and found a significant

41 sponse to the immunostimulatory nucleic acid polyinosinic:polycytidylic acid and UV light irradiation

42 D8(+) T cell epitope M282-90, a TLR agonist (polyinosinic-polycytidylic acid), and a costimulatory an

43 s, including Sendai virus, the dsRNA mimetic polyinosinic-polycytidylic acid, and LPS all activated d

44 In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in com

45 an ISCOMATRIX vaccine with the TLR3 agonist, polyinosinic-polycytidylic acid, and TLR9 agonist, CpG,

46 analog of viral double-stranded RNA (dsRNA) polyinosinic-polycytidylic acid, and type-II interferon-

47 uced in numbers upon in vivo activation with polyinosinic:polycytidylic acid, and have poor survival

48 -type BMDM upon treatment with LPS, E. coli, polyinosinic:polycytidylic acid, and herring sperm DNA.

49 ld be modulated by crude LPS, peptidoglycan, polyinosinic:polycytidylic acid, and rIFN-gamma in cell

50 hilic airway inflammation induced by HDM and polyinosinic-polycytidylic acid, APOE reached a concentr

51 cted with a modified form of the viral mimic polyinosinic:polycytidylic acid at the end of the first

52 ated with a modified form of the viral mimic polyinosinic:polycytidylic acid at the end of the first

53 major producers of IFN-lambda in response to polyinosinic-polycytidylic acid but are similar to CD1c(

54 XCR1(+) DC were strongly activated by polyinosinic-polycytidylic acid but not LPS, and convers

55 jection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in

56 Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced exp

57 Downregulation upon polyinosinic-polycytidylic acid challenge and expression

58 l effect of IFN-alpha/beta induced by either polyinosinic-polycytidylic acid complex or by lymphocyti

59 ated pathogen-exposed mice intranasally with polyinosinic-polycytidylic acid condensed with poly-l-ly

60 We demonstrated that polyinosinic:polycytidylic acid consistently up-regulate

61 ull cells treated with lipopolysaccharide or polyinosinic-polycytidylic acid coordinate with constitu

62 rejection, and the interferon-inducing agent polyinosinic:polycytidylic acid did not induce allograft

63 mice exposed to the viral mimetic poly I:C (polyinosinic:polycytidylic acid) either on gestational d

64 bromide/monomycoloyl glycerol liposomes with polyinosinic:polycytidylic acid electrostatically adsorb

65 ecipient exposure to the viral-like adjuvant polyinosinic:polycytidylic acid enhanced anti-FVIII anti

66 Rather, polyinosinic:polycytidylic acid exposure activates ISGs,

67 beta)-, prion peptide-, double-stranded RNA (polyinosinic-polycytidylic acid)-, HIV-1 Tat-, 1-methyl-

68 ion is observed in macrophages after LPS and polyinosinic:polycytidylic acid in vitro.

69 Treatment of BAFF-RFP mice with polyinosinic:polycytidylic acid increased BAFF expressio

70 -activating lipopeptide-2, or a TLR3 ligand, polyinosinic-polycytidylic acid, increased Cox-2 mRNA an

71 d by TNF-a, HIV-1 Tat, and viral dsRNA mimic polyinosinic-polycytidylic acid, indicating the specific

72 macrophage activation by TLR ligands LPS and polyinosinic-polycytidylic acid induced a time-dependent

73 fibrosis, natural killer cell activation by polyinosinic-polycytidylic acid induced cell death to ac

74 Notably, polyinosinic:polycytidylic acid induced nuclear localiza

75 In contrast, a synthetic dsRNA, polyinosinic polycytidylic-acid, induced CD11c(+) DC, bu

76 in LP hosts were markedly less responsive to polyinosinic-polycytidylic acid-induced acute proliferat

77 Polyinosinic-polycytidylic acid-induced antiviral genes

78 ttern recognition receptors was required for polyinosinic-polycytidylic acid-induced IFN-alpha/beta p

79 Compound II inhibited polyinosinic-polycytidylic acid-induced immune activatio

80 Importantly, we discovered that the polyinosinic-polycytidylic acid-induced increase in prod

81 essing RIPK1 D138N are resistant to TNF- and polyinosinic-polycytidylic acid-induced necroptosis in v

82 A defect in polyinosinic-polycytidylic acid-induced TLR3 responses c

83 HDM-SLIT resulted in increased polyinosinic:polycytidylic acid-induced expression of IF

84 induced or synthetic dsRNA-based viral mimic polyinosinic:polycytidylic acid-induced expression of pr

85 , unlike those transfused in the presence of polyinosinic:polycytidylic acid-induced inflammation.

