ライフサイエンスコーパス: postsynaptic receptor

1 , whereas the D2 long isoform is primarily a postsynaptic receptor.

2 transmitter, and they establish ASICs as the postsynaptic receptor.

3 which two neurotransmitters act on the same postsynaptic receptor.

4 a reduction of available functional GABA(A) postsynaptic receptors.

5 presynaptic mechanisms or saturation of the postsynaptic receptors.

6 ed and the manner by which it interacts with postsynaptic receptors.

7 utamate transients and from the diversity of postsynaptic receptors.

8 n the synapse with a resultant activation of postsynaptic receptors.

9 that the transmitters can activate the same postsynaptic receptors.

10 g neurotransmitters produce their effects on postsynaptic receptors.

11 ke of neurotransmitter efficiently activates postsynaptic receptors.

12 portionally through changes in the number of postsynaptic receptors.

13 scape the cleft and activate presynaptic and postsynaptic receptors.

14 es, in part because they likely contain more postsynaptic receptors.

15 acts on, and can be photoincorporated into, postsynaptic receptors.

16 a vesicle is much larger than the number of postsynaptic receptors.

17 amate release may lead to desensitization of postsynaptic receptors.

18 transmitter release or increased opening of postsynaptic receptors.

19 ther unitary packets of transmitter saturate postsynaptic receptors.

20 se to direct iontophoresis of glutamate onto postsynaptic receptors.

21 and/or a reduction of the desensitization of postsynaptic receptors.

22 has a potent effect at both presynaptic and postsynaptic receptors.

23 ly segregated and pharmacologically distinct postsynaptic receptors.

24 ration profile of neurotransmitter acting on postsynaptic receptors.

25 e presynaptic plasma membrane and opposed to postsynaptic receptors.

26 operating on a separate functional group of postsynaptic receptors.

27 of synaptic vesicles, or desensitization of postsynaptic receptors.

28 ing postsynaptic signals upon recognition by postsynaptic receptors.

29 tic plasticity elicited by acute blockage of postsynaptic receptors.

30 ed synapse-organizing molecule that clusters postsynaptic receptors.

31 ion of dendritic proteins, including several postsynaptic receptors.

32 nectivity and the localization of inhibitory postsynaptic receptors.

33 lease is assumed to activate the same set of postsynaptic receptors.

34 ite; and (2) the GluR4 AMPA receptors as the postsynaptic receptors.

35 vesicle mobilization and by the response of postsynaptic receptors.

36 eHg on transmitter release or sensitivity of postsynaptic receptors.

37 n composition and functional contribution of postsynaptic receptors.

38 y to release glutamate and on the density of postsynaptic receptors.

39 l release events engage a high proportion of postsynaptic receptors (62%), revealing a larger compone

40 This increase in postsynaptic receptor abundance is not accompanied by ot

41 on and stabilization, synaptic transmission, postsynaptic receptor abundance, axonal degeneration and

42 transmission depends, to a large extent, on postsynaptic receptor abundance.

43 ransmitter released, as well as the class of postsynaptic receptors activated by their firing remain

44 what is known about glutamate signaling and postsynaptic receptor activation is based on experiments

45 concentration time course and ensuring that postsynaptic receptor activation remains brief and prima

46 le biogenesis, neurotransmitter release, and postsynaptic receptor activation.

47 ant deficits in evoked, but not spontaneous, postsynaptic receptor activation.

48 , consequently, the duration and location of postsynaptic receptor activation.

49 including presynaptic vesicle tethering and postsynaptic receptor aggregation.

50 re there is a high probability of opening of postsynaptic receptors, all of which are occupied by the

51 the context of years of work characterizing postsynaptic receptor and signaling functions of learnin

52 elopmental stages occurs independent of both postsynaptic receptor and synaptic responses in zebrafis

53 Thus, both postsynaptic receptor and transmitter release properties

54 tine, but not muscarinic agonists, activates postsynaptic receptors and a depolarizing inward current

55 naptic function through its interaction with postsynaptic receptors and adhesion molecules.

