ライフサイエンスコーパス: posttranslational modification

1 distinct nucleotide states or with different posttranslational modifications).

2 this modification thereby blocking this pp71 posttranslational modification.

3 cal functions, some of which are mediated by posttranslational modification.

4 localized changes in protein conformation or posttranslational modification.

5 on through this dynamic and multi-functional posttranslational modification.

6 mediate responses to hypoxia by an identical posttranslational modification.

7 egionella has over this unusual Ub-dependent posttranslational modification.

8 ITM3 is activated by palmitoylation, a lipid posttranslational modification.

9 alter Runx1 transcriptional function through posttranslational modification.

10 secondary metabolites that undergo extensive posttranslational modification.

11 adequate, since protein activities depend on posttranslational modification.

12 supporting a direct signaling role for this posttranslational modification.

13 d highly sensitive to salt concentration and posttranslational modifications.

14 and mouse gut, including their sequences and posttranslational modifications.

15 ry of gene expression through their covalent posttranslational modifications.

16 licable to diverse organisms, cell types and posttranslational modifications.

17 erent environmental cues through a myriad of posttranslational modifications.

18 ecursor processed by 49 mostly non-canonical posttranslational modifications.

19 microtubule-associated proteins, and tubulin posttranslational modifications.

20 in interactions, proteolytic activities, and posttranslational modifications.

21 types and display strain-specific subsets of posttranslational modifications.

22 se to DNA damage and is tightly regulated by posttranslational modifications.

23 Wnt signaling, beta-catenin regulation, and posttranslational modifications.

24 SBT function is rapidly regulated by several posttranslational modifications.

25 cts in eNOS protein-protein interactions and posttranslational modifications.

26 stoichiometry, compositions, paralogues, and posttranslational modifications.

27 , we examined the effects of different Foxo1 posttranslational modifications.

28 aside from canonical regulation through its posttranslational modification, 3) mechanistically link

29 polarity, lipophilicity, and the presence of posttranslational modifications, add complexity to the s

30 Like other, more well-studied posttranslational modifications, AMPylation is predicted

31 is used to improve quantitative accuracy for posttranslational modification analysis.

32 els of genes associated with translation and posttranslational modification and chaperones and reduct

33 This posttranslational modification and cis regulation of PRC

34 Our studies of mutant protein posttranslational modification and localization indicate

35 -associated membranes (MAMs), is involved in posttranslational modification and protein folding, and

36 ctivity by simultaneously repressing Fat via posttranslational modification and recruiting Dachs to t

37 region of Ras isoforms underlie differential posttranslational modification and subcellular trafficki

38 rmal instability, interfering with efficient posttranslational modification and subsequent receptor s

39 Poly(ADP-ribose) a dynamic and reversible posttranslational modification and the enzymes that cata

40 vived in recent years, owing to its numerous posttranslational modifications and its "phase-separatio

41 environmental cues, acquiring distinguishing posttranslational modifications and performing discrete

42 iii) at the protein level comprising altered posttranslational modifications and protein-protein inte

43 Posttranslational modifications and protein-protein inte

44 in with diverse functions that depend on its posttranslational modifications and subcellular localiza

45 findings in CESA complex organization, CESA posttranslational modifications and trafficking, and oth

46 DAXX's activity is regulated by posttranslational modifications and ubiquitin-dependent

47 ew current approaches, genetic manipulation, posttranslational modification, and small molecule prote

48 htly controlled through cyclin interactions, posttranslational modifications, and binding of inhibito

49 ous levels, including transcription, co- and posttranslational modifications, and by various protein-

50 tionships between strain-specific structure, posttranslational modifications, and disease phenotype a

51 ionship between a strain-specific structure, posttranslational modifications, and disease phenotype.

52 mical biology for peptide/protein synthesis, posttranslational modifications, and DNA labeling.

