ライフサイエンスコーパス: positive selection

1 e rapid evolution of protein diversity under positive selection.

2 ing data can influence the quantification of positive selection.

3 genome with frequencies of up to 80% without positive selection.

4 ssfully annotated 123 GBS loci (10.5%) under positive selection.

5 dulating B cell receptor signal strength and positive selection.

6 apoptotic DP thymocytes that fail to undergo positive selection.

7 humans and an outgroup species were fixed by positive selection.

8 d amino acid sites that experienced episodic positive selection.

9 revealing abundant signatures of convergent positive selection.

10 quent variants exhibiting evidence of strong positive selection.

11 tiviral proteins by leveraging signatures of positive selection.

12 seriformes and showed that they evolve under positive selection.

13 instead displays characteristics of impaired positive selection.

14 ergoing rapid convergent evolution driven by positive selection.

15 at inherently mutable genomic sites under no positive selection.

16 ne signal pathway through gene expansion and positive selection.

17 are biased towards the CD8 lineage prior to positive selection.

18 treatment and shows evidence of being under positive selection.

19 development, whereas weak TCR signals induce positive selection.

20 identify genomic regions that have undergone positive selection.

21 roevolution standpoint, these are subject to positive selection.

22 ne expression is rapidly extinguished during positive selection.

23 s, whereas TRC miRNAs appear to evolve under positive selection.

24 uced in DKO mice, implying defects in thymic-positive selection.

25 ecifics, which is indicative of a paucity of positive selection.

26 dicating the basal translation rate is under positive selection.

27 te of specific genes that are actively under positive selection.

28 ired to transmit weak TCR signals leading to positive selection.

29 eadenylation of mRNA poly(A) tails, enabling positive selection.

30 tly rediscovered D. clarki shows evidence of positive selection.

31 tatistics, and 8 displayed robust signals of positive selection.

32 Drosophila species, and evolves under strong positive selection.

33 all approaches showed a conclusive signal of positive selection.

34 ion up-regulates Dab2ip at an early stage of positive selection.

35 extra copy of fatty acid desaturase is under positive selection.

36 plexity does not seem to be driven by strong positive selection.

37 present driverMAPS (Model-based Analysis of Positive Selection), a model-based approach to driver ge

38 ny and also performed a holistic analysis of positive selection acting in bat genomes.

39 We present a model whereby 'selfish' positive selection acting on a regulatory variant drives

40 It is feasible to assay positive selection acting on RNA secondary structures on

41 ected finding, along with our discovery that positive selection acts on structural clusters, opens pr

42 Most methods designed to detect positive selection along sequenced genomes, however, use

43 African wild dog-specific signals of positive selection also uncovered a putative mechanism o

44 We then search for signals of positive selection among these residue communities to id

45 observed in cancer samples, which are under positive selection and are highly enriched in many healt

46 in tumors, suggesting an ongoing process of positive selection and clonal expansion akin to what occ

47 BEC3 (A3) cytidine deaminases, has undergone positive selection and expansion via segmental gene dupl

48 se during development, whereas the amount of positive selection and expression of new genes increase.

49 We provide evidence for a history of positive selection and gene-content enrichments regardin

50 bserved patterns, but scenarios that involve positive selection and genetic incompatibilities are pla

51 rchaeal species, suggesting they result from positive selection and have a functional role.

52 chromosome 11) and presented a signature of positive selection and Iberian introgression in the HbS

53 py-number polymorphic duplications are under positive selection and include three to eight copies of

54 sed in double-positive thymocytes undergoing positive selection and is sustained in immature single-p

55 T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into sing

56 c variants that harbour signatures of recent positive selection and may facilitate physiological adap

57 uence of S that also displays a signature of positive selection and may have implications for tissue

58 conclusions about the relative importance of positive selection and neutral drift in clonal evolution

59 among species or strains, we found that both positive selection and population size play significant

60 elopment gene INNER NO OUTER (INO) was under positive selection and potentially contributed to the de

61 ion and further evaluated in the contexts of positive selection and protein structure.

62 4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development.

63 r inducing T cell lineage commitment, T cell positive selection and the establishment of self-toleran

64 iveri and observed that more genes underwent positive selection and there were more diverged disease

65 election on Secondary Structure) to identify positive selection and thus adaptive evolution.

