ライフサイエンスコーパス: polypeptide chain

1 -tryptophan variants encompassing the entire polypeptide chain.

2 ependent structural or functional units of a polypeptide chain.

3 space of folded structures accessible to the polypeptide chain.

4 ment that precedes the fusion peptide in the polypeptide chain.

5 ut because it forms a nanopore from a single polypeptide chain.

6 e efficiently performed by components of the polypeptide chain.

7 ously tested Shigella antigens into a single polypeptide chain.

8 nd thermodynamic consequences of threading a polypeptide chain.

9 related structures and includes the complete polypeptide chain.

10 Pasteurella heparosan synthases in a single polypeptide chain.

11 ing state or contain a defined translocating polypeptide chain.

12 s several distinct functions within a single polypeptide chain.

13 oglutamate can form on the N terminus of the polypeptide chain.

14 domain (DBD) occur multiple times within one polypeptide chain.

15 se domain, and a protease domain, all in one polypeptide chain.

16 ive molecular motion for the majority of the polypeptide chain.

17 are similar to those imposed on the nascent polypeptide chain.

18 ore with an unexpected crosslink to the main polypeptide chain.

19 increase the rigidity and compactness of the polypeptide chain.

20 mains present adjacent to each other along a polypeptide chain.

21 ching through different conformations of the polypeptide chain.

22 and transfers an Ala residue to the growing polypeptide chain.

23 chain connected by linkers to form a single polypeptide chain.

24 the characteristics of a completely unfolded polypeptide chain.

25 -ene and dioxygen) are derived from the same polypeptide chain.

26 hich we localize to specific segments of the polypeptide chain.

27 chanical transduction through titin's intact polypeptide chain.

28 structural and biophysical properties of the polypeptide chain.

29 ost always arranged sequentially in a single polypeptide chain.

30 omal RNA, and alters the path of the nascent polypeptide chain.

31 of an IgG1 and at multiple sites in the same polypeptide chain.

32 nce, but rather to the mature portion of the polypeptide chain.

33 llow the passive directional movement of the polypeptide chain.

34 multiple cellular functions within a single polypeptide chain.

35 ibosome exerts a destabilizing effect on the polypeptide chain.

36 n9GlcNAc2 oligosaccharides as well as to the polypeptide chain.

37 y a long intrinsically disordered N-terminal polypeptide chain.

38 tryptophan at different locations along the polypeptide chain.

39 ociated with the signal-transducing FcRgamma polypeptide chain.

40 wn function (DUF) near the C terminus of the polypeptide chain.

41 signal peptide produces N-terminal elongated polypeptide chains.

42 ng templates, such as properly folded DNA or polypeptide chains.

43 in to Levinthal's paradox for the folding of polypeptide chains.

44 ns seems to constitute a generic property of polypeptide chains.

45 ith the inherent aggregation propensities of polypeptide chains.

46 bunit is composed of one CL-L1 and two CL-K1 polypeptide chains.

47 the tight interleaving of their constituent polypeptide chains.

48 electrostatic interactions between adjacent polypeptide chains.

49 events premature degradation of such nascent polypeptide chains.

50 with the rate of formation differing between polypeptide chains.

51 ed with processes that involve misfolding of polypeptide chains.

52 ion of full-length, chemically denatured GFP polypeptide chains.

53 es that mediate the ATP-dependent folding of polypeptide chains.

54 ed with secondary structure formation of the polypeptide chains.

55 is to generate two non-covalently associated polypeptide chains.

56 mutual synergistic folding of two disordered polypeptide chains.

57 e ribosome through an exit tunnel as nascent polypeptide chains.

58 e of ribosomes and incorporates into nascent polypeptide chains.

59 ide bonds link pairs of cysteine residues in polypeptide chains.

60 e extended chains, hairpins, and crosslinked polypeptide chains.

61 ino acids away from the synthesis of nascent polypeptide chains.

62 increase of the number of GABs on individual polypeptide chains.

63 otein folding limits the lengths of cellular polypeptide chains.

64 t restrict the conformational freedom of the polypeptide chains.

65 ter reproductions of the local structures of polypeptide chains.

