ライフサイエンスコーパス: postmitotic

1 e cues is at least in part controlled by the postmitotic activity of the transcription factor Nkx2-1.

2 ferent ways, thus rendering bulk analyses of postmitotic adult cells difficult to interpret.

3 propose that the view of salivary glands as postmitotic and dependent on stem cells for renewal be r

4 ous system, myelinating oligodendrocytes are postmitotic and derive from proliferative oligodendrocyt

5 is patterning begins before the cells become postmitotic and is likely linked to the onset of asymmet

6 potent/multipotent stem/progenitor cell to a postmitotic and more differentiated cell.

7 Neurons are postmitotic and thus irreplaceable cells of the central

8 The WGs are postmitotic and wraps PR axons.

9 are derived from neural crest and because of postmitotic arrest lack competence to repair cell loss f

10 of adult mice in vivo and ex vivo, including postmitotic astrocytes.

11 nd maintenance of mechanosensory function in postmitotic auditory hair cells and could help identify

12 As EBs differentiate into ECs, they become postmitotic, but undergo extensive growth and DNA endore

13 xpressing progenitors/neuroblasts, and early postmitotic calretinin-expressing neurons were present c

14 Understanding cell cycle regulation in postmitotic cardiomyocytes may lead to new therapeutic a

15 sed at intercalated discs in human and mouse postmitotic cardiomyocytes.

16 ltiple cell types, as well as replication of postmitotic cardiomyocytes.

17 ater role than PAN1 in directing patterns of postmitotic cell expansion that determine the shapes of

18 or maintaining a balance between mitotic and postmitotic cell fates in development of the mammalian s

19 egeneration, and highlight the importance of postmitotic cell growth in gut epithelial repair.

20 ng that the growth of a key compartment of a postmitotic cell involves an extensive switch in gene ex

21 constitute the differentiation program of a postmitotic cell type.

22 scripts accumulate in both proliferating and postmitotic cell types of Arabidopsis plants.

23 persistent stress, as occurs in ageing, both postmitotic cells - including neurons - and proliferativ

24 de that LRCs in adult TECs are not senescent postmitotic cells and may represent the elusive progenit

25 Many adult tissues contain postmitotic cells as old as the host organism.

26 Nucleoli continued to diminish in postmitotic cells following fate specification.

27 mely susceptible to apoptotic signals, while postmitotic cells have developed several strategies to p

28 Because postmitotic cells in higher eukaryotes often do not star

29 present in the inner segment region of these postmitotic cells in several species, including mouse, t

30 how that Pk1 transcripts are detected in the postmitotic cells of the subplate and cortical plate dur

31 associated with dysfunction and loss of the postmitotic cells residing within this tissue.

32 Neurons are electrically excitable, postmitotic cells that perform sensory, relaying, and mo

33 Adult cardiomyocytes are postmitotic cells that undergo very limited cell divisio

34 ore, TGFbeta and growth pathways interact in postmitotic cells to precisely coordinate cell-specific

35 ate regulator, Notch1, were studied in newly postmitotic cells using a conditional allele of Notch1 (

36 meostasis and function, thus rendering these postmitotic cells vulnerable to premature death in retin

37 ifferentiation to hair cells of the normally postmitotic cells was restricted to the Lgr5-positive po

38 different intervals postinjection to follow postmitotic cells' positional changes.

39 e when neurons exit the cell cycle to become postmitotic cells, and it is generally accepted that, on

40 Long-lived proteins, in postmitotic cells, are particularly difficult to elimina

41 tand the protein composition of these unique postmitotic cells, in which irreversible protein degrada

42 clusively in a nonquiescent subpopulation of postmitotic cells, indicating an asymmetrical distributi

43 RATIONALE: Postmitotic cells, such as cardiomyocytes, seem to be pa

44 ry persists within one cell generation or in postmitotic cells, while long-term memory can survive mu

45 iched at the centrosome both in dividing and postmitotic cells.

46 proliferating cells but also in nondividing postmitotic cells.

47 been identified in extracellular matrices or postmitotic cells.

48 share protein derangements and attrition of postmitotic cells.

49 n the absence of Notch1 in mitotic and newly postmitotic cells.

50 igase that is active both in dividing and in postmitotic cells.