53 to multidomain proteins, lipidation to mimic posttranslational modifications, and formation of cyclic

54 interplay between alpha-syn fibrillization, posttranslational modifications, and interactions betwee

55 omeric states, depending on redox state, pH, posttranslational modifications, and other factors.

56 he reprogramming of DNA methylation, histone posttranslational modifications, and small noncoding RNA

57 Posttranslational modifications are a common feature of

58 Posttranslational modifications are covalent changes mad

59 Posttranslational modifications are essential for regula

60 Posttranslational modifications are key regulators of pr

61 Posttranslational modifications are reversibly added or

62 because tools and techniques to detect these posttranslational modifications are scarce.

63 ities in protein localization, function, and posttranslational modifications are targets of schizophr

64 lights a complex balancing between different posttranslational modifications as a way to refine the F

65 ear to change due to H2O2 treatment, nor did posttranslational modifications, as measured by two-dime

66 hemical reactions, such as the occurrence of posttranslational modifications, as well as to study sam

67 of histone H3K23 has emerged as an essential posttranslational modification associated with cancer an

68 In addition, posttranslational modifications associated with RA, such

69 um calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674).

70 itope in T1D and suggest there may be common posttranslational modifications at the C terminus of the

71 teins (IDPs) are known to undergo a range of posttranslational modifications, but by what mechanism d

72 ignatures and showed global changes in H3K27 posttranslational modifications, but relatively restrict

73 Effects of glucose and the posttranslational modification by beta-linked N-acetylgl

74 (using A549-UBA7(-/-) cells) confirmed that posttranslational modification by ISG15 (ISGylation) is

75 samine biosynthetic pathway leads to protein posttranslational modification by O-linked beta-N-acetyl

76 Here we show that TCR-activated posttranslational modification by O-linked N-Acetylgluco

77 mechanism in which the leader peptide guides posttranslational modification by positioning the cross-

78 Our data reveal a role for posttranslational modification by Pro hydroxylation in t

79 his study reveals that PKD2 channels undergo posttranslational modification by SUMO1, which enables p

80 rsulfide donor for protein persulfidation, a posttranslational modification by which H2S is postulate

81 FMRP(LCR) posttranslational modifications by phosphorylation and m

82 numbers in epithelial cell lines.IMPORTANCE Posttranslational modifications by phosphorylation can c

83 Posttranslational modifications can have profound effect

84 ADP-ribosylation is a unique posttranslational modification catalyzed by poly(ADP-rib

85 n)-acetylation of lysyl residues and how the posttranslational modification changes the cellular phys

86 Here, we show that SUMOylation, a posttranslational modification characterized by covalent

87 Studying posttranslational modifications classically relies on ex

88 Timing of this posttranslational modification coincides with the ATM-me

89 Acetylation is a posttranslational modification conserved in all domains

90 A series of posttranslational modifications contribute to the oscill

91 Posttranslational modifications control the functional a

92 Ubiquitinylation is a well-known posttranslational modification controlling cell-cycle tr

93 mechanism by which phosphorylation and other posttranslational modifications could modulate tau LLPS

94 A deeper understanding of the here-described posttranslational modification cross talk may lay the gr

95 phorylation at Ser-632, pointing to a mutual posttranslational modification cross talk of (cardio-det

96 find that, although SNPs affecting potential posttranslational modifications did not affect gasdermin

97 mation of PrPSc plaques and suggest that PrP posttranslational modifications direct pathogenicity as

98 irtually all proteins, undergoes a series of posttranslational modifications during its lifetime, whi

99 igurational entropy), have multiple sites of posttranslational modification (e.g., tyrosine phosphory

100 Ubiquitin can be subjected to further posttranslational modifications (e.g., phosphorylation a

101 rent subsets of p53 target genes may involve posttranslational modifications (e.g., phosphorylation a

102 was overexpressed, purified and analyzed for posttranslational modifications employing a proteomics L

103 suppressed by alpha-tubulin detyrosination-a posttranslational modification enriched on long-lived mi