86 w-derived macrophages; however, priming with polyinosinic-polycytidylic acid induces it and confers n

87 Instead, challenge of TM with LPS or polyinosinic-polycytidylic acid induces MAPK, AP-1, and

88 of stimulating anti-CD40 Ab and TLR3 ligand polyinosinic-polycytidylic acid induces protective respo

89 Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of

90 ytomegalovirus infection or after repetitive polyinosinic-polycytidylic acid injection.

91 s was seen in adult mice that received daily polyinosinic-polycytidylic acid injections, but not in a

92 eritoneal injection of lipopolysaccharide or polyinosinic:polycytidylic acid into mice, mimicking bac

93 lity of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its in

94 ernal immune activation (MIA) model in which polyinosinic:polycytidylic acid is injected into pregnan

95 TLR3 activation with polyinosinic-polycytidylic acid led to comparable or eve

96 Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta ex

97 for 24 hours with the virus/bacteria mimics polyinosinic:polycytidylic acid/lipopolysaccharide.

98 with matched controls using the viral ligand polyinosinic-polycytidylic acid-low-molecular-weight/Lyo

99 g HEK293 cells to stimulation with Pam3CSK4, polyinosinic-polycytidylic acid, LPS, and ODN2006, respe

100 s gene greatly sensitizes cells to cytosolic polyinosinic/polycytidylic acid-mediated induction of ty

101 31 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of T

102 r LPS to shorten allograft survival, whereas polyinosinic:polycytidylic acid mediates its effects thr

103 domain (ASC)-dependent, m-3M3FBS-activated, polyinosinic:polycytidylic acid-modulated inflammasome d

104 The observed protective effect of polyinosinic-polycytidylic acid on liver fibrosis was di

105 Treatment with polyinosinic-polycytidylic acid or a combination of mono

106 Moreover, treatment with polyinosinic-polycytidylic acid or interferon gamma enha

107 ted a cell-associated Ag upon stimulation by polyinosinic-polycytidylic acid or R848, likewise to wha

108 nal antibody and then exposed them to either polyinosinic:polycytidylic acid or a diabetogenic virus

109 accelerated following the administration of polyinosinic:polycytidylic acid or allogeneic cells (gra

110 DC) maturation induced by LPS, as opposed to polyinosinic:polycytidylic acid or cytosine-phosphate-gu

111 or ATI-free diet and in mice given low-level polyinosinic:polycytidylic acid or dextran sodium sulfat

112 l lysates, preventing PKR phosphorylation by polyinosinic:polycytidylic acid or HIV trans-activation

113 inistered systemically with the TLR3 agonist polyinosinic:polycytidylic acid or were given subcutaneo

114 domain-containing adapter inducing IFN-beta (polyinosinic-polycytidylic acid) or MyD88 (imiquimod), d

115 27(p28) after engagement of either the TLR3 (polyinosinic-polycytidylic acid) or TLR4 (LPS) receptor.

116 e TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted

117 during virus infection, cellular exposure to polyinosinic-polycytidylic acid, or TBK1 overexpression.

118 ed with macrophage-activating lipopeptide-2, polyinosinic-polycytidylic acid, or UVB (15 mJ/cm(2)), b

119 In the absence of polyinosinic:polycytidylic acid, or in the presence of a

120 nephrine both ameliorate lipopolysaccharide, polyinosinic:polycytidylic acid, or tripalmitoyl-S-glyce

121 poorly radioimmunogenic tumors, the adjuvant polyinosinic-polycytidylic acid overcomes this failure f

122 We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with t

123 ered that induction of LMP7 by a low dose of polyinosinic:polycytidylic acid (PI:C) reduced RV-mediat

124 in conjunction with the Th1-biased adjuvant polyinosinic:polycytidylic acid (pI:C).

125 MIA was induced in C57BL/6 mice by polyinosinic-polycytidylic acid (PIC) injected during em

126 sruption in beta-cells partially counteracts polyinosinic-polycytidylic acid (PIC)-induced STAT1 and

127 oaded with Torula Yeast RNA (TYRNA)(640 nm), polyinosinic: polycytidylic acid (pIC)(680 nm), or splic

128 To test whether retinoic acid (RA) and polyinosinic:polycytidylic acid (PIC), an inducer of int

129 Among the compounds tested, polyinosinic:polycytidylic acid (PIC, a Toll-like recept

130 on of the synthetic double stranded (ds) RNA polyinosinic-polycytidylic acid (poly (I:C)) widely, but

131 blast-like synoviocytes were stimulated with polyinosinic-polycytidylic acid (poly [I-C]) after trans

132 Here, by using the polyinosinic-polycytidylic acid (Poly I:C) model of gest

133 Polyinosinic-polycytidylic acid (Poly I:C) or IFN-gamma

134 Polyinosinic-polycytidylic acid (poly I:C) or IFN-gamma

135 y in murine astrocyte primary cultures using polyinosinic-polycytidylic acid (poly I:C), a synthetic

136 Polyinosinic-polycytidylic acid (poly I:C), a TLR3 ligan

137 d RI, were stimulated with the synthetic RNA polyinosinic-polycytidylic acid (poly I:C).

