ライフサイエンスコーパス: polymerase

1 to support the avian-origin influenza virus polymerase.

2 and the evolutionary implications of the RSV polymerase.

3 a block in the initiation phase of the viral polymerase.

4 or, but not by a host-like high fidelity DNA polymerase.

5 me an efficient and faithful replicative DNA polymerase.

6 arboring a mutation in the RNA-dependent RNA polymerase.

7 ty map to individual modular domains of this polymerase.

8 aracterized by low expression and poised RNA-polymerase.

9 ropensity to interact with influenza A virus polymerase.

10 in plants) are copied by host transcription polymerases.

11 suppressed in the catalytic site of most DNA polymerases.

12 ion forks lead to recruitment of error-prone polymerases.

13 n misincorporated by viral RNA-dependent RNA polymerases.

14 plication mode and nature of the replicative polymerases.

15 ding high selectivity and compatibility with polymerases.

16 with complementary DNA templates behind RNA polymerases.

17 Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme involved in DN

18 at catalyses this reaction, poly(ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years

19 tion forks from stalling at poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhib

20 ebellar neurons, supporting poly(ADP-ribose) polymerase-1 upregulation.

21 are instead processed into RNA-dependent RNA polymerase 6-dependent small RNAs, resulting in their co

22 aloxavir is a cap-dependent inhibitor of the polymerase acid (PA) protein of influenza viruses.

23 3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduce

24 sDNA showed binding of the conjugates at the polymerase active site, however, in different modes in t

25 s in a manner dependent on RNA-dependent RNA polymerase activity and on DRH-1.

26 We show that DNA-dependent NP-DNA polymerase activity depends on conserved active site res

27 M317V, and NP I109T) identified to increase polymerase activity in chicken cells.

28 HP-88309-a non-nucleoside inhibitor of viral polymerase activity that possesses unusual broad-spectru

29 er sequence as essential to the in vitro RSV polymerase activity, consistent with the results previou

30 Yeast Pole-P301R has increased DNA polymerase activity, which could underlie its high mutag

31 A combination of highly processive RNA polymerases, allosteric protein transcription factors an

32 Translocation of DNA and RNA polymerases along their duplex substrates results in DNA

33 In the DAMR system, recombinase polymerase amplification (RPA) and CRISPR-Cas12a derived

34 DNA amplification assay based on recombinase polymerase amplification (RPA) was developed.

35 like domain containing the RNA-dependent RNA polymerase and an appendage of globular domains containi

36 on of AceR to enable interaction between RNA polymerase and promoter DNA were also observed following

37 ted CD38 NADase and reduced poly(ADP-ribose) polymerase and SIRT1 activities, respectively, affecting

38 g of the functional relationship between RNA polymerase and the ribosome as well as the basis of tran

39 Polymerases and exonucleases act on 3' ends of nascent R

40 in the absence of this system, accessory DNA polymerases and MutY/M contribute to antibiotic-induced

41 Recent biophysical studies of RNA polymerases and their inhibition, as well as transcripti

42 ic RNA, nucleoprotein, the RNA-dependent RNA polymerase, and a polymerase cofactor, the phosphoprotei

43 Polymerases are commonly targeted by nucleotide analog i

44 de novo RNA synthesis using the purified RSV polymerase as 8 nucleotides (nt), shorter than previousl

45 escribe the well-known interactions with RNA polymerase as well as a broader range of cellular target

46 through viral RNA profiling and in vitro MeV polymerase assays identified a block in the initiation p

47 Both intra- and interchromosomal RNA polymerase-associated contacts involve multiple genes di

48 ase-polymerase, increase DNA reannealing and polymerase backtracking, and generate frayed primer-ends

49 These results indicate that DNA polymerase beta can induce a strain in the DNA that modu

50 DNA polymerase beta has two DNA-binding domains that interac

51 The RNA polymerase-binding protein DksA, together with the alarm

52 e rate of transcription by DNA-dependent RNA polymerases, but the influence of DNA sequence on transc

53 The evidence that a DNA polymerase can configure its active site entirely differ

54 We used droplet digital polymerase chain reaction (ddPCR) to demonstrate that hu

55 tein expression were assessed with real-time polymerase chain reaction (n=4-6/group) and Western blot

56 parum infections, using both microscopy- and polymerase chain reaction (PCR) -based methods, was perf

