ライフサイエンスコーパス: postinoculation

1 d pigs as early as 8 months of age (6 months postinoculation).

2 r and spleen colonization levels up to 120 h postinoculation).

3 n), and plates were imaged at 0 and 24 hours postinoculation.

4 tics of a chronic state within fourteen days postinoculation.

5 Colonization was assessed 12 weeks postinoculation.

6 lected at time points ranging from 3 to 14 h postinoculation.

7 rain stem response thresholds at 3 or 7 days postinoculation.

8 associated with S. aureus 30 min and/or 6 h postinoculation.

9 s in the airway and the alveoli at 2 and 4 h postinoculation.

10 f 31 serial plasma samples as early as day 1 postinoculation.

11 that began on day 6 and was lethal by day 9 postinoculation.

12 reus conferred >90% protection up to 60 days postinoculation.

13 d pneumonia were observed histologically 6 h postinoculation.

14 f 51 serial plasma samples as early as day 1 postinoculation.

15 lated from the fourth recipient about 1 year postinoculation.

16 mediated clearance during the first few days postinoculation.

17 . meliloti at the early time point of 3 days postinoculation.

18 expressed in infected rosette leaves at 12 d postinoculation.

19 -infected groups and euthanized at 18 months postinoculation.

20 ed pigtailed macaques on days 4, 14, and 114 postinoculation.

21 ion of bacterial colonization 1, 4, and 48 h postinoculation.

22 ) exhibited chronic colitis through 7 months postinoculation.

23 hite blood cells and in lung tissue at day 2 postinoculation.

24 iglets were challenged with PC21A at 3 weeks postinoculation.

25 ecomes associated with the lesions by 5 days postinoculation.

26 gh level until they were euthanized 8 months postinoculation.

27 inimal to mild inflammation at days 7 and 28 postinoculation.

28 RNA (vRNA) were detected in blood by 2 weeks postinoculation.

29 VCC, and MAb-8 staining was optimal on day 2 postinoculation.

30 d draining lymph nodes between 3 and 10 days postinoculation.

31 number of Vsa variants were seen by 21 days postinoculation.

32 ent mice but only after a minimum of 21 days postinoculation.

33 sis thaliana, causing plant mortality 7 days postinoculation.

34 al numbers of the deltapagP mutant on day 14 postinoculation.

35 positive-control pigs at 9, 10, and 11 days postinoculation.

36 d are capable of causing plant mortality 7 d postinoculation.

37 s positive and seroconverted by 3 to 5 weeks postinoculation.

38 adders, or kidneys of mice harvested at 48 h postinoculation.

39 he lower respiratory tract for up to 49 days postinoculation.

40 cyte responses were observed at 2 to 4 weeks postinoculation.

41 hology in mice examined at both 2 and 4 days postinoculation.

42 this defect was apparent within 1 to 2 days postinoculation.

43 caques that progressed to AIDS 9 to 16 weeks postinoculation.

44 fter bacterial colonization starting 15 days postinoculation.

45 5), or mild (n = 2) encephalitis at 3 months postinoculation.

46 d with HPS (r = -0.95, P = 0.01) at 530 days postinoculation.

47 a reference live attenuated SIV at 12-14 mo postinoculation.

48 examined at 109, 150, 245, 368, and 530 days postinoculation.

49 nimals but were upregulated at 7 and 14 days postinoculation.

50 ung histopathology was normal up to 368 days postinoculation.

51 M antibodies (titer, 1:5 to 1:1,280) 14 days postinoculation.

52 Ureaplasma was undetectable 28 days postinoculation.

53 died with opportunistic infections 5.9 years postinoculation.

54 6) CFU/ml of blood between day 14 and day 36 postinoculation.

55 inoculation and macrophages at 2 and 14 days postinoculation.

56 ar tissue on day 14, and in joints on day 28 postinoculation.

57 , and samples were collected at 6 to 7 weeks postinoculation.

58 M. pneumoniae and sacrificed at 0 to 42 days postinoculation.

59 d 100% of mice, even when delayed until 96 h postinoculation.

60 g in fewer than 200 cells/microl by 96 weeks postinoculation.

61 mation in some mice that resolves by 28 days postinoculation.

62 of the infection from 60 hours to 110 hours postinoculation.

