ライフサイエンスコーパス: potential drug target

1 sion injury, and suggest that Plexin C1 is a potential drug target.

2 and INPP4B alterations, supporting IGF2 as a potential drug target.

3 arasitic nematode Haemonchus contortus, as a potential drug target.

4 patch on the NTD of TbBILBO1 is therefore a potential drug target.

5 ese humans, strengthening its prospects as a potential drug target.

6 en considered essential and is proposed as a potential drug target.

7 neration of PD pathogenesis, making LRRK2, a potential drug target.

8 lism of microbial human pathogens, PPDK is a potential drug target.

9 iral maturation and has been identified as a potential drug target.

10 facing pathogen, Citrobacter rodentium, as a potential drug target.

11 an essential step in virus replication and a potential drug target.

12 an essential mediator in SIRS and, hence, a potential drug target.

13 thogens and its absence in humans make UGM a potential drug target.

14 as been identified as a virulence factor and potential drug target.

15 ilities for the utilization of center N as a potential drug target.

16 ronavirus replication and thus constitutes a potential drug target.

17 purine nucleoside phosphorylase (PfPNP) is a potential drug target.

18 g, validating the Vif-APOBEC3 interface as a potential drug target.

19 viral precursor polyprotein and therefore a potential drug target.

20 cific inhibition of LysRS1 indicates it is a potential drug target.

21 ammation and cancer, which qualifies it as a potential drug target.

22 l aid in identifying new inhibitors for this potential drug target.

23 f-splicing reaction and thus is a model of a potential drug target.

24 investigated its recombinase, PfRad51, as a potential drug target.

25 al for LP activation, and therefore, it is a potential drug target.

26 ntified as a pan-enterovirus host factor and potential drug target.

27 multi-drug efflux we suggest that CsrA is a potential drug target.

28 nd will enable therapeutic targeting of this potential drug target.

29 upregulated in numerous cancers making it a potential drug target.

30 ription factor within the top GO term, and a potential drug target.

31 oteomics to identify novel BCR effectors and potential drug targets.

32 survival in Mtb, commending both proteins as potential drug targets.

33 nteracting proteins, that may thus represent potential drug targets.

34 dium lipid synthesis enzymes are emerging as potential drug targets.

35 e siRNA gene knockout studies and identified potential drug targets.

36 genesis of ALS and merit further analysis as potential drug targets.

37 rpin RNA (shRNA) library to screen for novel potential drug targets.

38 milies or posttranslational modifications as potential drug targets.

39 om the host, these kinases are considered as potential drug targets.

40 genomes could identify key intermediates as potential drug targets.

41 s, KDM4 proteins present themselves as novel potential drug targets.

42 important biological pathways, rhomboids are potential drug targets.

43 s may represent a promising reservoir of new potential drug targets.

44 genetic screens to identify and characterize potential drug targets.

45 the process of fibril extension and provide potential drug targets.

46 te the highly conserved trypanosomal PDEs as potential drug targets.

47 tamate excretion in cancer and points toward potential drug targets.

48 ase family C (GT-C) members, which represent potential drug targets.

49 have been implicated in pathogenesis and are potential drug targets.

50 site and, consequently, can be considered as potential drug targets.

51 ences in their properties and to predict new potential drug targets.

52 uld be particularly valuable for identifying potential drug targets.

53 o the identification of many more kinases as potential drug targets.

54 -2 virology provides a significant number of potential drug targets.

55 ole in signal transduction and are therefore potential drug targets.

56 ion of KS tumor markers for diagnosis and as potential drug targets.

57 aid in drug discovery and identification of potential drug targets.

58 vealing structure-function relationships and potential drug targets.

59 known as falcipains, are hemoglobinases and potential drug targets.

60 el new pathways of vessel growth to identify potential drug targets.

61 an important characteristic when looking for potential drug targets.

62 ls to study essential genes and characterize potential drug targets.

63 insights about molecular pathophysiology and potential drug targets.

64 isms underpinning these diseases and suggest potential drug targets.

65 M. tuberculosis EH's have been identified as potential drug targets.

66 es of trypanosomatid ribosome assembly offer potential drug targets.