57 The evaluation of miRNA polymerase chain reaction (PCR) arrays indicated that th

58 Multiplexed polymerase chain reaction (PCR) assays increase the dete

59 While polymerase chain reaction (PCR) detection corresponded w

60 to test positive for the causative virus by polymerase chain reaction (PCR) even after clinical reco

61 The polymerase chain reaction (PCR) has been the gold standa

62 cidence of SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) in seropositive and sero

63 for haemosporidian parasites using a nested polymerase chain reaction (PCR) protocol that targets th

64 navirus 2 (SARS-CoV-2) infection detected on polymerase chain reaction (PCR) screening of a large hom

65 n epidemiology study characterizes trends in polymerase chain reaction (PCR) test positivity for seve

66 This study documents results of SARS-CoV-2 polymerase chain reaction (PCR) testing of environmental

67 te swabs daily (days 1 to 14) for SARS-CoV-2 polymerase chain reaction (PCR) testing.

68 observed significant reaction inhibition of polymerase chain reaction (PCR), loop-mediated isotherma

69 ries of the first 18 patients diagnosed with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 inf

70 genotyped for the rs4680 SNP using realtime polymerase chain reaction (PCR).

71 Through quantitative polymerase chain reaction (qPCR) analysis, we found that

72 In this paper, multiplex quantitative polymerase chain reaction (qPCR) assay using TaqMan prob

73 Quantitative polymerase chain reaction (qPCR) is the technique of cho

74 id or ventricular disease using quantitative polymerase chain reaction (qPCR).

75 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to rul

76 eptic ulcer, real time reverse transcriptase polymerase chain reaction (RT-PCR) examination of abdomi

77 r influenza viruses by reverse-transcription polymerase chain reaction (RT-PCR) in Australia, Canada,

78 currently employed is reverse transcription polymerase chain reaction (RT-PCR), which can have good

79 n of several genes via reverse transcriptase polymerase chain reaction (RT-PCR).

80 lysis and reverse transcription quantitative polymerase chain reaction (RT-qPCR).

81 We performed reverse-transcription polymerase chain reaction analyses of 166 samples and im

82 quantitative polymerase chain reaction analyses of representative gen

83 eloping palatal tissues was verified by ChIP-polymerase chain reaction analyses.

84 termined using Western blot and quantitative polymerase chain reaction analyses.

85 Toxoplasma gondii coinfection documented by polymerase chain reaction analysis.

86 Among 12 persons who infected mosquitoes, polymerase chain reaction and amplicon deep sequencing w

87 ase serum by real-time reverse transcription polymerase chain reaction and analyzed in relation to pr

88 (TLs) by quantitative reverse-transcription polymerase chain reaction and evaluated the prognostic i

89 were tested for PeV by reverse-transcription polymerase chain reaction and genotypes determined by su

90 nd IL34 mRNA in GF was analyzed by real-time polymerase chain reaction and protein expression visuali

91 files (by quantitative reverse transcription polymerase chain reaction and RNAscope) of small intesti

92 Polymerase chain reaction and Sanger sequencing therefor

93 icity and apoptotic assays, and quantitative polymerase chain reaction and Western blot analyses, wer

94 and a previously developed RLEP quantitative polymerase chain reaction assay for M. leprae, were vali

95 Reverse transcription-quantitative polymerase chain reaction assay, flow cytometry analysis

96 plasma ctHPVDNA using a multianalyte digital polymerase chain reaction assay.

97 vaginalis species-specific and clade-typing polymerase chain reaction assays.

98 ges were evaluated by quantitative real-time polymerase chain reaction at the end of each incubation

99 r SARS-CoV-2 RNA by nasal swab and real-time polymerase chain reaction between March 21 and May 4, 20

100 s (classical and nonclassical), custom-built polymerase chain reaction devices, gas-phase analyte det

101 t) for viremia detected by weekly plasma CMV polymerase chain reaction for 100 days (n = 100) or valg

102 blot, and quantitative reverse transcription polymerase chain reaction for markers of autophagy, DNA

103 Polymerase chain reaction for severe acute respiratory s

104 TL was measured using quantitative polymerase chain reaction in leukocytes extracted from c

105 tested positive for SARS-CoV-2 infection by polymerase chain reaction of nasopharyngeal swab or sero

106 , a negative result on reverse-transcription polymerase chain reaction testing, and no oligoclonal ba

107 This study describes the point prevalence of polymerase chain reaction tests positive for severe acut

108 We used patch clamp and quantitative polymerase chain reaction to measure electrophysiologica

109 microscopy) or expensive and time-consuming (polymerase chain reaction) to perform.