104 he processing proteases and the relevance of posttranslational modifications for peptide biogenesis a

105 Rac1 activation requires a posttranslational modification, geranylgeranylation, of

106 ntain repeated sequence motifs and extensive posttranslational modifications (glycosylation), and the

107 PRC2 catalyzes a specific histone posttranslational modification (hPTM) that fosters chrom

108 However, it is unknown how regulatory posttranslational modifications impact TIP60 acetyltrans

109 demonstrate that acetylation is a widespread posttranslational modification impacting proteins encode

110 d the potential for metabolites to influence posttranslational modifications important to tumorigenes

111 (K13) residue and that we could detect this posttranslational modification in a heterologous experim

112 mitoylation, a form of S-acylation, is a key posttranslational modification in cellular signaling.

113 Moreover, we identified the same posttranslational modification in eEF1A from Schizosacch

114 Maximal activity of EF-P requires a posttranslational modification in Escherichia coli, Pseu

115 Arginine methylation is a common posttranslational modification in eukaryotes catalyzed b

116 l 4-hydroxylase (P4H), is the most prevalent posttranslational modification in humans and requires vi

117 ography-mass spectrometry, we studied APOE's posttranslational modification in L5 from human plasma.

118 to further interrogate the function of this posttranslational modification in the assembly of replic

119 The role of this posttranslational modification in the formation of virop

120 and the core peptide for the installation of posttranslational modifications in RiPPs than previously

121 nto how radical SAM (AdoMet) enzymes install posttranslational modifications in RiPPs.

122 pertoires of PRDs and uncovers the impact of posttranslational modifications in the modulation of rev

123 ion between alternative splicing and histone posttranslational modifications in the nucleus accumbens

124 a different docking mode and is regulated by posttranslational modifications including a membrane-dis

125 Posttranslational modifications, including acetylation a

126 mental details of how peptidases accommodate posttranslational modifications, including glycosylation

127 ated EB1 tracking and Western blotting of MT posttranslational modifications indicated no change in M

128 symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in oncogenesis a

129 identify asparagine hydroxylation as a novel posttranslational modification involved in the regulatio

130 P-ribosylation is an intricate and versatile posttranslational modification involved in the regulatio

131 are phosphorylated by host kinases, and this posttranslational modification is important for their ac

132 One reversible posttranslational modification is S-acylation, involving

133 The net result of this posttranslational modification is to render a viral prot

134 s to centromeric nucleosomes is regulated by posttranslational modifications is unknown.

135 nts the most prolific and well-characterized posttranslational modification known.

136 On a genome-wide scale, some of the histone posttranslational modification landscapes show significa

137 ural features, and delineate the sequence of posttranslational modifications leading to its formation

138 itional layer of control toward ORE1 via its posttranslational modification linked to the calcium-reg

139 owever, nothing is known about how potential posttranslational modifications may affect different asp

140 e structure, providing further evidence that posttranslational modifications may be an important feat

141 The p53 NT-interacting proteins and posttranslational modifications may regulate DNA binding

142 y of RIPK1 is tightly controlled by multiple posttranslational modification mechanisms, including ubi

143 Mechanisms underlying posttranslational modification-mediated Akt activation h

144 tely equal proportion of transcriptional and posttranslational modification-mediated regulation.

145 criptome responses of genes that function in posttranslational modification, metabolism, and muscle d

146 d is vital to understand how these important posttranslational modifications modulate biological func

147 ifier (SUMO1-3) conjugation (SUMOylation), a posttranslational modification, modulates almost all maj

148 cal organization levels, including isoforms, posttranslational modifications, nucleoporins, and highe

149 A compelling link is emerging between the posttranslational modification O-GlcNAc and protein aggr

150 Our data identify the posttranslational modification, O-GlcNAc, as a key molec

151 Here we report that age-related loss of the posttranslational modification, O-linked beta-N-acetylgl

152 dified by this glutaminylation and that this posttranslational modification occurs at all stages of y