138 t and human islets with dsRNA in the form of polyinosinic-polycytidylic acid (poly IC) and IFN-gamma

139 y, we assessed the effect of the TLR3 ligand polyinosinic-polycytidylic acid (poly IC) on CD8 T cell

140 The synthetic dsRNA molecule polyinosinic-polycytidylic acid (poly IC) stimulates bet

141 randed RNA (dsRNA) (in the form of synthetic polyinosinic-polycytidylic acid (poly IC)) on islet expr

142 ly induced by the Toll-like receptor ligands polyinosinic-polycytidylic acid (poly(I:C)) and flagelli

143 an absence of response to TLR3 activation by polyinosinic-polycytidylic acid (poly(I:C)) and related

144 C57BL/6J mouse dams were treated with polyinosinic-polycytidylic acid (Poly(I:C)) at embyronic

145 tured microglia responded to synthetic dsRNA polyinosinic-polycytidylic acid (poly(I:C)) by increasin

146 ecific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting fr

147 of systemic IFN-beta expression elicited by polyinosinic-polycytidylic acid (poly(I:C)) treatment or

148 lung fibroblasts, the synthetic TLR3 ligand polyinosinic-polycytidylic acid (poly(I:C)), a dsRNA ana

149 TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic

150 Polyinosinic-polycytidylic acid (poly(I:C)), an analog o

151 f toll-like receptor 3, by the viral mimetic polyinosinic-polycytidylic acid (poly(I:C)), led to disr

152 -regulates the induction by a viral mimetic, polyinosinic-polycytidylic acid (poly(I:C)), of the endo

153 ry molecules such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly(I:C)), TNF-alpha,

154 P2), expressed in the presence or absence of polyinosinic-polycytidylic acid (poly(I:C)), which elici

155 Anti-CD40 also increased polyinosinic-polycytidylic acid (poly(I:C))-inducible IF

156 64.7 macrophage cells stimulated with LPS or polyinosinic-polycytidylic acid (poly(I:C)).

157 opolysaccharide (LPS, bacterial antigen) and polyinosinic-polycytidylic acid (poly(I:C), viral antige

158 Escherichia coli (TLR4), lipoprotein (TLR2), polyinosinic-polycytidylic acid (poly-IC) (TLR9), and th

159 ctive cytokine responses upon challenge with polyinosinic-polycytidylic acid (poly-IC).

160 ith the antiviral immune response activating polyinosinic-polycytidylic acid (poly[I:C]) completely p

161 As polyinosinic-polycytidylic acid (poly[I:C]), which mimic

162 Of the TLRs ligands tested, the TLR3 ligand, polyinosinic/polycytidylic acid (Poly(I:C)), most highly

163 5416 rats were treated with the TLR3 agonist polyinosinic/polycytidylic acid (Poly[I:C]).

164 Here, we used a MIA rodent model in which polyinosinic: polycytidylic acid (poly (I:C)) was inject

165 osed to HRV16 (multiplicity of infection 5), polyinosinic:polycytidylic acid (poly I:C) 30 mug/ml, IF

166 We treated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C) on gestationa

167 al inflammation induced by the viral mimetic polyinosinic:polycytidylic acid (poly I:C) on gestationa

168 d to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expres

169 Polyinosinic:polycytidylic acid (poly I:C), a synthetic

170 ariable that determines fever severity using polyinosinic:polycytidylic acid (poly I:C), a synthetic

171 We stimulate fish systemically with polyinosinic:polycytidylic acid (poly I:C), a synthetic

172 ts and develop diabetes after treatment with polyinosinic:polycytidylic acid (poly I:C), a synthetic

173 that lipopolysaccharide, a TLR4 ligand; and polyinosinic:polycytidylic acid (poly I:C), a TLR3 ligan

174 r ability to prime T cells: the TLR3 ligand, polyinosinic:polycytidylic acid (poly I:C), and immunost

175 aradigm, we treated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C), which simula

176 llenged with virus or with the viral mimetic polyinosinic:polycytidylic acid (poly I:C).

