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1 vasopressin) and VIP (vasoactive intestinal polypeptide).
2 igate real-time cotranslational folding of a polypeptide.
3 can also function when anchored by an apolar polypeptide.
4 onally interacts with newly synthesized Var1 polypeptide.
5 facilitate dimerization of the 90 amino acid polypeptide.
6 s oligomeric solution of human islet amyloid polypeptide.
7 ould facilitate the recruitment of a nascent polypeptide.
8 ecomposition or in their polymerization into polypeptide.
9 uiring two domains to be present on the same polypeptide.
10 ent antibody conjugated with an elastin-like polypeptide.
11 inct non-canonical amino acids into a single polypeptide.
12 atory properties are present within a single polypeptide.
13 ich include a variety of polysaccharides and polypeptides.
14 e composed of sixteen pairs of the alphabeta-polypeptides.
15 ion of faulty mRNA and partially synthesized polypeptides.
16 onic, anionic, short oligopeptides, and long polypeptides.
17 paucimannose structures to nascent secretory polypeptides.
18 ynthesis to prevent accumulation of aberrant polypeptides.
19 t for understanding associations of l- and d-polypeptides.
20 composed of bound water and unwound gelatin polypeptides.
21 processes that determine the fate of nascent polypeptides.
22 rnal out-of-frame ORFs, which generate novel polypeptides.
23 ator (CFTR) have distinct effects on nascent polypeptides.
24 n-functional and potentially toxic truncated polypeptides.
25 modifications and elimination of individual polypeptides.
26 r nuclear membrane protein lamina-associated polypeptide 1 (LAP1) caused defective VLDL secretion and
27 embrane-spanning cofactor, lamina associated polypeptide 1 (LAP1) or lumenal domain like LAP1 (LULL1)
28 lance in the levels of the lamina-associated polypeptide 1 (LAP1), an activator of ER-resident Torsin
29 r torsinA or its cofactor, lamina-associated polypeptide 1 (LAP1), resulted in fatty liver disease an
30 ol-cytochrome c reductase Rieske iron-sulfur polypeptide 1 (UQCRFS1), the Rieske FeS protein in RCIII
31 well as wild-type C57BL/6 and glucagon-like polypeptide 1 receptor deficient (Glp-1r(-/-)) mice on c
32 C19 (cytochrome P450, family 2, subfamily C, polypeptide 19) *2 and *3 alleles leads to a loss of fun
33 Apolipoprotein B editing enzyme, catalytic polypeptide 3 (APOBEC3) family members are cytidine deam
34 riphosphatase/RNA helicase X-linked DEAD-box polypeptide 3 (DDX3X) emerged as a novel therapeutic tar
35 ogy in the presence of vasoactive intestinal polypeptide, a potent stimulator of ion secretion classi
37 onal repression mechanism that reduces eEF2K polypeptide abundance to preclude eEF2 phosphorylation,
38 itions exhibits increased thermal stability, polypeptide accessibility and ceruloplasmin-mediated inh
40 ocon" sufficient for translocation of the AC polypeptide across the plasma membrane of target cells.
42 n (Delta(Spont)) contained mainly C-terminal polypeptides akin to C1, the cell-surface anchored C-ter
43 This review focuses on the applications of polypeptides alongside the synthetic advances in the rin
44 the amyloid-beta peptide, the islet amyloid polypeptide, alpha-synuclein, and the hungingtin protein
45 via immunoglobulin-G1 Fc domains and 2 XTEN polypeptides (Amunix Pharmaceuticals, Inc, Mountain View
46 t PPXY motifs at the C-terminus of the Warts polypeptide and additional WW domains bind unoccupied mo
49 anged symmetrically along the D1 and D2 core polypeptides and comprise four chlorophyll (P(D1), P(D2)
55 s tuned by intrinsic features of the nascent polypeptides and timely association of factors with the
56 yloids, including Abeta, human islet amyloid polypeptide, and tau have been found to assemble as fibr
57 istry of alpha-amino acids, on occurrence of polypeptides, and more generally on organic electrochemi
59 heat-induced misfolding of newly synthesized polypeptides, and so has been thought to depend on ongoi
60 rophobic residues in the constituent keratin polypeptides, and the extent to which the electrolyte io
62 role of a cotranslational chaperone, nascent polypeptide-associated complex (NAC), in regulating subs
63 d palmitoylation, reduced the level of beta1 polypeptides at the plasma membrane, and reduced the ext
64 ein, Na(+)/taurocholate (TCA) cotransporting polypeptide, at the site of a pharmacologically relevant
66 ins in which the chemical composition of the polypeptide backbone has been partially altered; and pro
67 d homologs indicate that the knot within the polypeptide backbone plays a significant role in the bio
68 Alfalfa protein isolates exhibited complex polypeptide banding ranging from molecular weight of 11-