66 ms the binding interface between interacting polypeptide chains.

67 tively affected the retention of most of the polypeptides chains.

68 The polypeptide chain adopts the typical alphabetaalpha PTP

69 mprising 51 residues in two disulfide-linked polypeptide chains, adopts a predominantly alpha-helical

70 re located in different positions within the polypeptide chains, alignment of their structures show t

71 complex Gordian knot topology formed by the polypeptide chain alone.

72 is sp. is heterodimeric, with two homologous polypeptide chains, alpha and beta, derived from a commo

73 Hsp70 that binds ribosome-associated nascent polypeptide chains, also binds to the TPR domain of Sec7

74 els considering the net global charge of the polypeptide chain, although the kinetics of the process

75 f proteins, stabilizing domains, and linking polypeptide chains, although some cases of extracellular

76 known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair i

77 mical protein synthesis to prepare three ShK polypeptide chain analogues, each containing either an a

78 l protease ClpXP steps through a substrate's polypeptide chain and construct a quantitative kinetic m

79 acteria and eukaryotes, consists of a single polypeptide chain and contains three major domains: the

80 which either the knot simply slips along the polypeptide chain and falls off the free terminus, or on

81 ification entails partial duplication of the polypeptide chain and mutation of a key catalytic residu

82 that shows users the knot type of the entire polypeptide chain and of each of its subchains.

83 0 particle images, shows the trace of the L1 polypeptide chain and reveals how the N- and C-terminal

84 Interaction between the nascent polypeptide chain and the ribosomal exit tunnel can modu

85 resence of topological permutations within a polypeptide chain and/or subunit rearrangements.

86 ans, formed from sequentially non-homologous polypeptide chains and affecting human or animals.

87 insic dynamic properties of emerging nascent polypeptide chains and guides them toward their biologic

88 Oligomeric interactions between Ca-ATPase polypeptide chains and their modulation by phospholamban

89 ystallography allowing tracing of structural polypeptide chains and visualization of transmembrane pr

90 functional interactions between neighboring polypeptide chains and, in turn, result in increased rat

91 the product of both the overall fold of the polypeptide chain, and, typically, structural motifs mad

92 simulations were started from fully extended polypeptide chains, and no external information was incl

93 ycin is covalently incorporated into nascent polypeptide chains, anti-puromycin immunofluorescence en

94 cular forces responsible for configuring the polypeptide chain are also changed.

95 Collagen I is a major tendon protein whose polypeptide chains are linked by covalent crosslinks.

96 inct from the fibril lattice even though the polypeptide chains are organized in an immunologically i

97 No functional human beta globin polypeptide chains are produced.

98 ngly facilitated incorporation of Ser in the polypeptide chain as compared with selenocysteine at the

99 hat the coarse-graining of the structures of polypeptide chains as self-avoiding tubes can provide an

100 factor (TF) interacts directly with nascent polypeptide chains as they emerge from the ribosome exit

101 RNA (tRNA) for each amino acid added to the polypeptide chain, as directed by messenger RNA.

102 ic interactions between various sites in the polypeptide chain, as would occur during the initiation

103 nal Ag-presentation pathways via unprocessed polypeptide chains, as free IGRP206-214 peptide or via p

104 ollagen C-propeptide trimer, where the three polypeptide chains associate together, at the junction w

105 also correlate with increased intermolecular polypeptide chain association and aggregation.

106 es also revealed a well ordered break in the polypeptide chain at Lys(147), resulting in a large conf

107 Caspase-3 cleaves the polypeptide chain at the exposed DEVD motif; however, th

108 genetic modifications are limited to natural polypeptide chains at the Cas9 termini, which excludes a

109 FAD and FMN binding domains within a single polypeptide chain, bacterial NOS is only composed of an

110 signal recognition particle (SRP) recognizes polypeptide chains bearing a signal sequence as they eme

111 It is now clear which polypeptide chains become disordered and which become re

112 mpanied by a fission of the radical-carrying polypeptide chain between the Gly436 and His437 residues

113 The channel itself does not bind the polypeptide chain but provides "friction" that minimizes

114 ular interactions between the fibril-forming polypeptide chains, but it has so far remained difficult

115 athway: the ongoing synthesis of the nascent polypeptide chain by the ribosome.