51 are often expressed in both progenitors and postmitotic cells.

52 erges at distinct embryonic ages and only in postmitotic cells.

53 is particularly crucial for interactions of postmitotic cells.

54 is, and induces an aberrant NE morphology in postmitotic cells.

55 be functional; appear most frequently within postmitotic cells; have diverse sequences; change with a

56 xpresses both Atoh1 and NeuroD1, a marker of postmitotic cerebellar granule cells.

57 nstrated a p53-independent abrogation of the postmitotic checkpoint by HPV E6 that induces polyploidy

58 lower affinity than Cdk2, in abrogating the postmitotic checkpoint in E6-expressing cells.

59 mutant-expressing cells while bypassing the postmitotic checkpoint.

60 degradation but competent in abrogating the postmitotic checkpoint.

61 (2014) show that the ATPases RuvBL1/2 drive postmitotic chromatin decondensation, demonstrating that

62 Strikingly, in the postmitotic context, p53-binding landscapes were poorly

63 hila system to interrogate p53 function in a postmitotic context.

64 ver, whether extrinsic signals contribute to postmitotic cortical neuronal development is unclear.

65 used conditional inactivation restricted to postmitotic cortical neurons in mice to investigate the

66 s- and gain-of-function, that high levels of postmitotic COUP-TFI (Nr2f1) expression are necessary an

67 study, we demonstrate that the ISL1 controls postmitotic cranial branchiomotor (BM) neurons including

68 ergic fate survive and integrate better than postmitotic DA neurons.

69 Furthermore, postmitotic depletion of Pav-KLP in Drosophila neurons i

70 3, but migrate dorsally and laterally during postmitotic development.

71 ls (ACs), beginning with the early stages of postmitotic development.

72 Postmitotic differentiated neurons are among the most di

73 tivity is critical for cell cycle reentry of postmitotic, differentiated cells, whereas an increase i

74 lopmental programs of in vivo progenitor and postmitotic differentiation and whether they develop int

75 nd the transcription factor Runx1 coordinate postmitotic differentiation of nonpeptidergic nociceptor

76 as a developmental mechanism underlying the postmitotic differentiation of V3 INs into distinct subp

77 le newborn V3 INs to interact with different postmitotic differentiation pathways.

78 We conclude that SYNGAP1 regulates the postmitotic differentiation rate of developing human neu

79 ides an attractive new system to address how postmitotic diploid cells contribute to repair.

80 Here we show that, in postmitotic Drosophila follicular epithelia, aberrant bu

81 r data demonstrates that Bclaf1expression in postmitotic early-born cells facilitates the differentia

82 trointestinal motility due to a reduction in postmitotic enteric neurons.

83 reveal a remarkable homeostatic mechanism in postmitotic epithelia that ensures not only elimination

84 variety of progenitor cells, is expressed in postmitotic epithelial cells of the mouse airways and ep

85 vivo, we conditionally deleted (cKO) Top1 in postmitotic excitatory neurons in the mouse cerebral cor

86 ped corpus callosum astrocytes are uniformly postmitotic, express glutamate receptors, and form aquap

87 f fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator

88 We report a profound disruption of postmitotic expression trajectories in Pet-1(-/-) neuron

89 ic) factor subsequently globally coordinates postmitotic expression trajectories of genes necessary f

90 ve role for steroidal signaling by promoting postmitotic fate when local signaling is deteriorated.

91 ast pluripotency, molecular pathways driving postmitotic fates remain poorly defined.

92 acking the class I HDACs, HDAC1 or HDAC2, in postmitotic forebrain neurons to investigate the specifi

93 We generated progenitor-stage and postmitotic forebrain-specific Cited2 conditional knock-

94 Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C

95 ronal life history, from development through postmitotic function.

96 hter cells but must be reversed to allow for postmitotic functions.

97 e midbody has gained prominence for exerting postmitotic functions.

98 ave demonstrated a novel role of Cdk1 at the postmitotic G1-like checkpoint in the presence of Cdk2.