71 ging from 10 to 225 kDa, built from the same polypeptide blocks with no post-translational and other
72 emained an outstanding challenge for natural polypeptides, building blocks of life, which are fragile
73 In vertebrates, RTKs are mostly activated by polypeptides but are not naturally sensitive to amino ac
74 n, not only at the same or proximal sites on polypeptides, but also by regulating each other's enzyme
75 rence for association with newly synthesized polypeptides, but each responds differently to changes i
77 ngly heterogeneous because multiple distinct polypeptides can be synthesized from a single mRNA seque
78 a specialized scaffold against which nascent polypeptides can begin to form structure in a highly coo
81 t time the SFC-MS separation of a mixture of polypeptides carried out using poly(styrene-co-divinylbe
85 irmed that fennel nsLTP1 is a 9433 Da single polypeptide chain consisting of 91 amino acids with eigh
86 and translocates to the periplasm where the polypeptide chain does an about turn in order to enter a
87 hoice of dye attachment positions within the polypeptide chain has a substantial impact on which unfo
90 ed denatured state we find that knotting the polypeptide chain of MJ0366 increase the folding energy
91 Single-chain FLARE (scFLARE) is a single polypeptide chain that incorporates a transcription fact
92 l slip site generates a force on the nascent polypeptide chain that scales with observed frameshiftin
93 ifferent icosahedral symmetries, causing the polypeptide chain to exist in seven quasi-equivalent env
94 d state presents ample opportunities for the polypeptide chain to transiently sample nonnative struct
96 the product of both the overall fold of the polypeptide chain, and, typically, structural motifs mad
97 it players can now-starting from an extended polypeptide chain-generate a diversity of protein struct
101 insic dynamic properties of emerging nascent polypeptide chains and guides them toward their biologic
102 Collagen I is a major tendon protein whose polypeptide chains are linked by covalent crosslinks.
103 genetic modifications are limited to natural polypeptide chains at the Cas9 termini, which excludes a
105 e novo protein folding by protecting nascent polypeptide chains from misfolding and maintain translat
110 gies to label endogenously occurring nascent polypeptide chains within cells using O-propargyl-puromy
111 ycin is covalently incorporated into nascent polypeptide chains, anti-puromycin immunofluorescence en
112 hat water can be a good solvent for unfolded polypeptide chains, even those with a hydrophobic and ch
113 odel system for the study of folding of long polypeptide chains, including related phenomena such as
118 rid biomaterials called cholesterol-modified polypeptides (CHaMPs) that exhibit programmable self-ass
120 liquid phase separation (LLPS) occurs when a polypeptide coalesces into a dense phase to form a liqui
123 uch techniques facilitate the development of polypeptide conjugates to advance therapeutics, diagnost
124 ing several structural units within a single polypeptide, constitute a large fraction of all proteome
125 nst toxoplasmosis by (i) this novel chimeric polypeptide, containing epitopes that elicit CD8(+) T ce
126 er, we propose that individual intestinal IF polypeptides contribute in different ways to endotube mo
127 equent accumulation of partially synthesized polypeptides could explain the neurodevelopmental and ne
129 6 binds the N-terminal domain of ERFE, and a polypeptide derived from the N terminus of ERFE was suff
130 he changing information in a growing nascent polypeptide dictates the recruitment of functionally dis
131 la DEVELOPMENTALLY REGULATED PLASMA MEMBRANE POLYPEPTIDE (DREPP), a member of the MT binding DREPP/PC
134 njugated and recombinant A99 to elastin-like polypeptides (ELPs) as the scaffold and characterize the
135 tionary model whereby adaptive transmembrane polypeptides emerge de novo from thymine-rich non-genic
136 al in all cells and initiates when a nascent polypeptide emerges from the ribosome exit tunnel, where
137 drial ribosomes (mitoribosomes) with over 70 polypeptides encoded in nuclear DNA, translated on cytop
138 ight roles for glycans in sterically masking polypeptide epitopes and directly modulating Spike-ACE2
142 dyl transferase center (PTC) and the nascent polypeptide exit tunnel (NPET), and export of assembling
143 n eL24, the protein-folding machinery at the polypeptide exit tunnel (PET), and the ribosomal stalk,
144 rmational changes in MRP mL45 at the nascent polypeptide-exit site within the large mitoribosomal sub
147 and, ultimately, intestinalized spasmolytic polypeptide-expressing metaplasia (SPEM) was detected in