56 s function like high efficacy agonists at D2 postsynaptic receptors and autoreceptors (i.e., tergurid

57 at released neurotransmitter acts locally on postsynaptic receptors and is cleared from the synaptic

58 ic plasticity: changes in both the number of postsynaptic receptors and loading of synaptic vesicles

59 s responsible for limiting the activation of postsynaptic receptors and maintaining low levels of amb

60 antagonist-like effects at normosensitive D2 postsynaptic receptors and synthesis modulating autorece

61 ntent is increased, yet the abundance of the postsynaptic receptors and the amplitude of miniature ex

62 tamate spillover to adjacent presynaptic and postsynaptic receptors and the consequent induction of p

63 In the vSt, 5-HT1A (a postsynaptic receptor) and 5-HT1B (a presynaptic recepto

64 e volume, ultrafast fusion pore closure, the postsynaptic receptor, and the location between release

65 neous trains, do not require the function of postsynaptic receptors, and are all-or-none overshooting

66 modulation of striatal inputs is mediated by postsynaptic receptors, and that of globus pallidus-evok

67 s, relative placement of fusing vesicles and postsynaptic receptors, and the rate of release of gluta

68 ary to delineate the exact properties of the postsynaptic receptors, and their role in transmission a

69 wo that antagonize excitatory and inhibitory postsynaptic receptors, and two that allosterically pote

70 pecific vesicular trafficking route taken by postsynaptic receptors appears to depend on the stimulus

71 in the mammalian brain, in which the primary postsynaptic receptors are alpha-bungarotoxin-sensitive

72 or chick ciliary ganglion neurons, where the postsynaptic receptors are concentrated on somatic spine

73 Neuropeptides acting on pre- and postsynaptic receptors are coreleased with GABA by inter

74 r PNMT-containing dendrites, suggesting that postsynaptic receptors are more readily available for li

75 n synaptic physiology is the extent to which postsynaptic receptors are saturated by the neurotransmi

76 It is not well understood how postsynaptic receptors are selectively enriched in dendr

77 e agonistic effects of terguride at pre- and postsynaptic receptors are short-lived, but terguride ma

78 bitory synapses with large and gephyrin-rich postsynaptic receptor areas are likely indicative of hig

79 Quinpirole acted on postsynaptic receptors as it reversed the reduced prolif

80 IPSG neither by changing the sensitivity of postsynaptic receptors, as tested by iontophoretically e

81 cells might be presynaptic autoreceptors or postsynaptic receptors at afferent or efferent synapses.

82 receptors of a putative efferent system, or postsynaptic receptors at synapses with other taste cell

83 ity can determine the subunit composition of postsynaptic receptors at this synapse.

84 ow clearance of glutamate is likely to limit postsynaptic receptor availability through desensitizati

85 blocks fast IPSCs by acting directly on the postsynaptic receptors, because it reduces the amplitude

86 covered from restricting-type AN, the 5-HT1A postsynaptic receptor binding in mesial temporal and sub

87 Homeostatic potentiation induced by postsynaptic receptor block mirrored octopamine-induced

88 Tetrodotoxin (TTX), but not postsynaptic receptor blockade, reversed depolarization-

89 during train stimulation in the presence of postsynaptic receptor blockers.

90 y, focusing on the assembly of C1ql1 and its postsynaptic receptor brain-specific angiogenesis inhibi

91 nically blocking action potential firing and postsynaptic receptors but was markedly reduced on DG de

92 d not be totally eradicated, suggesting that postsynaptic receptor changes may also play a role in th

93 ariability were considered: stochasticity of postsynaptic receptors ("channel noise"), variations of

94 ng the role of the loss of responsiveness of postsynaptic receptor channels to neurotransmitter owing

95 eneral anesthetics exert their action on the postsynaptic receptor channels.

96 lts in rapid and near-synchronous opening of postsynaptic receptor channels.

