ライフサイエンスコーパス: potency of

1 electivity score of 0.006 and an outstanding potency of 1.0 nM.

2 nct binding features and superior inhibitory potency of 10a, together with its excellent efficacy in

3 a from multiple sites that measured blocking potency of 12 blinded drugs (with different levels of pr

4 d a binding affinity of 11 nM and inhibition potency of 14 nM, anti-BACE1 IgG B2B2 reduced amyloid be

5 However, the potency of 17nt sgRNAs relative to the full-length 20nt

6 Broad cellular antiproliferative potency of 24 is supported by demonstration of JAK-STAT

7 Verinurad specifically inhibits URAT1 with a potency of 25 nM.

8 ne's antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhibit NMDARs has not been es

9 gen bonding to contribute to the outstanding potency of 34.

10 rsely, the LasR L130F mutation increases the potency of 3OC(12)HSL and other homoserine lactones.

11 lizing antibody showed an estimated relative potency of 454 IU/mg and minimal effective dose 50% (MED

12 tures appeared to contribute to the anti-HIV potency of [5P7]CCL5, including the distinct chemokine o

13 re antibodies in combination, resulting in a potency of 79.4 IU/mg in the in vivo intradermal challen

14 enic potency based on the concentrations and potencies of a small number of targeted PAHs results in

15 randomized study is designed to evaluate the potency of a combination of 1.2 mg RSV in situ gel with

16 Here we show that the potency of a drug to reverse cancer-associated gene expr

17 for the quantification of the dose-response potency of a gene-signature as EC(50) and IC(50) values.

18 ctivity is often critical in such cases: the potency of a macrocyclic compound can depend on the ster

19 gh computational modeling, we found that the potency of a monovalent antibody targeting Met could be

20 mor and its associated stroma, and prove the potency of a novel combined approach suitable for immedi

21 studies demonstrate the enhanced therapeutic potency of a novel Dual-CAR T cell product with the pote

22 The potency of a novel triangular multinuclear complex conta

23 These results highlight the potency of a PTM-binding protein to regulate DNA accessi

24 Moreover, the anti-cancer potency of a series of benzamide analogs strongly correl

25 stem cell (CSC) and bulk breast cancer cell potency of a series of metallopeptides containing dichlo

26 site-directed mutagenesis, and measuring the potency of a series of Tg analogues.

27 -cell RNA-Seq profiles, that differentiation potency of a single cell can be approximated by computin

28 gh portion of beta-sheet), the antimicrobial potency of AAMPs, and the AAMPs' ability to form hydroph

29 These five parameters affect the potency of Abs in vitro and should be further tested as

30 , respectively, based on a difference in the potency of acetylcholine to activate them.

31 The risk increased with increasing potency of acid inhibition and decreased after medicatio

32 NA loading capacity, system versatility, and potency of action, ProSilic provides unique attributes a

33 re found to be important determinants of the potency of activation and entry inhibition.

34 a mouse model of aGVHD, we investigated the potency of active and passive immunization against the c

35 Thus, the objectives were to evaluate the potency of ADHLSCs to control bleeding in a hemophilia A

36 The potency of adoptive T cell therapies targeting the cell

37 tify this as a contributor to the higher IRI potency of AFGPs.

38 Herein, we discuss the increased potency of (-)-agelastatin E as compared to (-)-agelasta

39 Potency of aggregates to serve as Ag source was directly

40 of the molecular switch confers an increased potency of agonists by stabilizing an active conformatio

41 The potency of airway-delivered anti-HA bNAbs was highly dep

42 f the sulfopeptide dramatically improved the potency of all bNAb classes against isolates with more-o

43 ins of bNAbs, this sulfopeptide improved the potency of all classes of bNAbs against HIV-1 isolates t

44 This study highlights the potency of alpha-RIT in MM treatment.

45 ing that they can predict the cAMP-signaling potencies of AM and AM2/IMD chimeras.

46 conformations, the spectrum of activity and potency of AMPs often varies considerably.