99 ndependent function of E6 in attenuating the postmitotic G1-like checkpoint that can lead to polyploi

100 However, it is still unknown whether postmitotic gene expression gradients can determine area

101 Thus, features of postmitotic gene reactivation can provide insights into

102 Here we reveal a new connection between postmitotic genome surveillance and cytokinetic abscissi

103 at ATR activity in midbody-stage cells links postmitotic genome surveillance to abscission timing and

104 titutively activated FGFR3 (FGFR3(K650E)) in postmitotic glutamatergic neurons.

105 inating enzyme required for p97/p47-mediated postmitotic Golgi membrane fusion, is phosphorylated at

106 usters compared with granule progenitors and postmitotic granule neurons.

107 unknown, whether such mechanisms operate in postmitotic, highly differentiated cell types, such as n

108 This postmitotic Hippo network behavior relies on a tissue-re

109 ardiomyocytes in the adult heart are largely postmitotic, Hippo deficiency can increase proliferation

110 Importantly, cytokinesis in postmitotic hPSC-cardiomyocytes can be induced with tran

111 In both GATA4(+) hPSC cardiac precursors and postmitotic hPSC-cardiomyocytes, RB1 is hyperphosphoryla

112 ression of mitotic chondrocytes to a mature, postmitotic hypertrophic fate.

113 ng for transplantation and demonstrated that postmitotic iDA neurons stably and functionally integrat

114 ndlin localization and function at a stable, postmitotic intercellular bridge in the Caenorhabditis e

115 rise to distinct, but highly heterogeneous, postmitotic interneuron (IN) populations.

116 monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day.

117 However, in postmitotic larval cells, none of these factors individu

118 (from data in the literature), the earliest postmitotic lateropallial cells likewise express Nr4a2 a

119 d increased expression of Meis1, a marker of postmitotic LGE neurons.

120 1-expressing progenitors express mCherry and postmitotic Lhx6-expressing MGE-derived interneurons exp

121 pecified cells that give rise to an abundant postmitotic lineage, including epidermal cells, and are

122 ation of adipocyte stem cells (ASCs) to form postmitotic, lipid-filled mature adipocytes.

123 Disruption of postmitotic maintenance mechanisms may result in neurops

124 Postmitotic mammalian cells and cells of invertebrates s

125 nelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory orga

126 Adult postmitotic mammalian cells, including neurons and cardi

127 We conclude that SYNGAP1 regulates the postmitotic maturation of human neurons made from hiPSCs

128 We conditionally removed both genes in postmitotic mDA neurons using the dopamine transporter-c

129 nvestigated the Drosophila ortholog Bap60 in postmitotic memory-forming neurons of the adult Drosophi

130 is a pro/pre- or pre-B cell rather than the postmitotic Merkel cells.

131 he progenitors and only become detectable in postmitotic MNs.

132 s the transmission of positional identity to postmitotic motor neurons later in development.

133 ges in ultrastructure and gene expression in postmitotic mouse cones, between birth and eye opening,

134 conditional deletion of the subunit NF-YA in postmitotic mouse neurons induces progressive neurodegen

135 tion against mtDNA deletions by mitophagy in postmitotic muscle fibers.

136 otentially due to novel mechanisms governing postmitotic mutation.

137 Additionally, terminally differentiated, postmitotic myofiber nuclei from obese individuals had e

138 Almost all newly postmitotic N1-CKO cells became rod photoreceptors, wher

139 due to their morphology, size, polarity, and postmitotic nature.

140 they are one of the first genetic markers of postmitotic neural cells.

141 Depletion of Fezf2 induces apoptosis in postmitotic neural progenitors, with concomitant reducti

142 t, function-defining signaling features of a postmitotic neuron are hardwired together through coordi

143 ivation, and neurotransmitter signaling in a postmitotic neuron represents one key approach to unders

144 ion of neural progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorl

145 ting effects occur in the context of a fixed postmitotic neuronal genome has been an enduring questio

146 Postmitotic neuronal migration was independently disrupt

147 ial glial progenitor cells and impairment of postmitotic neuronal migration, were also observed.

148 E1 and NDEL1 RNAi have comparable effects on postmitotic neuronal migration.

149 highlight the role of heterochronic genes in postmitotic neuronal patterning events.

150 ex formation provides a robust mechanism for postmitotic neuronal subtype specification.

