ライフサイエンスコーパス: possess @1 activity

1 UNG, and mismatch repair (MMR) proteins and possess UNG activity.

2 possibility, recombinant lipin-2 and lipin-3 possess PAP1 activity.

3 the synthetic derivative oxo-aglaiastatin to possess such activity.

4 was identified as the enzyme most likely to possess this activity.

5 y lipoprotein, and reconstituted HDL did not possess this activity.

6 rated in vitro that proteins do not uniquely possess this activity.

7 ANT has been genetically inactivated, still possess mtPTP activity.

8 7 amino acid residues that has been shown to possess porin activity.

9 st fractions derived from these preparations possess TGase activity.

10 results showed the NPs supported on PDA also possessed HER activity.

11 of an endogenous retrovirus, HERV-K18, that possesses SAg activity.

12 gkA mutant, and only the essential yerQ gene possessed DagK activity.

13 olecular complex by showing that the complex possesses HDAC activity.

14 nt SPG20 present in Troyer syndrome does not possess these activities.

15 ied the cDNA encoding a novel 40 kDa protein possessing DcpS activity.

16 single-stranded DNA binding, and it does not possess helicase activity.

17 gonaute proteins the RNase H-like domain may possess nuclease activity.

18 also present conclusive evidence that GRP94 possesses ATPase activity.

19 okinesis in yeast and vesicle transport, and possesses GTPase activity.

20 ication of SMARCA1 and RAD54L, both of which possess annealing activity.

21 Farnesyltransferase inhibitors (FTIs) possess antitumor activity.

22 44 and CD56, and do not produce IFN-gamma or possess cytolytic activity.

23 lized TIR domain is a protein motif that can possess enzymatic activity.

24 nt proportions, indicating that both enzymes possess epimerase activity.

25 ative-sense RNA virus that has been shown to possess oncolytic activity.

26 We report that mammalian catalase also possesses oxidase activity.

27 lial progenitor cells, have been reported to possess angiogenic activity.

28 seful as tools to dissect recombination, and possess antibiotic activity.

29 h suppressant and more recently was shown to possess anticancer activity.

30 been reported that modified forms of pectin possess anticancer activity.

31 fonylureas are inhibitors of this enzyme and possess antifungal activity.

32 as discovered that some deubiquitinases also possess derubylase activity.

33 nd utilize DNA damage response pathways that possess proviral activities.

34 de chain and 25-hydroxyl group were found to possess comedolytic activity.

35 tic domain, and Flag-tagged HDAC9 and HDAC9a possess deacetylase activity.

36 among the other human RecQ family members to possess exonuclease activity.

37 f its lack of enzymatic activity, human OASL possesses antiviral activity.

38 Many of these are known to possess antibiotic activities.

39 30 degrees C suggesting that Hsp31 does not possess disaggregase activity.

40 the vascular endothelial growth factor which possess neurotrophic activity.

41 that compound 18 was orally bioavailable and possessed anticancer activity.

42 produces prostaglandins, and the enzyme also possesses peroxidase activity.

43 vity evolved from an ancestral parent enzyme possessing lactonase activity.

44 ls, and truncated versions of these peptides possess antimicrobial activity.

45 that adult sources of endothelial cells also possess hematopoietic activity.

46 f the heparan sulfate proteoglycan perlecan, possesses angiostatic activity.

47 cells transiently transformed with HA-PAPP2C possesses phosphatase activity.

48 both pathways through common targets and by possessing multiple activities.

49 eat of thrombospondin-1 (TSP-1), is known to possess antiangiogenic activity.

50 f structurally related natural products that possess antiangiogenic activity.

51 ion to its antianginal actions, the drug may possess antiarrhythmic activity.

52 se, demonstrating for the first time that it possesses intraspecies activity.

53 evaluation of panaxytriol indicates that it possesses neurotrophic activity.

54 in-1 (SIRT1) is an NAD-dependent deacetylase possessing antiaging activities.

55 , including artemisinin and its derivatives, possess antileishmanial activity.

56 ways in the Escherichia coli periplasm, also possess denitrosylating activity.

57 indicating that, like tyrosinase, NspF also possesses monophenolase activity.

58 es, have been shown in laboratory studies to possess anticarcinogenic activity.

59 s of antidiabetic agents, have been shown to possess antiinflammatory activity.

