ライフサイエンスコーパス: potent

1 tion and chromatographic fractionation, five potent ACEi peptides, VRP, LKY, VRY, KYKA, and LKYKA, wi

2 a critical role in synaptic development; its potent activation by NAP suggests that ADNP may mediate

3 stability in human serum (t(1/2) > 12 h) and potent activation of Vgamma9/Vdelta2 T-cells (EC(50) ran

4 ide derived from Gram-negative bacteria is a potent activator of circulating immune cells including n

5 ision deficient K249Q mutant was even a more potent activator of gene expression; whereas, mutant OGG

6 Cell death induced by nuclear MLKL was a potent activator of neutrophils, a cell type known to dr

7 Unedited Alu RNAs are potent activators of both IFN and NF-kappaB responses vi

8 3,4-oxadiazol-2-yl)benzamides displayed very potent activities [sub-mug/mL minimum inhibitory concent

9 copying macrophage activation, and exhibited potent adjunctive activity in the standard mouse model o

10 nzyladenine substituent, proved particularly potent against USA300 and additional strains of MRSA and

11 uced emphysema we demonstrated that the most potent agents exhibited a significant decrease in emphys

12 converts the simple binding compound into a potent allele-selective cleaver of r(CUG)(exp).

13 Trametinib is an extremely potent allosteric inhibitor of mitogen-activated protein

14 roteins, structured RNA elements represent a potent alternative as drug targets.

15 .e., MOR agonism and sigma antagonism) and a potent analgesic activity, comparable to the MOR agonist

16 Cebranopadol is known as a highly potent analgesic.

17 Epibatidine is a potent analgetic agent with very high affinity for brain

18 alicylanilides was synthesized, and the most potent analog was selected through an in vitro inhibitor

19 The most potent analogue, 8-[(1H-benzotriazol-1-yl)amino]octanoic

20 ural features led to the identification of a potent analogue, PK150, that showed antibacterial activi

21 immunogenicity was demonstrated in mice with potent and broad induction of FSP-specific CD8 and CD4 T

22 benzimidazoles and the identification of the potent and highly selective TBK1/IKKepsilon inhibitor BA

23 protein-based vaccines often fail to elicit potent and long-lasting immune responses.

24 nistered vesicles provoke significantly more potent and long-lasting immune stimulation in terms of i

25 ong them, OP-5244 (35) proved to be a highly potent and orally bioavailable CD73 inhibitor.

26 crobial MR1-dependent activation remained as potent and polyfunctional as with younger adults.

27 irion in complex with Fab fragments of these potent and protective antibodies reveal the details of a

28 ies of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a

29 s selectively bind A(2B)AR, with a number of potent and selective antagonists further confirmed by fu

30 t of which will be aided by the discovery of potent and selective antibodies against relevant viral e

31 n this report we describe the discovery of a potent and selective DYRK1A inhibitor GNF2133, which was

32 asingly rapid progress in the development of potent and selective inhibitors for a wide range of DUBs

33 ndation for further developments toward more potent and selective inhibitors for the tumor-expressed

34 e results provide useful insights to develop potent and selective inhibitors for undesired GUSs.

35 constitute the basis for the development of potent and selective inhibitors.

36 The new compounds showed to be endowed with potent and selective inhibitory activity against the can

37 hat led to the development of several highly potent and selective inverse agonists of GHSR based on t

38 for the design of chemically stable, highly potent and selective Kv7 agonists.

39 ve (S)-17 (UCM-05194) stands out as the most potent and selective LPA(1) receptor agonist described s

40 Specifically, we identify highly potent and selective photoswitchable inhibitors of the d

41 scaffold-hybrid strategy, we develop a novel potent and selective SPAK inhibitor, 5-chloro-N-(5-chlor

42 hemistry campaign to simultaneously preserve potent and specific NCEH1 labeling in live cells and ani

43 rug conjugate was developed and demonstrated potent and specific tumor killing in vitro and in vivo a

44 f compound BAY 1214784, an orally available, potent, and selective hGnRH-R antagonist.

45 Marijuana is becoming increasingly potent, and smoking marijuana carries many of the same c

46 incidence with the widespread use of highly potent androgen receptor (AR)-pathway inhibitors (APIs)

47 rom adrenal dehydroepiandrosterone (DHEA) to potent androgens and has a germline missense-encoding po

48 Moreover, tatM2NX is a potent antagonist with an IC(50) of 396 nM.

49 We have found the potent anti-biofilm activity of Bald's eyesalve cannot b

50 bvert type III CRISPR immunity by means of a potent anti-CRISPR ring nuclease variant AcrIII-1.

