ライフサイエンスコーパス: polyploidy

1 ore than two sets of homologous chromosomes (polyploidy).

2 ized in antimesometrial decidualization with polyploidy.

3 w, and its subsequent absence contributes to polyploidy.

4 identifying tumor subclonal populations and polyploidy.

5 le and cytokinesis defects, micronuclei, and polyploidy.

6 ycle oscillation frequency and the extent of polyploidy.

7 ion and returned to a physiological state of polyploidy.

8 ty of both wild-type and mutant E6 to induce polyploidy.

9 the DNA content in the nucleus and leads to polyploidy.

10 h diploidy providing a growth advantage over polyploidy.

11 r to mitosis and concomitant upregulation of polyploidy.

12 rvening mitosis or cytokinesis, resulting in polyploidy.

13 ls to achieve repeated rounds of S phase and polyploidy.

14 ostmitotic checkpoint by HPV E6 that induces polyploidy.

15 thylation in regulating gene expression post polyploidy.

16 me to find changes in soybean resulting from polyploidy.

17 on in genome size and different histories of polyploidy.

18 malities such as chromosomal aberrations and polyploidy.

19 as not significantly affected by apomixis or polyploidy.

20 merotelic attachments, anaphase lagging, and polyploidy.

21 essing unresolved problems about the role of polyploidy.

22 ts of a very common correlate of asexuality, polyploidy.

23 analysis of the evolutionary consequences of polyploidy.

24 ted in megakaryocyte endomitosis, leading to polyploidy.

25 works of kinases that regulate the switch to polyploidy.

26 ion and cell proliferation while inducing 8N polyploidy.

27 , followed by endomitosis and acquisition of polyploidy.

28 ition of LOX activity has no influence on MK polyploidy.

29 gents and promoting chemotherapeutic-induced polyploidy.

30 ging as a powerful new model system to study polyploidy.

31 abnormalities, which further result in cell polyploidy.

32 to liver regeneration in mice with increased polyploidy.

33 h every endomitotic cycle as cells grow into polyploidy.

34 rstanding of phenotypic novelty accompanying polyploidy.

35 kely enabled by genomic redundancy following polyploidy.

36 ained duplicate genes from the ancient maize polyploidy.

37 ding to mitotic arrest and subsequently cell polyploidy.

38 A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement

39 Our results revealed two rounds of polyploidy: a paleopolyploid event predating the African

40 morphometric analysis of leaves showed that polyploidy affected epidermal pavement cells, with incre

41 Polyploidy (alias whole genome amplification) refers to

42 Polyploidy also frequently confers resistance to environ

43 tmitotic G1-like checkpoint that can lead to polyploidy, an early event during cervical carcinogenesi

44 eases of P62, leading to an increase of cell polyploidy and an impairment of autophagy maturation.

45 Here I review the sparse information on polyploidy and community context and then present a set

46 insights into the functional consequences of polyploidy and epigenetic regulation in plant genomes.

47 h clinical and biological parameters such as polyploidy and estrogen receptor negative status.

48 t economic potential, has become a model for polyploidy and evolutionary studies.

49 endoreduplication, which is associated with polyploidy and genome instability.

50 ed mechanisms that control the generation of polyploidy and have recently begun to provide clues to i

51 complex plant genomes remains elusive due to polyploidy and high repeat content.

52 ial role of sexual and asexual reproduction, polyploidy and host domestication in A. candida speciali

53 The mechanisms that induce polyploidy and how these mechanisms contribute to CIN ar

54 Because polyploidy and impaired DDRs can promote cancer, our fin

55 ision, but the molecular mechanism promoting polyploidy and limiting cell division remains poorly und

56 frequency, age, and phylogenetic position of polyploidy and lineage separation events that have marke

57 during normal ageing and after injury led to polyploidy and multinucleation, but also to new diploid,

58 ric division into daughter cells, leading to polyploidy and multinucleation.