47 21CFR680.3(e) states that when measured, the potency of an allergenic extract is assessed according t

48 end on mlpt function, demonstrating enduring potency of an ancestral developmental switch despite evo

49 The trapping potency of anchors is dictated by association rates and

50 These effects could hinder the potency of animal weapons, such as the mantis shrimp's r

51 We use this assay to test the potency of anti-fibrotic compounds and screen siRNAs for

52 d that whole semen significantly reduces the potency of antibodies and microbicides that target glyca

53 this more open conformation, neutralization potency of antibodies targeting the S protein receptor-b

54 We improve the potency of antibody-drug conjugates (ADCs) containing th

55 , their small-solute composition impacts the potency of antiviral microbicides and mucosal antibodies

56 e three ApoE variants exhibit a differential potency of ApoE4>ApoE3>ApoE2, which mirrors their relati

57 secreted (RANTES) (CCL5) that have anti-HIV potencies of around 25 pM, which is more than four order

58 lycoprotein receptor (ASGR) has improved the potency of ASO drugs approximately 30-fold in the clinic

59 us represent a viable approach for enhancing potency of ASO drugs in the clinic without adding signif

60 esents a possible approach for enhancing the potency of ASOs with diverse nucleic acid modifications.

61 y, and significantly enhanced the inhibitory potency of ATRA on HCC cell growth, improving IC50 by ov

62 ated the phenotypic markers and chondrogenic potency of avascular and vascular meniscal cells and cho

63 eversibly with their potency approaching the potencies of azole drugs currently used to inhibit micro

64 The potency of bifenthrin (a pyrethroid insecticide) in topi

65 -has been shown to dramatically increase the potency of biologically active molecules(1-3).

66 d arrhythmias require the measurement of the potency of block of voltage-gated potassium channel subt

67 The potency of blood and intestinal gammadelta T-APCs was co

68 Specifically, mim6 improved the potency of bNAbs of the V3-glycan class, including PGT12

69 We found that the coverage and potency of bNAbs were often significantly lower than wha

70 coreceptor-mimetic peptide mim6 improved the potency of bNAbs with different epitopes.

71 c state-dependent modulators, the inhibitory potency of both compounds is highly dependent on the amb

72 nant protein account for the greater seeding potency of brain aggregates.

73 this coreceptor-mimetic peptide improves the potency of broadly neutralizing antibodies (bNAbs) targe

74 The relative potency of C47 to the reference compound flutamide was o

75 e rise globally alongside an increase in the potency of cannabis sold on both black and legal markets

76 ons to reduce or even abolish the allergenic potency of cashew and pistachio.

77 ock of VACCs accounts for the apparent lower potency of Cd(2+) on spontaneous release of GABA than on

78 is without negative impact on the antitumor potency of CD19 CAR T cells.

79 Previous studies have demonstrated that the potency of CD4-Ig is markedly increased by appending a c

80 he Keap1-Cul3 complex, thereby enhancing the potency of CDDO-Im.

81 ing data has been reported on the inhibitory potency of CDKi's and a systematic characterization of a

82 mediated through the nitric oxide scavenging potency of CFH, increasing basal vascular tone and impai

83 STING-NPs increase the biological potency of cGAMP, enhance STING signalling in the tumour

84 Here we demonstrate the potency of chemoselective reactions to accomplish sequen

85 Regarding inhibitory potency of ciproxifan on rat brain MAO, these findings s

86 is change also leads to decreased inhibition potency of clavulanic acid.

87 The potency of complement activation by IgG Abs can be incre

88 Interestingly, the increased potency of compound 27 was facilitated by the formation

89 r prior SARS-CoV-2 infection, as well as the potency of convalescent plasma or human monoclonal antib

90 lls from reactive metabolites, increased the potency of curcumin and decreased the amount of curcumin

91 manage fungal infections and to modulate the potency of current drugs against drug-sensitive and -res

92 nsplant and has decreased with the increased potency of current immunosuppressive agents.

93 n this study the molecular basis for reduced potency of current inhibitors against GT-3 NS3/4A protea

94 Potencies of CXCL12/CXCL12(1)/CXCL12(2) were higher than

95 osteric modulator of CXCR4 that enhances the potency of CXCR4 ligands.

96 We found that optimization beyond potency of degradation, including degradation efficiency

97 Antiradical potency of DHCA and DHFA was compared with that exerted

98 However, the apparent potency of different interventions can vary considerably

99 and molecular conformation in antioxidative potency of dihydrocaffeic acid (DHCA) and dihydroferulic

100 of native TRAIL and poor apoptosis-inducing potency of dimeric agonist mAbs despite their long serum

101 binding pocket and likely underlie the high potency of Diprovocim.

