ライフサイエンスコーパス: posttranslational

1 ed by neurodegeneration-causing mutations or posttranslational acetylation in its RNA recognition mot

2 mammalian NF-kappaB p100 proteins, and their posttranslational activation appears to have aspects of

3 -generating enzyme (FGE) is required for the posttranslational activation of type I sulfatases by oxi

4 ynthesized as inactive protoxins and undergo posttranslational acylation on epsilon-amino groups of t

5 Viral macrodomains, enzymes that remove posttranslational ADP-ribosylation of proteins, and vira

6 tural applications, but key details of their posttranslational biosynthesis have remained elusive.

7 s, should enable the design of sophisticated posttranslational control logic over a wide range of bio

8 r tuning this balance, but the mechanisms of posttranslational control of RUNX2 remain to be fully el

9 at exert transcriptional, translational, and posttranslational control over the nighttime O(2) consum

10 ing surface TfR1 may represent an additional posttranslational control to prevent iron overload.

11 ELK-1 is subject to multiple levels of posttranslational control, including phosphorylation, SU

12 Whereas the posttranslational Cti regulation has been previously rep

13 Gram-negative bacteria have evolved diverse posttranslational defense mechanisms to protect their pr

14 number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadi

15 bohydrates, termed "glycans," are ubiquitous posttranslational effectors that can tune cancer progres

16 otential of plant-based systems for multiple posttranslational engineering and production of fully ac

17 y O-GlcNAc transferase (OGT), is an abundant posttranslational event essential for proper animal deve

18 cellular reductases that possess a conserved posttranslational flavinylation modification.

19 However, the molecular players involved in posttranslational FOXP3 regulation are just beginning to

20 Unintegrated DNAs were marked by posttranslational histone modifications characteristic o

21 active TSSs, suggesting an ancient role for posttranslational histone modifications in transcription

22 ltimately linked to cancer development, with posttranslational histone modifications representing att

23 tance chromatin remodeling, DNA methylation, posttranslational histone modifications, and involvement

24 protein complex (EMC) is a conserved co- and posttranslational insertase at the ER.

25 ed that YohP engages an unique SRP-dependent posttranslational insertion pathway that is likely prece

26 Our data indicate that posttranslational KCC2 regulation controls the GABAergic

27 ells (U2OS) and also stabilizes UNC5B at the posttranslational level.

28 , we discovered a novel effect of miR-298 on posttranslational levels of two specific tau moieties.

29 an be controlled at both transcriptional and posttranslational levels.

30 s at the transcriptional, translational, and posttranslational levels.

31 so referred to as S-acylation), a reversible posttranslational lipid modification of proteins, in reg

32 ovided the framework to characterize dynamic posttranslational lipid modifications of proteins in the

33 Mechanistically, hresistin promoted HMGB1 posttranslational lysine acetylation by preserving the N

34 ation of H3K4me3 and H3K27me3, two chromatin posttranslational marks that are subject to removal by s

35 srupts cotranslational folding and imposes a posttranslational mechanism on the folding of the C-term

36 is and exodermis, suggesting the presence of posttranslational mechanisms controlling the abundance o

37 Post-transcriptional or posttranslational mechanisms have been proposed to contr

38 ed MYC loss through both transcriptional and posttranslational mechanisms, and suppresses PDAC anchor

39 n endothelial cells, is regulated by complex posttranslational mechanisms.

40 negatively regulated by transcriptional and posttranslational mechanisms.

41 nges in IGF2R mRNA levels, indicating likely posttranslational mechanisms.

