ライフサイエンスコーパス: postreceptor

1 beta-adrenergic receptor downregulation and postreceptor abnormalities.

2 y related, share receptors, and have similar postreceptor actions.

3 and saturated amplitude of photoreceptor and postreceptor activity were derived from ERG a- and b- wa

4 eared, implying leptinergic blockade at both postreceptor and receptor levels.

5 Ps), representing activity in photoreceptor, postreceptor, and inner retinal cells, respectively.

6 In this study, we elucidated the postreceptor attachment stages of HCV entry using HCV ps

7 ffect of MnCl(2) on photoreceptor a-wave and postreceptor b-wave relative to baseline at either obser

8 clustering, and distinguish these from later postreceptor binding events such as changes in cell shap

9 ARS-S may interfere with other early pre- or postreceptor-binding events necessary for efficient vira

10 In contrast, ion demand of central postreceptor, but not receptor, retina was significantly

11 patterns of expression and activation of the postreceptor components of the TGF-beta signaling pathwa

12 dies implicate increased cGMP synthesis as a postreceptor contributor to reduced cardiac sympathetic

13 lpha, and IL-2 on the beta-adrenoceptor- and postreceptor-coupled transmembrane signaling mechanisms

14 prehypertensive SHR kidneys the receptor or postreceptor defect causing impaired AT(2)R signaling an

15 In contrast, humans with a selective postreceptor defect in AKT2 manifest increased lipogenes

16 In conclusion, CRF causes a postreceptor defect in GH signal transduction characteri

17 mice, it has been proposed that a selective postreceptor defect in hepatic insulin action is central

18 we found that (1). HCV infection leads to a postreceptor defect in IRS-1 association with the IR and

19 This postreceptor defect may be a cause of the skeletal muscl

20 These postreceptor defects in insulin signaling may contribute

21 and lusitropic responses, thus demonstrating postreceptor defects.

22 ta suggest that there are multiple levels of postreceptor desensitization to insulin action.

23 nic overstimulation of this pathway leads to postreceptor desensitization, indicating the critical ba

24 by such pathways has been modeled in detail, postreceptor down-regulation is less well understood.

25 hreshold is due to photoreceptor rather than postreceptor dysfunction.

26 hat impaired biological activity is due to a postreceptor effect.

27 Immediate postreceptor events activated by IL-1-IL-1R interaction

28 malignancies; however, less is known of the postreceptor events important to TNF action in endotheli

29 lex are used to propose a model of the early postreceptor events in Drosophila Toll receptor signalin

30 sensitive Ca2+ channels, one of the earliest postreceptor events in ET-1 signaling, mediated inductio

31 L-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma produ

32 inhibition of DNA synthesis is likely due to postreceptor events.

33 addition suggests that the synergy involves postreceptor events.

34 ce were associated with a virtual absence of postreceptor function.

35 s of insulin resistance suggest that partial postreceptor hepatic insulin resistance is a key element

36 reduced in muscle of IRMOE mice, indicating postreceptor insulin resistance.

37 xosamine pathway may directly modulate early postreceptor insulin signal transduction, perhaps via po

38 lic effects were paralleled by inhibition of postreceptor insulin signaling critical for glucose tran

39 These alterations in postreceptor insulin signaling were time-dependent and p

40 Alterations in postreceptor insulin signaling, therefore, may be respon

41 scaffold and possibly affect the balance of postreceptor insulin signaling.

42 e oxygen species (ROS) are key components of postreceptor intracellular signaling pathways; however,

43 spatial and temporal links with receptor and postreceptor ion demand.

44 y of severe receptor IR (INSR, n = 7) versus postreceptor IR that was severe (lipodystrophy, n = 14),

45 In contrast, in postreceptor IR, FFA contributes to both gluconeogenesis

46 ailability to the liver in both receptor and postreceptor IR.

47 In 6 days of a HFD, mRNA of the postreceptor leptin inhibitor, suppressor of cytokine si

48 activities of signaling intermediates at the postreceptor level account for smoking-induced immunosup

49 ity stimulated at either the receptor or the postreceptor level and (2) does not affect agonist-induc

50 decreases in NMDA receptor signaling at the postreceptor level and propose Src as a nodal point of c

51 ance in the majority of patients lies at the postreceptor level of insulin signaling.