67 a phosphorylation of CDK1 and are considered potential drug targets.

68 seful in identifying novel disease genes and potential drug targets.

69 gs, their side effects, withdrawn drugs, and potential drug targets.

70 n of gene function and the identification of potential drug targets, a process often known as target

71 dentify malignancy-associated biomarkers and potential drug targets, a signature proteome.

72 ysLT(2)R has recently started to emerge as a potential drug target against atopic asthma, brain injur

73 se-1,6-bisphosphatase has been proposed as a potential drug target against Leishmania parasites that

74 bECT is therefore genetically validated as a potential drug target against the African trypanosome.

75 ssential pyruvate transporter and provides a potential drug target against the mammalian life cycle s

76 d genes encoding proteins that represent new potential drug targets against hookworms.

77 ggest that macrophage PAR1 and calpain 1 are potential drug targets against leishmaniasis.

78 In silico screening identified numerous new potential drug targets against trichuriasis.

79 ites in their vicinity are anticipated to be potential drug targets aimed at inhibiting viral infecti

80 of attention from both the perspective of a potential drug target and a catalyst for the development

81 Thus, Ldp27 can be explored as a potential drug target and parasites devoid of the p27 ge

82 abotropic glutamate receptor 4 (mGluR4) as a potential drug target and predicted that selective activ

83 ing site in cysteine protease cathepsin B, a potential drug target and prognostic marker for tumor me

84 synthesis, identifying HMG-CoA synthase as a potential drug target and suggesting that identification

85 , can provide pathogenic insights as well as potential drug targets and biomarkers for T2D and other

86 wnstream genes valuable candidates for being potential drug targets and exploratory biomarkers.

87 cobacterial essential functions, identifying potential drug targets and for exploring mycobacteriopha

88 Then, we prioritised a panel of kinases as potential drug targets and inferred chemicals that bind

89 lved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their prot

90 ate the identification and prioritization of potential drug targets and selection of suitable patient

91 nome to lead to tumorigenesis, and highlight potential drug targets and therapeutic agents for DIPG.

92 nd previously unconsidered cellular genes as potential drug targets and to provide insight into basic

93 teins play important roles in cancer and are potential drug targets and tumor markers.

94 ied 562 NF-kappaB/RelA modulators, which are potential drug targets, and clarified mechanisms of achi

95 ul for study of gene functions, discovery of potential drug targets, and gene therapy applications.

96 rapid acceleration in the identification of potential drug targets, and in high-throughput screens f

97 They represent excellent potential drug targets, and it is likely that additional

98 usage with functional importance, identifies potential drug targets, and provides insight into the ne

99 sequences of uncoupling V-ATPases in vivo as potential drug targets are discussed.

100 ed significantly, its underlying biology and potential drug targets are still unexplored.

101 FtsZ is a potential drug target, as illustrated by the small-molec

102 te cancer above Gleason grade 3, ERbeta is a potential drug target at the initial stage of the diseas

103 The LT superfamily is a potential drug target because it is active in essential

104 eins have received considerable attention as potential drug targets because of their ability to modul

105 Topoisomerases are valuable as potential drug targets because they have indispensable f

106 of the menaquinone (Vitamin K2) pathway are potential drug targets because they lack human homologs.

107 spases have been intensively investigated as potential drug targets, both in academic and industrial

108 lective of biological predisposition and are potential drug targets) brought to the fore APOE and IL6

109 g number of proteins are being identified as potential drug targets but are difficult to obtain in a

110 iology, both enzymes have been identified as potential drug targets, but few useful inhibitors have b

111 proteases are increasingly being explored as potential drug targets, but their potent and specific in

112 us validating the products of these genes as potential drug target candidates.

113 dentify genes or pathways for new and unique potential drug targets, determine premorbid diagnosis, p

114 cells (NF-kappaB)-inducing kinase (NIK) as a potential drug target driving NF-kappaB signaling and Me

115 p90 ribosomal S6 family of kinases (RSK) are potential drug targets, due to their involvement in canc

116 ressentiality can help choose an enzyme as a potential drug target, especially because the index is n

117 s of metabolism can be useful in identifying potential drug targets, especially in unicellular organi

118 and processing in AD, suggesting Golgi as a potential drug target for AD treatment.