97 ations between presynaptic release sites and postsynaptic receptor/channels.

98 or, and the location between release and the postsynaptic receptor cluster at glutamatergic, calyx of

99 in this model precede structural changes on postsynaptic receptor cluster density.

100 We concluded that postsynaptic receptor cluster dissolution seemed more di

101 er distance between the release site and the postsynaptic receptor cluster.

102 he effects of long-term synaptic blockade on postsynaptic receptor clustering at central inhibitory g

103 Postsynaptic receptor clustering is induced in a highly

104 Postsynaptic receptor clustering is thought to be of cri

105 We propose that presynaptic terminals induce postsynaptic receptor clustering through the action of b

106 bute to efficient recruitment of gephyrin to postsynaptic receptor clusters and are essential for res

107 tic neurofilament bundles do not overlap the postsynaptic receptor clusters but do codistribute with

108 tory interneurons) were also associated with postsynaptic receptor clusters of variable shapes and co

109 presynaptic specializations, align them over postsynaptic receptor clusters, and increase synaptic fu

110 of synaptic vesicles in nerve terminals and postsynaptic receptor clusters.

111 alcium entry, of presynaptic release, and of postsynaptic receptors combine to produce a postsynaptic

112 uts onto Pyr and FS neurons also differed in postsynaptic receptor composition and organization of pr

113 cells is developmentally regulated, with the postsynaptic receptor composition established during syn

114 lts demonstrate precise input specificity of postsynaptic receptor composition via differential activ

115 SC responses are thought to be determined by postsynaptic receptor composition.

116 cellular synaptic scaffold that controls the postsynaptic receptor content.

117 demonstrating that both GABA(A) and GABA(B) postsynaptic receptors contribute to seizure-induced enh

118 azide (CTZ) revealed that desensitization of postsynaptic receptors contributed to synaptic depressio

119 C to accumbens shell and local dopamine D(1) postsynaptic receptors contributes to context-induced re

120 ease in conductance and number of functional postsynaptic receptors contributing to single quanta.

121 c inputs to shape the subunit composition of postsynaptic receptors could be an important mechanism f

122 Therefore, reductions in postsynaptic receptor density and compromised presynapti

123 of muscle cells and thus the maintenance of postsynaptic receptor density and synaptic function.

124 Our findings indicate that the reduced postsynaptic receptor density resulting from defective r

125 astoid muscles with shRNA, we found that the postsynaptic receptor density was dramatically reduced,

126 in quantal efficacy associated with reduced postsynaptic receptor density.

127 s) is critical for the maintenance of a high postsynaptic receptor density.

128 een neighboring synapses, thereby minimizing postsynaptic receptor desensitization and improving sens

129 lls (HBC(R)s) in the salamander retina evade postsynaptic receptor desensitization by using (1) multi

130 ime how a tonic glutamatergic synapse avoids postsynaptic receptor desensitization, a strategy that m

131 didate mechanisms including neuromodulation, postsynaptic receptor desensitization, and use-dependent

132 n unitary quantal size, which was not due to postsynaptic receptor desensitization.

133 y was increased, suggesting that it reflects postsynaptic receptor desensitization.

134 junction (NMJ) in vivo, where an increase in postsynaptic receptors does not contribute.

135 , and direct neurotransmitter release toward postsynaptic receptor domains.

136 ransmitter neurons extends beyond actions on postsynaptic receptors, due in part to differential spat

137 glutamate is a strong negative regulator of postsynaptic receptor field size and function during dev

138 onsible for initiation or maintenance of the postsynaptic receptor field.

139 dulation of the presynaptic active zones and postsynaptic receptor fields mediating synaptic function

140 on that prevents activity-induced changes in postsynaptic receptor fields.