102 of Earth's biosphere; for understanding the potency of disease-causing microorganisms; and in biotec

103 Conjugation of palmitic acid improved potency of DMPK, Cav3, CD36 and Malat-1 ASOs (3- to 7-fo

104 DPHP impacts cardiac development, albeit the potency of DPHP is significantly less than TPHP within d

105 In this study, we observed that the potency of drugs targeting the cytochrome bc(1):aa(3) is

106 The potency of E-101 solution was also measured in the prese

107 estrogens after correcting for the in vitro potency of each compound.

108 multiple C. elegans tissues, underscore the potency of early exercise experience to influence long-t

109 Toward this goal, we directly compared the potency of eight drugs known to block EBOV entry with th

110 the human blood-brain barrier and the lower potency of elacridar to inhibit ABCG2 may be an explanat

111 Herein, we describe the potency of electrospray ionization mass spectrometry (ES

112 t to be the primary drivers of reinforcement potency of energy sources.

113 ing is a key to accurate assessment of toxic potencies of environmental pollutants.

114 late) intermediate significantly reduces the potency of enzyme inhibition.

115 The potency of evofosfamide in 30 genetically diverse cancer

116 otypes in EV-producing cells can enhance the potency of EVs for vascularization.

117 release strategy to enhance the therapeutic potency of EVs.

118 It is expected that the high potency of FA-displaying exosome in cytosolic siRNA deli

119 that may define binding affinity and agonist potency of formyl peptides.

120 enoid compounds as well as the antioxidative potency of fruit and their parts, such as peel, flesh, a

121 and T47C substitutions reduced the apparent potency of GABA at alpha1beta2gamma2 receptors by 50-fol

122 residue (D43C or T47R) reduced the apparent potency of GABA.

123 ceptors, expressed in HEK cells, reduced the potencies of glycine, beta-alanine and taurine by 9-, 6-

124 alanine at position 168 (D168A) reduced the potency of grazoprevir, its combination with R155K unexp

125 The greater UDB potency of GS-967 and eleclazine was attributed to the h

126 inhibition is at the base of the exceptional potency of herbicides and potentially a target for the d

127 Treatment with IL-13 increased the potency of histamine, carbachol, and leukotriene D(4) as

128 , but not IL-5 or IL-17A, also increased the potency of histamine.

129 y among the family of galectins and bridging potency of homodimers.

130 RanBP9 significantly diminishes the anti-tau potency of Hsp90/Hsc70 inhibitors as well as Hsc70 varia

131 Given the rapid kinetics and potency of HSPC mobilization provided by the VLA4 inhibi

132 M, quantitatively ranked the selectivity and potency of hundreds of compounds and identified previous

133 to be able to predict the bilayer-perturbing potency of hydrophobic/amphiphilic drugs candidates.

134 ardiac-lineage cells; and test the embryonic potency of iCPCs via injection into the cardiac crescent

135 complex contributes to the immunomodulatory potency of IL-10.

136 igen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for an

137 Mechanistic studies reveal that the potency of ILs in enhancing transdermal drug delivery co

138 and prospective trials have demonstrated the potency of immunotherapeutic approaches with antibody-dr

139 t a mechanism for diminishing the functional potency of individual cMyBP-C molecules.

140 ible for differences in both flexibility and potency of inhibition among RGS isoforms.

141 cted mutagenesis of GluN1-Glu781 reduced the potency of inhibition by NVP-AAM077, thus confirming the

142 correlation between protein flexibility and potency of inhibition by the TDZD 4-[(4- fluorophenyl)me

143 ased thermal stability in RGS8 and increased potency of inhibition of both RGS4 and RGS8 by 4- and 2-

144 thermal stability of RGS19 and decreased the potency of inhibition of CCG-50014 by 8-fold.

145 Our results confirm the potency of INSTI on HIV-2 clinical isolates with wild-ty

146 This assumption explains the superior potency of isavuconazole against A. castellanii The dime

147 y aberrant enzyme would explain the superior potency of isavuconazole against A. castellanii.

148 to be a strong indicator for the functional potency of islets.