153 We identified a novel posttranslational modification of 53BP1 by ADP-ribosylat

154 ains from AD patients; thus, it represents a posttranslational modification of AKT, which primarily c

155 Posttranslational modification of ApoE did not alter C1q

156 Our results point to posttranslational modification of chromatin-bridging pro

157 his proteostatic mechanism, dependent on the posttranslational modification of GRP78, allows cells to

158 Taken together, our findings reveal a novel posttranslational modification of HBx by HDM2 which regu

159 Mechanistically, the posttranslational modification of HDAC4 at serine (Ser)-

160 regulation by epigenetic mechanisms, such as posttranslational modification of histone proteins.

161 hese results expand our understanding of the posttranslational modification of KLF4 and of its role i

162 Peptidylarginine deiminases (PADI) catalyze posttranslational modification of many target proteins a

163 , modulated transcriptional upregulation and posttranslational modification of microglial Kv1.3.

164 Even though the ubiquitin-like posttranslational modification of neddylation, that conj

165 The p-tau tangle unit is a posttranslational modification of normal tau protein.

166 Lysine methylation is a common posttranslational modification of nuclear and cytoplasmi

167 It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic prot

168 O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic prot

169 Whether posttranslational modification of PKD2 modifies channel

170 erein, we identified a previously unreported posttranslational modification of pp71, protein S-nitros

171 Diabetes promotes the posttranslational modification of proteins by O-linked a

172 Posttranslational modification of proteins by ubiquitin

173 ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered ne

174 of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted

175 at identifying the S-cyanylation of Cys as a posttranslational modification of proteins.

176 ms involving nitric oxide (NO) synthesis and posttranslational modification of proteins.

177 esis, LanB-like dehydratases involved in the posttranslational modification of ribosomal peptides, an

178 For each group, diaphragm force production, posttranslational modification of ryanodine receptor, ox

179 Our findings indicate that posttranslational modification of SR proteins underlies

180 k of processes that generate ssDNA, and that posttranslational modification of ssNucs may generate no

181 Ubiquitination is a stable, reversible posttranslational modification of target proteins by cov

182 Ubiquitination, a covalent posttranslational modification of target proteins with u

183 ins, resulting in a widespread, irreversible posttranslational modification of the protein's structur

184 describe novel roles for Hsp90 in regulating posttranslational modification of the Rvb1-Rvb2-Tah1-Pih

185 ription of the POR and CHLP genes but to the posttranslational modification of their protein products

186 al therapies to target it, is to examine the posttranslational modification of viral proteins and its

187 Although a posttranslational modification of VP7 (other than glycos

188 mall-molecule inhibitors targeting essential posttranslational modification of Wnt reduced tumour gro

189 dent integral membrane enzyme that catalyzes posttranslational modification of Wnts with palmitoleic

190 is-unsaturated fatty acyl group, a necessary posttranslational modification of Wnts, by multiple FZD

191 Our data show that posttranslational modifications of ApoE alter its intera

192 myloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP pro

193 Protein methyltransferases mediate posttranslational modifications of both histone and nonh

194 osomes and phenocopied the IFN-alpha-induced posttranslational modifications of cccDNA-associated his

195 ted to cccDNA minichromosomes and induce the posttranslational modifications of cccDNA-associated his

196 cular the cerebellum, nor the effects of any posttranslational modifications of FOXP2 in the brain an

197 elevance of these findings and the potential posttranslational modifications of HDAC1 remained elusiv

198 m may include more than 100 residue-specific posttranslational modifications of histones forming the

199 Little is known about posttranslational modifications of hK(2P)17.1.

200 Estrogen signaling involves numerous posttranslational modifications of its receptor ERalpha,

201 ns of the core histones constitute sites for posttranslational modifications of major epigenetic impa

202 Specifically, we show that posttranslational modifications of MTs have differing ef

203 but have since diverged to control distinct posttranslational modifications of NCAM1.