42 and its receptor FtsY are essential for the posttranslational membrane insertion of YohP by either t

43 Therefore, posttranslational methylation of flagellin facilitates a

44 igurational entropy), have multiple sites of posttranslational modification (e.g., tyrosine phosphory

45 PRC2 catalyzes a specific histone posttranslational modification (hPTM) that fosters chrom

46 we identified that O-GlcNAcylation, a unique posttranslational modification (PTM) involved in cancer

47 This posttranslational modification (PTM) is catalyzed by Rad

48 osylation, the nitric oxide (NO(*))-mediated posttranslational modification (PTM) of cysteine thiols

49 As such, the incorporation of this posttranslational modification (PTM) or mimics thereof i

50 Assessing posttranslational modification (PTM) patterns within pro

51 ntify the highly reversible, stress-induced, posttranslational modification (PTM) protein S-nitrosyla

52 e binding of ATAD2, a bromodomain-containing posttranslational modification (PTM) reader that recogni

53 Protein-lysine methylation is a common posttranslational modification (PTM) throughout the huma

54 ibosylation, a highly conserved, fundamental posttranslational modification (PTM).

55 is used to improve quantitative accuracy for posttranslational modification analysis.

56 els of genes associated with translation and posttranslational modification and chaperones and reduct

57 This posttranslational modification and cis regulation of PRC

58 Our studies of mutant protein posttranslational modification and localization indicate

59 -associated membranes (MAMs), is involved in posttranslational modification and protein folding, and

60 region of Ras isoforms underlie differential posttranslational modification and subcellular trafficki

61 rmal instability, interfering with efficient posttranslational modification and subsequent receptor s

62 Poly(ADP-ribose) a dynamic and reversible posttranslational modification and the enzymes that cata

63 of histone H3K23 has emerged as an essential posttranslational modification associated with cancer an

64 Effects of glucose and the posttranslational modification by beta-linked N-acetylgl

65 (using A549-UBA7(-/-) cells) confirmed that posttranslational modification by ISG15 (ISGylation) is

66 samine biosynthetic pathway leads to protein posttranslational modification by O-linked beta-N-acetyl

67 Here we show that TCR-activated posttranslational modification by O-linked N-Acetylgluco

68 Our data reveal a role for posttranslational modification by Pro hydroxylation in t

69 his study reveals that PKD2 channels undergo posttranslational modification by SUMO1, which enables p

70 ADP-ribosylation is a unique posttranslational modification catalyzed by poly(ADP-rib

71 n)-acetylation of lysyl residues and how the posttranslational modification changes the cellular phys

72 Here, we show that SUMOylation, a posttranslational modification characterized by covalent

73 Acetylation is a posttranslational modification conserved in all domains

74 Ubiquitinylation is a well-known posttranslational modification controlling cell-cycle tr

75 A deeper understanding of the here-described posttranslational modification cross talk may lay the gr

76 phorylation at Ser-632, pointing to a mutual posttranslational modification cross talk of (cardio-det

77 suppressed by alpha-tubulin detyrosination-a posttranslational modification enriched on long-lived mi

78 (K13) residue and that we could detect this posttranslational modification in a heterologous experim

79 mitoylation, a form of S-acylation, is a key posttranslational modification in cellular signaling.

80 l 4-hydroxylase (P4H), is the most prevalent posttranslational modification in humans and requires vi

81 ography-mass spectrometry, we studied APOE's posttranslational modification in L5 from human plasma.

82 to further interrogate the function of this posttranslational modification in the assembly of replic

83 The role of this posttranslational modification in the formation of virop

84 symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in oncogenesis a

85 identify asparagine hydroxylation as a novel posttranslational modification involved in the regulatio

86 P-ribosylation is an intricate and versatile posttranslational modification involved in the regulatio

87 are phosphorylated by host kinases, and this posttranslational modification is important for their ac

88 One reversible posttranslational modification is S-acylation, involving

89 The net result of this posttranslational modification is to render a viral prot

90 itional layer of control toward ORE1 via its posttranslational modification linked to the calcium-reg

91 y of RIPK1 is tightly controlled by multiple posttranslational modification mechanisms, including ubi

92 A compelling link is emerging between the posttranslational modification O-GlcNAc and protein aggr

93 We identified a novel posttranslational modification of 53BP1 by ADP-ribosylat

94 ains from AD patients; thus, it represents a posttranslational modification of AKT, which primarily c

95 Posttranslational modification of ApoE did not alter C1q

96 Mechanistically, the posttranslational modification of HDAC4 at serine (Ser)-

97 regulation by epigenetic mechanisms, such as posttranslational modification of histone proteins.