60 molecules targeted to this RNA structure may possess antiretroviral activities.

61 s that contain an ovarian tumor (OTU) domain possess deubiquitinating activity.

62 as become apparent that certain cannabinoids possess immunomodulatory activity.

63 in (ES) is a fragment of collagen XVIII that possesses antiangiogenic activity.

64 s discrepancy suggests that the H37Rv strain possesses compensatory activities.

65 ation that often includes multiple enhancers possessing overlapping activities.

66 ANG is the only human angiogenic factor that possesses ribonucleolytic activity.

67 main, whereas GABPbeta does not bind DNA but possesses transactivation activity.

68 tural cell wall polymers of many fungi which possess immunomodulatory activities.

69 were incorporated into various biomaterials possessing antibacterial activities.

70 raries of compounds previously identified as possessing antimicrobial activities.

71 ransferases in budding yeast, Gcn5 and Esa1, possess crotonyltransferase activity.

72 n pairs of primary and shadow enhancers that possess overlapping activities [1-5].

73 tatory synaptic input (74% compared to 17%), possess spontaneous activity (46% compared to 3%), and g

74 Neither LC/A3 nor LC/A4 possessed autocatalytic activity, a property of LC/A1 an

75 into versions that accumulate in E. coli and possess antibacterial activity against high-priority Gra

76 tylpantothenamide and N-heptylpantothenamide possess antibiotic activity against Escherichia coli.

77 These new HDACi possess anticancer activities against various cancer cel

78 Prenylated flavonoids and isoflavonoids possess antimicrobial activity against fungal pathogens

79 -alkyl-lysines have been earlier reported to possess antimicrobial activity against pathogenic bacter

80 idase inhibitors omapatrilat and sampatrilat possess dual activity against these enzymes by blocking

81 These compounds possess excellent activity against FQR methicillin-resis

82 ss of benzophenone containing compounds that possess good activity against MRSA, VISA, VRSA, and VRE

83 by two different approaches and was shown to possess hydrolytic activity against fluorogenic dipeptid

84 lysis revealed that the pyrimidoquinazolines possess inhibitory activity against both topoisomerase I

85 ction of multiple extracellular factors that possess lytic activity against prokaryotic and eukaryoti

86 The new analogues possess micromolar activities against Trypanosoma brucei

87 The resultant lead compounds possess potent activity against a multidrug resistant st

88 ons have resulted in MCoTI-II analogues that possess potent activity against two therapeutically sign

89 These compounds possess potent activity against VRE, inhibiting growth o

90 Potent DOT1L inhibitors possess selective activity against this type of leukemia

91 ed that the acetic acid-solubilized chitosan possessed antibacterial activities against 3 single-spec

92 Each of the BTDs possessed antimicrobial activity against bacterial and f

93 om a MARV-naive donor recognized MARV GP and possessed neutralizing activity against the virus.

94 anionic bacteriocin called subtilosin A that possesses antibacterial activity against certain gram-po

95 ely potent nucleoside inhibitor of MbtA that possesses excellent activity against whole-cell Mtb but

96 Although the hybrid possesses potent activity against MDR, P. aeruginosa iso

97 anti-rat TfR IgG3 or a nonspecific IgG3-Av, possesses proapoptotic activities against Y3-Ag1.2.3 and

98 In an effort to identify other MAEs possessing inhibitory activity against HIV-1 Tat, we tes

99 articular mutation, with some of the mutants possessing more activity against hippuryl-His-leucine th

100 These compounds possess antibacterial activity and are produced by fruit

101 time, that shrimp hemocyte histone proteins possess antimicrobial activity and represent a defense m

102 t cellular DNA damage response pathways that possess antiviral activities and utilize DNA damage resp

103 Many of these metabolites possess biological activities and have the potential to

104 C. jejuni OMVs possess cytotoxic activity and induce a host immune resp

105 ilarity to glycoside hydrolases was shown to possess endoxylanase activity and subsequently assigned

106 how for the first time that both SK1 and SK2 possess enzymatic activities and undergo autophosphoryla

107 We show that Cdc10 and Cdc12 possess GTPase activity and appropriate mutations in con

108 However, a proportion possess multiple activities and are considered moonlight

109 ress-inducing agents, metal complexes, which possess redox activity and modular structures, have aris

