ライフサイエンスコーパス: positive charge

1 LNA with 2'-glycylamino-LNA, contributing a positive charge.

2 ed by, but does not require, the presence of positive charge.

3 recovery only for peptides that carried net positive charge.

4 ining aqueous nanodroplets that carry excess positive charge.

5 nge on the 6'-substituent and the drug's net positive charge.

6 probably by neutralization of its side chain positive charge.

7 ransition state, with an overall decrease in positive charge.

8 ional modification that neutralizes lysine's positive charge.

9 clude a hydrophobic region followed by a net positive charge.

10 her sites in the pore to host this important positive charge.

11 n of an oxygen atom to 1 and the loss of one positive charge.

12 sitively charged EDA-derived products with a positive charge.

13 f our detection method for transmitters with positive charge.

14 ss an immense capacity to accommodate excess positive charge.

15 or near the Mg(2+) site, due to its high net positive charge.

16 specific regions within Ssb characterized by positive charges.

17 s a potential candidate for counterbalancing positive charges.

18 iched in aromatic residues and surrounded by positive charges.

19 , peptides react to contain fixed, permanent positive charges.

20 fications of intracellular proteins that add positive charges.

21 but not for a mutant with extreme clustered positive charges.

22 dual ability to stabilize both negative and positive charges.

23 actin analogues with an increasing number of positive charges.

24 de chain cyclodepsipeptide that contains two positive charges.

25 s were nanoparticulate (199nm) with a slight positive charge (21.82mV); CLG-shAnx2 was of similar siz

26 tes were long MWNT-OVA (~386nm), bearing net positive charge (5.8mV), or short MWNTs-OVA (~122nm) of

27 strongly affected by the graphene charge: a positive charge accelerates the motion, whereas a negati

28 t analysis of the reaction kinetics revealed positive charge accumulation in the transition state (rh

29 Positive charge adjacent to the native N terminus is sur

30 Moving the positive charge also restored open-channel blocker inter

31 boost PA, (a) the ability to delocalize the positive charge and (b) steric pressure/ring strain whic

32 sting of a cyclopentadienyl cation bearing a positive charge and a negatively charged BF3 unit.

33 while maintaining a proper distance between positive charge and aromatic ring (Me13) or with homolog

34 ent and magnitude of surface hydrophobicity, positive charge and negative charge in the CDRs, and asy

35 This modification leads to the loss of a positive charge and reduction in hydrogen-bonding abilit

36 lpha-helical 30-residue sequence, with a net positive charge and several aromatic amino acids, as a p

37 substitutions were used to determine if the positive charge and susceptibility to posttranslational

38 predicted by the presence of domains of high positive charge and that PRC1 components from a variety

39 Further analysis reveals that positive charge and volume of residue 436 are determinan

40 y to the PM, suggesting a role for the total positive charge and/or MA-bound RNA in navigating Gag to

41 the peroxisome, while a stretch of conserved positive charges and a central pleckstrin homology-like

42 vely charged [2Fe(H)] precursor requires the positive charges and individual structural features of t

43 is in partially oxidized form-it is bearing positive charges and its emission is quenched.

44 Our results show that positive charges and multivalency are sufficient to mimi

45 bosomal proteins by neutralizing unfavorable positive charges and thus facilitate their transports.

46 ccepting capabilities), ammonium (preserving positive charge), and methylene (preserving neither pi-a

47 oximately 320 amino acids long with dominant positive charge, and its interaction with sulfated GAG-p

48 AMPs differ in length, composition, and net positive charge, and the tested bacteria include two wil

49 When a binding event occurs, positive charges are formed in the nanosphere, leading t

50 he negative deviation observed when the four positive charges are replaced by four negative charges b

51 We found that only 3 positive charges are similarly positioned and essential

52 itutions that increased or decreased the net positive charge around the haemagglutinin receptor-bindi

53 heir lack of a ribose moiety, phosphate, and positive charge as present in m7-GMP.