116 ammals the enzymes are expressed as a single polypeptide chain (CAD) in the order CPS-DHO-ATC and ass

117 y the cotranslational folding of the nascent polypeptide chain can also enhance PRF.

118 The translocating polypeptide chain can be traced through both SecA and Se

119 hesis on the ribosome, an elongating nascent polypeptide chain can begin to fold, in a process that i

120 ich contains a number of routes by which the polypeptide chain can convert its primary sequence into

121 a heterodimer of 18 to 19 kDa composed of 2 polypeptide chains, CL2 and AL.

122 residue hydrophilic, unstructured N-terminal polypeptide chain comprising proline, alanine, and serin

123 at of an overall extended and highly dynamic polypeptide chain comprising three helical segments and

124 as a "cupin" fold, extremely similar both in polypeptide chain conformation and in dimer geometry to

125 well as the effects of the properties of the polypeptide chain connecting the contiguous domains, are

126 irmed that fennel nsLTP1 is a 9433 Da single polypeptide chain consisting of 91 amino acids with eigh

127 -terminal domain and is composed of a single polypeptide chain containing fragment 2 (residues 156-27

128 Interactions between polypeptide chains containing amino acid residues with o

129 ind that the topological organization of the polypeptide chain critically determines the folding coop

130 nt change in the mass of any fragment of the polypeptide chain depends uniquely on the rate of exchan

131 tional translocation, the ribosome feeds the polypeptide chain directly into the channel.

132 The resulting truncated BdlA polypeptide chains directly interact and are required fo

133 and translocates to the periplasm where the polypeptide chain does an about turn in order to enter a

134 -grained, minimalistic representation of the polypeptide chain driven by a structure-based angular po

135 nd addition of the amino acid to the growing polypeptide chain during protein synthesis.

136 Sec is incorporated into the growing polypeptide chain during translation elongation and is k

137 le is known about the progressive folding of polypeptide chains during chain synthesis by the ribosom

138 it the conformational space available to the polypeptide chains during misfolding and fibrillization.

139 including cotranslational folding of nascent polypeptide chains during their synthesis by the ribosom

140 (EF2K), which inhibits elongation of nascent polypeptide chains during translation.

141 In addition to its roles in polypeptide chain elongation, unique cellular and viral

142 n pausing, roughly at the site where nascent polypeptide chains emerge from the ribosomal exit tunnel

143 gnal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome.

144 the 5-fold axis; residues 81-100 link the 10 polypeptide chains emerging from a 5-fold hub to the N-t

145 g, including the balance between solvent and polypeptide chain entropies.

146 hat water can be a good solvent for unfolded polypeptide chains, even those with a hydrophobic and ch

147 hosphorylation of PLB, neighboring Ca-ATPase polypeptide chains exhibit a 4 +/- 2 A decrease in the p

148 ange of experimental techniques suggest that polypeptide chains expand with increasing denaturant con

149 assess the internal scaling behavior of the polypeptide chain, expressed as a mass fractal dimension

150 The synthetic ester insulin polypeptide chain folded much more rapidly than proinsul

151 domain initiates with an extended region of polypeptide chain followed by two turns of an amphipathi

152 n and extraction of ribosome-stalled nascent polypeptide chains for proteasomal degradation.

153 n aberrant, translationally arrested nascent polypeptide chains for proteasomal degradation.

154 g that bound water is crucial to connect the polypeptide chains for the electron-conductivity.

155 We consider the mechanical stretching of a polypeptide chain formed by multiple interacting repeats

156 bacteriophage T4 is synthesized as a single polypeptide chain from a discontinuous reading frame as

157 e novo protein folding by protecting nascent polypeptide chains from misfolding and maintain translat

158 hesizing factories of the cell, polymerizing polypeptide chains from their constituent amino acids.

159 slation by labeling and releasing elongating polypeptide chains from translating ribosomes.