110 We demonstrated that purified HopPtoD2 possessed PTP activity and this activity required a cons

111 of this study were to determine if EA and EB possessed similar activity and if these actions were IGF

112 d by the plant pathogen Pseudomonas syringae possesses acetyltransferase activity and acetylates plan

113 Particularly, EGCG possesses antiviral activity and impairs cellular lipid

114 ISIS 13312 possesses antiviral activity and pharmacokinetic propert

115 These data indicate that DHX9 possesses antiviral activity and that SM may suppress th

116 tors, US28, is expressed in glioblastoma and possesses constitutive activity and oncomodulatory prope

117 Usp possesses DNase activity and, particularly when coapplie

118 That PAF possesses hypothermic activity and mediates LPS-induced

119 effects on insulin sensitivity, glucosamine possesses immunosuppressive activity and could be benefi

120 We demonstrate that human Tim50 possesses phosphatase activity and is present in a compl

121 The sequence upstream of the CP49 gene possesses promoter activity and is able to drive lens-pr

122 Here, we show that SAMHD1 possesses RNase activity and that the RNase but not the

123 f the matrix metalloproteinase (MMPs) family possess collagenolytic activity, and the mechanisms by w

124 CdpA is shown to possess PDE activity, and this activity is regulated by

125 ost of these inhibited both reductase steps, possessed antibacterial activity, and inhibited cellular

126 led that not all plants emitted veratrole or possessed GOMT activity, and SlGOMT1 expression was only

127 Interestingly, R226A and R226K SsuD variants possessed undetectable activity, and there was no detect

128 kinase-5 (GRK5) has previously been shown to possess nuclear activity as a HDAC5 kinase, promoting an

129 RadA is unlikely to possess protease activity as the putative active site se

130 Furin-cleaved MMP-2 does not possess proteolytic activity as examined in a cell-free

131 and stable than human laforin in vitro, and possesses similar activity as a glucan phosphatase.

132 f epidermal and mesophyll cells, but did not possess AO activity, as shown by heterologous expression

133 to be a deubiquitinating enzyme (DUB) and to possess deISGylating activity, as previously reported fo

134 We also found that XPLN possesses transforming activity, as determined by focus

135 ion of hesperidin which has been observed to possess biological activities associated with a healthy

136 unction of Syk(L) indicated that nuclear Syk possesses biological activities associated with tumor su

137 cate that both rasagiline and propargylamine possess neurorescue activity, associated with regulation

138 It possesses excellent activity at the recombinant human mo

139 rawn from a Chinese population predominately possessing lower activity BDNF genotypes (Val/Met, Met/M

140 They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regu

141 Purified AGPAT6 protein possessed GPAT activity but not AGPAT activity.

142 ified IFN-gamma(+) Tregs expressed FOXP3 and possessed suppressive activity but lacked Helios express

143 an immunodeficiency virus type 1 gp120 often possess neutralizing activity, but these generally are h

144 Similarly, a liverwort receptor possesses basal activity, but it is further activated by

145 Our data suggest that SLPI may possess antitumorigenic activity by virtue of its abilit

146 cells in the spleens of sensitized mice that possess initiation activity (CD19(+)CD5(+)Thy-1(int)IgM(

147 The chimeric protein possessed endonucleolytic activity, cleaving both strand

148 of these elements were subsequently shown to possess IRES activity comparable to that of a variant of

149 IGRP overexpressed in insect cells possesses enzymatic activity comparable to the previousl

150 ing groups to generate more stable compounds possessing antitumor activity consistent with on-target

151 of 16 different proteins, 9 members of which possess catalytic activity, dephosphorylating phosphatid

152 ubiquitin ligase, MdmX has not been shown to possess this activity despite the extensive sequence hom

153 l) or 15-carbon (farnesyl) isoprenoid chains possess biological activities distinct from their non-pr

154 n the nucleus and demonstrate that RGS12TS-S possesses biological activities distinct from those of o

155 ducted on [Dap2]ramoplanin A2 aglycon, which possesses antimicrobial activity equal to or slightly mo

156 was constructed, expressed, and purified and possessed specific activity equivalent to a severe hemop