54 atibility with proteins bearing considerable positive charge as well as modulation of molecular align

55 and identify symmetry-related clustering of positive charges as one mechanism by which HSPG binding

56 e charge, while Lu, Hgamma, and Sibeta carry positive charges; as the number of O-based ligands incre

57 hesized with the aim to decrease the overall positive charge associated with these molecules and incr

58 formed by Asp313 and Glu341 to stabilize the positive charge at C2.

59 egative charge at the substrate C(alpha) and positive charge at C4' of the cofactor, consistent with

60 ber of O-based ligands increases so does the positive charge at Lu, which in turns shortens the Lu...

61 Removal of the positive charge at Lys544 or a negative charge in the C-

62 Histidine carries a partial positive charge at neutral pH, and so our result suggest

63 odified activated carbon (ZrOx-AC) possesses positive charge at pH lower than 7, and FTIR analysis de

64 directed mutagenesis, we demonstrated that a positive charge at position 435 is required but not suff

65 and R75V) at this position suggest that the positive charge at position 75 in Cx32 is required for n

66 port the idea that Arg at position 295 and a positive charge at positions 141 and 363 are required fo

67 ations at R175 are active, indicating that a positive charge at R175 is not necessary.

68 abilization of intermediates that accumulate positive charge at the acetal carbon atom.

69 tion of a lysine isosteric residue bearing a positive charge at the appropriate position leads to the

70 his shows that there is a strong, developing positive charge at the benzylic position in the transiti

71 Membrane permeabilization is enhanced by a positive charge at the carboxy terminus of the peptide,

72 The compensating positive charge at the exposed surface of GTO charge dis

73 Introducing a positive charge at the Glu-68 site (the E68R mutation) i

74 were introduced per subunit to increase the positive charge at the inner surface of the capsid.

75 Introducing a positive charge at the interface (Glu(32) to Lys) also l

76 therefore, better able to support incipient positive charge at the locus of reaction.

77 Glu324, or on Asn408 to Lys to increase the positive charge at the rim of the interdomain region.

78 exon9 charge-changing mutations, providing a positive charge at the substituted amino acid residue, w

79 The positive charge at the vacuum surface that compensates t

80 The loss of a positive charge at these positions is very likely to low

81 of the highest performing variants contained positive charge at this position.

82 -aminoproline (amp), was used to specify the positive charges at the Xaa positions of (Xaa-Yaa-Gly) t

83 electively labeled at their N-termini with a positive charge-bearing group, are subjected to controll

84 two chlorophylls was found to be broken, the positive charge being preferentially located on P(D1).

85 II binding motif PXXPXRpXR, where additional positive charges between the two constant arginine resid

86 transition state that has considerably less positive charge buildup on the incoming nucleophile and

87 he smaller tip sizes for proteins with a net positive charge but not for proteins with a net negative

88 in cases of sufficient stabilization of the positive charge by appropriate substituents.

89 Redistribution of positive charges by placing three Lys residues at both t

90 engths, the former being stronger due to the positive charge centralized on the pyridyl nitrogen, N-H

91 s captured by the nanoparticles owing to its positive charge (chitosan coating).

92 ulomb energy as a result of bringing the two positive charges closer together in the folded structure

93 paration of soluble and insoluble subsets by positive charge clustering (area under the curve for a R

94 ucture-based mutational studies revealed two positive-charge clusters, near the center and apex of th

95 ty of the AAD band increases with increasing positive charge, consistent with a greater population of

96 free-OH stretch red-shift with increasingly positive charge, consistent with a Stark effect as a res

97 he structure of citrocin contains a patch of positive charge consisting of Lys-5 and Arg-17.

98 ioning of hydrophobic moieties while keeping positive charges constant.

99 A hole is a site of positive charge created when an electron is removed.

100 ly through a hydrogen bond network using net positive charges created upon oxidation of a heme iron (

101 of the two nitrogen atoms, and a state with positive charge delocalized over both nitrogen atoms.