151 etion of lamin B1 in retinal progenitors and postmitotic neurons affects nuclear integrity, leads to

152 ived cells such as terminally differentiated postmitotic neurons and glia must cope with the accumula

153 neural progenitor pool and the production of postmitotic neurons and glia.

154 ne-threonine kinase that is highly active in postmitotic neurons and in many cancers, allows medullob

155 system includes the functional remodeling of postmitotic neurons and the onset of adult-specific beha

156 Its functions in postmitotic neurons are not known.

157 iated with neurodegenerative disease because postmitotic neurons are particularly reliant on the elim

158 but the consequences of genotoxic stress to postmitotic neurons are poorly understood.

159 Postmitotic neurons are subject to a vast array of envir

160 genome editing via HDR is possible in mature postmitotic neurons as well as mitotic cells in mice bra

161 tic neurons not only alters axonal growth of postmitotic neurons but also impairs RGC neurogenesis an

162 Disruption of RA signaling in postmitotic neurons by dominant-negative retinoid recept

163 1 determines multipolar neuron morphology in postmitotic neurons by regulating genes involved in nucl

164 We have now tested this system in postmitotic neurons by targeting two well-characterized

165 They can be differentiated to postmitotic neurons by the addition of tetracycline, gli

166 iple that neuronal identity is maintained in postmitotic neurons by the sustained, and often autoregu

167 Specifically, neighboring postmitotic neurons communicate through Notch signaling

168 st that the persistent expression of CUX2 in postmitotic neurons contributes to the maintenance of ge

169 Depletion of Myt1l in primary postmitotic neurons de-repressed non-neuronal programs a

170 In contrast, specific populations of postmitotic neurons derived from these progenitors, incl

171 us trophic factors signaling pathways during postmitotic neurons differentiation.

172 at it is highly expressed in progenitors and postmitotic neurons during cortical development.

173 utual inhibition among groups of neighboring postmitotic neurons during development regulates the rob

174 ethality, while genetic deletion of Bcl7a in postmitotic neurons elicits motor abnormalities and affe

175 Postmitotic neurons express a neuron-specific assembly,

176 In control mice, postmitotic neurons expressed Mef2a, -c, and -d, whereas

177 n LGE progenitors readily differentiate into postmitotic neurons expressing the striatal projection n

178 During nervous system development, postmitotic neurons face the challenge of generating and

179 nt to rescue, in an isoform-specific manner, postmitotic neurons from defects in differentiation caus

180 CLK-GFP is only detected in postmitotic neurons from L3 larvae, suggesting that thes

181 However, the role of Bif-1 in postmitotic neurons has not been investigated.

182 lls display a developmental phenotype: young postmitotic neurons have smaller cell bodies, more exten

183 Dar1 determines the multipolar morphology of postmitotic neurons in Drosophila.

184 ; its expression persists in a population of postmitotic neurons in the 8-week-old retina.

185 nding, deletion of Bcl-xL selectively in the postmitotic neurons in the brain (Bcl-xL(Nex-Cre)) also

186 Sip1 deletion from all postmitotic neurons in the neocortex results in lack of

187 ble expression of terminal effector genes in postmitotic neurons is controlled by a dynamic relay of

188 The dynamic regulation of DNA methylation in postmitotic neurons is necessary for memory formation an

189 that the role of 5-hydroxymethylcytosine in postmitotic neurons is to functionally demethylate expre

190 pic overexpression of miR-26b in rat primary postmitotic neurons led to the DNA replication and aberr

191 Postmitotic neurons migrate tangentially from the RMTW t

192 Loss of Notch in postmitotic neurons modulates an axon's target choice.

193 s able to process sensory information, young postmitotic neurons must maintain occasional bursts of a

194 The survival of postmitotic neurons needs continuous degradation of cycl

195 ectively, our data suggest that FGFR3 GOF in postmitotic neurons not only alters axonal growth of pos

196 the cell cycle exit and differentiation into postmitotic neurons of NPCs derived from embryonic stem

197 elanogaster SETD1A orthologue is required in postmitotic neurons of the fly brain for normal memory,

198 ly, RNAi-mediated knockdown of En and Inv in postmitotic neurons reduces SEP amplitude but also reduc

199 Postmitotic neurons require microtubules and dynein to m

200 Thus, deletion of La from postmitotic neurons results in defective pre-tRNA and pr

201 rast, loss of Notch in clones of neighboring postmitotic neurons results in erroneous coinnervation b

202 Intriguingly, postmitotic neurons still express DNA methyltransferases

203 hotomous pattern of PKM expression, in which postmitotic neurons throughout the brain expressed the c

204 mitotic stem cell lineages, is reutilized in postmitotic neurons to control postdifferentiation event

205 hese repressors are continuously required in postmitotic neurons to prevent UNC-3, which is active in

206 scratch2 knockdown induces postmitotic neurons to re-enter mitosis.