63 ins in different organs and at various times postinoculation.

64 ed in diarrhea that lasted from 1 to 10 days postinoculation.

65 onary inflammation, which cleared by 28 days postinoculation.

66 the middle ear were monitored up to 1 month postinoculation.

67 low the limit of detection at 30 and 60 days postinoculation.

68 with wild-type B. bronchiseptica at 10 days postinoculation.

69 uce a positive test response through 10 days postinoculation.

70 those of the transparent variant for 10 days postinoculation.

71 a halo around their colonies at 8 to 10 days postinoculation.

72 nd the number of 6BPS plasma cells increased postinoculation.

73 VcpzBF1167 (Env H280Q and Q380R) at 14 weeks postinoculation.

74 nt lethal challenge with WT virus at 21 days postinoculation.

75 ed these transcripts at 10 min, 3 h, and 6 h postinoculation.

76 mice were indistinguishable from 1 to 3 days postinoculation.

77 tance 1 mRNA) were determined up to 72 hours postinoculation.

78 e to the virus-only inoculation group at 3 h postinoculation.

79 ory tracts of mice and was complete by day 6 postinoculation.

80 allbladder epithelial cells as early as 12 h postinoculation.

81 le to eliminate S. aureus even after 28 days postinoculation.

82 ice and showed that clearance begins 14 days postinoculation.

83 static conditions were completely lysed 24 h postinoculation.

84 both CD4(+) and CD8(+) T cells within 1 week postinoculation.

85 nts undergoing treatment as early as 5 weeks postinoculation.

86 served by week 4 and on the palate by week 6 postinoculation.

87 zation of the denture and palate for 8 weeks postinoculation.

88 ufficient to persist during the first 3 days postinoculation.

89 nd liver tissues of infected mice at 19 days postinoculation.

90 ays postinoculation and for at least 21 days postinoculation.

91 V, and tumors were not detectable at 21 days postinoculation.

92 initiated synthesis of EMICE within 4 to 6 h postinoculation.

93 chs (9-fold-lower bacterial load) at 9 weeks postinoculation.

94 and the pgdA mutant was observed at 3 weeks postinoculation (1.32 x 10(4) versus 1.85 x 10(3) CFU/gr

95 Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, an

96 By 2 h postinoculation, 70.0% (+/- 5.5%) of intracellular bacte

97 day 14 to 18 postinoculation, and by 3 weeks postinoculation, 75% of pregnant guinea pigs experienced

98 At 1 day postinoculation, a seronegative calf (contact animal) wa

99 urs, and were at baseline levels by 24 hours postinoculation, a time when high levels of circulating

100 rapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit,

101 d G1N4 were cleared from the brain by 7 days postinoculation and all animals survived without apparen

102 wer than that of the parental strain by 12 h postinoculation and decreased further by 24 h.

103 her viremia and tissue titers at 24 and 48 h postinoculation and faster neuroinvasion than mice given

104 st challenge with WT FMDV as early as 2 days postinoculation and for at least 21 days postinoculation

105 all became seropositive around 2 to 3 weeks postinoculation and had a decline in CD4/CD8 T-cell rati

106 vels in intestinal tissue between 2 and 24 h postinoculation and increased OPN protein in intestinal

107 honuclear leukocytes 1 to 2 days and 14 days postinoculation and macrophages at 2 and 14 days postino

108 using on the innate immune response at day 2 postinoculation and on gene expression in affected lung

109 sured by plethysmography, was detected 1 day postinoculation and persisted even after pulmonary infla

110 nal antibodies reacting to MgpB were induced postinoculation and persisted throughout the infection.

111 duced number of transformed cells at 5 weeks postinoculation and the presence of fewer gross tumors.