59 ited cells showed enhanced radiation-induced polyploidy and nuclear fragmentation, consistent with th

60 ude that Hippo-Yap signaling suppresses cell polyploidy and oncogenesis through Skp2.

61 -induced apoptosis, and increased pX-induced polyploidy and oncogenic transformation, suggesting ZNF1

62 agation of damaged DNA, resulting in partial polyploidy and oncogenic transformation.

63 Numerous hypotheses about the mechanism of polyploidy and parental genome donors have been proposed

64 ion in the fate/evolution of genes following polyploidy and speciation has not been fully explored.

65 Even though the connections between polyploidy and species interactions have been recognized

66 In flowering plants, polyploidy and subsequent reductions in chromosome numbe

67 TLR2 signaling promoted macrophage polyploidy and suppressed genomic instability by regulat

68 scriptome size, but the relationship between polyploidy and transcriptome changes remains poorly unde

69 ing mitosis reportedly include prevention of polyploidy and transmission of aberrant chromosomes.

70 of the reproductive barriers observed (e.g., polyploidy and uniparental reproduction), however, may h

71 ystem evolved, and whether it is affected by polyploidy and/or apomixis.

72 enetic program leading to cell cycle arrest, polyploidy, and apoptosis.

73 feration, triggering G2/M cell-cycle arrest, polyploidy, and apoptosis.

74 KA levels leading to G2/M delay, chromosomal polyploidy, and cell death.

75 y, the potential contribution of DNA repair, polyploidy, and cell fusion to the measurement of myocyt

76 ly, the widespread species divergence, major polyploidy, and lineage separation events during Brassic

77 nous DNA damage leads to an earlier onset of polyploidy, and polyploid cells in the adult brain are m

78 markers (CD41, CD42a, and CD61), a decreased polyploidy, and significantly reduced PLP counts.

79 e mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide

80 reby driving cell proliferation, chromosomal polyploidy, and tumorigenesis.

81 naling in vitro leads to multinucleation and polyploidy, and we demonstrate that this is caused by al

82 To study relationships among liver polyploidy, aneuploidy, and adaptation, mice lacking E2f

83 aberrant centrosome content, DNA damage, and polyploidy/aneuploidy.

84 rs ago, followed by a genus Glycine-specific polyploidy, approximately 10 million years ago.

85 he genetic and morphological consequences of polyploidy are being rapidly elucidated, the effects on

86 Apomixis and polyploidy are closely associated in angiosperms, but th

87 Studies of the macroevolutionary legacy of polyploidy are limited by an incomplete sampling of thes

88 Chromosome losses and polyploidy are recovered as the main evolutionary mechan

89 eath following mitotic failure and increased polyploidy as a consequence of cellular inhibition of au

90 We see value in recognizing polyploidy as a key player in generating diversity in de

91 gulfment involving live cells, also leads to polyploidy, as internalized cells disrupt cytokinesis of

92 he optic lobes exhibit the highest levels of polyploidy, associated with an elevated DNA damage respo

93 Here, we review the current understanding of polyploidy at the organismal and suborganismal levels, i

94 Duplicate genes descending from polyploidy augmented the transcription factor diversity

95 sues within an organism it is termed somatic polyploidy, because it is distinct from the increase in

96 ion bursts in Zea may have been initiated by polyploidy, but the great majority of transposable eleme

97 xygen as a proximal trigger for the onset of polyploidy, (c) the relationship between polyploidizatio

98 ntitative evidence that in some environments polyploidy can accelerate evolutionary adaptation.

99 olution experiments to test directly whether polyploidy can accelerate evolutionary adaptation.