204 lammasome-activating stimuli trigger diverse posttranslational modifications of NLRP3 that are import

205 Posttranslational modifications of proteins have been im

206 n ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regul

207 Posttranslational modifications of proteins, such as pho

208 tractility and performance are controlled by posttranslational modifications of sarcomeric proteins.

209 if the positive charge and susceptibility to posttranslational modifications of these lysines contrib

210 We further show that mutagenic or posttranslational modifications of transmembrane helix (

211 The idea that posttranslational modifications of viral proteins coordi

212 homopolymer of alpha2,8-linked glycans, is a posttranslational modification on a few glycoproteins, m

213 eir cell surface, and MS analysis revealed a posttranslational modification on cysteine 328 (C328) by

214 Okp1/Ame1 heterodimer is a reader module for posttranslational modifications on Cse4, thereby targeti

215 signaling is also a result from dysregulated posttranslational modifications on key pathway members,

216 Posttranslational modifications on several amyloid formi

217 , which is removed after the installation of posttranslational modifications on the core sequence.

218 or microenvironment, and the consequences of posttranslational modifications on their function.

219 This study highlights the influence of posttranslational modifications on viral protein functio

220 teogenic amino acids, which may then require posttranslational modification or the recruitment of coe

221 ROS-induced oxidative posttranslational modifications (oxPTMs) can regulate pr

222 ty acid pathways are regulated by reversible posttranslational modifications, particularly by lysine

223 The posttranslational modification pathway leading to lipopr

224 flanking amino acids and an underappreciated posttranslational modification perturb epitope affinity

225 Proteins may undergo a type of posttranslational modification - polyglutamylation, wher

226 As one of the few irreversible protein posttranslational modifications, proteolytic cleavage is

227 we identified that O-GlcNAcylation, a unique posttranslational modification (PTM) involved in cancer

228 This posttranslational modification (PTM) is catalyzed by Rad

229 osylation, the nitric oxide (NO(*))-mediated posttranslational modification (PTM) of cysteine thiols

230 As such, the incorporation of this posttranslational modification (PTM) or mimics thereof i

231 Assessing posttranslational modification (PTM) patterns within pro

232 ntify the highly reversible, stress-induced, posttranslational modification (PTM) protein S-nitrosyla

233 e binding of ATAD2, a bromodomain-containing posttranslational modification (PTM) reader that recogni

234 Protein-lysine methylation is a common posttranslational modification (PTM) throughout the huma

235 ibosylation, a highly conserved, fundamental posttranslational modification (PTM).

236 ncluding altered DNA methylation and histone posttranslational modifications (PTM) are central to the

237 Loss of PRC2 resulted in increased histone posttranslational modifications (PTM) associated with ac

238 characterisation of CAP256-VRC26 bNAbs with posttranslational modifications (PTM).

239 the individual nuclei using histone type- or posttranslational modification- (PTM-) specific antibodi

240 Posttranslational modifications (PTMs) affecting E2 func

241 insight into the nature and localization of posttranslational modifications (PTMs) affecting single

242 Posttranslational modifications (PTMs) and alternative s

243 ique for mapping the distribution of histone posttranslational modifications (PTMs) and chromatin-ass

244 Posttranslational modifications (PTMs) are common among

245 Histone posttranslational modifications (PTMs) are covalent chem

246 Posttranslational modifications (PTMs) are important phy

247 (TDMS) strategy for identifying proteins and posttranslational modifications (PTMs) in bovine seminal

248 genetic marks, including DNA methylation and posttranslational modifications (PTMs) in histones, are

249 otential regulatory mechanism may be through posttranslational modifications (PTMs) of axonal microtu

250 al transcription is subject to regulation by posttranslational modifications (PTMs) of histone protei

