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1  Escherichia coli, and its activity requires polyphosphoinositides.
2 inases that phosphorylate the 3' position of polyphosphoinositides.
3  the synthesis of agonist-sensitive pools of polyphosphoinositides.
4 -bisphosphate and two 3-phosphate-containing polyphosphoinositides.
5 f phospholipase C, which hydrolyzes membrane polyphosphoinositides.
6 )P showed significantly less binding to most polyphosphoinositides.
7 rostatic effects for lateral organization of polyphosphoinositides.
8 h BSA had increased (4-5-fold) hydrolysis of polyphosphoinositides.
9 in the ability of the MARCKS-ED to sequester polyphosphoinositides.
10 e proteins to cell membranes through binding polyphosphoinositides.
11                       This insulin-sensitive polyphosphoinositide 5'-phosphatase did not catalyze dep
12                        The insulin-regulated polyphosphoinositide 5'-phosphatase was not immunoreacti
13 e observed previously that overexpression of polyphosphoinositide 5-phosphatase IV (5ptaseIV) that de
14 ge of HIV-1 in an A3.01 clone that expresses polyphosphoinositide 5-phosphatase IV (5ptaseIV), which
15 evious studies showed that overexpression of polyphosphoinositide 5-phosphatase IV (5ptaseIV), which
16  we examined the impact of overexpression of polyphosphoinositide 5-phosphatase IV (5ptaseIV), which
17  cell membrane (approximately 50 A(2)), only polyphosphoinositides achieve this threshold.
18 show that PLDbeta is stimulated by different polyphosphoinositides, among which PI(4,5)P2 is most eff
19 permeant synthetic 10-mer peptide that binds polyphosphoinositides and increases PI 3-kinase activity
20                    The findings implicate D3 polyphosphoinositides and integrin signaling in PMA-medi
21 permeant synthetic 10-mer peptide that binds polyphosphoinositides and leads to activation of PI 3-ki
22 l significance of a PLD that is regulated by polyphosphoinositides and physiological concentrations o
23 gated the putative roles of phospholipase C, polyphosphoinositides, and inositol 1,4,5-trisphosphate
24 l, phosphatidylserine, phosphatidylinositol, polyphosphoinositides, and sphingosine 1-phosphate) show
25 ects of this diversity: the evolution of the polyphosphoinositides, and the synthesis and functions o
26                                              Polyphosphoinositides are among the most highly charged
27                                              Polyphosphoinositides are an important class of lipid th
28                                              Polyphosphoinositides are lipid signaling molecules gene
29                                              Polyphosphoinositides are needed for exocytosis, but it
30                                              Polyphosphoinositides are thought to be mediators of cel
31          PROPPINs (beta-propellers that bind polyphosphoinositides) are a family of PtdIns3P- and Ptd
32          PROPPINs (beta-propellers that bind polyphosphoinositides) are PtdIns3P and PtdIns(3,5)P2 bi
33 p85beta) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane.
34 ations of residues known to be essential for polyphosphoinositide binding in previously characterized
35  a heterogeneous gene family and that direct polyphosphoinositide binding is required for the activit
36 n-associated AP-2 adaptor protein is a major polyphosphoinositide-binding protein in mammalian cells.
37                                         This polyphosphoinositide binds the pleckstrin homology (PH)
38 increase in intracellular calcium levels and polyphosphoinositide bis phosphate (PIP2) hydrolysis.
39                                              Polyphosphoinositides both integrate signaling pathways
40 ed after phospholipase C activation, causing polyphosphoinositide breakdown, and was accelerated by e
41                         Run-down of cellular polyphosphoinositides by concentrations of wortmannin th
42  of CD45 phosphatase/protein tyrosine kinase/polyphosphoinositide/Ca2+/protein kinase C pathway rathe
43                           This connection to polyphosphoinositides, compounds whose levels are physio
44            This fraction is also enriched in polyphosphoinositides, containing approximately one-fift
45 ulates PLD by mediating its interaction with polyphosphoinositide-containing membranes; this might al
46 in cleaves actin filaments in a calcium- and polyphosphoinositide-dependent manner.