149 uncouplers, interfere with the bactericidal potency of isoniazid and moxifloxacin.

150 Potencies of ISs are defined in international units (IU)

151 ly maintained the high in vitro and cellular potency of its quinazoline counterpart, but also display

152 ~200 fold lower (~60 nanomolar), whereas the potency of its stimulatory effect is >100 fold higher, t

153 In the presence of serum albumin, the potency of JMS-053 as an in vitro inhibitor of PTP4A3 an

154 ing a bioluminescent assay, the efficacy and potency of kappa opioids was determined.

155 to K(v)1.2 and systematic assessment of the potency of kappaM-RIIIJ block of heteromeric K(+) channe

156 362 is responsible for the generally greater potency of KCa activators on KCa3.1.

157 y correctly predicted the relative signaling potencies of known agonists and nonagonists but also ach

158 Murine studies have validated the potency of laser illumination of skin as an adjuvant for

159 The potency of latency reversal was significantly higher fol

160 To improve the potency of lead PDI inhibitor BAP2 (( E)-3-(3-(4-hydroxy

161 to simultaneously evaluate the dynamics and potency of ligands that bind to ERalpha.

162 Overall, these results highlight the potency of localized TRM deposition as a means of pathog

163 in, we have improved the reproducibility and potency of LPS in the model using two injections distal

164 continues, the effects of increased use and potency of marijuana on water and wastewater treatment p

165 es the generation, survival, and suppressive potency of MDSC, and that a feedback homeostatic mechani

166 g capacity of MRL/MpJ mice by increasing the potency of MDSPCs.

167 of cellular compartments could modulate the potency of membrane curvature to recruit lipidated prote

168 e findings, to evaluate the cardioprotective potency of metformin (Met).

169 the rat ventral tegmental area attenuate the potency of methadone, but not other opioids, in stimulat

170 eptors, rendering a profound decrease in the potency of methadone.

171 ugs from classical chemotherapeutics and the potency of mitotic kinase inhibitors to generate a class

172 Neurotensin conjugation also improved the potency of morpholino ASO designed to correct splicing o

173 efficient to activate the channels, and the potency of most of them significantly exceeded that of t

174 Cellular potency of MSA-2 increased upon extracellular acidificat

175 vironmental changes from pFUS also increased potency of MSCs in situ to further enhance their efficac

176 matrix, leading to markedly greater trapping potency of multiple invading species without saturating

177 We evaluated the prevalence, breadth, and potency of NAb responses in 98 CRF07_BC-infected individ

178 Here we study the nucleation inhibition potency of natural or artificial proteins in connection

179 This study examines the potency of neoadjuvant TSL HT combination therapy in two

180 be expanded to acquire increased breadth and potency of neutralization merits further investigation.I

181 ization did not recapitulate the breadth and potency of neutralization observed in these infected ind

182 idening of the breadth or an increase in the potency of neutralizing antibody responses compared to u

183 idening of the breadth or an increase in the potency of neutralizing antibody responses compared with

184 esistance arises regardless of the nature or potency of new drugs.

185 Here, we evaluate the differential potency of NGF, glial cell line-derived neurotrophic fac

186 Overall, we observed that the potency of NK cell education was directly related to the

187 However, the speed and potency of NO's metabolic effects at physiological conce

188 Potencies of NOD2 and NLRP3 stimulation are found compar

189 tional piece of experimental evidence on the potency of nonpathogenic ALV-E, MDV-2, and ALV-E plus MD

190 This manuscript emphasizes the potency of nuclear imaging techniques to monitor recepto

191 These studies improve the potency of one class of bNAbs, show that coreceptor-mime

192 -specific antibiotics, and for improving the potency of orthosomycins.

193 onstrate that the 011A compound can increase potency of other antibiotics, presumably by permeabilizi

194 Notably, the potencies of our allosteric ligands to inhibit CK2 varie

195 ecent studies have highlighted the increased potency of oxygen analogs of organophosphorus pesticides

196 it distinctly affected both the efficacy and potency of partial kappa agonists, such as the benzomorp

197 Firstly, we confirmed the vasodilating potency of PDGFbeta-receptor targeted Y27632 in vitro in

198 We studied the antiviral potency of pegylated interferon-alpha (pegIFNalpha) agai

199 The various bioactivity types and potencies of peptidic natural products (PNPs) are of hig

200 l approach can be widely used to improve the potency of peptidic fusion inhibitors against other enve

201 ntially reflecting the nearly 10-fold-higher potency of PGT121 against this SHIV.