207 th PAXX and XLF are embryonic lethal because postmitotic neurons undergo massive apoptosis in embryos

208 rized the effects of genome modifications in postmitotic neurons using biochemical, genetic, electrop

209 Specific deletion of paxillin in postmitotic neurons using Nex-Cre-mediated recombination

210 thereby explaining its contrasting effect in postmitotic neurons versus proliferating cell lines.

211 , production of intermediate progenitors and postmitotic neurons were markedly suppressed.

212 dients arise in intermediate progenitors and postmitotic neurons, and are necessary to implement area

213 ism of gene expression regulation in various postmitotic neurons, both over time and in response to e

214 To investigate the function of TET3 in adult postmitotic neurons, we crossed Tet3 floxed mice with a

215 that SIRT1 was rapidly recruited to DSBs in postmitotic neurons, where it showed a synergistic relat

216 lcytosine (5hmC) occurs at maximal levels in postmitotic neurons, where its accumulation is cell-spec

217 ion of the p53 tumor suppressor to reprogram postmitotic neurons, which can result in tumorigenesis o

218 cycle exit, differentiation, and survival of postmitotic neurons.

219 ving the cell cycle and differentiating into postmitotic neurons.

220 nvolved in presynaptic protein expression in postmitotic neurons.

221 volved in expression of synaptic proteins in postmitotic neurons.

222 and promotes differentiation and survival of postmitotic neurons.

223 ronal cells and continues to be expressed in postmitotic neurons.

224 crease of both proliferating progenitors and postmitotic neurons.

225 efficient differentiation of hPS cells into postmitotic neurons.

226 ysis, we identify genes controlled by p53 in postmitotic neurons.

227 ylation states at multiple sites on MeCP2 in postmitotic neurons.

228 ferase 3A (DNMT3A) for active maintenance in postmitotic neurons.

229 stoma cells to induce differentiation toward postmitotic neurons.

230 ural stem cell genes and cell-cycle genes in postmitotic neurons.

231 uired to promote neuronal differentiation of postmitotic neurons.

232 c metabolites and lifelong survival of these postmitotic neurons.

233 vior with age and produce the same number of postmitotic neurons.

234 tion, regulation of cell cycle, and death in postmitotic neurons.

235 l is essential for the long-term survival of postmitotic neurons.

236 are the first to explore KIFC1 in terminally postmitotic neurons.

237 s it challenging to elucidate their roles in postmitotic neurons.

238 ing it challenging to apply the technique in postmitotic neurons.

239 ti-nucleolar effects were most pronounced in postmitotic neurons.

240 cascade that enhances the survival of young postmitotic neurons; and (2) a previously unrecognized R

241 rt that TCF7l2 is upregulated transiently in postmitotic, newly differentiated oligodendrocytes.

242 plasmic transport, spindle organization, and postmitotic nuclear assembly.

243 cting on proliferating progenitors and their postmitotic offspring.

244 different transcription factors to diversify postmitotic olfactory cell types.

245 In vitro Mettl14 ablation disrupts postmitotic oligodendrocyte maturation and has distinct

246 repressor Fezf1 is selectively expressed by postmitotic ON SACs and promotes the ON fate and gene ex

247 The heart is no longer considered a postmitotic organ, but is viewed as a self-renewing orga

248 e mammalian heart has long been considered a postmitotic organ, implying that the total number of car

249 d by H3S10 phosphorylation in differentiated postmitotic osteoblasts and cycling B cells.