98 Peptidylarginine deiminases (PADI) catalyze posttranslational modification of many target proteins a

99 , modulated transcriptional upregulation and posttranslational modification of microglial Kv1.3.

100 The p-tau tangle unit is a posttranslational modification of normal tau protein.

101 Lysine methylation is a common posttranslational modification of nuclear and cytoplasmi

102 It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic prot

103 Whether posttranslational modification of PKD2 modifies channel

104 erein, we identified a previously unreported posttranslational modification of pp71, protein S-nitros

105 Diabetes promotes the posttranslational modification of proteins by O-linked a

106 ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered ne

107 of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted

108 at identifying the S-cyanylation of Cys as a posttranslational modification of proteins.

109 For each group, diaphragm force production, posttranslational modification of ryanodine receptor, ox

110 Ubiquitination is a stable, reversible posttranslational modification of target proteins by cov

111 Ubiquitination, a covalent posttranslational modification of target proteins with u

112 describe novel roles for Hsp90 in regulating posttranslational modification of the Rvb1-Rvb2-Tah1-Pih

113 Although a posttranslational modification of VP7 (other than glycos

114 dent integral membrane enzyme that catalyzes posttranslational modification of Wnts with palmitoleic

115 homopolymer of alpha2,8-linked glycans, is a posttranslational modification on a few glycoproteins, m

116 flanking amino acids and an underappreciated posttranslational modification perturb epitope affinity

117 inated by studies of how this small chemical posttranslational modification regulates gene expression

118 These findings identify S-acylation as a posttranslational modification regulating DNA repair.

119 Protein glycosylation is an essential posttranslational modification that affects a myriad of

120 human disease, further establishing a novel posttranslational modification that may contribute to th

121 Lysine acetylation is a posttranslational modification that occurs on thousands

122 S-palmitoylation is a reversible posttranslational modification that plays an important r

123 uitination of ribosomes has emerged as a new posttranslational modification that regulates protein sy

124 lucosamine (O-GlcNAcylation) is a reversible posttranslational modification that regulates the activi

125 Ubiquitination is a posttranslational modification that regulates these infl

126 lation is an abundant and dynamic regulatory posttranslational modification that remains poorly chara

127 , we characterized the contributions of APOE posttranslational modification to L5's atherogenicity.

128 tylation of K40 in alpha-tubulin is the sole posttranslational modification to mark the luminal surfa

129 hemical signals such as expression level and posttranslational modification to regulate droplet forma

130 he interplay between cellular metabolism and posttranslational modification underlies immune homeosta

131 Lysine acylation is a posttranslational modification used by cells of all doma

132 ified as being hypusinated by MS analysis, a posttranslational modification which may be relevant for

133 nd arginine into citrulline, an irreversible posttranslational modification with loss of a positive c

134 n to support healthy host physiology through posttranslational modification without altering microbia

135 aside from canonical regulation through its posttranslational modification, 3) mechanistically link

136 ew current approaches, genetic manipulation, posttranslational modification, and small molecule prote

137 Rac1 activation requires a posttranslational modification, geranylgeranylation, of

138 criptome responses of genes that function in posttranslational modification, metabolism, and muscle d

139 ifier (SUMO1-3) conjugation (SUMOylation), a posttranslational modification, modulates almost all maj

140 Our data identify the posttranslational modification, O-GlcNAc, as a key molec

141 Here we report that age-related loss of the posttranslational modification, O-linked beta-N-acetylgl

142 in conjugates, histone H2A with a C-terminal posttranslational modification, RNase H that actively hy

143 Moreover, neoantigen generation (through posttranslational modification, the formation of hybrid

144 Mechanisms underlying posttranslational modification-mediated Akt activation h

145 tely equal proportion of transcriptional and posttranslational modification-mediated regulation.