160 it players can now-starting from an extended polypeptide chain-generate a diversity of protein struct

161 hoice of dye attachment positions within the polypeptide chain has a substantial impact on which unfo

162 hich the conformational state of the nascent polypeptide chain has been linked to PRF.

163 ing NMR spectroscopy, we show that the PAGE4 polypeptide chain has local and long-range conformationa

164 plings between amino acids within and across polypeptide chains have allowed for inference of native

165 position, which is expected for an extended polypeptide chain having little or no propensity to form

166 The regions of the polypeptide chain immediately preceding or following an

167 constrains the conformations of the nascent polypeptide chain in a manner not experienced by full-le

168 myloids consist of repetitions of a specific polypeptide chain in a regular cross-beta-sheet conforma

169 lory exponent (nu) of the thermally unfolded polypeptide chain in both states.

170 onotonic trend between the dimensions of the polypeptide chain in bulk and the degree of compaction:

171 ther, these data suggest that SecA binds the polypeptide chain in its ATP state and releases it in th

172 observe simultaneous folding of the nascent polypeptide chain in real time.

173 erage conformational degeneracy of a lattice polypeptide chain in water and quantitatively show that

174 kbone and side chain conformational space of polypeptide chains in a united-residue representation an

175 a unified picture of the nature of unfolded polypeptide chains in the absence of denaturant.

176 role in the folding and assembly of nascent polypeptide chains in the ER.

177 616 non-interface residues extracted from 99 polypeptide chains in the Protein Data Bank.

178 We have traced the VP7 polypeptide chain, including parts not seen in its X-ray

179 n permits a nearly complete trace of the VP4 polypeptide chain, including the positions of most side

180 odel system for the study of folding of long polypeptide chains, including related phenomena such as

181 Spontaneous folding of a polypeptide chain into a knotted structure remains one o

182 se that the two-helix finger of SecA moves a polypeptide chain into the SecY channel with the tyrosin

183 ong bacteria, which converts Arg residues in polypeptide chains into citrulline.

184 ructure--the ordered aggregation of separate polypeptide chains into multisubunit assemblies.

185 rectly modifying, folding and assembling the polypeptide chains into the native quaternary structure.

186 s simulations revealed that ESI for unfolded polypeptide chains involves protein ejection from nanodr

187 ks via linker sequences into one multivalent polypeptide chain is an elegant alternative to affinity

188 approximately 13 amino acid residues as the polypeptide chain is apparently shortened by approximate

189 uential addition of amino acids to a growing polypeptide chain is carried out by the ribosome in a co

190 donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltrans

191 he compact packing typical of a fully folded polypeptide chain is disrupted and suggest that the incr

192 ect to the distance between hemes, along the polypeptide chain is exactly the same in both redox syst

193 During co-translational folding, the nascent polypeptide chain is extruded sequentially from the ribo

194 ns explored and show that this region of the polypeptide chain is involved in both the nucleation and

195 SecY complex raises the possibility that the polypeptide chain is moved by a two-helix finger domain

196 The knotted/slipknotted polypeptide chain is one of the most surprising topologi

197 ore unusually, the N-terminal portion of the polypeptide chain is pinned to the "Kunitz head" by two

198 ng a covalent-loop through which part of the polypeptide chain is threaded (as seen in knotted protei

199 tides are moved by different mechanisms: the polypeptide chain is transferred directly into the chann

200 cid from a non-cognate tRNA into the growing polypeptide chain leads to a general loss of specificity

201 We show that by varying polypeptide chain length and dendron generation, an orga

202 Comparisons are usually performed at the polypeptide chain level, however the functional form of

203 named insulin-like 3 (INSL3) consists of two polypeptide chains linked by two interchain and one intr

204 omplexes between the ligand and the extended polypeptide chain may act as nucleation sites for foldin

205 et been resolved, but the arrangement of the polypeptide chain may have a strong influence on the cap

206 te that tunnel interactions with the nascent polypeptide chain might be relevant for the regulation o

207 that targets the associated mRNA and nascent polypeptide chain (NC).

