ライフサイエンスコーパス: polymodal

1 sentative of the TRP family, TRPM3 is highly polymodal.

2 erstand the structural basis underlying this polymodal activation and the regulation by intracellular

3 ed as calcium-permeable cation channels with polymodal activation properties.

4 that mediate transmembrane cation flux with polymodal activation, ranging from chemical to physical

5 veling the molecular underpinnings governing polymodal activation.

6 ate multiple stimuli through their typically polymodal activation.

7 ngeal afferent neurones regulating cough are polymodal Adelta-fibres that arise from the nodose gangl

8 minergic pathways control sleep-loss-induced polymodal affective state transitions.

9 Fasting, to unload mechanically sensitive polymodal afferents in the proximal gastrointestinal tra

10 tively low mechanical forces are detected by polymodal and pure mechanosensory trigeminal ganglion ne

11 These include polymodal anion channels activated by both dopamine and

12 Future risk stratification using a polymodal approach could combine basal ganglia network c

13 shing for the first time in humans that this polymodal area is modified after early sensory deprivati

14 of deep compared with superficial, nuclei to polymodal areas in the temporal pole.

15 Projections to other sensory and polymodal areas, in contrast, terminate in a columnar ma

16 esponses to soluble repellents sensed by the polymodal ASH neurons.

17 aptation to soluble repellents sensed by the polymodal ASH nociceptors.

18 The C. elegans polymodal ASH sensory neurons detect mechanical, osmotic

19 The perirhinal cortex is a polymodal association area that contributes importantly

20 , but also with a wide range of unimodal and polymodal association areas.

21 jections from temporal auditory, visual, and polymodal association cortices.

22 cortical, paralimbic, and limbic structures, polymodal association, and ventromedial prefrontal corte

23 izing principles: the first being a rotating polymodal-association pinwheel structure around which ac

24 tmc-1 is expressed in the ASH polymodal avoidance neurons, where it is required for sa

25 studies provide a paradigm for understanding polymodal behavior in TRPM8 and other proteins with the

26 me, providing a fresh perspective on complex polymodal behavior.

27 class of ion channels, many of which exhibit polymodal behavior.

28 d not affect the axotomy-induced decrease in polymodal C-fiber (CPM) heat threshold, but transiently

29 (TRPV1) cation channel is characteristic of polymodal C-fiber nociceptors and is sensitive to noxiou

30 an primates (Macaca nemestrina), subtypes of polymodal C-fiber nociceptors are preferentially activat

31 whage-stimulated pathway primarily involving polymodal C-fibres.

32 ical stimulation at 5 Hz (75 pulses) whereas polymodal C-nociceptors in the pig follow stimulation at

33 Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to re

34 l, subfamily M, member 3 (TRPM3) serves as a polymodal calcium sensor in diverse mammalian cell-types

35 TRPV4 is a polymodal, calcium-permeable cation channel that has eme

36 TRPV4 is a polymodal cation channel gain-of-function (GOF) allele w

37 ptor potential vanilloid type 4, TRPV4, is a polymodal cation channel which can be activated by diver

38 TRPV1 receptors are polymodal cation channels that open in response to diver

39 nsient receptor potential (TRP) channels are polymodal cell sensors responding to diverse stimuli and

40 ensory neurons where it acts as an important polymodal cellular sensor for heat, acidic pH, capsaicin

41 receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that responds to moderate heat

42 or potential (TRP) ion channel family act as polymodal cellular sensors, which aid in regulating Ca(2

43 TRPV1 is a polymodal channel activated by noxious heat, capsaicin,

44 ids needed to restore protein expression and polymodal channel activity.

45 ne, as well as the first evidence of a truly polymodal channel, LGC-39, which is activated by both ch

46 The carotid body (CB) is a polymodal chemosensor of arterial blood located next to

47 ce of a previously unidentified cholinergic, polymodal chemosensory cell in the mammalian urethra, th

48 RP activity localized to auditory cortex and polymodal cortex of the temporal lobe, concurrent with g

49 he axonal and somatodendritic surface of the polymodal dendritic arborization (da) neuron of the Dros

50 ently cloned and confirmed functionally as a polymodal detector of multiple pain stimuli: heat, acid,

51 neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physic

52 loid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as cap

53 ptor potential ion channels (thermoTRPs) are polymodal detectors of various stimuli including tempera

54 the noise-dependent stabilization exhibits a polymodal distribution with multiple, well defined, and

55 plays a role in stimulus-response mapping in polymodal fashion.