146 supporting a direct signaling role for this posttranslational modification.

147 this modification thereby blocking this pp71 posttranslational modification.

148 cal functions, some of which are mediated by posttranslational modification.

149 localized changes in protein conformation or posttranslational modification.

150 on through this dynamic and multi-functional posttranslational modification.

151 mediate responses to hypoxia by an identical posttranslational modification.

152 egionella has over this unusual Ub-dependent posttranslational modification.

153 adequate, since protein activities depend on posttranslational modification.

154 rent subsets of p53 target genes may involve posttranslational modifications (e.g., phosphorylation a

155 ROS-induced oxidative posttranslational modifications (oxPTMs) can regulate pr

156 ncluding altered DNA methylation and histone posttranslational modifications (PTM) are central to the

157 Loss of PRC2 resulted in increased histone posttranslational modifications (PTM) associated with ac

158 characterisation of CAP256-VRC26 bNAbs with posttranslational modifications (PTM).

159 insight into the nature and localization of posttranslational modifications (PTMs) affecting single

160 Posttranslational modifications (PTMs) and alternative s

161 ique for mapping the distribution of histone posttranslational modifications (PTMs) and chromatin-ass

162 Posttranslational modifications (PTMs) are common among

163 Histone posttranslational modifications (PTMs) are covalent chem

164 Posttranslational modifications (PTMs) are important phy

165 (TDMS) strategy for identifying proteins and posttranslational modifications (PTMs) in bovine seminal

166 otential regulatory mechanism may be through posttranslational modifications (PTMs) of axonal microtu

167 al transcription is subject to regulation by posttranslational modifications (PTMs) of histone protei

168 Posttranslational modifications (PTMs) of histones alter

169 Manipulating these posttranslational modifications (PTMs) prevented the mat

170 Amyloid-beta (Abeta) harbors numerous posttranslational modifications (PTMs) that may affect A

171 ein complex known as chromatin is subject to posttranslational modifications (PTMs) that regulate cel

172 hat this conformer is heavily decorated with posttranslational modifications (PTMs), enabling us to m

173 ical forms in different cells due to tubulin posttranslational modifications (PTMs).

174 vived in recent years, owing to its numerous posttranslational modifications and its "phase-separatio

175 Posttranslational modifications and protein-protein inte

176 iii) at the protein level comprising altered posttranslational modifications and protein-protein inte

177 in with diverse functions that depend on its posttranslational modifications and subcellular localiza

178 findings in CESA complex organization, CESA posttranslational modifications and trafficking, and oth

179 DAXX's activity is regulated by posttranslational modifications and ubiquitin-dependent

180 Posttranslational modifications are a common feature of

181 Posttranslational modifications are essential for regula

182 Posttranslational modifications are key regulators of pr

183 Posttranslational modifications are reversibly added or

184 ities in protein localization, function, and posttranslational modifications are targets of schizophr

185 lights a complex balancing between different posttranslational modifications as a way to refine the F

186 In addition, posttranslational modifications associated with RA, such

187 um calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674).

188 FMRP(LCR) posttranslational modifications by phosphorylation and m

189 numbers in epithelial cell lines.IMPORTANCE Posttranslational modifications by phosphorylation can c

190 Studying posttranslational modifications classically relies on ex

191 A series of posttranslational modifications contribute to the oscill

192 mechanism by which phosphorylation and other posttranslational modifications could modulate tau LLPS

193 find that, although SNPs affecting potential posttranslational modifications did not affect gasdermin

194 mation of PrPSc plaques and suggest that PrP posttranslational modifications direct pathogenicity as

195 irtually all proteins, undergoes a series of posttranslational modifications during its lifetime, whi

196 was overexpressed, purified and analyzed for posttranslational modifications employing a proteomics L

197 he processing proteases and the relevance of posttranslational modifications for peptide biogenesis a

198 However, it is unknown how regulatory posttranslational modifications impact TIP60 acetyltrans

199 d the potential for metabolites to influence posttranslational modifications important to tumorigenes

200 and the core peptide for the installation of posttranslational modifications in RiPPs than previously

201 nto how radical SAM (AdoMet) enzymes install posttranslational modifications in RiPPs.