66 ently expressed in iNKT cells upon exit from positive selection and was required for their proper dev

67 on in the thymus occurs through negative and positive selection, and both processes are controlled by

68 rry signatures of selective sweeps driven by positive selection, and discovered that they often displ

69 We identify multiple regions under strong positive selection, and multi-allelic traits including h

70 CTVT displays little evidence of ongoing positive selection, and negative selection is detectable

71 curring during thymopoiesis: beta-selection, positive selection, and negative selection.

72 How negative selection, positive selection, and population size contribute to th

73 tion with divergence of one paralog and weak positive selection appear to underlie hidden orthology i

74 lowest ratios among the 21 species studied, positive selection appears to have contributed significa

75 , detailed mechanisms underlying this thymic positive selection are not clear.

76 ound gibbon-specific signatures of purifying/positive selection at 27 LAVA insertions.

77 Further, we observed signatures of positive selection at genes involved in muscle developme

78 conservation of MIM, has been combined with positive selection at key sites.

79 We observe positive selection at sites clustered around T592, a res

80 pulations, and we found strong signatures of positive selection at the locus.

81 This method explicitly models positive selection at the single-base level, as well as

82 ifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction

83 abling thymocytes to reach the threshold for positive selection, avoiding death by neglect.

84 size, evolutionary rate heterogeneities and positive selection between homoeologs within and among l

85 ung novel genes are not preferentially under positive selection but older novel genes more often over

86 product of various mutational processes and positive selection, but might also be shaped by negative

87 ptor (TCR) signaling in the thymus initiates positive selection, but the CD8(+)-lineage fate is thoug

88 text of a diverse population of B cells, and positive selection by endogenous Ags shapes the mature B

89 Thus, THEMIS facilitates thymocyte positive selection by enhancing the T cell antigen recep

90 We seek evidence of recent positive selection by identifying loci with unusually st

91 hus, this study proves that signaling during positive selection by lineage-specifying cytokines is re

92 circulating trophoblast (SCT) testing using positive selection by magnetic-activated cell sorting an

93 CHMP5 enabled positive selection by promoting post-selection thymocyte

94 ocyte survival during two-distinct stages of positive selection by suppressing expression levels of p

95 ate null model, against which the effects of positive selection can be assessed.

96 In sub-genotypes B5 and C4, positive selection can be detected at two surface sites

97 portant regions of proteins, indicating that positive selection can contravene the well-known princip

98 However, following positive selection, CD31 expression differs dramatically

99 Some mutations are under positive selection, conferring a competitive advantage o

100 s sympatric with D. setosum and D. savignyi, positive selection could arise from avoidance of maladap

101 ce and functional diversity, suggesting that positive selection counteracted the effect of drift.

102 yield coherent signals for both negative and positive selection, demonstrating the functionality of t

103 Resistant cancer cells thus arise from a positive selection driven by BCL-XL modulation of RAS-in

104 p in the Faroese population, suggesting that positive selection drove the fixation of the variant aft

105 ns, raising the possibility that it is under positive selection due to malaria.

106 ide (LOS) of Neisseria gonorrhoeae undergoes positive selection during human infection.

107 demonstrate a very strong strand bias due to positive selection during infection.

108 in the promoter of ENO had been targeted by positive selection during the domestication process, set

109 ta from influenza A infection, suggests that positive selection during within-host infection is prima

110 ions with tree biomass, suggesting that both positive selection effects and complementarity occur.

111 these 'lineage-specifying cytokines' during positive selection eliminated Runx3d expression and comp

112 lf pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation o

113 ositive selection of the overall repertoire, positive selection favored shorter shared sequences that

114 ions of minor variants confirmed no apparent positive selection following sustained exposure to UV-4B

115 lict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replica

116 s of birds to estimate parameters related to positive selection for 11,000 genes conserved across bir

117 ptive evolution is at least partly driven by positive selection for advantageous mutations that compe

118 ncestral primates were subjected to enhanced positive selection for bright-light vision and relativel

119 he ancestral amniotes, which featured strong positive selection for bright-light vision.

120 esults suggest that only under conditions of positive selection for cells with extra centrioles, cont

121 stor of the extant Mammalia was dominated by positive selection for dim-light vision, supporting the

122 d food, the sex-sorter line establishes 100% positive selection for female progeny, while the food su

123 evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to

124 rated in the recipient genome, likely due to positive selection for genes encoding proteins that adde

125 We detect signals of positive selection for genes involved in peroxidase and

126 ile sites from regions showing signatures of positive selection for homozygous deletions and identify

127 in this genetic region, with indications of positive selection for its variants, we decided to compa

128 onships among factors such as tumor subtype, positive selection for mutations, and gross tumor charac

129 Our results implicate positive selection for promiscuous TCRbeta sequences tha

130 conserved beyond Drosophila, although under positive selection for rapid evolution, and that at leas

131 Our data collectively implicate preferential positive selection for shared human CDR3betas that are h

132 isolates of L. pneumophila have a potential positive selection for the ER-retention KNKYAP motif.