177 inflammatory cytokine induction elicited by polyinosinic:polycytidylic acid (poly I:C; a synthetic d

178 toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most

179 dified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late f

180 dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated in

181 c acid) (PLGA) nanoparticles adjuvanted with polyinosinic:polycytidylic acid (poly(I:C) as an adjuvan

182 Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind and act

183 esponse to stimulation by the dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) was dependen

184 necrosis factor (TNF), lipopolysaccharide or polyinosinic:polycytidylic acid (poly(I:C))-induced necr

185 on of NK cells by influenza-infected DCs and polyinosinic:polycytidylic acid (poly(I:C))-treated DCs

186 Week 24 and stimulated with the viral mimic polyinosinic:polycytidylic acid (poly(I:C)).

187 ere treated by i.p. injection of alphaPD-L1, polyinosinic:polycytidylic acid (poly[I:C]), or both.

188 y reported that viral-like inflammation with polyinosinic polycytidylic acid [poly (I:C)] significant

189 Polyinosinic-polycytidylic acid [Poly (I:C)], a dsRNA re

190 edge, we demonstrate for the first time that polyinosinic-polycytidylic acid [poly (I:C)], a syntheti

191 Alpha/beta interferon induction by polyinosinic-polycytidylic acid [poly(I-C)] treatment ef

192 mice treated with the IFN-alpha/beta inducer polyinosinic-polycytidylic acid [poly(I-C)].

193 or peptidoglycan (PGN; a TLR 2 agonist) and polyinosinic-polycytidylic acid [poly(I:C); a TLR3 agoni

194 diator production induced by the viral mimic polyinosinic-polycytidylic acid [poly(I:C)] in primary h

195 Polyinosinic-polycytidylic acid [poly(I:C)] is a known i

196 of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A pr

197 Application of polyinosinic-polycytidylic acid [poly(I:C)] or LPS induc

198 antigen (GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized b

199 n regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, co

200 lovirus (MCMV) infection and the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] were used to

201 hat preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic o

202 CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer

203 port that a potent inducer of IFN-alphabeta, polyinosinic-polycytidylic acid [poly(I:C)], led to the

204 se combinations were resiquimod (R-848) plus polyinosinic-polycytidylic acid [Poly(I:C)], R-848 plus

205 by treatment of cells or fish with the dsRNA polyinosinic-polycytidylic acid [poly(I:C)], which induc

206 phorothioate oligonucleotide [Poly(dT)], and polyinosinic-polycytidylic acid [Poly(I:C)].

207 ied in Montanide ISA51 with or without TLR3 (polyinosinic-polycytidylic acid [poly-IC]), TLR4 (monoph

208 ant dams received either saline (control) or polyinosinic: polycytidylic acid [poly(I:C)] injections

209 in humans to synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized wit

210 ured vascular smooth muscle cells (VSMCs) to polyinosinic:polycytidylic acid [poly(I:C)] and was nece

211 ls were purified and cultured overnight with polyinosinic:polycytidylic acid [poly(I:C)] as a viral a

212 MIA are induced by injecting Polyinosinic:polycytidylic acid [Poly(I:C)] at 10 mg/kg

213 uvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also sup

214 served in mice born to mothers injected with polyinosinic:polycytidylic acid [poly(I:C)] during pregn

215 ing the Toll-like receptor 3 (TLR-3) agonist polyinosinic:polycytidylic acid [poly(I:C)] in the SN of

216 Tlr4(-/-) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pr

217 n of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments r

218 n vivo administration of the synthetic dsRNA polyinosinic:polycytidylic acid [poly(I:C)], but not lip

219 A toll-like receptor 3 agonist, polyinosinic:polycytidylic acid [poly(I:C)], was also en

220 ive transcriptional regulator STAT3 inhibits polyinosinic:polycytidylic acid [poly(I:C)]-induced cDC1

221 nge with the double-stranded viral RNA mimic polyinosinic:polycytidylic acid [Poly(I:C)].

222 In combination, synthetic dsRNA (polyinosinic-polycytidylic acid, poly(I-C)) and interfer

223 n mice than the previously employed adjuvant polyinosinic:polycytidylic acid, ((poly(I:C), InvivoGen,

224 Vaccine was administered in combination with polyinosinic-polycytidylic acid-poly-I-lysine carboxymet

225 he effects of double-stranded RNA (synthetic polyinosinic-polycytidylic acid; poly(I-C)) on macrophag

226 Activation of TLR3 by polyinosinic-polycytidylic acid (polyI:C) leads to induc

227 by the synthetic double-stranded RNA ligand, polyinosinic-polycytidylic acid (polyI:C), leads to decr

228 une programming of fetal loss in response to polyinosinic:polycytidylic acid (polyI:C), a viral mimic

229 8.5) by administering the viral dsRNA mimic polyinosinic:polycytidylic acid (PolyI:C).