202 pertoires of PRDs and uncovers the impact of posttranslational modifications in the modulation of rev

203 a different docking mode and is regulated by posttranslational modifications including a membrane-dis

204 s to centromeric nucleosomes is regulated by posttranslational modifications is unknown.

205 ural features, and delineate the sequence of posttranslational modifications leading to its formation

206 owever, nothing is known about how potential posttranslational modifications may affect different asp

207 e structure, providing further evidence that posttranslational modifications may be an important feat

208 Our data show that posttranslational modifications of ApoE alter its intera

209 myloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP pro

210 Protein methyltransferases mediate posttranslational modifications of both histone and nonh

211 osomes and phenocopied the IFN-alpha-induced posttranslational modifications of cccDNA-associated his

212 ted to cccDNA minichromosomes and induce the posttranslational modifications of cccDNA-associated his

213 Little is known about posttranslational modifications of hK(2P)17.1.

214 Estrogen signaling involves numerous posttranslational modifications of its receptor ERalpha,

215 Specifically, we show that posttranslational modifications of MTs have differing ef

216 lammasome-activating stimuli trigger diverse posttranslational modifications of NLRP3 that are import

217 Posttranslational modifications of proteins have been im

218 tractility and performance are controlled by posttranslational modifications of sarcomeric proteins.

219 We further show that mutagenic or posttranslational modifications of transmembrane helix (

220 The idea that posttranslational modifications of viral proteins coordi

221 Okp1/Ame1 heterodimer is a reader module for posttranslational modifications on Cse4, thereby targeti

222 signaling is also a result from dysregulated posttranslational modifications on key pathway members,

223 Posttranslational modifications on several amyloid formi

224 , which is removed after the installation of posttranslational modifications on the core sequence.

225 or microenvironment, and the consequences of posttranslational modifications on their function.

226 However, posttranslational modifications such as phosphorylation,

227 Here, I focus on the posttranslational modifications that are encompassed by

228 e thiols within proteins, inducing oxidative posttranslational modifications that can couple to alter

229 tant library to uncover histone residues and posttranslational modifications that regulate histone ge

230 s highlight the potential of drugs targeting posttranslational modifications to restore TRIP8b phosph

231 via mating-dependent mechanisms that include posttranslational modifications to seminal proteins and

232 abundance, protein-protein interactions, and posttranslational modifications together determine net s

233 Other known posttranslational modifications were near or below our d

234 se-1 (SOD1) maturation comprises a string of posttranslational modifications which transform the nasc

235 Assessment of histone posttranslational modifications within the Ifng locus de

236 polarity, lipophilicity, and the presence of posttranslational modifications, add complexity to the s

237 ous levels, including transcription, co- and posttranslational modifications, and by various protein-

238 tionships between strain-specific structure, posttranslational modifications, and disease phenotype a

239 ionship between a strain-specific structure, posttranslational modifications, and disease phenotype.

240 mical biology for peptide/protein synthesis, posttranslational modifications, and DNA labeling.

241 to multidomain proteins, lipidation to mimic posttranslational modifications, and formation of cyclic

242 interplay between alpha-syn fibrillization, posttranslational modifications, and interactions betwee

243 omeric states, depending on redox state, pH, posttranslational modifications, and other factors.

244 hemical reactions, such as the occurrence of posttranslational modifications, as well as to study sam

245 ignatures and showed global changes in H3K27 posttranslational modifications, but relatively restrict

246 ty acid pathways are regulated by reversible posttranslational modifications, particularly by lysine

247 6 and SKN-1 is further modulated by specific posttranslational modifications, such as phosphorylation

248 equence of PDs, as well as their complicated posttranslational modifications, the synthetic route can

249 -activating stimuli, and how this relates to posttranslational modifications, to delineate the organe

250 SBT function is rapidly regulated by several posttranslational modifications.

251 cts in eNOS protein-protein interactions and posttranslational modifications.