51 his study, we have used Sinomenine (Sino), a potent anti-inflammatory and antioxidant drug conjugated

52 orious adverse effects, glucocorticoids (GC, potent anti-inflammatory drugs) are used extensively in

53 pe or mutant RAS Intracellular delivery of a potent anti-RAS biologic through a receptor-mediated mec

54 s, an efficient first total synthesis of the potent anti-trypanosomal macrolide (+)-actinoallolide A

55 lling of human melanoma cells in vitro and a potent anti-tumor effect in vivo.

56 the first report of triterpenoid acids with potent anti-virulence effects against S. aureus.

57 t multiple receptor tyrosine kinases, exerts potent antiangiogenesis.

58 ns demonstrated that the dressings exhibited potent antibacterial activity.

59 Thiostrepton is a potent antibiotic against a broad range of Gram-positive

60 thogen typically stimulate the production of potent antibodies specific for the pathogen through a Da

61 oxoolean-1,12-dien-30-oate (CF(3)DODA-Me), a potent anticancer agent, were studied on cancer-lymphati

62 SimCells were used to synthesize catechol (a potent anticancer drug) from salicylic acid to inhibit l

63 immature, whereupon they can transform into potent antigen-presenting cells upon full maturation.

64 Boiled rhizome powder exhibited potent antihyperglycemic activity against sugar-induced

65 tes (MAIT, gammadeltaT, and iNKT cells) with potent antimicrobial and regulatory functions.

66 naturally occurring caffeoyl conjugate and a potent antioxidant found in the phenolic fraction of The

67 pha lipoic acid (ALA) is a nutraceutical and potent antioxidant that has shown efficacy in the retina

68 restored primary cilium length and exhibited potent antiproliferative activity.

69 This BTC demonstrated potent antitumor activity in vivo but was poorly tolerat

70 ion led to the identification of a number of potent antitumor agents and the first structure-activity

71 -like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity.

72 ith bacterial l-Met-degrading enzymes exerts potent antitumor effects.

73 wed dose-dependent pharmacokinetics, and had potent antiviral activity in patients with CHB.

74 e but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals

75 es exhibited characteristics associated with potent antiviral function: memory T cells secreted cytok

76 Dnmt3b3 is equally potent as Dnmt3L in stimulating the activities of Dnmt3a

77 The most potent azaindole 45 inhibits SHP2 with an IC(50) = 0.031

78 Ospemifene displayed the most potent azole chemosensitizing activity, and its combinat

79 hat Omomyc and analogues presented here, are potent binders of the E-box DNA engaged by Myc for trans

80 humans and mice, and explains the failure of potent biotin biosynthesis inhibitors in standard mouse

81 onses and serves as a target for some highly potent broadly neutralizing antibodies.

82 Acalabrutinib is a selective, potent Bruton tyrosine-kinase inhibitor.

83 Potent C3aR antagonists are now available for interrogat

84 bonuclease activity in the Csx1 domain and a potent cA4 ring nuclease activity in the C-terminal Crn2

85 The first total synthesis of potent cannabinoid, 9beta-11-hydroxyhexahydrocannabinol,

86 Two mAbs displayed broad and potent capacity to inhibit IBV NA enzymatic activity, ne

87 tion, most such studies inhibited the highly potent catalytic enzyme for ACh, AChE, to facilitate mea

88 Among them, compound 51 emerged as a potent CB2R agonist able to reduce pain in rats carrying

89 both G-quadruplexes and R loops and showed a potent cell killing activity associated with the formati

90 and cellular activity profiles of GSK789, a potent, cell-permeable, and highly selective inhibitor o

91 Thus, these novel compounds are potent CEN inhibitors with in vitro and in vivo activity

92 In murine models, CX-6258 induced a potent cGAS-dependent type-I IFN response in tumor cells

93 The most potent chitin derivative was used for the film coating o

94 d to the successful synthesis of a novel and potent combi-molecule JS230.

95 The strong preclinical efficacy of this potent combination against multiple patient-derived xeno

96 We present evidence that MDMX is a potent competitive inhibitor of CK1alpha kinase activity

97 The most potent compound, 45 (LSP12-3129), inhibited N-acetylneur

98 eation and absorption properties of the most potent compounds, which were zwitterionic in nature, cou

99 isk factors, suggesting it is a particularly potent contributor.