102 yaniline frameworks, which provide large net positive charge densities, excellent structural stabilit

103 re problems for its toxicity due to the high positive charge density and non-degradability although t

104 Proteins that have the highest positive charge density at their C-terminus are overwhel

105 erformance of the FG-TENG is due to the high positive charge density of the regenerated cellulose.

106 tions in the C-terminal cluster reducing the positive-charge density completely abolished binding of

107 lenges, such as how to decrease the multiple positive charges derived from basic amino groups, which

108 d transition state in which there is partial positive charge developing on the C-O carbon atom progre

109 ids and thus may moderate the combined local positive charge, diminishing tropomyosin-actin interacti

110 ent of the negatively charged Asp(22) led to positive charge displacements over the entire pH range,

111 Thirty positive charges distributed throughout the mature domai

112 Our findings suggest that the positive charge distribution across H4c domain controls

113 g surface exhibited a dominant and extensive positive charge distribution compared with that in the s

114 4) while electrostatic repulsion and loss of positive charge due to destruction of oxonium and pyridi

115 BMV mutants with decreased positive charges encapsidated lower amounts of RNA while

116 e, coupled to the surrounding region of high positive charge, explain the remarkable ability of SNM1A

117 arges impact CRY2 homo-oligomerization, with positive charges facilitating oligomerization and negati

118 inker forms a straight alpha-helix, with the positive charges facing the lipid phosphates of the inne

119 or its recognition and binding by SRP, while positive charges fine-tune the SRP-signal sequence affin

120 embrane-active small molecules featuring two positive charges, four nonpeptidic amide groups, and var

121 Because of their positive charge, 'free' (non-chromatin associated) histo

122 The acpcPNA probe contains a single positive charge from the lysine at C-terminus and causes

123 Ultrafast transfer of positive charge from the molecular assembly to a metal o

124 ein-mediated signal transduction, removal of positive charge from this residue produced a signalling-

125 protein receptors requires the removal of a positive charge from water.

126 In addition, a string of consecutive positive charges generally had a more significant effect

127 cales of the evolution of the photogenerated positive charge (hole) and the subsequent proton transfe

128 d correlation exists among the extent of the positive charge, hydrophobicity, and amphipathicity of a

129 enotypically associated with reduced surface-positive charge, (iii) this net reduction in surface-pos

130 However, engineering an increasingly positive charge in a critical phosphorylation site, S318

131 Introducing a second positive charge in addition to that at K95 did not incre

132 charge, (iii) this net reduction in surface-positive charge in graR and vraG mutants, in turn, corre

133 induced carbonylation, and thus removal of a positive charge in Lys, abrogates binding of cyt c to ne

134 Both Caf20p and Eap1p contain stretches of positive charge in regions of predicted disorder.

135 aller tip sizes for proteins that have a net positive charge in solution, and additional high-charge-

136 ization of negative charges or addition of a positive charge in the Cx26 equivalent region reduced th

137 roA's catalytic strategy is to stabilize the positive charge in the EPSP cation.

138 proline-rich region (PRR), and a decrease in positive charge in the microtubule binding domain (MBD).

139 We further show that the threshold of positive charge in the mutant CALR C terminus influences

140 ine substitution (G347R), which introduces a positive charge in the ninth transmembrane domain (TMD)

141 nstances a radical adjacent to the incipient positive charge in the precursors led to significant enh

142 ates with SUMO1 and not SUMO2, due to a more positive charge in the SUMO1-loop.

143 of the C-S bond cleavage an increase of the positive charge in the trityl moiety and of the spin den

144 e, glutamate, and lysine demonstrated that a positive charge in this position prevents alpha-conotoxi

145 urfaces which results in a similar number of positive charges in film materials forming dipoles with

146 Mutation of a conserved patch of positive charges in FtsN(Cyto) to negative charges aboli

147 BPEI has multiple amino groups and more positive charges in PBS buffer, therefore few of the BPE

148 so reduced in BIN1 mutants where negative or positive charges in the BAR domain have been eliminated.

149 inserted into the membrane to position more positive charges in the cytoplasm, suggesting an interpl

150 Thus, additional positive charges in the phage RuvC binding site apparent

151 The positive charges in the signal sequence helped it to ove

152 utational modeling shows that the introduced positive charge interacts with PI(4,5)P2 in TRPV6.