208 m a trefoil knot in the denatured state of a polypeptide chain of 120 residues is 5.8 +/- 1 kcal mol(

209 threonine protein kinase comprising a single polypeptide chain of 4,128 amino acids and belonging to

210 d the potential benefits of reorganizing the polypeptide chain of a protein by circular permutation (

211 e internal redox steps occur within the same polypeptide chain of mammalian QSOX and commence with a

212 ed denatured state we find that knotting the polypeptide chain of MJ0366 increase the folding energy

213 The polypeptide chain of rabbit uterine smMLCK (Swiss-Prot e

214 The predicted 81 amino acid residue polypeptide chain of sfAFP contains Cys residues at posi

215 The target 148 residue polypeptide chain of sortase ADeltaN59 was synthesized b

216 th both TS and DHFR active sites on a single polypeptide chain of the enzyme.

217 The vicilin consisted of two polypeptide chains of about 43 and 45 kDa in size when a

218 The polypeptide chains of FrhB, for which there was no homol

219 The entire polypeptide chains of GKalphabeta are structurally defin

220 We found that the C-tails of the two polypeptide chains of the rat Abeta(1-16) dimer are orie

221 1q is a hexameric molecule assembled from 18 polypeptide chains of three different types encoded by t

222 Changes along the polypeptide chains of Tmods and Lmods exquisitely adapt

223 f multifunctional proteins in which a single polypeptide chain performs multiple biochemical function

224 olvent accessible surface area (SASA) of the polypeptide chain plays a key role in protein folding, c

225 The assumption is that unfolded polypeptide chains possess an intrinsic propensity to fo

226 is a heterodimer consisting of 2 homologous polypeptide chains, PPO1 and PPO2.

227 is is the first evidence that folding of the polypeptide chain precedes disulfide formation within a

228 e ring forms a 'gasket-like' seal around the polypeptide chain, preventing the permeation of small mo

229 ge attractions, which can be encoded by both polypeptide chain primary sequence and nucleic acid base

230 nfounded by release of puromycylated nascent polypeptide chains prior to fixation.

231 Propagation of the polypeptide chains proceeds through the transfer of the

232 ion of its C-terminal domain with eukaryotic polypeptide chain release factor, eRF3.

233 in the central region of phospho-PAGE4, the polypeptide chain remains highly dynamic overall.

234 ons of two opposite topologies from the same polypeptide chain remains unclear.

235 specifically an aromatic-rich region of the polypeptide chain (residues 62-70) that has been predict

236 xpression of the corresponding complementary polypeptide chains, retain tetrameric architecture and a

237 er of Escherichia coli SecA interacts with a polypeptide chain right at the entrance into the SecY po

238 e TRAIL protomers were expressed as a single polypeptide chain (scTRAIL), and a novel TRAIL variant,

239 e formation of beta-sheet structures, as the polypeptide chain searches for the native stabilizing cr

240 caffeate acts by disordering precisely those polypeptide chain segments that make up the active site

241 e disulfides spanning a large portion of the polypeptide chain shifts the structure and dynamics of h

242 Simulations in the presence of a polypeptide chain show that the substrate associates wit

243 the plastid envelope and the importing PORA polypeptide chain such that no photoexcitative damage oc

244 re conducted using a single monomer gammaTIM polypeptide chain that folds as a monomer and two gammaT

245 Single-chain FLARE (scFLARE) is a single polypeptide chain that incorporates a transcription fact

246 Thus, the proportion of polypeptide chain that is locally and presumably transie

247 l slip site generates a force on the nascent polypeptide chain that scales with observed frameshiftin

248 he excluded volume of a local segment of the polypeptide chain that transiently stalls in the nanopor

249 onformationally restricted in regions of the polypeptide chain that ultimately form helices I, II and

250 BoNTs are synthesized as single inactive polypeptide chains that are cleaved by endogenous or exo

251 al machineries for the synthesis of thirteen polypeptide chains that are components of the complexes

252 matic, because immune receptors comprise two polypeptide chains that are encoded by separate mRNAs.