133 current amplification could be solely due to positive selection for the tumor-promoting effects of am

134 Using a structure-function approach and positive selection for transgenic C. elegans, we explore

135 Using a novel, positive selection, functional genomic strategy, DEADPOO

136 The IgG3-H435 allele may be under positive selection, given its relatively high frequency

137 ssed from indicine into taurine cattle under positive selection, harbouring genes with functions rela

138 Positive selection has, however, been under-studied in A

139 of nonhomologous end joining and markers for positive selection, has stalled the adaptation of CRISPR

140 etions and buffy coat cells lacked extensive positive selection; however, characteristics of the muta

141 is of gene family dynamics and signatures of positive selection identified genes involved in the spec

142 To detect and quantify signatures of positive selection, ImaGene implements a convolutional n

143 ical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signaling down

144 mpendium of genes that potentially underwent positive selection in >1 of these six species consisted

145 We found widespread positive selection in 17 genes.

146 combinatorial mutagenesis of positions under positive selection in a host antiviral protein could enh

147 eas alleles within supertypes are subject to positive selection in a Red Queen arms race.

148 related to genetic signatures ascribable to positive selection in Arctic or Antarctic mammalian spec

149 Further, we provide evidence for positive selection in bat Mx1 genes that might explain s

150 can explicitly model co-existing neutral and positive selection in cancer.

151 In a previous genome-wide scan for positive selection in contemporary humans, we identified

152 fied many cerQTLs that have undergone recent positive selection in different human populations, and s

153 akes (SWS1, LWS, and RH1) have evolved under positive selection in elapids, and in sea snakes they ha

154 e contributed to the previously demonstrated positive selection in Europe for the enhancer variant re

155 ntemporary humans, we identified a signal of positive selection in European and Asians at the genetic

156 Positive selection in Europeans at the 2q21.3 locus harb

157 Consistent patterns of positive selection in functionally similar genes can sug

158 We found signatures of positive selection in genes involved in chemoreception,

159 rlapping reading frames, which is subject to positive selection in genotypes 3 and 4.

160 mino acid substitutions occur at sites under positive selection in high-altitude catfishes, located a

161 ood, we found evidence of similarly enhanced positive selection in human carriers of the PTPN22 C1858

162 ed in 110 candidates that appear to be under positive selection in human.

163 ancer activity and colocalizes with peaks of positive selection in humans.

164 in 17 and Toll-like receptor pathways, under positive selection in IBD.

165 which have been claimed to harbor signals of positive selection in Inuit populations due to adaptatio

166 ion for wound healing was also evident, with positive selection in key genes involved in the wound-he

167 The detection of human-specific positive selection in lncRNAs associated with cognitive

168 significantly associated with signatures of positive selection in Melanesians and provide evidence f

169 warfism in domesticated animals is linked to positive selection in minor spliceosome components.

170 omplicating the identification of targets of positive selection in modern human populations is their

171 The importance of positive selection in molecular evolution is debated.

172 over, we show that the E1297G locus is under positive selection in non-African populations, and that

173 actors characterizing this cluster and under positive selection in other Mtb lineages.

174 hose of related species, we find evidence of positive selection in pathways related to energy metabol

175 entify genomic regions showing signatures of positive selection in present-day Zoroastrians that migh

176 CCM distribution across the green algae and positive selection in RbcS was estimated.

177 Using codon-based likelihood models, we find positive selection in SAMHD1 within each mammal lineage

178 sruptive epidermal mutations that manifested positive selection in SCCIS.

179 arative genomic analyses found signatures of positive selection in several genes, including those inv

180 organisms, most notably a consistent role of positive selection in shaping the molecular evolution of

181 2)max) is a critical performance trait under positive selection in some high-altitude taxa, and sever

182 osomiasis susceptibility, resulting in their positive selection in sub-Saharan Africa.

183 ed tissue expression preceded major bouts of positive selection in the African ape lineage, suggestiv

184 entified local structures that have signs of positive selection in the human lineage.