47  in dry seeds and mature leaves, whereas the polyphosphoinositide-dependent PLD activity was greater
48                                          The polyphosphoinositide-dependent PLD requires calcium for
49                   myo-Inositol (Ins) and its polyphosphoinositide derivatives that are important in m
50        Results of previous work suggest that polyphosphoinositides disrupt this interaction and there
51 te a requirement for phospholipase C and for polyphosphoinositides for activation of capacitative cal
52 osphatidylinositol (PI) 3-kinase-mediated 3'-polyphosphoinositide generation and activation of Akt/pr
53 fied in Arabidopsis thaliana, and Ca(2+) and polyphosphoinositides have been suggested as key regulat
54                                              Polyphosphoinositides have many roles in cell signalling
55 tor expression and mGlu1/5 receptor-mediated polyphosphoinositide hydrolysis were also unchanged in t
56 to polybasic clusters known to interact with polyphosphoinositides identified in other ion channels.
57 ction, suggesting an important role for this polyphosphoinositide in vesicular trafficking.
58           This review emphasizes the role of polyphosphoinositides in recruiting signaling proteins t
59 useful to probe the location and function of polyphosphoinositides in vivo.
60 nositide-requiring PLDbeta and PLDgamma, and polyphosphoinositide-independent PLDalpha.
61 and HIP1-related (HIP1r), have an N-terminal polyphosphoinositide-interacting epsin N-terminal homolo
62  phosphatidylinositol (PI), the precursor of polyphosphoinositides, is distributed within cell membra
63 , a process that is known to be dependent on polyphosphoinositide lipids.
64 ositol-4-phosphate rather than a build-up of polyphosphoinositides or changes in the activity of phos
65 ate (PMA), did not alter the distribution of polyphosphoinositides or the polyphosphoinositide phosph
66 tool for pharmacological intervention in the polyphosphoinositide pathway and an important lead compo
67 seems causally related to alterations in the polyphosphoinositide pathway.
68 zymatic activity that defines a new class of polyphosphoinositide phosphatase (PPIPase).
69 ings suggest that polyphosphoinositides, the polyphosphoinositide phosphatase and protein kinase C pl
70  study, we have identified synaptojanin 2, a polyphosphoinositide phosphatase as a novel Rac1 effecto
71                          Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presyna
72                       Inp53p contains a SacI polyphosphoinositide phosphatase domain, a 5-phosphatase
73  of FIG4, whose gene product contains a Sac1 polyphosphoinositide phosphatase domain, which suppresse
74 Ins(3,5)P(2) is mediated in part by the Sac1 polyphosphoinositide phosphatase family member Fig4.
75                          Synaptojanin 1 is a polyphosphoinositide phosphatase implicated in synaptic
76                                   Synj1 is a polyphosphoinositide phosphatase important at convention
77                  Synaptojanin 1 (SynJ1) is a polyphosphoinositide phosphatase involved in clathrin-me
78   Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to
79 nes during endocytosis, or that it binds the polyphosphoinositide phosphatase synaptojanin and recrui
80 gh SH3 domain-mediated interactions with the polyphosphoinositide phosphatase synaptojanin and the GT
81 nzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve t
82 minals that binds the GTPase dynamin and the polyphosphoinositide phosphatase synaptojanin, two prote
83      Finally, depleting endogenous PIP2 with polyphosphoinositide phosphatase synaptojanin-1, known t
84 otein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin.
85   Synaptojanin 2 is a ubiquitously expressed polyphosphoinositide phosphatase that displays a high de
86                            Synaptojanin is a polyphosphoinositide phosphatase that is found at synaps
87 poral recruitment of synaptojanin 1 (SJ1), a polyphosphoinositide phosphatase, and its binding partne
88                      We report here that the polyphosphoinositide phosphatase, but not several other
89                            Synaptojanin 1, a polyphosphoinositide phosphatase, is expressed as two ma
90 wed that synaptojanin 1 (SJ1), a presynaptic polyphosphoinositide phosphatase, is required for normal
91                                            A polyphosphoinositide phosphatase, synaptojanin 1, was id
92 distribution of polyphosphoinositides or the polyphosphoinositide phosphatase.
93 osphate-5-Phosphatase F (INPP5F), one of the polyphosphoinositide phosphatases, is differentially exp
94 es in the cell membrane, and the most common polyphosphoinositide, phosphatidylinositol-4,5-bisphosph
95 sent studies, therefore, we examined whether polyphosphoinositide-phospholipase C-gamma (PI-PLC-gamma
96 s(1,4,5)P3, D-Ins(1,3,4,5)P4, and InsP6, and polyphosphoinositides PI(4,5)P2 and PI(3,4,5)P3, which c
97 yvitamin D3 (1,25[OH]2D3) rapidly stimulated polyphosphoinositide (PI) hydrolysis, raised intracellul
98  translocation in intact adipocytes, and the polyphosphoinositide, PI 4,5-(PO4)2, stimulated Rho tran
99                                              Polyphosphoinositides PI4-P and PI4,5P2 and cardiolipin
100 s of signal transduction, a process in which polyphosphoinositides play a central role.