141 (2) What is the occupancy of postsynaptic receptors following the release of a synapt

142 onstrains DA availability at presynaptic and postsynaptic receptors following vesicular release and i

143 GABAA receptors (GABAARs), the main postsynaptic receptors for GABA, have been recently demo

144 additionally function in the mature brain as postsynaptic receptors for presynaptic neurexin/Cbln4 co

145 perates through an increase in the number of postsynaptic receptors for the excitatory neurotransmitt

146 Postsynaptic receptors formed alpha1/beta-containing clu

147 rmally triggered as a result of reduction in postsynaptic receptor function at the Drosophila larval

148 her in retrograde signaling or in regulating postsynaptic receptor function or both, contribute to LT

149 btypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivit

150 in neurotransmitter release probability and postsynaptic receptor function, remodeling of GABAergic

151 lity, Ca2+-triggered presynaptic release, or postsynaptic receptor functions.

152 concentrations of GABA can both activate the postsynaptic receptors generating sustained low-amplitud

153 presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2 mediate synaptogenesis betwe

154 nsmitter diffusion and its interactions with postsynaptic receptors have been used to study propertie

155 derstanding the ensembles recruited by these postsynaptic receptors (heteroceptors) is necessary to u

156 on of DA synthesis-a possible consequence of postsynaptic receptor hypersensitivity, or increased ext

157 s to distinct sites within the MBs as both a postsynaptic receptor in Kenyon cells and a presynaptic

158 sts (e.g., terguride) may not affect D2-like postsynaptic receptors in an adult-typical manner during

159 it contribution in the molecular assembly of postsynaptic receptors in cerebellar glomeruli is respon

160 mission such as presynaptic transporters and postsynaptic receptors in living human brains.

161 d subunit composition of GABA(A) and glycine postsynaptic receptors in one example of gephyrin-rich s

162 ) in the terminals of nociceptors as well as postsynaptic receptors in spinal neurons regulate the tr

163 g between neurotransmitter release sites and postsynaptic receptors in synaptic transmission.

164 olves presynaptic protein kinases as well as postsynaptic receptor insertion.

165 tamate receptor field, and that the level of postsynaptic receptors is closely dependent on presynapt

166 The maintenance of a high density of postsynaptic receptors is essential for proper synaptic

167 The spatial organization of postsynaptic receptors is likely to determine many funct

168 ntaneous release, indicating a population of postsynaptic receptors is uniquely activated by this mod

169 for the tonic current changes and can affect postsynaptic receptor kinetics with a loss of paired-pul

170 Thus, a decrease in postsynaptic receptors leads to an increase in presynapt

171 r a potential link between AChE function and postsynaptic receptor lifetime.

172 aptosomes showed two types (type A and B) of postsynaptic receptor-like particles at resolutions of 2

173 Postsynaptic receptor localization is crucial for synaps

174 initial step in synapse disassembly involves postsynaptic receptor loss rather than dendritic retract

175 The presynaptic and postsynaptic receptors may prove to be future targets in

176 ty to alpha3-nAChR targeting due to a unique postsynaptic receptor microheterogeneity - under one pre

177 We demonstrate a unique postsynaptic receptor microheterogeneity on chick parasy

178 mechanisms underlying the establishment of a postsynaptic receptor mosaic on CNS neurons are poorly u

179 al motoneuron soma number or in serotonergic postsynaptic receptor mRNA copy numbers within single-ce

180 that during an IPSC, a substantial number of postsynaptic receptors must be exposed to subsaturating

181 nhibition is determined by the properties of postsynaptic receptors, neurotransmitter release, and cl

182 The heated debate over the level of postsynaptic receptor occupancy by transmitter has not b

183 We conclude that the level of postsynaptic receptor occupancy can depend on the probab

184 In contrast, mGluR1a appears to be a postsynaptic receptor of neurons in the neostriatum, glo

185 might be autoreceptors at afferent synapses, postsynaptic receptors of a putative efferent system, or

186 that an increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses

187 synapse, ELFN1 binds in trans to mGluR6, the postsynaptic receptor on rod ON-bipolar cells.

188 ed by enhancement of release, enhancement of postsynaptic receptors, or both.