110 ove duplicates in read counts resulting from polymerase chain reaction, a major source of noise.

111 ues were analyzed by histology, quantitative polymerase chain reaction, and 16S ribosomal RNA gene se

112 estern blot, immunohistochemistry, real-time polymerase chain reaction, and enzyme-linked immunosorbe

113 unohistochemistry, immunoblotting, real-time polymerase chain reaction, and flow cytometry.

114 al tumors by immunohistochemistry, real-time polymerase chain reaction, and flow cytometry.

115 chromatin immunoprecipitation, quantitative polymerase chain reaction, and immunoblot assays.

116 ls were analyzed by immunoblot, quantitative polymerase chain reaction, chromosome immunoprecipitatio

117 by gene-expression microarray, quantitative polymerase chain reaction, immunoblot, and immunofluores

118 nger RNA (quantitative reverse transcriptase polymerase chain reaction, RNAscope) content.

119 We genotyped polymerase chain reaction-detected parasites using deep

120 Polymerase chain reaction-positive (+) measles cases not

121 SAA) were analyzed by quantitative real-time polymerase chain reaction.

122 t proof of COVID-19 by reverse-transcriptase polymerase chain reaction.

123 ion was assessed by culture and quantitative polymerase chain reaction.

124 est CT versus those of reverse transcriptase polymerase chain reaction.

125 ime using reverse-transcription quantitative polymerase chain reaction.

126 CoPEC by quantitative reverse-transcription polymerase chain reaction.

127 18S rDNA by photo-induced electron transfer polymerase chain reaction.

128 immunohistochemistry, western blotting, and polymerase chain reaction.

129 sted for SARS-CoV-2 by means of quantitative polymerase-chain-reaction (qPCR) assay of nares swab spe

130 confirmed by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay.

131 sa virus depends on host mRNA, because viral polymerases cleave 5'-m7G-capped host transcripts to pri

132 ein, the RNA-dependent RNA polymerase, and a polymerase cofactor, the phosphoprotein (P), for transcr

133 are host factors that act as influenza virus polymerase cofactors.

134 These novel compounds inhibited polymerase complex activity, inhibited virus replication

135 icken ANP32A and the PB2 627 domain of viral polymerase complex both contribute to this enhanced inte

136 s backbone and either PB1, NP, or the entire polymerase complex of the chicken isolate, caused higher

137 The polymerase complex plays an important role in influenza

138 sorted polymerase complexes, showed that the polymerase complexes from the 2014-15 outbreak induced h

139 ) viruses, including viruses with reassorted polymerase complexes, showed that the polymerase complex

140 Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool a

141 nds cyclic oligoA (cOA) synthesized by Cas10 polymerase-cyclase and allosterically activates the effe

142 Both sites are important for polymerase de novo initiation and elongation activities

143 In eukaryotes, DNA polymerase delta (Pol delta) bound to the proliferating

144 than correcting OG incorporated by accessory polymerases (DinB1/DinB2/DinB3/DnaE2).

145 kly rejected, they nonetheless stabilize the polymerase-DNA complex, suggesting that Pol beta, when b

146 NA template/blocker scaffolds coupled to the polymerase/dNTP replication machinery leads, in the pres

147 P-OD associates with the RNA-dependent RNA polymerase domain of L and protrudes away from it, while

148 te residues in the metal-binding site of the polymerase domain were replaced by alanine is highly tox

149 onto the nascent RNA strand as it exits the polymerase during RNA replication.

150 X-ray crystal structure of the bacterial RNA polymerase engaged in reiterative transcription from the

151 his task, ribosomes make ribosomal proteins, polymerases, enzymes, and signaling proteins.