112 r bacteria present in a tight vacuole at 2 h postinoculation and the presence of numerous bacteria in

113 cylic acid signaling, was very low until 8 d postinoculation and then rose sharply, coinciding with t

114 ation to deep tissues for as long as 3 weeks postinoculation and to be critical for B. burgdorferi in

115 ak DC recruitment was detected at 10-15 days postinoculation and was significantly greater (p < 0.05)

116 macaques during acute SIV infection (10 days postinoculation) and during terminal infection when ther

117 Fever developed between day 14 to 18 postinoculation, and by 3 weeks postinoculation, 75% of

118 ased significantly in developing nodules 4 d postinoculation, and expression accompanied invading rhi

119 ower in the partially recovered cells at 5 h postinoculation, and lower still in the preadapted cells

120 Variants were detected by day 7 postinoculation, and multiple variants were present conc

121 mock-infected animals at days 1, 3, 5, and 7 postinoculation, and samples were analyzed for different

122 aried the time of initiation and duration of postinoculation antiretroviral treatment with tenofovir

123 rmined time points (1 h and 3, 5, and 7 days postinoculation), blood and bronchoalveolar lavage (BAL)

124 atory tracts of BALB/c mice beginning 1 week postinoculation but did not differ from the wt strain in

125 -DNA (bDNA) assay, reached a peak at 2 weeks postinoculation but dropped to below detectable levels b

126 s in the spinal cord and brain at late times postinoculation but lower titers in the liver in compari

127 onization, the mutant is outcompeted at 12 h postinoculation but then competes evenly by 24 h.

128 iters of autologous NAb developed by 4 weeks postinoculation but were not associated with control of

129 evels of viremia in the acute phase (2 weeks postinoculation) but are showing a relatively low viral

130 th SHIVs were potently suppressed by week 12 postinoculation, but a burst of viremia at week 51 was a

131 ding of prions in saliva increases with time postinoculation, but is common throughout the preclinica

132 ing vaginal colonization at 1, 5, and 8 days postinoculation compared to growth in culture medium.

133 ere severely defective during the first week postinoculation compared to their wild-type parent.

134 s in approximately 60% mortality within 48 h postinoculation, concomitant with amplified local inflam

135 ract infection was observed at up to 77 days postinoculation (d.p.i.).

136 In serum, IL-6 was significantly elevated at postinoculation day (PID) 1 in the VirHRV group and at P

137 kg of body weight/day, intramuscularly) from postinoculation day (PID) 1 to 6.

138 h virulent Wa (P1A[8],G1) human rotavirus at postinoculation day (PID) 21 (two-dose VLP regimen) or 2

139 CV-4408 and then challenged with BCoV DB2 at postinoculation day (PID) 21.

140 At postinoculation day (PID) 28, pigs either were euthanize

141 No viremia was detected through postinoculation day 10.

142 Both eyes of each mouse were enucleated on postinoculation day 15 and processed for histopathologic

143 re Mac-1-positive cells were detected early (postinoculation day 2) in the injected eyes of mice infe

144 by ELISPOT assay at the day of challenge, at postinoculation day 28 (WaV, WaA, and Mock) or at postch

145 yme-linked immunosorbent assay in the acute (postinoculation day 3 [PID 3]) and convalescent (PID 28)

146 nzyme-linked immunosorbent assay at selected postinoculation days (0 to 28).

147 Virus shedding began at postinoculation days (PID) 1 to 3 and continued up to PI

148 Pigs from postinoculation days (PID) 1 to 4 tested positive for Hu

149 Imaging was performed on postinoculation days 0, 1, 3, and 6 to document sites an

150 On postinoculation days 3, 7, and 10, injected eyes of non-

151 Culture supernatants, collected at various postinoculation days, were used for the analyses of chem

152 At 12 h, 3 days, 7 days, and 14 days postinoculation, DbpA/B-deficient spirochetes were signi

153 opsy specimens obtained at 3, 6, and 9 weeks postinoculation demonstrated no significant difference i

154 Nasal washes performed 7, 14, and 21 days postinoculation demonstrated that strain DBB25 colonized

155 On days 1 to 3 postinoculation, disease signs caused by oseltamivir-res

156 ubpatent levels within approximately 2 weeks postinoculation, double-KO mice developed high levels of

157 s, peak levels of viremia occurred at 5 days postinoculation (DPI) and were most consistently detecta

158 mRNA sequencing (mRNA-seq) at 3 and 12 days postinoculation (dpi) in 4 animals for each time point.

159 At 21 days postinoculation (dpi), all surviving pigs were challenge

160 , 7, 10, 13, 16, 20, 24, 28, 35, and 42 days postinoculation (dpi), and the remaining chickens were n

161 ed by cesarean sections performed 7 and 21 d postinoculation (dpi).