153 sign strategy has led to the introduction of positive charges into the vicinity of the heme edge thro

154 Both functions require the lysine's positive charge; intriguingly, the positive charge of K1

155 ted that electrostatic repulsion between the positive charge introduced at position 124 and the sodiu

156 tated by the high density of extra framework positive charge introduced by the dicationic structure d

157 tion in monomers and dimers (most of the net positive charge is equally distributed among the TTF gro

158 We show that the inclusion of a positive charge is more favorable than substitutions tha

159 pose that although the exact location of the positive charge is not crucial for normal pore propertie

160 gesting that the exact location of the fixed positive charge is not crucial to support high conductan

161 According to XPS and Raman, the positive charge is proposed to transfer from MB to GONR

162 proteoliposomes, indicating a reaction where positive charge is rapidly displaced into the proteolipo

163 a modified Tat-based CPP (Tatm) with reduced positive charge is secreted efficiently, but its transdu

164 tion of the initial state, i.e., whether the positive charge is smeared over the molecule or localize

165 That the positive charge is the main effector of transition state

166 Subsequently, positive charge is transported out of the cell associate

167 izing them to contain a net fixed, permanent positive charge, is described.

168 the carnitine moiety, with its nontitratable positive charge, is left dangling at the membrane surfac

169 t the PAH is associated with only 70% of the positive charges it could hold while the AH remains most

170 t the physiological pH sphingosine has a net positive charge, its interaction with negatively charged

171 consistent with occurring between the upper positive charge layer and the negative screening layer a

172 n of the mutant (AaLS-pos) revealed that the positive charges lead to the uptake of cellular RNA duri

173 termined the relative energy of a state with positive charge localized on one of the two nitrogen ato

174 propose that a surface of H3 with an excess positive charge may be the binding site for heparin.

175 ased from 4.0 to 6.0, indicating that higher positive charges (measured trough zeta potential) in the

176 change by AdiC is strongly electrogenic with positive charge moved outward, and thus that AdiC mainly

177 we demonstrate that ion beams, due to their positive charging nature, may be used to observe and tes

178 or coordination with Mg(2+), accumulation of positive charge near N7 of guanine can stabilize the exp

179 specificity, most notably the necessity of a positive charge near the end of TMH1 in the C-terminal d

180 The high positive charge not only modulates specific HVR binding

181 polymer-amphiphile systems with significant positive charge/number of oxyethylene in their single co

182 eoretical calculations indicate that induced positive charge occurs in the Au atoms which are adjacen

183 The positive charge of Arg-436, located within the HA stretc

184 bined data indicate that the positioning and positive charge of Arg-61 synergistically contribute to

185 e Arg155, interacts with the PB and that the positive charge of Arg155 plays a key role in photoprote

186 From these results, we propose that the positive charge of arginine 193 in the SH3-like domain o

187 basic proteins by SPR, wherein the naturally positive charge of basic protein was utilized to immobil

188 ghts the importance of amount and density of positive charge of cationic surfactants and oxyethylene

189 Because of the positive charge of CPZ, the presence of negatively charg

190 lysine's positive charge; intriguingly, the positive charge of K100 can be neutralized by acetylatio

191 The positive charge of Lys53 is critical for flavin reductio

192 ion efficiency, which may correlate with the positive charge of most CPPs, has emerged as one of the

193 A reduction in the net positive charge of myelin basic protein (MBP) via deimin

194 vely high Hamaker constant combined with the positive charge of Pu(IV) colloids under typical groundw

195 al in vivo, indicating the importance of the positive charge of the arginine/lysine residue for dimer

196 The positive charge of the Cu-NPs imparted by the PEI allowe

197 Correlation between the increased positive charge of the D + 2 and T + 2 side chains and f

198 In this study, we show that the overall positive charge of the exosite is the critical feature o

199 The overall positive charge of the HBR was needed for the interactio

200 Critically, the positive charge of the lysine residues was necessary for

201 rkable correlation was found between the net positive charge of the peptides and their capacity to in