252 stoichiometry, compositions, paralogues, and posttranslational modifications.

253 , we examined the effects of different Foxo1 posttranslational modifications.

254 d highly sensitive to salt concentration and posttranslational modifications.

255 and mouse gut, including their sequences and posttranslational modifications.

256 ry of gene expression through their covalent posttranslational modifications.

257 licable to diverse organisms, cell types and posttranslational modifications.

258 erent environmental cues through a myriad of posttranslational modifications.

259 se to DNA damage and is tightly regulated by posttranslational modifications.

260 types and display strain-specific subsets of posttranslational modifications.

261 Wnt signaling, beta-catenin regulation, and posttranslational modifications.

262 various amyloid proteins/peptides, including posttranslational modified Abeta (PTM-Abeta) subtypes.

263 eliminated by repurposing microRNA-mediated posttranslational mRNA regulation.Subsequently, we gener

264 er a previously unappreciated role for acute posttranslational palmitoylation at defined circuit comp

265 Thus, this posttranslational phosphorylation of RRM1 provides an al

266 MT) is the unique enzyme of the last step of posttranslational prenylation processing pathway that mo

267 Alterations of PrPC posttranslational processing can change PrPSc deposition

268 Posttranslational processing of these precursors generat

269 Deleterious mutations caused improper posttranslational processing, incorrect disulfide-bond f

270 ures to modulate protein synthesis speed and posttranslational protein behavior.

271 Posttranslational protein modification by ubiquitin (Ub)

272 Ubiquitination is a fundamental posttranslational protein modification that regulates di

273 review the crucial roles of redox-associated posttranslational protein modifications (PTMs) in mitoch

274 ould be chemically modified, for example, by posttranslational protein nitration, which also occurs v

275 Posttranslational protein targeting requires chaperone a

276 rovides mechanistic insights into eukaryotic posttranslational protein translocation.

277 chnology to unpick the steps that constitute posttranslational protein transport in bacteria.

278 ion, and activation of GSK3 with consecutive posttranslational reduction in p-Akt, Sox2, and beta-cat

279 CED3 and indicate a complex pattern of NCED3 posttranslational regulation in the chloroplast.

280 these differences to transcriptional and/or posttranslational regulation of acetyl-CoA synthetase an

281 Recent evidence indicates that posttranslational regulation of residual frataxin levels

282 Therefore, we investigated the posttranslational regulation of SMAX1 from the model pla

283 The posttranslational regulation of transferrin receptor (Tf

284 on of several PhANGs and highlight extensive posttranslational regulation that does not necessitate G

285 D-4 function is conferred by a novel mode of posttranslational regulation that involves sex-specific

286 ermine the contribution of translational and posttranslational regulation to plastid retrograde signa

287 Proteolysis is a major posttranslational regulator of biology inside and outsid

288 To discover novel posttranslational regulators of MYC protein stability an

289 These data suggest a posttranslational regulatory mechanism of the mechanosen

290 rofiling transcriptional, translational, and posttranslational reporters using CRISPR interference (C

291 Here we report that the posttranslational stability of the LdNT3 protein is unch

292 The posttranslational stabilization of UNC5B by PyST is regu

293 ty of all target molecules and revealed that posttranslational sulfation of specific tyrosine residue

294 n in intracellular organelles, inhibition by posttranslational sumoylation, a hydrophobic barrier wit

295 -terminal transmembrane domain that mediates posttranslational targeting and insertion into the endop

296 tructures revealed two alternative routes of posttranslational transformation, resulting in either ch

297 During posttranslational translocation in Escherichia coli, pol

298 Posttranslational transport is enabled by two additional

299 These results implicate TRAF6 as a key posttranslational, Treg-stabilizing regulator that may b

300 of the proline isomerization barrier through posttranslational truncation of alpha-synuclein reverses