162 eight loss and mortality beginning by 9 days postinoculation (dpi).

163 e necropsied at 3, 7, 14, 20, 27, or 55 days postinoculation (DPI).

164 from the three inoculated groups at 35 days postinoculation (DPI).

165 necropsied at 3, 7, 14, 20, 27, and 55 days postinoculation (DPI).

166 fluid samples were collected through 56 days postinoculation (dpi).

167 ebo was injected intraperitoneally at 2 days postinoculation (DPI; low dose) or 4 DPI (medium and hig

168 ed 2 animals from each group prior to (1 day postinoculation [dpi]) and at 1 (2 dpi) and 6 days postc

169 nt times after intrarectal inoculation (days postinoculation [dpi]) with simian immunodeficiency viru

170 reased in very early infection (8 to 10 days postinoculation [dpi]).

171 chieved a marked numerical dominance at 20 h postinoculation during pneumonia but did not exhibit a s

172 ases of the infection but was lost by day 14 postinoculation, during clearance of the infection; (iv)

173 ection in the bladder and kidneys by 6 hours postinoculation, fliC mutant bacteria were able to colon

174 Within 2 h postinoculation, fluorescently labeled C. neoformans had

175 ral therapy, initiated at a time point (48 h postinoculation) following simian immunodeficiency virus

176 reovirus 1/L, and evaluated at various days postinoculation for in situ apoptosis by TUNEL analysis

177 nt challenges and at 6, 16, 48, 60, and 72 h postinoculation for the cochallenges.

178 FU/g bladder or kidney was determined 3 days postinoculation for the independent challenges and at 6,

179 ens collected sequentially on different days postinoculation from chickens experimentally infected wi

180 Mycoplasmas were cultured 3, 14, and 21 days postinoculation from the nose, lung, trachea, liver, and

181 ed and 3 down-regulated genes in the month-1 postinoculation group and 31 up-regulated and 2 down-reg

182 ed and 2 down-regulated genes in the month-3 postinoculation group.

183 At 6 months postinoculation,H. pylori had successfully colonized wit

184 ncephalitis in 100% of animals within 7 days postinoculation; however, viruses G3N4 and G1N4 were cle

185 BLM imaging detected WEEV and VEEV at 12 h postinoculation (hpi) at the injection site (footpad) an

186 nfection in the bladder (P = 0.0295) at 48 h postinoculation (hpi).

187 MA104 cells, with maximum titer reached 24 h postinoculation (hpi).

188 inary tract infection at 4, 24, 48, and 72 h postinoculation (hpi).

189 cytes independent of DENV replication by 4 h postinoculation (hpi).

190 ive neutrophils and macrophages and, at 72 h postinoculation, IL-17-positive CD4(+) T cells, suggesti

191 By 8 wk postinoculation, immunocompetent mice resolved both card

192 ns to resist clearance during the first week postinoculation in a manner dependent on B- and T-cell-m

193 g lung bacterial clearance when administered postinoculation in animals with established infection an

194 e activities were present from weeks 4 to 12 postinoculation in both animals.

195 er tissues, decreased dramatically by 5 days postinoculation in both wild-type and Rag1(-/-) mice, su

196 rons were quantified from days 9 through 240 postinoculation in latently infected trigeminal ganglia

197 erplasia overlying infected dermis four days postinoculation in wild-type mice.

198 At 96 h postinoculation, in addition to memory CD4(+) T cells, H

199 genes were differentially expressed at 1 day postinoculation, including an increase in the expression

200 By week 6 and week 8 postinoculation, increasing percentages of rats exhibite

201 roscopic observations of hydathodes six days postinoculation indicated a digestion of the epithem cel

202 able in pancreas and liver as soon as 20 min postinoculation, indicating rapid systemic dissemination

203 At longer postinoculation intervals, infected neurons were found i

204 By 21 days postinoculation, levels of tetramer-binding cells had dr

205 s most severe in the nonadapted cells at 3 h postinoculation, lower in the partially recovered cells

206 At approximately 50 weeks postinoculation, mice were euthanized for histopathologi

207 At specific times postinoculation, mice were sacrificed, and lungs were re

208 were allowed to incubate for up to 73 months postinoculation (mpi).

209 (HAI) scores (P < 0.0001) at 6 and 11 months postinoculation (MPI).