56 ncapable of explaining the three-dimensional polymodal fault patterns that are widely observed in roc

57 sses, and can therefore account for observed polymodal fault patterns.

58 ere, we identify the molecular basis for the polymodal function of OCR-2 in its native cellular envir

59 Within ensembles, polymodal Gal(+) inhibitory neurons with monosynaptic co

60 red the effects of four antagonists on TRPV1 polymodal gating and core body temperature (CBT) in Trpv

61 To address the molecular basis of polymodal gating and ion-selectivity switching, we inves

62 Collectively, our data unveils the polymodal gating and proton-sensing mechanisms in the PA

63 for voltage, temperature, and osmotic swell polymodal gating of TRPP2.

64 eas attaining peak cortical thickness before polymodal, high-order association areas.

65 ntar injections of low dose STZ evoked acute polymodal hypersensitivities in mice.

66 udies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus mo

67 and size distribution, whether monomodal or polymodal in nature.

68 TRPV1 channels are polymodal in their function and exhibit multifaceted reg

69 The polymodal input from the perirhinal cortex (PR) is a maj

70 hin insular cortex provide the basis for its polymodal integration of all salient activity relevant t

71 receptor potential vanilloid 1 (TRPV1) is a polymodal ion channel involved in the detection of noxio

72 ensitivity and the proper biogenesis of this polymodal ion channel.

73 ressure affect activity of the prototypical, polymodal K(2P), K(2P)2.1 (KCNK2/TREK-1), at a common mo

74 rgets suggest that CGRP(+) SP(-) neurons are polymodal mechanoceptors.

75 The hypothesis that polymodal mechanoreceptors and capsaicin-sensitive affer

76 provide evidence suggesting that PIEZO2 is a polymodal mechanosensor that engages different protein d

77 ntial vanilloid type 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expre

78 nsient receptor potential (TRP) channels are polymodal molecular sensors involved in numerous physiol

79 Our studies reveal the polymodal nature of itch sensory neurons and identify a

80 panding PRh involvement, consistent with the polymodal nature of PRh connections and results from pri

81 ivotal role in the generation of a systemic, polymodal neurohumoral response to a hyperosmotic challe

82 ing model system of a Caenorhabditis elegans polymodal neuron named PVD, whose dendritic tree follows

83 nels carry mechanotransduction currents in a polymodal neuron, where they act upstream of transient r

84 n wild type worms on the function of the ASH polymodal neuron.

85 rs is critical for encoding information from polymodal neurons.

86 ates a single TrpA1 isoform in vivo and that polymodal nociception requires co-expression of TrpA1 is

87 ther nociceptive specific (NS, n = 20) or as polymodal nociceptive (HPC, responsive to heat, pinch an

88 pherally encoded in C-MIAs, and that primate polymodal nociceptive afferents form three functionally

89 inct subset of sensory neurons that transmit polymodal nociceptive information from the skin epidermi

90 ASH neurons are therefore hypothesized to be polymodal nociceptive neurons.

91 gans aversive behavior mediated by a pair of polymodal, nociceptive, ASH sensory neurons.

92 The capsaicin receptor VR1 is a polymodal nociceptor activated by multiple stimuli.

93 ound to have vasodilator actions were of the polymodal nociceptor afferent class, and fourteen (50%)

94 n both the rabbit and the rat, a subclass of polymodal nociceptor afferents form the majority of the

95 The afferent receptive fields of polymodal nociceptor afferents were mapped carefully usi

96 to analyse functional connectivity between a polymodal nociceptor and a command neuron that initiates

97 Cultured male and female mouse mechano- and polymodal nociceptor corneal neurons display rapidly, in

98 TRPV1 is a polymodal nociceptor for diverse physical and chemical s

99 major mechanotransduction channel in ASH, a polymodal nociceptor in Caenorhabditis elegans.