100 ld be suspended and intensive treatment with potent corticosteroids (topical, subtenon, intravitreal,

101 Animal studies demonstrated that the most potent cross-reactive neutralizing mAbs, HENV-26 and HEN

102 ic and pharmacological inhibition of HuR had potent cytostatic and cytotoxic effects on tumor growth,

103 igenetic drugs have been widely described as potent cytotoxic agents for cancer cells.

104 ory ligands CD70 and OX40L, thereby inducing potent cytotoxic CD4(+) and CD8(+) T cell responses.

105 lar to murine EMP-derived NK cells, harbor a potent cytotoxic degranulation bias.

106 These compounds were potent cytotoxins toward numerous pediatric cancer cell

107 evolved TE loci such as BANCR may represent potent de novo developmental regulatory elements that ca

108 The most potent derivatives, 22 and 30, inhibit early steps of th

109 iption factors, as a group of molecules, are potent determinants of synaptic partner choice and there

110 by BACE1, is released via exosomes, and is a potent diffusible inhibitor of regenerative growth in Ng

111 The potent DNA-binding compound triaminotriazine-acridine co

112 should be considered for development of more potent drugs.

113 A highly potent dual inhibitor (13 a) is identified to possess ex

114 f a lead compound 10, (SPR519) as an equally potent dual inhibitor of PI3Kalpha and mTOR kinases.

115 ied from a screen of FDA-approved drugs as a potent EBOV viral entry inhibitor, via binding to EBOV g

116 unctions throughout adulthood, and reveals a potent effect of colony stimulating factor 1 receptor in

117 n of L-Kyn levels in plasma, together with a potent effect on abrogating immunosuppressive properties

118 se, emerged as a promising target due to its potent effect on alpha-Syn and potential druggability as

119 different class ( e.g., IgE) could engender potent effector cell activation, and unleash previously

120 the angiopoietin-like protein 4 (ANGPTL4), a potent endogenous LPL inhibitor, was significantly incre

121 analogues revealed a number of exceptionally potent epothilone B analogues, demonstrating the potency

122 Together, we reveal a potent ERBB2-mediated YAP mechanotransduction signalling

123 The most potent ester modifications harbored unbranched C4 units,

124 autoimmune conditions can be converted into potent FcgammaR-independent agonists with remarkable ant

125 The role of lipid peroxidation, a potent form of oxidative stress, in mediating RV hypertr

126 Methane (CH(4)), a potent gas with a global warming potential 86-125x that

127 -type mice injected intramuscularly with the potent GPR30-selective agonist G-1 at 0 or 1 mug/day and

128 As a potent greenhouse gas and an ozone-depleting agent, nitr

129 sponsible for 70% of global emissions of the potent greenhouse gas methane (CH(4)).

130 Methane is a potent greenhouse gas; methane production and consumptio

131 residues into latent GDF9 generated a highly potent growth factor, called hereafter Super-GDF9.

132 on six lymphoma cell lines, and eight showed potent growth inhibitory effects with IC(50) values lowe

133 yl)-5-chloro-2-hydroxybenzamide analogues as potent HAdV inhibitors.

134 Ganetespib, a highly potent heat shock protein 90 inhibitor, blocks multiple

135 bioavailability led to the discovery of the potent, highly selective, orally available ATR inhibitor

136 The potent HIV-1 capsid inhibitor GS-6207 is an investigatio

137 tained throughout the ATI lifespan through a potent homeostatic reduction in presynaptic neurotransmi

138 sites of vulnerability on RBP recognized by potent human mAbs that inhibit virus by multiple mechani

139 n the Spectrum Collection, with the two most potent (IC(50) = ~2 mum) being symmetrically substituted

140 Here we describe a family of potent imaging probes that can be activated by molecules

141 enic rats were found to produce a variety of potent immune factors, both at the transcript and protei

142 n, but its complete deletion results in more potent immune responses to infection.

143 Biomaterial-based AML vaccination can induce potent immune responses, deplete AML cells and prevent d

144 MVWGP was the most potent immune-modulatory peptide across all cellular ass

145 ells (MSCs) have been studied for decades as potent immunomodulators.

146 Our findings suggest that PA can serve as a potent immunomodulatory supplement to MS drugs.

147 myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cells, we tested whether donor-d

148 roliferate in the setting of cancer and have potent immunosuppressive functions hindering anti-tumor

149 DBA/2J pDCs were more potent in inducing Foxp3 in B6 T cells than the reverse

150 ing CRL4(CDT2) by CDT2 knockdown can be more potent in killing cSCC cells than targeting CRLs or CRL4

151 27 was more potent in MCF-7:CFR cells than six BET inhibitors in cli

152 e-containing lipidoids that are particularly potent in T lymphocytes transfection.