251 Posttranslational modifications (PTMs) of histones alter

252 Manipulating these posttranslational modifications (PTMs) prevented the mat

253 Posttranslational modifications (PTMs) regulate protein

254 Amyloid-beta (Abeta) harbors numerous posttranslational modifications (PTMs) that may affect A

255 ein complex known as chromatin is subject to posttranslational modifications (PTMs) that regulate cel

256 Proteins can be modified by multiple posttranslational modifications (PTMs), creating a PTM c

257 hat this conformer is heavily decorated with posttranslational modifications (PTMs), enabling us to m

258 genesis revealed specific and well-conserved posttranslational modifications (PTMs), including O-myco

259 ical forms in different cells due to tubulin posttranslational modifications (PTMs).

260 inated by studies of how this small chemical posttranslational modification regulates gene expression

261 These findings identify S-acylation as a posttranslational modification regulating DNA repair.

262 in conjugates, histone H2A with a C-terminal posttranslational modification, RNase H that actively hy

263 However, posttranslational modifications such as phosphorylation,

264 6 and SKN-1 is further modulated by specific posttranslational modifications, such as phosphorylation

265 Protein glycosylation is an essential posttranslational modification that affects a myriad of

266 at eEF1A glutaminylation is a yeast-specific posttranslational modification that appears to influence

267 Disulfide bonds are a common posttranslational modification that contributes to the f

268 ADP-ribosylation is a posttranslational modification that exists in monomeric

269 independently of its gamma-carboxylation, a posttranslational modification that is known to hamper O

270 human disease, further establishing a novel posttranslational modification that may contribute to th

271 Lysine acetylation is a posttranslational modification that occurs on thousands

272 S-palmitoylation is a reversible posttranslational modification that plays an important r

273 Lysine acetylation is a key posttranslational modification that regulates diverse pr

274 Linear ubiquitination is a key posttranslational modification that regulates immune sig

275 uitination of ribosomes has emerged as a new posttranslational modification that regulates protein sy

276 lucosamine (O-GlcNAcylation) is a reversible posttranslational modification that regulates the activi

277 Ubiquitination, the crucial posttranslational modification that regulates the eukary

278 Ubiquitination is a posttranslational modification that regulates these infl

279 lation is an abundant and dynamic regulatory posttranslational modification that remains poorly chara

280 Here, I focus on the posttranslational modifications that are encompassed by

281 e thiols within proteins, inducing oxidative posttranslational modifications that can couple to alter

282 tant library to uncover histone residues and posttranslational modifications that regulate histone ge

283 Moreover, neoantigen generation (through posttranslational modification, the formation of hybrid

284 equence of PDs, as well as their complicated posttranslational modifications, the synthetic route can

285 , we characterized the contributions of APOE posttranslational modification to L5's atherogenicity.

286 tylation of K40 in alpha-tubulin is the sole posttranslational modification to mark the luminal surfa

287 hemical signals such as expression level and posttranslational modification to regulate droplet forma

288 s highlight the potential of drugs targeting posttranslational modifications to restore TRIP8b phosph

289 via mating-dependent mechanisms that include posttranslational modifications to seminal proteins and

290 -activating stimuli, and how this relates to posttranslational modifications, to delineate the organe

291 abundance, protein-protein interactions, and posttranslational modifications together determine net s

292 he interplay between cellular metabolism and posttranslational modification underlies immune homeosta

293 Lysine acylation is a posttranslational modification used by cells of all doma

294 While investigating the function of this posttranslational modification, we serendipitously disco

295 Other known posttranslational modifications were near or below our d

296 ified as being hypusinated by MS analysis, a posttranslational modification which may be relevant for

297 se-1 (SOD1) maturation comprises a string of posttranslational modifications which transform the nasc

298 nd arginine into citrulline, an irreversible posttranslational modification with loss of a positive c

299 Assessment of histone posttranslational modifications within the Ifng locus de

300 n to support healthy host physiology through posttranslational modification without altering microbia