157 All extracts possessed antibacterial activity especially methanolic e

158 We asked whether PAF possesses pyrogenic activity (Expt 1) and mediates LPS f

159 ecretions (sampled as induced sputum), which possess chemotactic activity for eosinophils and T cells

160 complex [Pd(mu-Br)(t)Bu(3)P](2) was found to possess unique activity for the catalytic double-bond mi

161 e that even the well-known deacetylase SIRT2 possesses efficient activity for the removal of long-cha

162 MMSET possesses methyltransferase activity for core histone H3

163 synthase) that lacks hydrolytic activity but possesses transglycosylation activity for glycoengineeri

164 monstrated that MOSP(C), previously shown to possess porin activity, forms amphiphilic trimers, while

165 ng up on our previous findings that the skin possesses steroidogenic activity from progesterone, we n

166 ructure of Mer with two compounds (7 and 22) possessing distinct activity have been determined.

167 Some members have been shown to possess acetyltransferase activity; however, whether thi

168 rombin binding have been previously shown to possess anticoagulant activity; however, problems with r

169 ymes against listeria have been isolated and possess listericidal activity; however, there has been n

170 ALD1 was shown to possess aminotransferase activity in vitro, suggesting i

171 agonists may be hypoxic cell sensitizers and possess antiangiogenic activity in vivo, thus extending

172 Moreover, compounds within this class possess antibacterial activity in the absence of a rapid

173 up and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-gamma-dependen

174 per respiratory tract, SPLUNC1 is thought to possess antimicrobial activity in host defense.

175 Microcins are small secreted proteins that possess antimicrobial activity in vitro, but whose role

176 All species analyzed were found to possess antioxidant activity in vitro and a wide range o

177 t, and one of these (NSC-65828) was shown to possess antitumor activity in mice.

178 rine protease and has recently been shown to possess antiviral activity in a phase I trial in patient

179 fic CD8(+) T cells have been demonstrated to possess antiviral activity in vivo.

180 Nudt8, Nudt12, Nudt15, Nudt16 and Nudt19, to possess deCoAping activity in vitro.

181 ) cells, our studies suggest that S100A7 may possess differential activities in ERalpha(+) compared w

182 These taxoids were found to possess exceptional activity in promoting tubulin assemb

183 e expression and SRF and CBP immunocomplexes possess HAT activities in smooth muscle cells, both SRF

184 ive compound in this series and was shown to possess neurochemical activity in vivo by producing acut

185 belong to the H-N-H endonuclease family and possess nicking activity in vitro.

186 the three TSSs validated that the sequences possess promoter activity in a cell type-specific manner

187 The cloned fragment was found to possess promoter activity in transiently transfected hum

188 scribe intergenic RNA; four of these regions possess promoter activity in vitro that could account fo

189 in and raises the possibility that APH-1 may possess proteolytic activity in the current or ancestral

190 or growth, demonstrating that T2-MZP B cells possess regulatory activity in tumor-bearing mice.

191 ticoids are a general class of steroids that possess renoprotective activity in glomeruli through the

192 internal ribosome entry site (IRES) elements possess restricted activity in neuronal tissues.

193 Only the dimeric PKM2 possess the activity in promoting tumor angiogenesis, wh

194 nalogue 2,4,6-trinitrophenol, which does not possess uncoupling activity in intact mitochondria, show

195 Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being ab

196 Herein, we demonstrate that GIVAPLA2 possessed full activity in the absence of Ca2+ when PI-4

197 amide, a drug approved for anthelmintic use, possessed promising activity in vitro against T. gondii.

198 udy was undertaken to examine whether U1 RNA possesses adjuvant activity in vivo.

199 Previous evidence indicates that adiponectin possesses antifibrogenic activity in inhibiting liver fi

200 Although this combination possesses antineoplastic activity in pediatric solid tum

201 um-dependent protein kinase 1 (TgCDPK1) that possesses antitoxoplasmosis activity in vitro and in viv

202 nctionally active and NF-kappaB binding site possesses enhancer activity in regulating Rgs4 transcrip

203 Here we demonstrate that NDV possesses oncolytic activity in tumor cells capable of a

204 l-free systems demonstrated that niclosamide possesses protonophoric activity in cells and in vitro.

205 PN-CTF, which assumes a new conformation and possesses substantial activity in enhancing chemokine-in

206 structural units permits access to analogues possessing cytotoxic activity in the nanomolar range.