210 At 4 h postinoculation, mutant LCVs had a significantly reduced

211 Herein we show that by 7 days postinoculation, nearly 30% of the CD4 T cells in the ac

212 IAV +RNA was detected 2 to 4 h postinoculation of MDCK cells, whereas synthesis of cold

213 A declined to undetectable levels by 14 days postinoculation of TriGAS, we speculate that a transient

214 At 48 h postinoculation, only one strain, Bp340::pDbpaC, demonst

215 sham-inoculated controls at both 4 and 24 h postinoculation (P < 0.05 in all cases).

216 ifferent at both 10 (P < 0.0001) and 28 days postinoculation (p.i.) (P = 0.002).

217 be detected in protoplasts as early as 12 h postinoculation (p.i.) and accumulated to high levels by

218 at eight time points from day 21 to day 217 postinoculation (p.i.) and examined their tissues for vi

219 us shedding in nasal washes for up to 5 days postinoculation (p.i.) and in lung tissue of inoculated

220 like lesions for 4/4 lungs at days 14 and 28 postinoculation (p.i.) and positive PCR detection of M.

221 collected on days -2, 1, 3, 5, 7, 14, and 21 postinoculation (p.i.) and tested by one of three commer

222 trols, and the inflammation resolved by 72 h postinoculation (p.i.) in both groups.

223 e effects of p53(+/-), infection status, and postinoculation (p.i.) time on inflammation, preneoplast

224 s earlier, and the percent survival on day 6 postinoculation (p.i.) was five times lower than for mic

225 odeficiency virus from SMs (SIVsm) by day 30 postinoculation (p.i.) with lepromatous tissue.

226 Animals were euthanized at 2 or 4 h postinoculation (p.i.), and tissues were collected to as

227 ed at comparable levels at 4, 7, and 10 days postinoculation (p.i.), as determined by virus isolation

228 ium was shown to replicate from 0 to 80 days postinoculation (p.i.), during which at most time points

229 d increasing levels of serum RNA from week 1 postinoculation (p.i.), reaching a peak of 10(6) copies/

230 Further, at 7 days postinoculation (p.i.), spliced SIV RNA levels were the

231 a collected from mice infected 8 to 120 days postinoculation (p.i.), we found that a subset of saliva

232 0(7) to 10(9) SIVrcm RNA copies/ml by day 10 postinoculation (p.i.).

233 proximately monthly thereafter until day 251 postinoculation (p.i.).

234 marrow, and spleen as early as 1 to 2 weeks postinoculation (p.i.).

235 d immunohistochemistry between days 1 and 12 postinoculation (p.i.).

236 nd viremia, with clearance under way by 96 h postinoculation (p.i.).

237 me infected and died at between 2 and 4 days postinoculation (p.i.).

238 Based on the postinoculation percent weight change per h and serum bi

239 monocytes of infected dogs during the 56-day postinoculation period.

240 Starting on postinoculation (PI) day 28, tear swabs were collected o

241 r lymph nodes, and inoculated eyes peaked at postinoculation (pi) day 5 and declined by pi day 7.

242 V) encephalitis with neuronal dysfunction by postinoculation (pi) day 84.

243 ma peaked at 2 weeks and declined by 4 weeks postinoculation (PI).

244 tive control), were killed at 6 and 18 hours postinoculation (PI).

245 of SIVmnd-1 viral replication (days 7 to 10 postinoculation), plasma VLs were high (8 x 10(6) to 8 x

246 o reduce survival despite reducing the 3 day-postinoculation pulmonary pathogen burden by 400-fold.

247 tion frequencies occurring at 30 and 120 min postinoculation, respectively.

248 CR in 70 and 22% of mice at 109 and 530 days postinoculation, respectively.

249 Analysis of isolates from 14 days postinoculation revealed less variation of the Vsa prote

250 Histological examination at 18 weeks postinoculation revealed minimal gastric inflammation in

251 Eight days postinoculation, rVSV was eliminated from the olfactory

252 Twelve weeks postinoculation, SIV-infected macaques had significantly

253 sculoskeletal tissues that peak from 10-14 d postinoculation, suggesting that CD8(+) T cells contribu

254 e, but not joint-associated tissues, at 14 d postinoculation, suggesting that the ability of CD8(+) T

255 tors were uniquely induced in soybean at 2 d postinoculation, suggestive of enhanced pathogen virulen

256 Within 7 days postinoculation, TC-PC177 caused mild diarrhea and lower

257 ibodies against SHIV-89.6 at 10 and 20 weeks postinoculation than Indian rhesus macaques.