101 suggest that attractive interactions between polyphosphoinositides, possibly mediated by hydrogen bon
102            Although chilling does not change polyphosphoinositide (ppI) levels, a ppI-binding peptide
103  particular interest in this context are the polyphosphoinositides (PPI's), especially phosphatidylin
104                                              Polyphosphoinositides (PPI) play crucial roles in cellul
105 that also serves as the common precursor for polyphosphoinositide (PPIn) lipids.
106                                          The polyphosphoinositides (PPIn) are central regulatory lipi
107 how acute depletion of negatively charged PM polyphosphoinositides (PPIns) from the PM alters the int
108                                              Polyphosphoinositides (PPIs) affect the localization and
109                                              Polyphosphoinositides (PPIs) and in particular phosphati
110                                     Membrane polyphosphoinositides (PPIs) are lipid-signaling molecul
111 , the susceptibility of membranes containing polyphosphoinositides (PPIs) to divalent cation-induced
112  the villin/gelsolin family are regulated by polyphosphoinositides (PPIs), and manipulation of cellul
113 sensitivity and is correlated with a fall in polyphosphoinositides (PPIs), including phosphatidylinos
114                                          The polyphosphoinositides (PPIs), phosphatidylinositol 3,4-b
115 arious lipid signaling molecules, designated polyphosphoinositides (PPIs).
116 agnesium on aggregation of PI4,5P2 micelles, polyphosphoinositides promote interactions with the tali
117                    beta-propellers that bind polyphosphoinositides (PROPPINs), a eukaryotic WD-40 mot
118 P] 5-kinase responsible for synthesis of the polyphosphoinositide PtdIns(3,5)P(2).
119 ,5)P3, Ins(1,3,4,5)P4, and InsP6, and of the polyphosphoinositides PtdIns(3,4,5)P3, PtdIns(4,5)P2, an
120  via their predicted beta-propeller fold the polyphosphoinositides PtdIns3P and PtdIns(3,5)P(2) using
121 rgeting of their host proteins by binding to polyphosphoinositides; recent results have increased our
122                                              Polyphosphoinositides regulate numerous steps in membran
123 t intermediate for the synthesis of membrane polyphosphoinositides, regulators of multiple cellular f
124 ey exhibit two distinct types of activities: polyphosphoinositide-requiring PLDbeta and PLDgamma, and
125 cally to PtdIns 3-phosphate (PtdIns-3-P) and polyphosphoinositides, respectively, can direct such mem
126                        Failure to catabolize polyphosphoinositides retards the fission process and en
127          Overexpressed pleckstrin can affect polyphosphoinositide second messenger-based signaling ev
128 ential participants in the generation of all polyphosphoinositide signaling molecules.
129 zation results in the biphasic activation of polyphosphoinositide-specific phospholipase C (PLC) acti
130  Ca(2+), alpha-latrotoxin does not stimulate polyphosphoinositide-specific phospholipase C. alpha-Lat
131 olysis of host PI and the activation of host polyphosphoinositide-specific PLC and host phospholipase
132 lta) are known to catalyze the hydrolysis of polyphosphoinositides such as phosphatidylinositol 4,5-b
133                            Furthermore, when polyphosphoinositide synthesis was allowed to proceed in
134 a catalytic mechanism, because the amount of polyphosphoinositides synthesized greatly exceeded the m
135 rk, however, has highlighted the role of the polyphosphoinositide synthetic pathways in activated cel
136 idylinositol-3-kinase (PI3K), which produces polyphosphoinositides that interact with protein kinases
137 inases is the first step in the synthesis of polyphosphoinositides, the lipid precursors of intracell
138                  These findings suggest that polyphosphoinositides, the polyphosphoinositide phosphat
139 ein kinase, which interacts with membrane 3'-polyphosphoinositides through its pleckstrin homology (P
140                                           As polyphosphoinositides turn over rapidly and are exceptio
141 ts during target cell stimulation, including polyphosphoinositide turnover and tyrosine phosphorylati
142 nd intrinsic activity of phenethylamines for polyphosphoinositide turnover but not for arachidonic ac
143                          Its requirement for polyphosphoinositides was further supported by its abili
144  vitro, although the other D5-phosphorylated polyphosphoinositides were also substrates.
145 y Rho-family GTPases such as Cdc42, membrane polyphosphoinositides, WIP/verprolin, and SH3 domain pro

 
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