189 revealed that endocytosis and exocytosis of postsynaptic receptors play a major role in the regulati

190 d, and these switches require changes in the postsynaptic receptor population.

191 resynaptic vesicular release of transmitter, postsynaptic receptor populations and clearance/inactiva

192 ptic release probability, demonstrating that postsynaptic receptor properties can contribute to facil

193 remaining axon did not reoccupy a site, the postsynaptic receptors rapidly disappeared.

194 three classes may reflect different types of postsynaptic receptor rather than dendritic location.

195 dominant interactors play important roles in postsynaptic receptor recycling.

196 Whether postsynaptic receptors regulate stabilization of presyna

197 tracellular neurexin-cerebellin signals into postsynaptic receptor responses.

198 Postsynaptic receptor saturation also accelerates recove

199 2+) influx, initial release probability, and postsynaptic receptor saturation and desensitization.

200 These findings establish that MVR and postsynaptic receptor saturation can influence transmiss

201 Thus, postsynaptic receptor saturation interacts with presynap

202 the univesicular release constraint and the postsynaptic receptor saturation lead to a limited amoun

203 We find that postsynaptic receptor saturation makes it difficult to d

204 As MVR increases the likelihood of postsynaptic receptor saturation, it is of interest to c

205 e in excitatory neurons was accounted for by postsynaptic receptor saturation.

206 easable vesicle per active zone, and (3) the postsynaptic receptor saturation.

207 ltivesicular release (MVR) in the absence of postsynaptic receptor saturation.

208 mechanisms of neurotransmitter exocytosis or postsynaptic receptor sensitivity did not contribute to

209 ltiple low-probability release sites, robust postsynaptic receptor sensitivity, and efficient transmi

210 ue to increased dopamine release or enhanced postsynaptic receptor sensitivity.

211 correlated with compensatory adaptations of postsynaptic receptor sensitivity.

212 ction may serve as an important modulator of postsynaptic receptor sensitivity.

213 ns to control muscle cells, without altering postsynaptic receptor sensitivity.

214 Surface diffusion of postsynaptic receptors shapes synaptic transmission.

215 ce a relatively low concentration of GABA at postsynaptic receptors, similar to slow IPSCs in mature

216 of schizophrenia involves blocking dopamine postsynaptic receptor sites, the authors investigated th

217 lso tested the hypothesis that variations in postsynaptic receptor subtype distribution between speci

218 ortical neurons as a result of variations in postsynaptic receptor subtypes as well as the types of n

219 e is controlled by the type of glutamatergic postsynaptic receptor that is expressed on their dendrit

220 male mice results in part from GIRK2-coupled postsynaptic receptors that are activated by endogenous

221 cation requires the expression of functional postsynaptic receptors that match the presynaptically re

222 acts as a negative regulator of its cognate postsynaptic receptor to sculpt receptor field size.

223 em, moment-to-moment communication relies on postsynaptic receptors to detect neurotransmitters and c

224 eptors to regulate synaptic transmission and postsynaptic receptors to hyperpolarize neurons.

225 The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic neurotran

226 Postsynaptic receptor trafficking plays an essential rol

227 ransmission, synaptic plasticity and impairs postsynaptic receptor trafficking.

228 l reference, and smaller contacts with fewer postsynaptic receptors were also modeled.

229 At birth postsynaptic receptors were localized in irregular patch

230 hitecture, and the densities of synapses and postsynaptic receptors were normal at the neuromuscular

231 rally insufficient to activate all available postsynaptic receptors, whereas the sum of transmitter f

232 involves changes in the number of responding postsynaptic receptors, which are dynamically recruited

233 onses is determined by the scatter of target postsynaptic receptors, which in turn depends on recepto

234 involves crosstalk between NMDA and GABA(A) postsynaptic receptors, whose strength is controlled by

235 quires activation of NMDA-type and AMPA-type postsynaptic receptors within the abdominal ganglion, be

236 5, suggesting a high response probability of postsynaptic receptors, without an unusually high releas