230 mmune activation (MIA) during pregnancy with polyinosinic:polycytidylic acid (polyI:C).

231 nt study, we employed the viral RNA mimetic (polyinosinic-polycytidylic acid [polyI:C]) to emulate vi

232 Polyinosinic-polycytidylic acid (PolyIC), a "mimic" of d

233 virus infection and treatment of cells with polyinosinic-polycytidylic acid (polyIC; a dsRNA mimetic

234 Using prenatal (E12.5) injection with polyinosinic-polycytidylic acid potassium salt as a mous

235 uction, whereas CpG oligodeoxynucleotide and polyinosinic:polycytidylic acid primarily stimulated Th1

236 nd did not decrease in spleen in response to polyinosinic-polycytidylic acid-promoted hepatitis.

237 Moreover, the IFN inducer polyinosinic:polycytidylic acid promotes fetal resorptio

238 XCL4-moDCs exclusively upon stimulation with polyinosinic-polycytidylic acid, R848, and CL075 ligands

239 st to subtle changes in antivirus-associated polyinosinic:polycytidylic acid response profiles, the b

240 Challenge with polyinosinic-polycytidylic acid results in a rapid and s

241 g via TLR7) and MyD88-independent receptors (polyinosinic:polycytidylic acid signaling via TLR3 or ds

242 emonstrate that treatment with radiation and polyinosinic-polycytidylic acid significantly expands th

243 duce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) t

244 M-CSF, rmIFN-gamma, rmIFN-alpha, rmIL-4, and polyinosinic-polycytidylic acid stabilized by lysine and

245 1 and given every 3 weeks with intramuscular polyinosinic-polycytidylic acid stabilized by lysine and

246 e viral mimic synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-l-l

247 viral mimic, synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-L-l

248 These data indicate that CpG DNA and polyinosinic-polycytidylic acid stimulate different type

249 In rainbow trout RTG-2 and RTS-11 cells, polyinosinic-polycytidylic acid stimulation resulted in

250 In contrast, polyinosinic:polycytidylic acid strongly represses CpG's

251 omodulators (monomycolyl glycerol analog and polyinosinic-polycytidylic acid) that efficiently induce

252 the effects of the inhaled viral TLR ligands polyinosinic-polycytidylic acid (TLR3) and resiquimod (T

253 including LPS (TLR4), peptidoglycan (TLR2), polyinosinic-polycytidylic acid (TLR3), CpG DNA (TLR9),

254 nistration of the TLR agonists LPS (TLR4) or polyinosinic:polycytidylic acid (TLR3) to mice treated w

255 LR7/8 activation, but selectively spared the polyinosinic-polycytidylic acid/TLR3 pathway.

256 s were coinjected with TLR2 (Pam3Cys), TLR3 (polyinosinic:polycytidylic acid), TLR4 (LPS), or TLR9 (C

257 t to necroptosis after stimulation with LPS, polyinosinic-polycytidylic acid, TNF-alpha, or IFN-beta

258 nation, even in the presence of anti-CD40 or polyinosinic:polycytidylic acid to induce DC maturation.

259 l growth factors and innate immune activator polyinosinic:polycytidylic acid to induce endothelial ce

260 ith the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid to mimic viral infection

261 However, KCs isolated from polyinosinic:polycytidylic acid-treated mice expressed s

262 Polyinosinic-polycytidylic acid treatment also ameliorat

263 Polyinosinic-polycytidylic acid treatment of RAG(-/-) mi

264 cted in primary head kidney leukocytes after polyinosinic-polycytidylic acid treatment, whereas a mod

265 of antiviral stress granule aggregates upon polyinosinic:polycytidylic acid treatment.

266 f 17 T1/3IFNs in response to the viral mimic polyinosinic-polycytidylic acid using a sensitive PCR as

267 lysaccharide, cytosine-phosphate-guanine, or polyinosinic:polycytidylic acid) using flow cytometry an

268 The Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid, was used to activate in

269 RNA viruses (polyuridine) and dsRNA viruses (polyinosinic-polycytidylic acid) were significantly weak

270 r subsequent transfusions in the presence of polyinosinic:polycytidylic acid, whereas anti-hGPA level

271 head kidney leukocytes when stimulated with polyinosinic:polycytidylic acid, whereas group II IFN wa

272 Treatment of infected mice with a complex of polyinosinic-polycytidylic acid with poly-L-lysine and c