100 Polyploidy can also affect gene regulation by amplifying

101 volution of increased genome complexity, but polyploidy can also arise in somatic cells of otherwise

102 es in increasing cell size/metabolic output, polyploidy can also promote nonuniform genome, transcrip

103 Both aneuploidy and polyploidy can arise from multinucleate states after fai

104 ilution of sensitive molecules and effective polyploidy can cause phenotypic delay over a wide range

105 Previous studies have shown that polyploidy can coincide with meiotic abnormalities and s

106 Polyploidy can lead to aneuploidy and tumorigenesis.

107 Polyploidy can occur because of cell fusion or abnormal

108 nomes (polyploidy), suggesting that study of polyploidy can reveal how cells with impaired DDRs/genom

109 els suggest that tetraploidy, one example of polyploidy, can promote tumorigenesis.

110 ade of autophagy maturation and promotion of polyploidy caused by LRPPRC depletion synergistically en

111 Inhibition of SPG polyploidy caused rupture of the septate junctions neces

112 ulted in apoptosis induction, G(2)-M arrest, polyploidy cells, and attenuation of cancer cell anchora

113 of cytokinesis, resulting in multinucleated, polyploidy cells.

114 However, polyploidy challenges chromosome folding architecture in

115 In the absence of polyploidy, changes in the amount of repetitive DNA (tra

116 Despite the wide-reaching importance of polyploidy, communication across disciplinary boundaries

117 Polyploidy complicates genomics-based breeding of many c

118 Polyploidy confers postzygotic reproductive isolation an

119 Whereas 0.42-0.47 million years ago (Ma) polyploidy constrained genetic variation, the peanut gen

120 rom a variety of animals and plants in which polyploidy controls organ size, the size and function of

121 We suggest that polyploidy could confer resource costs related to the di

122 Moreover, the polyploidy defect in Mir122 knockout mice was ameliorate

123 est that proper regional decidualization and polyploidy development requires FoxM1 signaling downstre

124 ion with perturbation of decidualization and polyploidy development, suggesting a role for Cbx4/Ring1

125 have led scientists to explore factors (e.g. polyploidy, developmental systems, floral evolution) tha

126 otentially cause phenotypic delay: effective polyploidy, dilution of antibiotic-sensitive molecules a

127 s, which may provide an alternative route to polyploidy, distinct from the one involving unreduced ga

128 rms, Brassicaceae, Poaceae), suggesting that polyploidy drives diversification.

129 variants of AURKC cause meiotic failure and polyploidy due to a failure in AURKC-CPC function that r

130 The widespread use of polyploidy during cell differentiation makes it importan

131 nd evidence consistent with a single ancient polyploidy event in the evolutionary history of Ceratopt

132 ts, providing strong evidence that the gamma polyploidy event occurred early in eudicot evolution.

133 analysis allows us to estimate that the teff polyploidy event occurred ~1.1 million years ago (mya) a

134 Although it is agreed that a major polyploidy event, gamma, occurred within the eudicots, t

135 event remains dominant through a subsequent polyploidy event.

136 (Glycine max L.) has undergone two separate polyploidy events (13 and 59 million years ago) that hav

137 cytogenetic approach to track occurrences of polyploidy events and to analyze their impact on the evo

138 We mapped the phylogenetic distribution of polyploidy events by both tree-based and distance-based

139 We identified 26 ancient and more recent polyploidy events distributed throughout Caryophyllales.

140 ocado lineage experienced 2 lineage-specific polyploidy events during its evolutionary history.

141 psis thaliana), which experienced two nested polyploidy events independent from the legume duplicatio

142 In species that lack recent polyploidy events that occurred in the past several mill

143 o single copy following numerous independent polyploidy events, a pattern that is probably not by cha

144 f genes within gene families due to multiple polyploidy events, gene loss and fractionation, and diff

145 Following polyploidy events, genomes undergo massive reduction in

146 ver, in species that experienced more recent polyploidy events, the percentage decreased to 21-65%.

147 ver more than 100 million years and repeated polyploidy events.

148 seed plants and then expanded by subsequent polyploidy events.