152 se domain mutations in the gene encoding DNA polymerase epsilon (POLE) have incredibly high mutation

153 mutant of the POL2A catalytic subunit of DNA polymerase epsilon and show that POL2A is required to st

154 domain substitution raised the organelle DNA polymerase error rate by 140-fold relative to the wild t

155 Interestingly, human DNA polymerase eta (poleta) proficiently incorporates dGTP o

156 Two mouse models of polymerase exonuclease deficiency shed light on mechanis

157 n microscopy structures of influenza C virus polymerase (FluPolC) in complex with human and chicken A

158 Ena/VASP-family actin polymerases, for example, modulate cell shape by acceler

159 allenging the notion that lagging-strand DNA polymerases frequently dissociate from replisomes during

160 DNA polymerase from bacteriophage T7 undergoes large, substr

161 involves removing the covalently bound viral polymerase from rcDNA, which produces a deproteinated-rc

162 s the removal of the covalently linked viral polymerase from the 5' end of the minus strand [(-)stran

163 ified Pol establishes a new paradigm for DNA polymerase function.

164 Direct-acting agents, targeting protease and polymerase functionalities, represent a milestone in ant

165 ork blocks, the coupling of DNA helicase and polymerase functions during replication stress (RS) and

166 f off-target inhibition of mitochondrial DNA polymerase gamma (Polgamma).

167 ed on nuclear chromosome 15, encodes the DNA polymerase gamma(Pol gamma).

168 ans and caused the 2009 pandemic, it evolved polymerase gene mutations that enabled it to more effici

169 ucleic acids and are often incompatible with polymerase-generated sequences.

170 istance mutations (DRMs) on individual HIV-1 polymerase genomes in the cerebrospinal fluid (CSF) and

171 nce of viral RNA and the processivity of the polymerase, giving insights into the way that ANP32A mig

172 fying enzymes (Taq DNA polymerase, Phi29 DNA polymerase) have been widely used for the diagnosis of v

173 tion elongation properties of eukaryotic RNA polymerase I (Pol I) from Saccharomyces cerevisiae has n

174 Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is the first key step of ribosome b

175 CSB and CSA also increase RNA Polymerase I loading to the coding region of the rDNA an

176 RNA polymerase II (Pol II) and its general transcription fac

177 domain (CTD) of the RPB1 subunit of the RNA polymerase II (Pol II) has been revived in recent years,

178 iption, and promoter-proximal pausing of RNA polymerase II (Pol II) is a critical step in transcripti

179 Condensates containing RNA polymerase II (Pol II) materialize at sites of active tr

180 RNA polymerase II (RNA Pol II) contains a disordered C-termi

181 increases Mediator-driven recruitment of RNA polymerase II (RNA Pol II) to promoters and enhancers.

182 hosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for activation.

183 n of transcription termination (DoTT) of RNA polymerase II (RNAPII) in host genes.

184 In eukaryotes, RNA polymerase II (RNApII) transcribes messenger RNA from te

185 RNA polymerase II (RNAPII) transcription is governed by the

186 (Ser2) of the carboxy-terminal domain of RNA polymerase II (RNAPII), which is initiated when RNAPII r

187 Elongin is an RNA polymerase II (RNAPII)-associated factor that has been s

188 ription factor II H (TFIIH) it activates RNA polymerase II by hyperphosphorylation of its C-terminal

189 fluenced by the Thr4 phospho-site in the RNA polymerase II CTD and the 3' processing/termination fact

190 lex as a terminator of promoter-proximal RNA polymerase II during piRNA biogenesis.

191 RNA polymerase II interacts with various other complexes and

192 he molecular process of transcription by RNA Polymerase II is highly conserved among eukaryotes ("cla

193 t at HIF target gene promoters increased RNA polymerase II loading through p300.

194 -kB, P-TEFb, and serine 2 phosphorylated RNA Polymerase II on the HEXIM1 gene.

195 was found across the range of eukaryotic RNA polymerase II subunits and their associated basal transc

196 nk the SnRK2.6-mediated ABA signaling to RNA polymerase II to promote immediate transcriptional respo

197 bly through promoting the recruitment of RNA polymerase II to their promoters.

198 Drosophila cells, splicing occurs after RNA polymerase II transcribes several kilobases of pre-mRNA,

199 ssed from an intron that is generated by RNA polymerase II transcribing the circular viral genome mor

200 2 (TBP2 or TRF3), which is essential for RNA polymerase II transcription.

201 al to the regulation of transcription by RNA-polymerase II, via its interaction with the positive tra

202 PAF1, a RNA polymerase II-associated factor 1 complex (PAF1C) compon

203 lpha-satellite expression occurs through RNA polymerase II-dependent transcription, but does not requ

204 pair, mRNA processing, and regulation of RNA polymerase II.