207 Invading mouse trophoblast cells also possess endocrine activities, including the expression o

208 It possesses multiple activities, including antibacterial,

209 PGN_0756 possessed an activity indistinguishable from that of the

210 The procapsid protease possesses autoproteolytic activity, it is required for d

211 ke other DNA tumor virus oncoproteins, which possess immortalizing activity, LMP1 does not bind to re

212 9.251/GLX3 from Candida albicans is shown to possess glyoxalase activity, making this the first demon

213 y expressed in malignant glioblastoma (GBM), possesses inflammatory activity modulated by proteolytic

214 These photosynthetic cells possess high activities of enzymes characteristic of C4

215 iated with veins of petioles of C(3) tobacco possess high activities of the decarboxylase enzymes req

216 Foxd1-deficient T cells possess increased activity of both NF-AT and NF-kappaB:

217 We found that Tet enzymes also possess the activity of catalyzing the formation of 5-hy

218 Compared with the leaf lamina, mid-veins possessed high activities of NADP-dependent malic enzyme

219 ld be formed in vivo as well as in vitro and possessed specific activities of both TteUvrD and Bstpol

220 Conversely, we have found that MIP-3alpha possesses antibacterial activity of greater potency than

221 ed that the purified G-CSF-Tf fusion protein possesses the activity of both Tf receptor (TfR) binding

222 cells expressing CD25 and GITR molecules and possessing suppressive activity on the proliferative res

223 These complexes possess two activities: one that binds RNA and another--

224 omyocytes, for example, to screen drugs that possess cardiac activity or cardiotoxicity, or to assess

225 electable marker reveal that the intron also possesses promoter activity, presumably providing an exp

226 protease inhibitors have also been shown to possess antimicrobial activity, presumed to contribute i

227 00A9, is an abundant neutrophil protein that possesses antimicrobial activity primarily because of it

228 NNRTIs that are potent against WT virus and possess favorable activity profiles against clinically r

229 A number of exemplars such as compound 41 possess interesting activity profiles in KDM4C and KDM5C

230 perfamily and recruit multiple proteins that possess enzymatic activity relevant to epigenetic change

231 These coregulator complexes possess "sensing" activities required for interpretation

232 n vitro can bind small molecules (aptamers), possess catalytic activity (ribozymes) or do both (aptaz

233 a C/EBPbeta molecule (C/EBPbeta T188D) that possesses adipogenic activity similar to that of the wil

234 ing the CTCF motif cluster in the LAT region possesses insulator activities, specifically, enhancer b

235 y expressed in the intestinal epithelium and possesses dual activity, stimulating mitochondrial bioge

236 processed to phosphoribosylation by enzymes possessing phosphodiesterase activity, such as snake ven

237 proteins of other human herpesviruses do not possess this activity, suggesting that the KSHV homolog

238 demonstrate that the PfhB2 Fic domains also possess adenylyltransferase activity that targets the sw

239 CeA(GA) neurons also possess basal activity that mostly reflects animals' int

240 Similar to canonical transglutaminases, MavC possess deamidase activity that targets ubiquitin at Gln

241 ExoS, ExoT, ExoY, and ExoU all possess enzymatic activities that disrupt host cellular

242 idase 1 (Glb1), and hexosaminidase B (HexB), possess hydrolytic activities that temporally remodel N-

243 Commensal bacteria possess immunostimulatory activities that can modulate h

244 Allergens possess proteolytic activity that is capable of disrupti

245 he bZIP DNA binding domain was also found to possess transcriptional activity that functions in yeast

246 the mutant proteins associated with disease possessed catalytic activities that were indistinguishab

247 1 and CD synthesized by in vitro translation possessed endoglucanse activity that was temperature-dep

248 The human ribosomal protein S3 (hS3) possesses associated activities that suggest alternative

249 of tuberculosis, the accessory SecA2 protein possesses ATPase activity that is required for bacterial

250 to other eukaryotic ORCs, wild-type HsORC1-5 possesses ATPase activity that is stimulated only 2-fold

251 This virulence protein possesses ubiquitination activity that depends on a cons

252 icient plasmid selection marker, but it also possesses unique activity that may facilitate molecular

253 Despite possessing these activities, the CTD lacks the cooperati

254 Rap1 and Sir4 also possess anchoring activity; the rotation of plasmids bou

255 These molecules may also possess hormonal activities; therefore, one or more may

256 vailable antiandrogens have been reported to possess agonist activity to induce prostate-specific ant

257 SsrB appears to possess dual activities to promote SPI-2 gene expression

258 ny actin-binding proteins have been shown to possess multiple activities to regulate filament dynamic

259 nthetases are multidomain enzymes that often possess two activities to ensure translational accuracy.