258 At 2 weeks postinoculation, the bacterial cells were mostly trapped

259 By 48 hours postinoculation, the fliC mutant bacteria were attenuate

260 However, by 21 days postinoculation, the level of pneumonia in the dual-infe

261 However, at 21 weeks postinoculation, the livers from mice inoculated with wi

262 By week 4 postinoculation, the majority of inoculated rats with de

263 fection in the ganglion; (ii) at early times postinoculation, the number of neurons expressing viral

264 By 6 h postinoculation, the release of proinflammatory cytokine

265 Ten weeks postinoculation, the severity of typhlocolitis was asses

266 tion of viral reporter proteins at different postinoculation times allowed us to determine the sequen

267 However, by day 12 postinoculation, titers in all organs examined were 10-

268 s and were necropsied at several time points postinoculation to assess inflammation, dysplasia, and n

269 from all P28 OMPs were detected from day 30 postinoculation to day 468 and from day 46 until day 159

270 In contrast, as early as 2 h postinoculation, transcriptional up-regulation of GST1-a

271 inoculated monkey developed AIDS at week 137 postinoculation, transfer of its infected blood to a nai

272 ous rechallenge achieved following transient postinoculation treatment compared favorably to the resu

273 Postinoculation treatment did not block the initial infe

274 Even postinoculation treatment regimens that did not prevent

275 ontrolled plasma viremia following transient postinoculation treatment showed substantial resistance

276 n regulating S. pneumoniae biofilms, at 24 h postinoculation, two different D39DeltaluxS mutants prod

277 At 40 and 42 months postinoculation, two i.c.-inoculated cats developed sign

278 ) percentages averaged nearly 70% within 7 d postinoculation using the TRBO-sgRNA constructs, which r

279 d prevention of chronic infection at 2 weeks postinoculation using two different P. aeruginosa strain

280 , KGF given every 3 days beginning on day 15 postinoculation was associated with reversal of weight l

281 ia recovered from the rat trachea at 10 days postinoculation was significantly decreased compared to

282 prion disease to assess various time points postinoculation, we identified 15 unreported genes that

283 L/DeltaUK were protected as early as 14 days postinoculation when challenged with ASFV-G.

284 ia in vivo would be inhibited at early times postinoculation, when the numbers of inflammatory cells

285 r deer became PrP(CWD) positive by 19 months postinoculation, whereas none of the four deer inoculate

286 e PrP(CWD) positive in as little as 6 months postinoculation, whereas none of the four deer receiving

287 IAI) results in 100% mortality by 48 to 72 h postinoculation, while monomicrobial infections are avir

288 spirochete numbers at 2, 4, 8, and 12 weeks postinoculation with 10(5) B. burgdorferi B31 clone 5A4

289 m or INP0341 treated intravaginally pre- and postinoculation with 5 x 10(2) inclusion-forming units (

290 strain colonized the birds as early as day 2 postinoculation with a density as high as 10(7) CFU/g of

291 in mouse hearts from 1 week to over 5 months postinoculation with CVB3/TD demonstrated that CVB3/TD v

292 d-type Arabidopsis leaves beginning 4 to 7 h postinoculation with P. syringae carrying either avrRpt2

293 e transcriptome at 0, 4, 8, 12, 24, and 48 h postinoculation with PM.

294 cid levels increased in V. vinifera at 120 h postinoculation with PM.

295 At 50 d postinoculation with Rocky Mountain Laboratory (RML) pri

296 e in extracellular proteins was observed 6 h postinoculation with S. aureus, with the increase domina

297 We assayed these sites 3 h postinoculation with transcript arrays for the Toll-like

298 ues were inoculated with SIVmac239 and, 4 wk postinoculation (WPI) treated with intramuscular injecti

299 itive for anti-avian HEV antibody at 4 weeks postinoculation (wpi).

300 ed severe neurological dysfunction 196-231 d postinoculation (x =198; 95% CI: 210-216) and tested pos