202 phenyl group to improve the selectivity and potency of PI3Kalpha.

203 Our findings suggest that the potency of poorly neutralizing antibodies, which are com

204 e, we report the optimization of the in vivo potency of pyrazolopyrimidines, a class of highly select

205 rk to redesign and improve the antibacterial potency of pyridopyrimidine inhibitors of biotin carboxy

206 B, the detrimental effect of glycerol on the potency of Q203 was abrogated.

207 tency is notably higher than the antioxidant potency of quercetin, was investigated in twenty quercet

208 ther, these results help to explain the high potency of RDV against RNA viruses in cell-based assays.

209 Cs, whose manipulation may lead to increased potency of reprogrammed HSCs for transplantation.

210 in vitro as well as in vivo evidence of the potency of rtPDT using exendin-4-IRDye700DX.

211 intervention strategies must target both the potency of SARS-CoV-2 and its evasiveness.

212 al evaluation with respect to efficiency and potency of selected bioreceptors and biotransducers.

213 ng variation in target copy number, inherent potency of sgRNA guides, and expression level of Cas9 an

214 into the origins of regiospecific changes in potency of siRNAs and the increased protection against 5

215 Prior efforts to improve the in vitro potency of site II-specific antibodies did not translate

216 corresponding residue in KCa2.3 reduces the potency of SKA-121 by 7-fold, suggesting that R362 is re

217 ifications have been identified that enhance potency of small interfering RNAs (siRNAs) and that redu

218 city of monoclonal antibodies (mAb) with the potency of small molecule therapeutics, are one of the f

219 ively investigated the long-acting (LA) PrEP potency of subcutaneous (SubQ) administrated tenofovir a

220 However, the potency of such antibodies is generally low.

221 the natural hormone contrasts with the high potency of synthetic Gce agonists of disparate chemistri

222 ngoing challenge, exacerbated by the extreme potency of synthetic opioids (e.g., fentanyl and fentany

223 ts at the T-B cell interface to modulate the potency of T cell help needed to promote autoantibody pr

224 relationship between RGS flexibility and the potency of TDZD inhibitors.

225 hese findings demonstrate a greater in vitro potency of tedizolid than linezolid against NTM and sugg

226 stant viruses, and this mutation reduced the potency of telaprevir in both the enzymatic and cellular

227 pathogen-contaminated edibles, to suboptimal potency of temperature-sensitive vaccines.

228 directly compared the in vitro chondrogenic potency of TGF-beta1 and KGN using a high resolution mic

229 0-nm-sized degradable polymeric nanogels the potency of the agonist to activate TLR7/8 in in vitro cu

230 It has been hypothesized that the ultrahigh potency of the analogs is due to their ability to bind p

231 mechanism, which enabled us to optimize the potency of the analogs.

232 ost on burying beetles, which rises with the potency of the antimicrobial defence.

233 Resynthesis confirmed the potency of the compound, which suppressed viral RNA synt

234 ity and those promoting exchange reduced the potency of the drug.

235 However, the breadth and potency of the elicited responses have been less than op

236 racellular Ca(2+) increases the affinity and potency of the endogenous agonist alpha-melanocyte-stimu

237 l and simple strategy to greatly enhance the potency of the existing peptide-based HIV fusion inhibit

238 In order to optimize the potency of the first serum-stable peptide agonist of CD4

239 The functional potency of the genetic variants within TAS1R2, TAS1R3, a

240 4 protease structure may explain the reduced potency of the GI-specific inhibitors against the GII pr

241 the triazolopyridine series was the moderate potency of the HTS hits.

242 rofiles is likely to enhance the breadth and potency of the humoral immune response against HCV.