153 Remdesivir has potent in vitro activity against SARS-CoV-2, but it is n

154 We found that C-subtypes displayed broad and potent in vitro antimicrobial activities comparable to t

155 s, MMH371, MMH409, and MMH410, which exhibit potent in vitro HDAC8 activity (IC(50) = 66, 23, and 66

156 It demonstrates potent in vivo target occupancy with an EC(90) of 1.6 mg

157 ughput screen, we identified decitabine as a potent inducer of immunogenic EBV antigens, including LM

158 nterleukin 6 (IL-6) or IL-23, which are both potent inducers of GVHD-induced colonic pathology, indic

159 s regulates their inhibitory input and has a potent influence on their activity.

160 We also describe potent inhibition of SARS-CoV-2 strain 2019-nCoV/USA-WA1

161 tly confirmed that quercetin is reasonably a potent inhibitor of 3CLpro.

162 Overall, the hC3Nb3 nanobody represents a potent inhibitor of both the alternative pathway and the

163 estigation of GW296115 has confirmed it as a potent inhibitor of kinases including BRSK1 and BRSK2 th

164 fter LPS treatment, whereas treatment with a potent inhibitor of the mitochondrial pyruvate carrier (

165 Tuberous sclerosis complex (TSC) is a potent inhibitor of TORC1.

166 Entrectinib is a potent inhibitor of tropomyosin receptor kinase (TRK) A,

167 G15, such as human ISG15, stabilize USP18, a potent inhibitor of type I interferon (IFN)-I.

168 The most potent inhibitor was NFLP, which had a competitive (with

169 EBOV GP and uncovered evidence that the most potent inhibitors act through multiple mechanisms.

170 mia (FA) factors active in the S/G2 phase as potent inhibitors and regulators of L1 activity.

171 be moderate inhibitors of alpha-amylase, but potent inhibitors of alpha-glucosidase, showing low-micr

172 Such potent inhibitors of class I HDACs may show benefits in

173 alogues synthesized in this study are highly potent inhibitors of DHODH in an enzymatic assay, while

174 tors do not inhibit serine proteases but are potent inhibitors of parasite cathepsins L and host lyso

175 of the V(H)Hs, V2A11, V8E6, and V2G10, were potent inhibitors of RTA in vitro and protected Vero cel

176 Here we describe three potent inhibitors of SauCas9 that we name AcrIIA13, AcrI

177 Several compounds were found to be potent inhibitors of the enzyme in biochemical and cell-

178 hlights the opportunity to develop more cell-potent inhibitors to elucidate the function of NTMTs in

179 ric sites and the way forward to design more-potent inhibitors.

180 date the inhibitory mechanisms of a group of potent inhibitors.

181 nds out as the most promising candidate with potent inhibitory activities against both PARP-1/2 and P

182 Due to their potent interfering and immunostimulatory properties, DVG

183 x receptor transporter protein 4 (RTP4) as a potent interferon (IFN)-inducible inhibitor of human pat

184 mor retention and limit systemic exposure of potent intratumoral therapies.

185 suggesting that SARS-CoV-2 RBD, albeit more potent, is less exposed than SARS-CoV RBD.

186 Pamoic acid is a potent ligand for G protein Coupled Receptor 35 (GPR35)

187 IC(50) of 68 mum), but LCA is also a highly potent ligand for TGR5 (EC(50) 0.52 mum).

188 eeded to inactivate des-Arg9 bradykinin, the potent ligand of the B1R.

189 fold was confirmed by resolving the two most potent ligands [(+/-)-47, and (+/-)-38 K(i) = 10.20 and

190 AGRP RFF hot spot sequence yielded novel and potent ligands of the SPRY domain-containing SOCS box pr

191 In contrast, Iso2 was a potent ligase that reduced levels of the mutant form of

192 om a survivor of natural EEEV infection with potent (<20 pM) inhibitory activity of EEEV.