202 lation with lysine mutations (preserving the positive charge of the residue) increased the turnover r

203 of PolyQ-expanded proteins in vitro, and the positive charge of this domain was critical for this act

204 Positive charges of acetylable lysine residues in the N-

205 When positive charges of lysines were eliminated by acetic an

206 e hydrated electrons will reduce the overall positive charges of the CTA(+) covered Au NPs and decrea

207 Acetylation-mediated neutralization of the positive charges of the lysine residues in the N-termina

208 ses, that reversible titration of the excess positive charges of the reflectins, comparable with that

209 phospholipid vesicles can enhance the local positive charge on a membrane and attract RNA polynucleo

210 s, the negative charge of the NA exceeds the positive charge on capsid.

211 ticle formation and reactivity, and that the positive charge on CO increases due to the stronger adso

212 8) for elevated stability and 2) addition of positive charge on MB (RC5K) for greater DNA associabili

213 That the 6-bromo substituent increased the positive charge on selenium was confirmed by NPA-analysi

214 oth DMF and DMA that increases the extent of positive charge on the amide, leading to C-H bond deacti

215 support into acceptor molecules results in a positive charge on the Au.

216 stabilizes the canonical resonance form with positive charge on the beta-nitrogen and negative charge

217 ng pocket and the other lobes coordinated by positive charge on the cysteine-rich head region and res

218 The adsorbed polyelectrolytes create a positive charge on the fiber surface that physically att

219 figuration is nonrepulsive, despite the high positive charge on the molecules.

220 te that increased stabilization of a partial positive charge on the nitro-substituted carbon in both

221 hat intramolecular hydrogen bonding and high positive charge on the nitronyl carbon could facilitate

222 light scattering established the presence of positive charge on the prepared nanocomposite.

223 d a sweeter mutant Y65R, containing an extra positive charge on the protein surface, in conditions mi

224 ion (to maximize the contiguous patch of the positive charge on the RBD surface), resulting in a nota

225 hifts suggest that the delocalization of the positive charge on the side arm over the three nitrogens

226 upport a model in which the local effects of positive charge on the translocation kinetics dominate o

227 The positive charge on two of these lysines, Lys(49) and Lys

228 ently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities we

229 hanging the surface friction by immobilizing positive charges on the constriction's walls primarily a

230 This liberates positive charges on the histone tail and allows for tigh

231 Owing to multiple positive charges on the inner rim of helicoid, double-st

232 Positive charges on the PCL fibrous substrate were estab

233 he effects of the number and distribution of positive charges on the transport time and transport eff

234 of this complex pointed to delocalization of positive charge onto both the beta-silyl groups and the

235 greater ability of FHCs 3 and 4 to stabilize positive charges opposed to Cp 2 favors a stepwise mecha

236 The ability of DNA to transport positive charges, or holes, over long distances is well-

237 mately 24% of the unit-cell volume as highly positive-charged organic templates were manipulated to c

238 n of helical segments into the membrane, and positive charges orient the protein with respect to the

239 r ability in many cases of spreading out the positive charge over several atoms.

240 The high surface area with a positive charge over the neutral pH range (pH 5-8) of Ol

241 amounts of RNA while mutants with increased positive charges packaged additional RNAs up to approxim

242 ospholipids and add an excess of up to three positive charges per phosphate group.

243 ding interface is highly electrostatic, with positive charge present on both C2 epitopes and compleme

244 is preoxidized, caused by the oxygen-induced positive charge produced on the perimeter Au atoms.