100 The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, an

101 he capsaicin receptor TRPV1 ion channel is a polymodal nociceptor that responds to heat with exquisit

102 C polymodal nociceptor units do not appear to be involved

103 Stimulation of C polymodal nociceptor units never caused increases in blo

104 The receptive fields (RFs) of polymodal nociceptor units of canine testis consist of s

105 The vasoactive polymodal nociceptor units tend to have relatively low m

106 lass, and fourteen (50%) of the twenty-eight polymodal nociceptor units tested were vasoactive.

107 fibres were nociceptive and comprised seven polymodal nociceptor units, two heat nociceptor units an

108 nnel subfamily V member 1) immunoreactivity (polymodal nociceptor) revealed that they express Piezo2.

109 eceptor potential cation channel family is a polymodal nociceptor.

110 family of non-selective cation channels is a polymodal nociceptor.

111 Recordings of mechano- and polymodal-nociceptor nerve terminals in the corneal surf

112 mal thresholds after regeneration, whereas C-polymodal nociceptors (CPMs) had lower heat thresholds.

113 ction and successful regeneration, cutaneous polymodal nociceptors (CPMs) lacking transient receptor

114 d on the responsiveness of cutaneous C-fiber polymodal nociceptors (CPMs) to sympathetic stimulation

115 Fewer than half the C polymodal nociceptors (CPMs) were positive.

116 t both in high threshold mechanoreceptor and polymodal nociceptors and also in units with either cuta

117 Polymodal nociceptors and mechanochemical receptors gave

118 In primates, C-fibre polymodal nociceptors are broadly classified into two gr

119 Polymodal nociceptors are one subclass of sensory neuron

120 Polymodal nociceptors detect noxious stimuli, including

121 igh-threshold CSNs and in a subpopulation of polymodal nociceptors expressing TRPM8, providing a gene

122 (MOPR) and delta opioid receptors (DOPR) in polymodal nociceptors have been recently challenged.

123 All C-polymodal nociceptors in glabrous (n = 4) but none in ha

124 Fifty-five C-polymodal nociceptors innervating hairy skin in human vo

125 It is concluded that a subpopulation of C-polymodal nociceptors is sensitive to noxious low temper

126 ion of corneal afferent neurons that are not polymodal nociceptors or cold-sensing neurons, and is li

127 ns are neurochemically distinct from corneal polymodal nociceptors or cold-sensing neurons.

128 receptors responding to mechanical stimuli; polymodal nociceptors responding to mechanical, noxious

129 t, but it also transforms a subpopulation of polymodal nociceptors signaling pain into neurons activa

130 Mechanical thresholds were higher in polymodal nociceptors than in either slowly adapting or

131 neurons of the Drosophila larva function as polymodal nociceptors that are necessary for behavioral

132 e we demonstrate that mechanically sensitive polymodal nociceptors that respond either quickly (QC) o

133 In contrast, untreated polymodal nociceptors with moderate ADS (15.2% 10.2%) fo

134 or population, C-mechanoheat fibres (C-MH or polymodal nociceptors) were markedly more responsive to

135 121 receptors recorded from 39 fish, 17 were polymodal nociceptors, 22 were mechanothermal nociceptor

136 sitive trigeminal nerve fibers, for example, polymodal nociceptors, rather than through taste buds.

137 In polymodal nociceptors, sensory Schwann cells signal mech

138 in gene-related peptide (CGRP), a marker for polymodal nociceptors, suggesting that trigeminal genera

139 onin gene-related peptide [CGRP]) trigeminal polymodal nociceptors, which respond to numerous odorant

140 ulation of nonpeptidergic, TRPV1-negative, C-polymodal nociceptors.

141 hermal nociceptors were higher than those of polymodal nociceptors.

142 form sensory neurons with the properties of polymodal nociceptors.

143 ons was largely observed in C-mechanoheat or polymodal nociceptors.

144 es and subsequently desensitizes a subset of polymodal nociceptors.

145 the rate they inhibit action potentials from polymodal nociceptors.

146 elocity, as those of the pure mechano-heat C-polymodal nociceptors.