149 Intraspecific hybridization and polyploidy exacerbate these defects, which segregate qua

150 Hybridization and polyploidy followed by genome-wide diploidization had a

151 Whole-genome duplication (WGD), or polyploidy, followed by gene loss and diploidization has

152 In addition, I highlight how polyploidy functions in wound healing and tissue regener

153 n in flowering plants is often punctuated by polyploidy, genome duplication events that fundamentally

154 have potential applications for the study of polyploidy, genome stability, chromosome segregation, an

155 mapping-by-sequencing to even poorly defined polyploidy genomes where chromosomes are incomplete and

156 Due to the polyploidy (>50 genome copies per cell) of Z. mobilis, w

157 Genomic instability in the form of polyploidy has been demonstrated to play an important ro

158 Polyploidy has been reported in Thermococcales and P. fu

159 Polyploidy has contributed to the evolution of eukaryote

160 Polyploidy has extensive genetic, physiological, morphol

161 d some animal species and today we know that polyploidy has had a role in the evolution of all angios

162 Polyploidy has played a central role in plant genome evo

163 rences 66 Whole-genome duplication (WGD), or polyploidy, has important effects on the genotype and ph

164 ger-term genomic and epigenetic responses to polyploidy have become appreciated.

165 n, detailed comparative molecular studies on polyploidy have been confined to only a few species and

166 The genomic consequences of polyploidy have been extensively studied, but the mechan

167 five plant species that experienced various polyploidy histories.

168 The adaptive value of polyploidy, however, remains uncertain; ecologists have

169 ted, cyclin E is essential for megakaryocyte polyploidy; however, it has remained unclear whether up-

170 lacking an open reading frame, especially in polyploidy human cell lines.

171 hat introgressive hybridizations (diploid or polyploidy hybrid speciation) and/or a series of whole-g

172 To determine whether reduced polyploidy impairs adaptation, LKO mice were bred onto a

173 nuclei range from 1N to >4N, with different polyploidies in the same cell and low levels of aneuploi

174 we speculate about the physiological role of polyploidy in cardiomyocytes and how this might relate t

175 h of the heart and the physiological role of polyploidy in cardiomyocytes are enigmatic.

176 view, we explore the biological relevance of polyploidy in different species and tissues to acquire i

177 ecent advances on the role and regulation of polyploidy in Drosophila and vertebrate models.

178 late from this to suggest that the rarity of polyploidy in gymnosperms may be due to slow diploidizat

179 well as the advantages and disadvantages of polyploidy in health and disease.

180 ocytes, suggesting a more complex picture of polyploidy in heart regeneration.

181 Despite the role of polyploidy in multiple evolutionary processes, its impac

182 dentified a phenotype of multinucleation and polyploidy in p27(CK-) mice not present in p27(-/-) anim

183 Although the prevalence of polyploidy in plants is well documented, the molecular a

184 cently found that HPV-16 E7 oncogene induces polyploidy in response to DNA damage; however, the mecha

185 ce from fossil guard cell size suggests that polyploidy in Sequoia dates to the Eocene.

186 that the most common evolutionary pathway to polyploidy in Solanaceae occurs via direct breakdown of

187 ues, suggesting that the main consequence of polyploidy in soybean may be at the regulatory level.

188 Following polyploidy in the Glycine lineage, NB-LRR genes have bee

189 determine how each of these is influenced by polyploidy in the legume-rhizobium mutualism.

190 rent study were to investigate the origin of polyploidy in the woody bamboos and examine putative hyb

191 ether up-regulated cyclin E is an inducer of polyploidy in vivo.