245 In vivo, positive charge promoted liver uptake.

246 uadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted

247 This suggests that the surface exposure of positive charges rather than a certain structural fold i

248 Abolishing either positive charge restored surface expression.

249 his, coupled with the presence of C-terminal positive charges, results in abortive insertion of this

250 ntaining predicted disordered segments, with positive charge runs, are enriched for nucleic acid bind

251 and Fe(III) tetraphenylporphyrins with their positive charges seemed likely to bind up to two axial C

252 Analogues with five positive charges show the lowest activity.

253 layer, creating a penalty for compounds with positive charge spread over a larger compound surface ar

254 and convert the polymer from a neutral to a positive-charged state, hence triggering the negative-ch

255 ructures of the CiOi(SiI) cluster result for positive charge states in dramatically distinct electron

256 ts, high-exposed surface coverage sites, and positive charge streams in saline.

257 r character of 1 that derives from its three positive charges substantially increases the intrinsic p

258 a typical MBL-beta-CASP domain, a region of positive charge surrounds the active site of SNM1A, whic

259 )-sensor Synaptotagmin-1 (Syt1), by adding a positive charge (Syt1(D232N)) or increasing its hydropho

260 osttranslational modification with loss of a positive charge that can influence protein-protein inter

261 ere we show that jumping droplets gain a net positive charge that causes them to repel each other mid

262 arization of the core electrons by the added positive charge that impacted the intraparticle charge d

263 nding site is located near a local pocket of positive charge that is complementary to the negatively

264 its hydration sphere and takes on a residual positive charge that promotes its binding to endogenous

265 phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA th

266 Contrastingly, increasing positive charge through arginine leads to enhanced conde

267 es hydride shift pathways to translocate the positive charge to a remote position and enables ring fo

268 Gboxin relies on its positive charge to associate with mitochondrial oxidativ

269 en binding site, allowing for an increase in positive charge to enhance the interaction with the nega

270 xclusive use of arginine over lysine for the positive charge to neutralize DNA.

271 gnal enhancing tag that imparted a permanent positive charge to the vitamin and reduced the limit of

272 rearrangements resulting in the exposure of positive charges to bulk solvent rather than to lipid ph

273 The maximum number of positive charges to maintain the activity are three to f

274 Fixing positive charges to the protein sequence reduces the ava

275 mphipathic polypeptides with substantial net positive charges to translocate across lipid membranes i

276 alization and the presence of complementary (positive) charges to ATP enhance reaction rates, though

277 t these materials do not obey a conventional positive charge-transfer picture, but instead exhibit a

278 ium ether formation, and the resulting fixed positive charge triggers a characteristic fragmentation,

279 f the R262 sidechain in CaiT indicates how a positive charge triggers the change between outward-open

280 rings led to an increase in the guest total positive charge up to 4+ and simultaneously generated tw

281 oated Ad complex significantly increases net positive charge upon exposure to hypoxic tumor microenvi

282 CIDs transporting positive charge upward (a) occurred at heights ranging f

283 gative charge upward and 8 CIDs transporting positive charge upward were analyzed.

284 between the radical center and the incipient positive charge was examined.

285 Positive charge was introduced via cationization that ad

286 an M412K point mutation in TMC1 that adds a positive charge, we found that Ca(2+) permeability and c

287 ed state, primarily changing from +13 to +17 positive charges, whereas beta-casein had charge states

288 f symmetry, presumably producing a region of positive charge which can interact with the negatively c

289 rocarbon groups at these sites bear a slight positive charge, which enhances anion binding without di

290 Inner-shell photoionization creates positive charge, which is initially localized on the iod

291 reveals the presence of a cluster of exposed positive charges, which potentially explains the affinit

292 mechanism for unfolding and a novel role for positive charges, which we propose chaperone negative ch

293 has been reported that nanoparticles with a positive charge will bind more efficiently to negatively

294 se peptide or protein ions carrying multiple positive charges with either free low-energy (~1 eV) ele

295 effect to the Coulombic interaction of these positive charges with the negative charge borne by the i

296 ne, and that sequential reduction of the net positive charge within the first EF-hand domain of PLCze

297 function is EB1-independent but requires net positive charges within Ctail which essentially contribu

298 We also find that accumulation of positive charges within the auxiliary motif can diminish

299 ing that the membrane interaction depends on positive charges within the linker.

300 Neutralization of the positive charges within the sequence (121)KRWRK(125), wh