185 Thus, during positive selection in the spleen, BCR signaling causes i

186 Immature T cells undergo a process of positive selection in the thymus when their new T cell r

187 copy orthologs and identified 46 genes under positive selection in the tree swallow lineage, includin

188 We are the first to detect positive selection in this overlap region.

189 muz) to investigate the modes and targets of positive selection in this part of the world.

190 Twelve of them showed traces of positive selection in three species.

191 tation and are therefore credible targets of positive selection in tumors.

192 In three genera it evolves under positive selection, in four under mostly purifying selec

193 rous mutant clones with multiple genes under positive selection, including Notch1, Notch2 and Trp53,

194 admixture selection at traits evolving under positive selection, including skin color, lactase persis

195 Enhancers with indels show evidence of positive selection, increased target gene expression, an

196 one of them) and have been spreading through positive selection, indicated by their high local freque

197 chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors

198 p-regulation of Bbc3 during a later stage of positive selection, inducing thymocyte apoptosis.

199 f ontogeny, underwent alphabeta TCR-mediated positive selection into CD4+ or CD8+ thymocytes, and con

200 For example, MHC restriction via positive selection is a unique property of epithelial ce

201 n growth under heat stress, and we find that positive selection is detectable in several members of t

202 ortion of genes showing signatures of recent positive selection is higher in small-scale (tandem and

203 tational method for identifying ncRNAs under positive selection is needed.

204 of evidence to show that the signal of FADS-positive selection is not restricted to the Arctic but i

205 e-TCR mediated selection, its role in thymic positive selection is unclear.

206 One locus of positive selection is unusual in that it encodes two dis

207 ive selection and above-normal expression of positive selection markers.

208 s demonstrate that NOD1 and NOD2 promote the positive selection/maturation of CD8 single-positive thy

209 carcinogenic potential and/or that are under positive selection may have important implications for v

210 Thus, persistent positive selection may have involved the adaptation of S

211 mino acid substitutions inferred to be under positive selection may modulate coupling efficiency and

212 acco organelle DNA polymerases using a novel positive selection method involving replication of the p

213 tocol to retrieve ultrapure single CTCs, the positive selection module is compatible for downstream s

214 The positive selection module of PIC&RUN identifies CTCs bas

215 The positive selection nature of APTi represents a fundament

216 Consistent with extensive balancing and positive selection, NLRs are encoded by one of the most

217 We show that positive selection, not drift, is the major force shapin

218 sity in different biogeographical scenarios: positive selection occurs broadly while introgression ac

219 cantly to d (N)/d (S) We found the view that positive selection occurs much more frequently in influe

220 ze subsequent laborious hybridoma efforts by positive selection of Ag-specific, Ab-secreting cells pr

221 28b transgene in murine B cells restored the positive selection of autoreactive B-1 B cells by self-a

222 ceptor programs, leading to broadly enhanced positive selection of B cells at two discrete checkpoint

223 , as in T cells, N-glycan branching promotes positive selection of B cells by augmenting pre-BCR/BCR

224 Thus, positive selection of B cells can take place in steady-s

225 ated family member 2 (Themis2) increased the positive selection of B1 cells and germinal center B cel

226 ered a common condition characterized by the positive selection of certain somatic mutations in haema

227 nd reproducible in vitro differentiation and positive selection of conventional human T cells from al

228 r to IL-7, IL-21 seems to be involved in the positive selection of double-positive lymphocytes and ap

229 lls, through B cell receptor (BCR)-dependent positive selection of fetally derived precursors.

230 mutations, indicating evolutionarily recent positive selection of FMF-associated mutations.

231 The positive selection of immature CD4(+)CD8(+) double-posit

232 These results are consistent with a positive selection of low-CR1-expressing alleles in viva

233 row production of granulocyte precursors and positive selection of mutants due to chronic G-CSF thera

234 We hypothesize that positive selection of novel phosphorylation sites in the

235 We observed positive selection of pre-LT variants and the appearance

236 rovide mechanistic insights for evolutionary positive selection of rs10166942[T] allele in adaptation

237 AChR-MG was further characterized by reduced positive selection of somatic mutations in the VH CDR an

238 We investigate the hypothesis for positive selection of spike D614G in the United Kingdom

239 faster germination may be implicated in the positive selection of the ancient PAPhy gene duplication

240 obicity analysis implicated self-peptides in positive selection of the overall repertoire, positive s

241 elopment, N-glycan branching is required for positive selection of thymocytes, inhibiting both death

242 o acids in the CDRH3s in both species showed positive selection of tyrosines and glycines, and negati

243 stance to 5-fluoroorotic acid, which enables positive selection of UMPS-knockout cells.