192 Therefore, Ph1 stabilises polyploidy in wheat by both promoting homologue pairing

193 ed the ubiquity of whole-genome duplication (polyploidy) in angiosperms, although subsequent genome s

194 We conclude that autophagy and polyploidy increase the immunogenicity of cancer cells m

195 ion, leading to the generation of cells with polyploidy, increased numbers of duplicated centrosomes,

196 Furthermore, polyploidy induces recombination suppression, which corr

197 Polyploidy is a central phenomenon in plant evolution, a

198 Polyploidy is a common characteristic of the mammalian l

199 er-than-diploid DNA content, suggesting that polyploidy is a common precursor to aneuploidy during tu

200 Polyploidy is a key driver of ecological and evolutionar

201 Polyploidy is a pervasive evolutionary feature of all fl

202 ten associated with these processes, whether polyploidy is a prerequisite or a consequence of hypertr

203 lts of this study indicate that induction of polyploidy is a promising breeding strategy to further t

204 Polyploidy is an evolutionary innovation for many animal

205 Polyploidy is an important aspect of the evolution of fl

206 Polyploidy is an important driving force in angiosperm e

207 Polyploidy is an important feature of plant genomes, but

208 Megakaryocyte polyploidy is characterized by cytokinesis failure resul

209 Polyploidy is common and an important evolutionary facto

210 Germline polyploidy is common in plants and occurs in some animal

211 Although polyploidy is common in plants and some animals, mechani

212 Although polyploidy is common, affecting approximately 90% of hep

213 In plants, polyploidy is considered a major factor in successful do

214 Polyploidy is defined as an increase in genome DNA conte

215 In this regard, polyploidy is followed by subsequent locus loss.

216 Polyploidy is found in many plants and some animal speci

217 Polyploidy is generally not tolerated in animals, but is

218 ution of agriculturally important traits via polyploidy is lacking.

219 Polyploidy is not restricted to the heart but also occur

220 Polyploidy is observed across the tree of life, yet its

221 Polyploidy is thought to be an efficient method of incre

222 One route to polyploidy is through chromosome missegregation due to a

223 Polyploidy is ubiquitous in eukaryotic plant and fungal

224 Whole-genome duplication resulting from polyploidy is ubiquitous in the evolutionary history of

225 etic and functional diversity resulting from polyploidy is unknown.

226 Summary Despite knowledge that polyploidy is widespread and a major evolutionary force

227 Our results suggest that polyploidy, lineage divergence, and complex reticulate e

228 are several features unique to plants (e.g. polyploidy, mating system, sessile habit) that may lead

229 Polyploidy may also affect adaptation independently of b

230 Our results suggest polyploidy may serve a protective role for neurons and g

231 While the effective polyploidy mechanism does not affect population survival

232 e I use an experimental approach to test how polyploidy mediates ecological divergence in Achillea bo

233 We hypothesized that hepatocyte polyploidy might be protective against TALEN-induced los

234 Polyploidy might therefore serve as a protective mechani

235 gnals that have been associated with hepatic polyploidy, miR-122 is the first liver-specific signal i

236 al report to test several predictions of the polyploidy model of gonococcal chromosome organization.

237 tic species, despite complications including polyploidy, multisomic inheritance, self-incompatibility

238 In this Primer, we focus on why somatic polyploidy occurs and how cells become polyploid - the f

239 vation of VEGFR-3 impaired the transition to polyploidy of CD41+ cells in primary BM cultures.

240 ome, and the variable chromosome numbers and polyploidy of sugarcane cultivars.

241 Polyploidy often confers emergent properties, such as th

242 Polyploidy often leads to an increase in cell or organis

243 widespread occurrence, the direct effect of polyploidy on evolutionary success of a species is still

244 resolved questions about cause and effect of polyploidy on evolutionary success of a species.

245 The effects of polyploidy on gene expression have been studied extensiv

246 We find that the impacts of polyploidy on population genomic processes are subtle ye

247 loids and allopolyploids, but the effects of polyploidy on proteomic divergence are poorly understood

248 re direct connections between the effects of polyploidy on the genome and the responses this conditio

249 cytokinesis defects and formation of nuclear polyploidy or aneuploidy.

250 nship, as it is not driven by traits such as polyploidy or annual life history whose evolution is som

251 cient for genes with high copy number due to polyploidy or gene amplification because frameshifts in

252 genome-wide sample properties, such as tumor polyploidy or polyclonality in cancer samples.