193 scular endothelial growth factor (VEGF)-C, a potent lymphangiogenic factor, is up-regulated in endome

194 The most potent mAb, CV07-209, neutralized authentic SARS-CoV-2 w

195 M repolarization, synergistically triggering potent macrophage immune responses.

196 t of cardiomyocyte maturation and identified potent maturation-enhancing ECMs through this simple and

197 inal chemists into making more selective and potent Mcl-1 inhibitors, the Mcl-1 protein is compared t

198 Metabolism has emerged as a potent means to control maturation with unexpected effec

199 e data suggest mesenchymal-derived NRG1 is a potent mediator of tissue regeneration and may inform th

200 growth restriction requires the synthesis of potent mediators called jasmonates (JAs).

201 tion of high-throughput screening hit 8 to a potent, metabolically stable, and orally bioavailable di

202 sent an in vivo analysis of Rh-PPO, our most potent metalloinsertor.

203 We notice that the most potent modifiers refer to the glycolysis pathway and tha

204 As stressful environment is a potent modulator of feeding, we seek in the present work

205 11, which can be inhibited with ispinesib, a potent molecularly-targeted drug.

206 , offering avenues for repurposing of highly potent molecules as probes for previously unreported tar

207 a starting point for the development of more potent molecules that allosterically regulate M(Pro) act

208 lium is constantly perturbed by biologically potent molecules, including the complement activation pe

209 We identified 14 potent Nape-pld inhibitors in the Spectrum Collection, w

210 ls for human retinal degeneration due to its potent neuroprotective effects in various animal models.

211 The potent neutralization activity of V(H)-Fc ab8 combined w

212 We isolated potent neutralizing antibodies (nAbs) to two epitopes on

213 ral and cellular immune responses, including potent neutralizing antibodies.

214 Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type

215 H building blocks were assembled into highly potent neutralizing complexes using bacterial superglue

216 cytolytic activity, pneumolysin serves as a potent neutrophil activating factor.

217 oth muscle, cytoglobin (Cygb) functions as a potent nitric oxide (NO) dioxygenase and regulates NO me

218 sion to estradiol, we further examined how a potent non-aromatizable androgen, dihydrotestosterone (D

219 These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists

220 processes, sex steroid hormones such as the potent oestrogen 17beta-oestradiol have been less well r

221 nd viral gene expression.IMPORTANCE MDV is a potent oncogenic herpesvirus that induces T-cell lymphom

222 benzofuran core led to the identification of potent, orally bioavailable compound 19.

223 the discovery and optimization of a class of potent, orally bioavailable inhibitors of glucose transp

224 ved from the mushroom Amanita muscaria and a potent orthosteric agonist of the GABA(A) receptor.

225 dverse outcomes across hospital quartiles of potent P2Y12 inhibitor use.

226 ll lines, including B-cell lymphomas, to the potent pan-NMT inhibitor PCLX-001.

227 Bradykinin is a potent part of the vasopressor system that induces hypot

228 t the crystal structure of FPR2 bound to the potent peptide agonist WKYMVm at 2.8 angstrom resolution

229 (Cys)(18)] and CV into the polymer activates potent photobactericidal activity.

230 ulated by inorganic pyrophosphate (PP(i)), a potent physiological inhibitor of hydroxyapatite crystal

231 we describe the design of a novel series of potent PI3Kgamma inhibitors that attain high isoform sel

232 We find that the most potent pore-forming peptides exhibit strong interpeptide

233 anolone, and their synthetic derivatives are potent positive allosteric modulators (PAMs) of GABA(A)

234 Kidney dysfunction was a potent predictor of 1-year mortality risk after incident

235 While horine was potent primarily against gram-positive pathogens, verine

236 ial-mesenchymal transition (EMT), VAL exerts potent pro-invasive and pro-metastatic effects through d

237 animals, environmental enrichment (EE) is a potent promoter of AHN and hippocampal function.

238 Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; ho

239 The microbicide-only group exhibited potent protection; 10 of 12 macaques remained uninfected

240 Thus, Skd3 is a potent protein disaggregase critical for human health.

241 Hydrogen (H(2)) is a potent reductant that can be generated when water intera

242 SynGAP is a potent regulator of biochemical signaling in neurons and

243 Although 25HC is a potent regulator of cholesterol storage, uptake, efflux

244 Hyperglycemia is a potent regulator of endogenous glucose production (EGP).

245 Conversely, these Tregs display potent regulatory activity in vivo, promoting long-term

246 a disrupted beta-turn were dramatically less potent relative to their parent compounds.

247 smaller and non-polar peptides were the most potent, respectively.

248 X-ray crystallography revealed that a potent, reversible, first-in-class small molecule inhibi

249 is a common chromosomal microdeletion and a potent risk factor for psychotic illness.