52 ng achieves an equivalent integration at the postreceptor level through adaptor protein complexes, in

53 Such disruption could occur at the postreceptor level, because chronic DAMGO also reduced G

54 At the postreceptor level, however, we found striking reduction

55 se, GIV serves as a key hub in the immediate postreceptor level, which coordinately enhances the meta

56 ERF1 inhibitory effects on ERK1/2 occur at a postreceptor locus.

57 hotoreceptor (S(rod), R(rod)) and rod-driven postreceptor (log sigma, V(max)) response parameters wer

58 ing that PDGFs increase binding avidity by a postreceptor mechanism.

59 esponses mediated by them due to a defect in postreceptor mechanisms of PLC activation.

60 n this process, much less is known about the postreceptor mechanisms that influence G-protein activit

61 hronic opiate treatment alters receptor- and postreceptor-mediated adenylyl cyclase activity.

62 kt enhances micro-opioid desensitization via postreceptor modifications that interfere with G-protein

63 tinal thinning, supporting the hypothesis of postreceptor neural loss.

64 s and (ii) an alteration of events following postreceptor occupancy (e.g., cell spreading).

65 LIBS have been suggested to contribute to postreceptor occupancy events such as full-scale platele

66 rized the impact of these mutations on three postreceptor pathways involving inhibition of cAMP synth

67 F both require drug binding to the DHPR, but postreceptor pathways may diverge in transmission to the

68 transcription in B lymphocytes; however, the postreceptor pathways that regulate CREB activity and CR

69 mations in CCR2 that are coupled to separate postreceptor pathways.

70 lin receptor signaling and serves as a novel postreceptor regulator of metabolic and behavioral activ

71 f 19-norD(2) seems to be due to an acquired, postreceptor resistance of the intestine and bone to chr

72 Rod-driven postreceptor response amplitude (V(MAX)) and sensitivity

73 se receptor level effects were paralleled by postreceptor responses.

74 Manganese ion uptake by receptor and postreceptor retina was subnormal in each untreated diab

75 mfERG responses represent postreceptor retinal activity.

76 rated photoresponse amplitude) and anomalous postreceptor retinal circuitry.

77 This study supports the concept of postreceptor retinal neuronal loss as a contributor to r

78 3-month-old diabetic male SD rats, total and postreceptor retinal thickness increased (P < 0.05) with

79 As part of a broader effort to identify postreceptor signal regulators involved in specific dise

80 by exogenous IL-6, suggesting that the IL-6 postreceptor signal transduction remained intact.

81 r and molecular neurobiology (in particular, postreceptor signal transduction) as well as to a better

82 d not adversely impact receptor or immediate postreceptor signaling as determined by tyrosyl phosphor

83 We studied postreceptor signaling by these HGF isoforms in the huma

84 Postreceptor signaling events that lead to stress respon

85 eptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed through

86 However, the precise postreceptor signaling pathways and specific roles playe

87 differentiation, and defined three distinct postreceptor signaling pathways important for this effec

88 ecrosis factor-alpha, modify the endothelial postreceptor signaling pathways of NPs, with downregulat

89 tion of beta-adrenergic receptors, depressed postreceptor signaling pathways, impaired calcium libera

90 tion drives the production of adaptations in postreceptor signaling pathways, including regulation of

91 sequencing reveals downregulation of several postreceptor signaling proteins that contribute to this

92 Postreceptor signaling through the insulin receptor subs

93 A role of RGS3 in postreceptor signaling was demonstrated by decreased cal

94 ite normal insulin receptor phosphorylation, postreceptor signaling was reduced and was correlated wi

95 atter is believed to be the sole conduit for postreceptor signaling.

96 eins into multiprotein complexes involved in postreceptor signaling.

97 receptor activation and the transduction of postreceptor signals.

98 ein activation or cAMP formation, implying a postreceptor site of action.

99 rotean agonism and begin to define the first postreceptor step in actions of protean agonist ligands.

100 gnaling pathway bifurcates at the very first postreceptor step, the G protein level.

101 lular alterations leading to this effect are postreceptor steps in insulin signaling.

102 sphorylation of the insulin receptor and its postreceptor substrates are essential determinants of in

103 After ouabain injection, receptor and postreceptor uptake of manganese were subnormal (P < 0.0

104 on, mean scotopic photoreceptor (R(rod)) and postreceptor (V(max) and SOPA(max)) amplitude parameters

105 D), S(ROD), R(CONE), S(CONE)) and rod-driven postreceptor (V(MAX), log sigma) response parameters wer