260 17, which is expressed in the MHB region and possesses similar activities to Fgf8a based on gain-of-f

261 e hypothesized that the innate immune system possesses specific activity to protect against biofilm i

262 y proteins, FTO and ALKBH5, showed that they possess demethylase activity toward N(6)-methyladenosine

263 Mammalian TORC2 has recently been shown to possess kinase activity toward the C-terminal hydrophobi

264 neurons suggest that the obtained compounds possess promising activity toward NMDA receptors.

265 Moreover, FAPalpha, but not DPPIV, possesses endopeptidase activity toward N-terminal benzy

266 tivity than either parental enzyme, and that possess new activity towards the anti-HIV prodrug 2',3'-

267 nd biochemical studies demonstrate that Rai1 possesses pyrophosphohydrolase activity towards 5' triph

268 ecular docking simulations predicted CYP6P12 possessing enzymatic activity towards pyrethroids.

269 tracts contained phenols up to 310 mg EE and possessed antioxidant activity up to 260 mg TAE per gram

270 wed that these purified recombinant proteins possessed AKR activity using various cytotoxic aldehydes

271 f the heparan sulfate proteoglycan perlecan, possesses angiostatic activity via dual receptor antagon

272 To test whether HR possesses HDM activity, we performed a series of in vitr

273 acid and 3,5 dicaffeoylquinic acid, known to possess antioxidant activity, were quantified.

274 It has been shown to possess DGK activity when assayed using a medium-chain d

275 n reporter proteins encoded by these vectors possess lesser activities when compared with the biolumi

276 he presence of TGase at 25 degrees C (FAT25) possessed antioxidant activity when tested in a linoleic

277 of the galectin family including galectin-1 possess apoptotic activities, whereas galectin-3 possess

278 CD8(+) T cells derived from normal controls possess regulatory activity, whereas both unfractionated

279 The C-terminal part of nsP2 possesses protease activity, whereas the N-terminal part

280 ovide the first evidence that B. burgdorferi possess proteolytic activity which may contribute to the

281 ical characterization demonstrated that SRRs possess ATPase activity, which appears to be a requireme

282 proteins extracted from the elongation zone possessed expansin activity, which increased substantial

283 The Escherichia coli SuhB gene product possesses IMPase activity, which is also strongly inhibi

284 ExoU possesses phospholipase activity, which is detectable in

285 navirus papain-like protease 2 (PLP2) domain possesses protease activity, which cleaves the viral rep

286 cis-caryophyllene, linalool, and eucalyptol possess antiviral activity, while (ii) thujones do not,

287 fide, where it is shown that the basal plane possesses uniform activity, while surface defects (i.e.,

288 racterization showed that while both enzymes possess optimal activities with short chain acyl derivat

289 A677G EZH2 possessed catalytic activity with a substrate specificit

290 LTA(4)H also possesses aminopeptidase activity with unknown substrate

291 termed Polycomb repressive complex (PRC) 2, possesses HMT activity with specificity for Lys 9 (K9) a

292 ll division and septum formation and FgCdc14 possesses phosphatase activity with specificity for a su

293 Endo-D also possesses transglycosylation activity with sugar oxazoli

294 stration-approved chemotherapeutic compounds possessing synergistic activity with leucovorin against

295 ated that non-fibrillar assemblies of A beta possess electrophysiologic activity, with the corollary

296 Both MKK9 and MPK6 possess kinase activities, with MPK6 an immediate target

297 sis revealed that one of the compounds, 15f, possessed antituberculosis activity, with an MIC value o

298 gans MPS-1, a bifunctional beta-subunit that possesses kinase activity, with Kv channels.

299 ymer-drug conjugates and macromolecules that possess biological activity without attached low molecul

300 Although zebrafish IGFBP-5b possesses transactivation activity, zebrafish IGFBP-5a l