205 interacts with transcriptionally engaged RNA polymerase II.

206 ctors and transcriptional machinery like RNA Polymerase II.

207 y stimulates transcription elongation by RNA polymerase II.

208 mediated by paradoxical upregulation of RNA polymerase in response to rifampicin.

209 Here we examined the functions of these two polymerases in bypassing major-groove O (6)-alkyl-2'-deo

210 tion initiation factors of mitochondrial RNA polymerases in Saccharomyces cerevisiae and humans, resp

211 e efficiency with which Escherichia coli RNA polymerase incorporates dinucleoside polyphosphates at t

212 late, slowed helicase, or uncoupled helicase-polymerase, increase DNA reannealing and polymerase back

213 grown in the presence and absence of the RNA polymerase inhibitor rifampicin, we identify hundreds of

214 Poly(ADP ribose) polymerase inhibitors (PARPi) have efficacy in triple ne

215 AF, and Onc-1 sensitized to poly(ADP-ribose) polymerase inhibitors both in vitro and ex vivo These fi

216 However, it is not clear how RNA polymerase initially recognizes such sequences.

217 RNA polymerases initiate transcription at DNA sequences call

218 The error prone organelle DNA polymerase introduced mutations at multiple locations ra

219 hogens and commensals, and the bacterial RNA polymerase is a proven target for antibiotics.

220 he enzyme responsible for transcription, RNA polymerase, is conserved in general architecture and cat

221 ng processes of the multidomain Y-family DNA polymerase IV (DPO4).

222 IBs, including VP35, VP24, VP30, and the RNA polymerase L.

223 The RNA-dependent-RNA polymerase (L) gene revealed phylogenetic relationship a

224 ding site in the central cavity of the viral polymerase (L) protein that was validated by photoaffini

225 Translesion DNA polymerases may also contribute.

226 Mitochondrial RNA polymerase (mtRNAP) is crucial in cellular energy produc

227 These RNA polymerase mutations cause large-scale transcriptional c

228 the cytoplasm, ZIKV and Dengue virus (DENV) polymerases, NS5 proteins, are predominantly trafficked

229 l to be highly mutagenic because it uses DNA polymerases, nucleases, and other enzymes that modify in

230 wo copies of the catalytic module of poly(A) polymerase (PAP) are recruited by the CPSF30-hFip1 compl

231 in and, at least in part, on poly-ADP ribose polymerase (PARP) activity.

232 on of autophagy, and robust poly(ADP-ribose) polymerase (PARP) cleavage indicative of DNA damage and

233 Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inhibition and BRCA deficiency is expl

234 diolabled poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor called (125)I-KX1 to deliver

235 quired tumour resistance to poly(ADP-ribose) polymerase (PARP) inhibitors and other therapeutics and

236 ow increased sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors, especially when combined w

237 Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link ei

238 nsitivity to inhibitors of poly (ADP-ribose) polymerase (PARP) that are being tested in clinical tria

239 targets available such as poly (ADP-ribose) polymerase (PARP), epidermal growth factor receptor (EGF

240 ision repair (BER) protein poly (ADP-ribose) polymerase (PARP).

241 nscriptional machinery, and facilitating RNA polymerase pause-release to regulate gene expression.

242 Recently, DNA-modifying enzymes (Taq DNA polymerase, Phi29 DNA polymerase) have been widely used

243 stimulates transcriptional elongation by RNA polymerase (Pol) II and regulates cell growth and differ

244 rylation in RPB1, the largest subunit of RNA polymerase (pol) II.

245 owth control as the central regulator of RNA polymerase (Pol) III activity.

246 RNA polymerase (Pol) III has a noncanonical role of viral DN

247 In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcriptio

248 licative and translesion synthesis (TLS) DNA polymerases (Pols) are retained in their cellular roles.

249 DNA polymerases (Pols) provide roles in both replication of

250 ed, including unusual ones such as giant RNA polymerase polyproteins.