147 is associated with reduced excitability of C-polymodal nociceptors.

148 re NF200-IR, suggesting they are not corneal polymodal nociceptors.

149 rature-sensitive TRP channels to function as polymodal nociceptors.

150 y plays an important role in the function of polymodal nociceptors.

151 rminants between vertebrate and invertebrate polymodal nociceptors.

152 s that process afferent input from Mrgprd(+) polymodal nociceptors.

153 Mechanothermal, but not polymodal, nociceptors showed an increase in firing resp

154 that ammonia activates TRPV1, TRPA1 (another polymodal nocisensor), and other unknown receptor(s) exp

155 Localization and function of the polymodal non-selective cation channel TRPV1 (transient

156 e that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and t

157 TRPM8 is a polymodal, nonselective cation channel activated by cold

158 Thus, Slurp knock-out mice exhibit polymodal PPK-associated pain that is associated with bo

159 r parietal cortex, higher-order auditory and polymodal processing regions in the superior temporal co

160 dorsal horn neurons and that, despite their polymodal properties, TRPV1+ and MrgprD+ nociceptors pro

161 tential vanilloid 1 (TRPV1) ion channel is a polymodal protein that responds to various stimuli, incl

162 TRPV1 channels and the relevance of accurate polymodal receptor biophysical characterization for drug

163 tential vanilloid 1 (TRPV1) ion channel is a polymodal receptor that mediates the flux of cations acr

164 We recently showed that the polymodal receptor transient receptor potential vanilloi

165 These membrane proteins are polymodal receptors that can be activated by cold or hot

166 Many primary sensory neurons are polymodal, responding to multiple stimulus modalities (c

167 Of ten multipolar cells, six were polymodal, responsive to heat, pinch and cold, and four

168 he primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, a

169 The carotid body (CB) is a polymodal sensor which increases its neural output to th

170 Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but t

171 ential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of phys

172 We focus on the polymodal sensory bilateral neuron pair PVD, which forms

173 atures and defective trafficking of OSM-9, a polymodal sensory channel protein and a functional homol

174 ptive-specific inputs (PB-->CeA synapse) and polymodal sensory inputs (BLA-->CeA synapse) in the arth

175 ivity could result from increased numbers of polymodal sensory nerve fibres expressing TRPV1.

176 Polymodal sensory neurons detect a wide range of nocicep

177 C. elegans ASH neurons function as polymodal sensory neurons that generate a characteristic

178 enorhabditis elegans nervous system: the ASH polymodal sensory neurons, the AVA, AVD and AVE interneu

179 mination of a variety of repellents by these polymodal sensory neurons.

180 To understand the nature of polymodal sensory response and adaptation at the cellula

181 thermosensory responses in L3s, suggesting a polymodal sensory role for Brugia osm-9.

182 nsient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide array

183 nsient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide range

184 r understanding how TRP channels function as polymodal signal integrators.

185 g how these excitatory ion channels serve as polymodal signal integrators.

186 convertase provides additional evidence that polymodal signaling in C. elegans occurs via the differe

187 To investigate the mechanisms of this polymodal signaling, we have characterized the role of p

188 This regulation involves the C-terminus as a polymodal stimulus sensor and the selectivity filter (SF

189 uggest that these receptors are expressed on polymodal, substance P-expressing neurons.

190 ient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel.

191 Polymodal thermo- and mechanosensitive two-pore domain p

192 Adjacent to the channel gate, this polymodal thermoTRP channel displays a TRP domain, refer

193 Polymodal transient receptor potential (TRP) channels ha

194 se retina expresses mRNA and protein for the polymodal transient receptor potential vanilloid 4 (TRPV

195 experiments, we found that HA also modulates polymodal transient receptor potential vanilloid subtype

196 l residues.SIGNIFICANCE STATEMENT TRPM8 is a polymodal TRP channel involved in cold temperature sensi

197 target side effect in clinical studies using polymodal TRPV1 antagonists has prompted companies to se

198 K(2P)2.1 (TREK-1) is a polymodal two-pore domain leak potassium channel that re

199 e dominant hemisphere were more likely to be polymodal, whereas those in nondominant hemisphere were