243 hibitory concentrations (MIC) quantified the potency of the in situ click products and demonstrated t

244 tamase variants is associated with decreased potency of the inhibitor clavulanic acid, which is used

245 e importance of several methyl groups to the potency of the inhibitors is highlighted as well as the

246 izing activity, and verified the therapeutic potency of the lead candidates in mice and non-human pri

247 Evaluating the potency of the many known inhibitory compounds is a tedi

248 fant serum; to study whether the TTR-binding potency of the mixtures follows the principle of concent

249 The TTR-binding potency of the mixtures was well predicted by concentrat

250 The potency of the new molecules, compounds 2-75 [4-(3-(4-cy

251 In this study, we investigated the relative potency of the nucleoside analogs and non-nucleoside ana

252 (2)AR, while the linkers alone decreased the potency of the orthosteric fragment.

253 The extreme potency of the plant toxin, ricin, is due to its enzymat

254 esults further reveal that the difference in potency of the positive modulators in potentiating SK2 c

255 muli further enhances both the diversity and potency of the response.

256 onal novelties speaks to the persistence and potency of the selective forces in marine environments t

257 copy number, but is highly dependent on the potency of the sgRNA guide sequence.

258 elicit target mutation, particularly if the potency of the sgRNA is also low.

259 The potency of the sHsps to suppress aggregation of model su

260 of cytokine signals, altering the nature or potency of the signal can be important in pathophysiolog

261 ugmented SSFs reduced the overall estrogenic potency of the supplied water by 25% on average and remo

262 The potency of the synthetic cannabinoid identified in these

263 Thus, the potency of the T cell response to histoincompatible tiss

264 irulence-mediated UPR(mt) repression and the potency of the UPR(mt) as an antibacterial response.

265 Nine variants vastly exceeded the potency of their parental antibodies with >=90% inhibiti

266 h the aim to improve nuclease resistance and potency of therapeutic siRNAs by introducing 4'-C-methox

267 161, providing a molecular mechanism for the potencies of these drugs, including the activity of VT-1

268 cells and a correlation existed between the potencies of these two activities.

269 The potency of these compounds in inhibiting human T cell ac

270 culated from the crystal structures, and the potency of these compounds in potentiating the SK2 chann

271 The specificity and potency of these drug candidates is further documented i

272 e efforts are in urgent need to preserve the potency of these essential antibiotics.

273 ry, with the aim to estimate the antiradical potency of these molecules.

274 insights into the mechanisms underlying the potency of thienopyrimidinones as TrmD inhibitors, with

275 vated by the ten-fold increase in antibiotic potency of thiotetroamide C ascribed to the acetamide gr

276 The viability and potency of this approach are demonstrated with an electr

277 Although the potency of this approach with regard to transplantation

278 Such enhanced retention may increase the potency of this chemotherapy agent and allow for reduced

279 uction of tachycardia and the arrhythmogenic potency of this drug.

280 These results highlight the potency of this model and raise the question of how usef

281 on does not fully explain the antithrombotic potency of this or other thrombin mutants.

282 The potency of this Prot- FOLR1-TCB is recovered following p

283 death in MDA-MB-231 cells, demonstrating the potency of this treatment.

284 ary expressed in human cells to quantify the potency of thousands of CRISPR/Cas9 sgRNAs.

285 s study sought to compare the antithrombotic potency of ticagrelor alone versus ticagrelor plus ASA a

286 ving drug-eluting stents, the antithrombotic potency of ticagrelor monotherapy is similar to that of

287 trasensitive enzymatic assay to evaluate the potency of tight binding inhibitors.

288 y of proteins can be applied to increase the potency of topical microbicides and vaccine-elicited ant

289 These studies demonstrate the remarkable potency of trehalose and a subset of hydrophilins as the

290 AHR-activating potencies of Turkish, filter, and instant coffee were de

291 Here we compare the potency of two previously described inhibitors of wild t

292 L12/CXCL12(1)/CXCL12(2) were higher than the potency of ubiquitin.

293 Here we demonstrate the potency of ULF Raman spectromicroscopy to harness the ex

294 We compared the tumoricidal potency of ultra-high dose rate and conventional dose ra

295 show that mim6 can consistently improve the potency of V3-glycan antibodies and suggest that these a

296 These concepts can be applied to enhance the potency of vaccine-elicited antibodies and microbicides

297 g a promising strategy to enhance safety and potency of vaccines.

298 NS9283 increased the potency of varenicline to activate and desensitize (alph

299 n with Env trimers accounts for the increase potency of VRC01 and CD4i antibody mixtures.

300 the solubility profile and true stimulatory potency of Vx-770 towards wild-type (WT) and mutant huma