244 ection and the general absence of widespread positive selection of within-host variants.

245 esis that, relative to protein-coding genes, positive selection on cis-regulatory elements is likely

246 the ongoing speciation process is linked to positive selection on core genes in the newly forming sp

247 We identified evidence of positive selection on full length gamma-c clade genes.

248 Our genome-wide screens revealed positive selection on hearing-related genes in the ances

249 Finally, we observe no footprint of positive selection on P-element insertions in piRNA clus

250 anges in gene expression can be explained by positive selection on single mutations that either creat

251 le short-term LGT integration is mediated by positive selection on some of the transferred genes, phy

252 has revealed widespread footprints of recent positive selection on standing genetic variation.

253 in amino acid properties provide evidence of positive selection on the ND2 and ND5 genes against a ba

254 n sites, as well as codons that evolve under positive selection on the viral surface proteins, and di

255 reover, we detected widespread signatures of positive selection on young male-biased genes.

256 n can only be performed either for affinity (positive selection) or for specificity (negative selecti

257 he rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is abo

258 Given that Gm13030 shows no signs of positive selection, our findings support the hypothesis

259 Unlike species evolution, positive selection outweighs negative selection during c

260 eased proliferation of LCLs and demonstrated positive selection over time.

261 tra-pure single live CTCs using Negative and positive selection (PIC&RUN).

262 cific, yet their bindins show no evidence of positive selection, possibly because the two species spa

263 alyses found only a few strong signatures of positive selection, primarily in replication- and transc

264 , and HLA-DRB5, show independent evidence of positive selection prior to admixture, based on extended

265 by coopting negative-selection programs and positive-selection programs, respectively.

266 y approximately 4 coding substitutions under positive selection, ranging from <1/tumor in thyroid and

267 and the proportion of outliers was <=5%, the positive selection rate of Ensemble was similar to that

268 Furthermore, a CRISPR-UMI positive-selection screen uncovered new roadblocks in re

269 ression must be extinguished by TCR-mediated positive selection signals to allow migration of TCR-sig

270 Recurrent CNVs reveal genes under positive selection, sites of genome instability, and rep

271 evolution is largely driven by diversifying positive selection so that relative fitness of different

272 t the E1297 variant shows subtle evidence of positive selection specifically within the Peruvian popu

273 compensatory substitutions without invoking positive selection, speculative mechanisms, or implausib

274 Thus, at the GC positive selection stage, MYC-MIZ1 complexes are require

275 e sites on the VP1 protein, also detected in positive selection studies performed prior to 2008.

276 ptxD/Phi has proven to be a very efficient, positive selection system for the generation of transgen

277 ing selection and (ii) undergo less frequent positive selection than other genes.

278 human populations and exhibits signatures of positive selection that are consistent with this gene pl

279 Here we estimate the intensity of positive selection that drives mutations to high frequen

280 f sequence evolution may provide evidence of positive selection that drove sexual specialization.

281 ion can drive adaptations of immune genes by positive selection that erodes genetic variation (Red Qu

282 African ape lineage, we detect signatures of positive selection that occurred after a transition to m

283 ogenetic relationship, revealing patterns of positive selection that suggest a coevolution with viral

284 tive approaches revealed that RTP4 undergoes positive selection, that a flavivirus can mutate to esca

285 om the depleted sample displayed evidence of positive selection, the lambda genes in sIgkappa(+) cell

286 netic mosaicism provides evidence for strong positive selection, the sequences of PorB serotypes comm

287 ll effector differentiation independently of positive selection through the modulation of cytokine re

288 biology, yet linking detected signatures of positive selection to molecular mechanisms remains chall

289 We show that positive selection triggered by T cell help activates th

290 As expected, positive selection was a significant force shaping the h

291 Signatures of positive selection were also investigated.

292 ed gene modules and genes showing signals of positive selection were associated with GRN and body sha

293 Signals of positive selection were detected in Ethiopian population

294 onse differences, however, the signatures of positive selection were disproportionately observed in t

295 regulated in thymocytes before initiation of positive selection, where in turn, it inhibits up-regula

296 s is often reflected in a genetic signature, positive selection, which is conspicuously missing in SE

297 TECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose cent

298 In addition, reQTLs are enriched for recent positive selection with an evolutionary trend towards en

299 enetic insights into the interplay of strong positive selection with other evolutionary processes.

300 e other species, we find strong evidence for positive selection within promoters of this species.