148 flammation, oxyntic atrophy, and spasmolytic polypeptide-expressing metaplasia (SPEM), a putative pre
149 stric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the
150 indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCN(VIP)) neurons, including
151 of SNORC on SDS-PAGE was due to its primary polypeptide features, suggesting no additional post-tran
152 ction-to-structure relationships of the NPC1 polypeptide fold required for membrane trafficking and g
154 ular chaperones have evolved to help nascent polypeptides fold correctly and multimeric protein compl
156 The method can uncover numerous inhibitory polypeptides for a protein and thereby define small inhi
158 ple of AMP is Epsilon-Poly-L-lysine (EPL), a polypeptide formed by ~ 25 lysine residues with known an
160 tro testing of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappaB) signali
161 Expression of nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor (IkappaB)
163 sistance to glucose-dependent insulinotropic polypeptide (GIP) action may occur through desensitizati
164 in hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) ar
165 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two incretins secreted from gastro
166 nism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain a
167 -1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), cholecystokinin (CCK), peptide YY (PY
168 incretins, glucose-dependent insulinotropic polypeptide (GIP), has garnered much attention as a pote
171 to fold during translation before the entire polypeptide has been produced, which may be particularly
174 each the functional state, newly synthesized polypeptides have to become enzymatically processed, fol
177 an Amylin, also known as human islet amyloid polypeptide (hIAPP), is the major factor for categorizin
180 se cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referr
181 that the antimicrobial and immunomodulatory polypeptide human cathelicidin LL-37 binds IAPP with nan
184 ic type II diabetes-associated islet amyloid polypeptide (IAPP), a hydrophobic-hydrophilic interface-
185 amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin
187 trol (RQC) purges aberrant mRNAs and nascent polypeptides in a multi-step molecular process initiated
189 -puromycin staining of puromycylated nascent polypeptides in fixed cells accurately reports on their
190 ical assays and live cell imaging of nascent polypeptides in mammalian cells, that puromycylated nasc
191 stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for p
192 nslational modification of newly synthesized polypeptides in the oxidizing environment of the endopla
197 ergence demands a transition from disordered polypeptides into structured proteins with well-defined
198 uestration of misfolded proteins and nascent polypeptides into two distinct compartments, stress gran
200 erization of backbone-extended monomers into polypeptides is challenging due to their poor compatibil
201 However, how the substrate CtA, a 90-residue polypeptide, is recognized by PCAT1 remained elusive.
202 ng reductively stabilized, site-specific 5fC-polypeptide lesions and employed a quantitative MS-based
204 is review documents the discovery of several polypeptide ligands and their cognate receptors mainly e
205 h efficient for in vitro applications, these polypeptide ligases have not been utilized for the semis
206 lipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases, raising q
207 in B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA
208 and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) mutagenesis over time, includi
209 olipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3 or A3) family of cytidine de
210 lipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3, A3) family member proteins
212 r dynamics simulation results, suggest how a polypeptide loop of an ERAD-L substrate moves through th
213 Our results suggest that phase-separating polypeptides may have been an evolutionary resource for
215 e Small nuclear ribonucleoprotein-associated polypeptide N (Snrpn), contributing to transcriptional r
218 se, histone H3 methyltransferase SET7/9, and polypeptide N-acetylgalactosaminyltransferase with unpre
219 shed carrier-an immune-tolerant elastin-like polypeptide nanoparticle (iTEP NP)-with the peptides tha
221 arget the sodium-taurocholate cotransporting polypeptide (NTCP; SLC10A1) on the sinusoidal membrane o
222 C inhibitors with organic anion transporting polypeptide (OATP) substrate properties, which facilitat
223 that a Drosophila organic anion-transporting polypeptide (OATP), which we named Ecdysone Importer (Ec
224 ced expression of organic anion transporting polypeptide (OATP)1A1, a transporter expressed in hepato