253 but also several further versions of the two polypeptide chains that most likely differ with respect

254 Collagens are composed of three polypeptide chains that wind into triple helices.

255 MCM2-7 is a heterocomplex made of different polypeptide chains, the MCM complexes of many Archaea fo

256 n, because sortase A enables the splicing of polypeptide chains, the transpeptidation reaction cataly

257 roEL-GroES sterically confines the unknotted polypeptide chain thereby promoting knotting is unlikely

258 s protein synthesis by accepting the growing polypeptide chain, thereby killing bacterial cells.

259 ding nucleators by preorganizing the pendant polypeptide chains, thereby lowering the activation barr

260 te release and allows passive sliding of the polypeptide chain through the SecA-SecY complex until th

261 ich ATP hydrolysis by SecA is used to move a polypeptide chain through the SecY channel.

262 suggests a dimeric arrangement of Ca-ATPase polypeptide chains through the proximal association of N

263 lectively oxidizes the N-terminal amine of a polypeptide chain to a ketone or an aldehyde group.

264 te modulates the intrinsic propensity of the polypeptide chain to aggregate and that the algorithm de

265 cause the protein slipknot to untie and the polypeptide chain to completely extend.

266 ifferent icosahedral symmetries, causing the polypeptide chain to exist in seven quasi-equivalent env

267 lix motifs) facilitate bending and allow the polypeptide chain to fold into a hollow circular structu

268 binding provides a major driving force for a polypeptide chain to fold.

269 d state presents ample opportunities for the polypeptide chain to transiently sample nonnative struct

270 coarse-grained C(alpha)-side chain model for polypeptide chains to simulate the folding of src SH(3)

271 tudied folding events at the early stages of polypeptide chain translocation into the mammalian ER us

272 alent folding and assembly of macromolecular polypeptide chains, ultimately preventing the formation

273 haracterize the crowding effects on the same polypeptide chain under two drastically distinct folding

274 It is generally held that random-coil polypeptide chains undergo a barrier-less continuous col

275 Essentially the entire MeCP2 polypeptide chain underwent H/DX at rates faster than co

276 n a substrate and then translocate along the polypeptide chain, unfolding and degrading protein domai

277 ecause of simplified UNRES representation of polypeptide chains, use of enhanced sampling methods, co

278 Type 2 RIPs contain two polypeptide chains (usually named A, for "activity", and

279 The iron hemes of MtrA are bound to its polypeptide chain via proximal (CXXCH) and distal histid

280 The synthetic polypeptide chain was folded in vitro into a defined ter

281 or and acceptor fluorescent dyes on the same polypeptide chain, was developed.

282 and allo-Ile, both l-allo-ShK and d-allo-ShK polypeptide chains were prepared by total chemical synth

283 forming Met66 residue is eliminated from the polypeptide chain, whereas Leu66 in Blue102 is cleaved o

284 Our results suggest that polypeptide chains which form amyloid fibrils with narro

285 and P-domain elements of proximal Ca-ATPase polypeptide chains which restore functional interactions

286 of a flexible, scaled, physical model of the polypeptide chain, which accurately reproduces the bond

287 mic model for nearly all of the 2109-residue polypeptide chain, which comprises three enzymatic domai

288 synthesis to make the central segment of the polypeptide chain, which forms the transmembrane beta-ba

289 eral copies of the cruciferin alpha and beta polypeptide chains, which are present in various isoform

290 -puro forms covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the

291 o-acid sequence result in shorter or cleaved polypeptide chains while the incomplete processing of th

292 le-chain trimers (SCTs) composed of a single polypeptide chain with a linear composition of antigenic

293 ies of cyanovirin-N that all are formed by a polypeptide chain with the identical amino acid sequence

294 isms as well as the interactions of unfolded polypeptide chains with other cell components.

295 n only be measured at high concentrations of polypeptide chains with slow scanning rates, for example

296 le of hindered dihedral rotations within the polypeptide chain, with a proportionality coefficient b

297 RT is expressed as a single polypeptide chain within the Gag-Pol polyprotein, and ei

298 gies to label endogenously occurring nascent polypeptide chains within cells using O-propargyl-puromy

299 During protein synthesis, nascent polypeptide chains within the ribosomal tunnel can act i

300 oteasome is selective for unfolded, extended polypeptide chains without ubiquitin tags.