253 Polyploidy, or whole genome duplication, has played a ma

254 Polyploidy, or whole-genome duplication often with hybri

255 The role of polyploidy, particularly allopolyploidy, in plant divers

256 l methods that cannot distinguish effects of polyploidy per se from genic differences that accumulate

257 However, it is unknown how polyploidy per se might affect plasticity in a plant's s

258 These studies demonstrate that cellular polyploidy plays important roles during normal developme

259 s, raising the hypothesis that cardiomyocyte polyploidy poses a barrier for cardiomyocyte proliferati

260 We found that polyploidy presented a major challenge when assessing co

261 s accumulate in the adult fly brain and that polyploidy protects against DNA damage-induced cell deat

262 m, lineage-specific signaling with increased polyploidy proves possible and novel with phospho-regula

263 Polyploidy provides new genetic material that facilitate

264 pectedly, chromosome fusions, aneuploidy and polyploidy rates in Mdm2 transgenic mice, but not chromo

265 tected high ploidy diversity in Allium and a polyploidy-related diversification rate shift with a pro

266 fusions and aneuploidy, but the frequency of polyploidy remained stable over time.

267 Polyploidy, resulting from the duplication of the entire

268 le an abundance of theoretical work suggests polyploidy should leave distinct population genomic sign

269 is richardii to address the processes (e.g., polyploidy, spread of repeat elements) by which the larg

270 tly inactivated in cells with extra genomes (polyploidy), suggesting that study of polyploidy can rev

271 Massive polyploidy supports the acquisition of unstable genetic

272 g cardiomyocytes were more likely to undergo polyploidy than replication.

273 te of prominence of reticulate evolution and polyploidy that affects the evolutionary history of all

274 ue to expanded wild introgressions following polyploidy that captured alleles outside of their geogra

275 ologous genomic regions from three rounds of polyploidy that contributed to the current Glycine max g

276 d frequencies of a number of processes (e.g. polyploidy) that have shaped the genomes of other vascul

277 Polyploidy (the more than doubling of a cell's genome) f

278 Polyploidy, the condition of possessing more than two co

279 To achieve polyploidy, the S. meliloti cell cycle program must be a

280 ogenomic sampling, we show the propensity of polyploidy throughout the evolutionary history of Caryop

281 pose new directions to integrate research on polyploidy toward confronting interdisciplinary grand ch

282 Aside from polyploidy, transposable elements are the major drivers

283 Polyploidy, usually whole-genome duplication, is propose

284 lihood of duplicate gene retention following polyploidy varies by functional properties (e.g. gene on

285 Polyploidy was first observed in plants more than a cent

286 Acute polyploidy was generated by knockdown of the essential r

287 Increased hepatocyte polyploidy was not associated with altered regenerative

288 In contrast, chromosome polyploidy was reduced in the presence of an activated M

289 olyploid research, of relevance here because polyploidy was suggested to be associated with increased

290 o test whether miRNAs could regulate hepatic polyploidy, we examined livers from Dicer1 liver-specifi

291 ts into the molecular basis of adaptation to polyploidy, we investigated genome-wide patterns of diff

292 e evolution of centromeric repeats following polyploidy, we studied a model diploid progenitor (Gossy

293 d breaks, chromosome fusions, aneuploidy and polyploidy were increased in older Mdm2 transgenic mice

294 Failure in this process causes polyploidy, which in turn can generate chromosomal insta

295 al attention to the meiotic recombination in polyploidy, which is a common genomic feature for many c

296 Here we show that polyploidy, which is often observed in human cancers, le

297 o the S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability

298 thesize that this is tolerated due to genome polyploidy, which we found for certain strains of both S

299 g plants have experienced repeated rounds of polyploidy (whole-genome duplication), which has in turn

300 eases the frequency and degree of hepatocyte polyploidy without permanently altering levels of ANLN.