251 ork reversal in vivo and rely on the primase-polymerase PRIMPOL for repriming, unrestrained replicati

252 the primary function of MeV C is to improve polymerase processivity and accuracy, rather than unique

253 Silencing expression of RNA-directed RNA polymerases RdR1 and RdR2 (but not RdR3) and Dicer-like3

254 the thumb subdomain of the RNA-dependent RNA polymerase (RdRp) and the methyltransferase (MTase) doma

255 e (3CL(pro)) and the nsp12 RNA-dependent RNA-polymerase (RdRp) are the best characterized SARS-CoV-2

256 NS5 methyltransferase and RNA-dependent RNA polymerase (RdRP) domains form a conserved interdomain c

257 expressing a picornavirus RNA-dependent RNA polymerase (RdRP) outside the viral context (RdRP mice)

258 Dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRp), an important drug target, synthesizes

259 s motifs representative of RNA-dependent RNA polymerase (RdRp), whereas the dsRNA2 ORF sequence showe

260 is performed by the viral RNA dependent RNA polymerase (RdRp).

261 ty SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases (RdRps), serving as an immediate polymerase

262 polymerases (RdRps), serving as an immediate polymerase reaction terminator, but not by a host-like h

263 htly more thermodynamically favorable in the polymerase relative to these DNA duplexes.

264 tions and components on bacteriophage T7 RNA polymerase (RNAP) activity using a common quantitative P

265 Pausing by RNA polymerase (RNAP) during transcription elongation, in wh

266 additional initiation factor Bdp1 in the RNA polymerase (RNAP) III system, however, remained elusive.

267 nation factor playing essential roles in RNA polymerase (RNAP) recycling, gene regulation, and genomi

268 gella-specific sigma factor that targets RNA polymerase (RNAP) to control the expression of flagella-

269 vitro transcription system with purified RNA polymerase (RNAP) to investigate rRNA synthesis in the p

270 The RNA polymerase (RNAP) trigger loop (TL) is a mobile structur

271 ortant DNA repair mechanism that removes RNA polymerase (RNAP)-stalling DNA damage from the transcrib

272 1) [comparable to the speed of bacterial RNA polymerase (RNAP)].

273 63) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005-2019.

274 NAD-consuming enzymes (e.g. poly(ADP-ribose) polymerases, sirtuins, and others).

275 verse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length and

276 n, replication error by polymerase zeta, and polymerase slippage at repeat junctions - on the generat

277 edicted virion proteins, including three RNA polymerase subunits.

278 eactions is predicted to be different in the polymerase than in aqueous solution and the DNA duplexes

279 s, gene expression is performed by three RNA polymerases that are targeted to promoters by molecular

280 t of specialized translesion synthesis (TLS) polymerases that have evolved to incorporate nucleotides

281 Bacteriophage T7 encodes its own DNA polymerase, the product of gene 5 (gp5).

282 t evidence suggests that in Arabidopsis, DNA polymerase theta (PolQ) may be a crucial enzyme involved

283 Recent studies have implicated DNA polymerases theta (Pol theta) and beta (Pol beta) as med

284 eam effector TCDD-inducible poly(ADP-ribose) polymerase (TiPARP) during infection.

285 thers change domain-domain interfaces in the polymerase to enable RNA-DNA hybrid binding and reverse

286 that the response of a model replicative DNA polymerase to variously structured DNA is sufficient to

287 esults in the recruitment of error-prone DNA polymerases to the replication fork.

288 RNA polymerase transcribes certain genomic loci with higher

289 istant from the active site in a Klentaq DNA polymerase variant (ZP Klentaq) contribute to its abilit

290 RNA polymerase variants that are thought to increase or decr

291 The viral RNA-dependent RNA polymerase (vRdRp) of MuV consists of the large protein

292 The virus encodes an RNA-dependent RNA polymerase, which replicates and transcribes the vRNA ge

293 parameters of cellular and viral DNA and RNA polymerases with respect to cellular levels of their nuc

294 he DNA duplexes but slightly exoergic in the polymerase, with Arg517 and Asn513 providing electrostat

295 e same B-family as high-fidelity replicative polymerases, yet is specialized for the extension reacti

296 fically dependent on the Polzeta translesion polymerase, yields COSMIC signature 3 observed in BRCA1/

297 DNA polymerase zeta (Polzeta) belongs to the same B-family a

298 During translesion synthesis, eukaryotic DNA polymerase zeta (zeta) carries out extension from a wide

299 isms - CpG deamination, replication error by polymerase zeta, and polymerase slippage at repeat junct

300 flection of distal upstream DNA over the RNA polymerase zinc-binding domain, NusA rotates underneath