226 was co-assembled with a photo-cross-linkable polypeptide of 2-hydroxyethyl methacrylate modified poly
228 protein MPT64, which is a highly immunogenic polypeptide of Mycobacterium tuberculosis, a causative a
229 ed when bound to a 69-residue two-PPXY motif polypeptide of the synaptic and podocyte protein synapto
230 If Ltn1 fails to ubiquitylate those stalled polypeptides or becomes limiting, CAT tails act as degro
232 stem, pituitary adenylate cyclase-activating polypeptide (PACAP), and its cognate receptor, PAC1R, in
234 tage, but favor somatostatin- and pancreatic polypeptide-positive cells at the expense of insulin- an
235 c studies of CshA_RD1-17, indicate that this polypeptide possesses a highly unusual dynamic transitor
237 eta-cells, namely alpha-cells and pancreatic polypeptide (PPY)-producing gamma-cells, obtained from d
239 ediating proteolytic targeting of incomplete polypeptides produced by ribosome stalling, and Ltn1 mut
241 mammalian cells, that puromycylated nascent polypeptides rapidly dissociate from ribosomes even in t
244 osphotyrosine (pY) motifs embedded in folded polypeptides remains highly challenging because of the s
247 ptide 1 and glucose-dependent insulinotropic polypeptide secretion were lower after lunch but unalter
248 olecular interactions between the disordered polypeptide segments of protofilaments in directing the
250 gous genes, designated NnOMT1-5 and encoding polypeptides sharing >40% amino acid sequence identity,
253 several rounds of binding to and release of polypeptide substrates at the substrate-binding domain (
255 (RCI, RCIII, RCIV, and RCV) by combining 13 polypeptides synthesized within mitochondria on mitochon
256 surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both
258 These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor
259 (RQC) pathway for the degradation of nascent polypeptides that are encoded by defective messenger RNA
261 ich domains emerged from shorter and simpler polypeptides that bound phospho-ligands via N-helix site
262 o collect information about the structure of polypeptides that interact with a supported lipid bilaye
263 on is mediated by ribosome-bound nascent ATI polypeptides that interact with ATI protein in inclusion
264 ation produces incomplete, ribosome-tethered polypeptides that the ribosome-associated quality contro
265 gating mitoribosomes bound to tRNAs, nascent polypeptides, the guanosine triphosphatase elongation fa
268 adual evolutionary trajectory leading from a polypeptide to a ubiquitous nucleic acid-binding protein
269 nesis factors (RPBs) compete for the nascent polypeptide to influence their localization, folding, or
273 otease (M(pro) ) cleaves along the two viral polypeptides to release non-structural proteins required
274 The doses are lower than reported for other polypeptide tracers such as somatostatin analogs (2.1-2.
275 ore conserved in the upper part close to the polypeptide transferase center, while in the lower part,
276 ence stopped-flow methods to the analysis of polypeptide translocation catalyzed by these ATPase moto
277 nded transmembrane beta-barrel with a single polypeptide-transport-associated (POTRA) domain extendin
278 s glycosylation, oxidation, chlorination and polypeptide truncation variants and a previously unrepor
280 The approach enables the rapid synthesis of polypeptides using low concentrations of reactants witho
281 llate (EGCG), found in green tea, with Abeta polypeptides, using a combination of in vitro immuno-inf
283 t SCN cells expressing vasoactive intestinal polypeptide (VIP) or its cognate receptor, VPAC2, are ne
284 In particular, while vasoactive intestinal polypeptide (VIP) signalling is essential for SCN functi
286 (Translational Relocalization with Aberrant Polypeptides), was generalizable beyond the ES7L mutatio
287 Synthetic genes encoding Nanoluciferase polypeptides were inserted between the variable heavy an
289 e similarity between specific regions of the polypeptide, whereas the global structural similarity is
290 It is a heterodimer of KIF3A and KIF3C motor polypeptides which have distinct biochemical and motile
291 nctionalization of serine residues in native polypeptides, which uses a reagent platform based on the
293 several fungi, Coq10 is encoded as a fusion polypeptide with Coq11, a recently identified protein of
295 the large ribosomal subunit elongate stalled polypeptides with carboxy-terminal alanine and threonine
297 70 client association and aggregation toward polypeptides with predicted disorder, indicating that th
298 n of mammalian cells that express the target polypeptide within a natural membrane environment on the
300 meters, and glucagon-like peptide-1 (GLP-1), polypeptide YY (PYY), and cholecystokinin peptides were