250 in temperature, when blowfly larvae are more potent rivals for the limited resources on the carcass.

251 Taken together, these results convey the potent role of DR3 as an ILC2 regulator and introduce DR

252 ing tri-specific VHH-Fc antibodies show more potent S1 binding, S1/ACE2 blocking, and SARS-CoV-2 pseu

253 hyperactive AR signaling and will respond to potent second-line antiandrogen therapies, including bic

254 Fulvestrant is a potent selective estrogen receptor degrader (SERD), whic

255 Capivasertib (AZD5363) is a potent selective oral inhibitor of all three isoforms of

256 discovery and clinical validation of highly potent selective RET inhibitors (pralsetinib, selpercati

257 s highlight the discovery of IACS-13909 as a potent, selective inhibitor of SHP2 with drug-like prope

258 Herein, we disclose our efforts to identify potent, selective, and orally bioavailable inhibitors of

259 armacophore exploration to identify a highly potent, selective, brain penetrant TORKi.

260 open science approach to develop a series of potent, selective, orally bioavailable, and brain-penetr

261 a-8-azaspiro[4.5]decan-4-amine (1), a highly potent, selective, orally efficacious, and first-in-clas

262 Two potent sigma(1) receptor agonists, TC1 and SA4503, showe

263 with the clinical data, MVT-602 induced more potent signaling of KISS1R-mediated IP1 accumulation and

264 Here, we report two potent small-molecule FTO inhibitors that exhibit strong

265 dency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate

266 d-chiro-Inositol ribophostin is the most potent small-molecule Ins(1,4,5)P(3) receptor agonist wi

267 port the discovery of CG416 and CG428 as two potent small-molecule proteolysis-targeting chimera (PRO

268 of toxic steroids (cardenolides), provide a potent source of exogenous immunity.

269 Mutagenic compounds are a potent source of human disease.

270 Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote

271 enolpyruvate (PEP), Pro, and Ala as the most potent stimulators of plant leaf R(N) Using metabolite c

272 ic immunotherapy may represent a general and potent strategy for cancer vaccination.

273 HASPIN inhibition by CX-6258 is a novel and potent strategy for RAF/MEK inhibitor-resistant melanoma

274 Here, we present a specific and potent substrate, an inhibitor, and an activity-based pr

275 access to taltobulin (HTI-286), a similarly potent synthetic analogue.

276 tain the native biological properties of the potent taccalonolide, AJ.

277 Thus, we screened new potent targets from beta-catenin destruction complex ass

278 i-action inhibitors are efficacious and more potent than single inhibitory chemotypes.

279 glutination-inhibiting activity and are less potent than strain-specific antibodies.

280 The R diastereomer is significantly more potent than the S diastereomer and N-terminal modificati

281 to the discovery that (S)-isomers were more potent than their corresponding (R)-enantiomers.

282 The MSA samples were more potent than those of idiopathic PD in seeding aggregatio

283 cts as a reservoir for effector T cells with potent therapeutic characteristics.

284 antigen-specific T cell receptors (TCRs) are potent therapies for viral infections and cancer.

285 timately becomes resistant and requires more potent therapies.

286 Camptothecins are potent topoisomerase I inhibitors used to treat high-ris

287 riched for EVs from HIV-infected men induces potent transcriptional responses in epithelial and strom

288 A potent trypsin inhibitor from Tityus obscurus scorpion v

289 these effects on MBNL1 may therefore, yield potent tumor suppressor activities, uncovering new thera

290 The p53 transcription factor confers its potent tumor suppressor functions primarily through the

291 aryl hydrocarbon receptor (AHR) pathway as a potent tumour suppressor in a SHH medulloblastoma mouse

292 olyketide macrolides, which present the most potent V-ATPase inhibitors known to date.

293 of diverse symmetries towards generation of potent vaccines.

294 dependent conversion of angiotensin I to the potent vasoconstrictor angiotensin II while simultaneous

295 of mutated EGFR promotes the secretion of a potent vasoconstrictor, endothelin-1 (EDN1), which conti

296 Endothelin-1, a very potent vasoconstrictor, is a key modulator of blood flow

297 that neonatal T cells are not inert or less potent versions of adult T cells but instead are a broad

298 We show that this structure is a potent viral inhibitor and that it can act as a sensor b

299 a valuable adjunct to reducing the usage of potent volatile anaesthetics, thereby improving their sa

300 The most potent, with new binding modes, are 56- and 64-residue p