250 Our data indicate a crucial role for postmitotic patterning genes in areal specification and

251 virus (AAV)-mediated CRISPR/Cas9 delivery to postmitotic photoreceptors is used to target the Nrl gen

252 Postmitotic podocytes do not have an infinite life span;

253 ication but arose through differentiation of postmitotic precursor cells.

254 rotonin (5-HT) neurons and initially acts in postmitotic precursors to control acquisition of 5-HT tr

255 tch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-

256 Elevating replication stress increases this postmitotic process and delays cytokinetic abscission by

257 C/C controls both cell-cycle progression and postmitotic processes through ubiquitin-dependent proteo

258 tin(+) progenitors that, together with their postmitotic progeny expressing NeuN, comprise tumor bulk

259 reening to uncover markers and regulators of postmitotic progeny.

260 ccelerated cell death, and slow migration of postmitotic progeny.

261 We report that HuR is expressed in postmitotic projection neurons during mouse brain develo

262 p53 accumulation in single cells: an initial postmitotic pulse, followed by low-amplitude oscillation

263 1-positive recycling endosomes in Drosophila postmitotic pupal eye epithelia.

264 erficial layer CPN birth, with a progressive postmitotic refinement in expression, becoming restricte

265 -1 orchestrates maturation through secondary postmitotic regulatory factors.

266 s prompted greater characterization of their postmitotic repertoire of fate determinants, which inclu

267 hat cell fate decisions can be made in newly postmitotic retinal cells, and reveal some of the regula

268 When SoxC genes are deleted in postmitotic RGCs, contralateral RGC axons grow poorly on

269 teins function during dendrite regeneration, postmitotic RNA interference (RNAi) was performed and de

270 del, we report that loss of DICER1 in mature postmitotic rods leads to robust retinal degeneration ac

271 K-pathway via Ras(V12)-overexpression in the postmitotic salivary glands (SGs) of Drosophila larvae,

272 ing of sexually dimorphic differentiation of postmitotic, sex-shared neurons in the nervous system of

273 sible early, at embryonic (E) 10.5, when few postmitotic SF1 neurons have been born, suggesting that

274 Neurons are postmitotic, so it was surprising to identify transcript

275 served HMG-box transcription factor SOX-2 in postmitotic specification and alternative differentiatio

276 teristics of neurons following their initial postmitotic specification.

277 ), which is restricted to VTA neurons at the postmitotic stage and selectively controls the neurogene

278 coincides with wing cells entering a robust postmitotic state that is strongly refractory to cell cy

279 Neurons live for decades in a postmitotic state, their genomes susceptible to DNA dama

280 related to terminal cell differentiation and postmitotic state.

281 ent exit from the cell cycle and arrest in a postmitotic state.

282 lea, like most neuronal populations that are postmitotic, terminally differentiated, and non-regenera

283 s not occupy the p53RE(rpr) enhancer in this postmitotic tissue as it does in embryos.

284 beginning is a proven strategy to ameliorate postmitotic tissue degeneration.

285 iew redox paracrine signalling mechanisms in postmitotic tissue regeneration and discuss current chal

286 Skeletal muscle is a highly specialized, postmitotic tissue that must withstand chronic mechanica

287 Postmitotic tissues are incapable of replacing damaged c

288 Their high efficiency of transduction of postmitotic tissues in vivo, such as heart, brain, and r

289 oprecipitation-seq studies of developing and postmitotic tissues, we further determined that p53 regu

290 n, however, about this homeostasis system in postmitotic tissues, where tissue-intrinsic genetic prog

291 l with recent findings showing senescence in postmitotic tissues, wound healing, obesity, and develop

292 accumulation of mtDNA multiple deletions in postmitotic tissues.

293 of pluripotent stem cells with remodeling of postmitotic tissues.

294 Furthermore, we found that the postmitotic transcription factor, Sim1, although express

295 s timing can modulate the functions of early postmitotic transcription factors and, thus, subpopulati

296 (Sox4, 11, and 12) act on the progenitor-to-postmitotic transition to implement contralateral, but n

297 Types I-III; and basally situated, immature postmitotic type, Type IV cells.

298 CEACAM6-expressing cells remain essentially postmitotic under conditions in which the other cells of

299 SG1 likely represents a postmitotic unresponsive "resting" population.

300 transcription factor, which is expressed in postmitotic V3 INs.