119 inant of tumor angiogenesis and, hence, as a potential drug target for adjuvant therapy of solid tumo

120 ls and zebrafish, MAP2K5 kinase emerged as a potential drug target for ALS therapy.

121 It was identified as a potential drug target for Alzheimer's disease, Down synd

122 ique sensor of noxious stimuli and, hence, a potential drug target for analgesics.

123 as a host factor for HCV infection and as a potential drug target for antiviral therapy.

124 ocking ADAM8 function, highlighting ADAM8 as potential drug target for asthma therapy.

125 nd myelomonocytic fate and suggests Glut1 as potential drug target for atherosclerosis.

126 s between estrogen-related receptor alpha, a potential drug target for cancer and metabolic diseases,

127 ions allows critical evaluation of Plk1 as a potential drug target for cancer therapy.

128 The HAT domain of p300/CBP is a potential drug target for cancer.

129 ulator of neurovasculature development and a potential drug target for cerebrovascular diseases.

130 radation of these client proteins makes it a potential drug target for certain forms of cancer.

131 ic marker of cancer chemoresistance and as a potential drug target for CSC therapy.

132 this study supports the notion that sT is a potential drug target for dampening MCPyV infection.

133 The GIVD cPLA2 (cPLA2delta) is a potential drug target for developing a selective therape

134 a critical regulator of the Hh pathway and a potential drug target for Hh-driven cancers.

135 three phenotypes in HSP neurons, providing a potential drug target for HSP treatment.

136 These data suggest a new potential drug target for human C. difficile treatment a

137 f PI3K signaling, and is also discussed as a potential drug target for immunomodulation and the treat

138 bitor of both inflammation and cancer, and a potential drug target for inflammatory and neoplastic di

139 , suggesting that the JAK/STAT1 pathway is a potential drug target for inhibiting HMGB1 release.

140 mmalian parasitization and thus represents a potential drug target for leishmaniasis.

141 ion in cancerous tissues and is considered a potential drug target for liver and lung cancer.

142 acid homeostasis, has recently emerged as a potential drug target for liver disease.

143 et of Hh signaling regulation, and reveals a potential drug target for modulating Hh signaling activi

144 st as both a biomarker for neuroinjury and a potential drug target for neuroinflammation and other di

145 Purinergic receptor is a potential drug target for neuropathic pain, Alzheimer di

146 Parasite lactate dehydrogenase (pLDH) is a potential drug target for new antimalarials owing to par

147 arrest and apoptosis, so it is considered a potential drug target for oncology.

148 the enzyme in cuticle production makes it a potential drug target for parasitic nematodes.

149 absorption and macrophage iron release, is a potential drug target for patients with iron overload sy

150 that the AMP site of FBPase may represent a potential drug target for reducing the excessive glucose

151 The NorA efflux pump is a potential drug target for reversal of resistance to sele

152 atening disease, and supports COUP-TFII as a potential drug target for the intervention of metastatic

153 C8, encoding thymidylate kinase (TMPK), as a potential drug target for the management of C. albicans

154 o uroporphyrinogen III and serves as a novel potential drug target for the pharmaceutical industry.

155 icotinic acetylcholine receptor (nAChR) is a potential drug target for the treatment of a number of n

156 receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Par

157 The restricted expression makes it a potential drug target for the treatment of gastric and p

158 This identifies Star-PAP as a potential drug target for the treatment of HPV-positive

159 rrent inhibition by nifedipine, CaV1.1e is a potential drug target for the treatment of myotonic dyst

160 (GOAT), is receiving increased interest as a potential drug target for the treatment of obesity, diab

161 The adenosine A(2A) receptor (A(2A) R) is a potential drug target for the treatment of Parkinson's d

162 The H3R has attracted interest as a potential drug target for the treatment of several impor

163 tor of insulin receptor (IR) signaling and a potential drug target for the treatment of type 2 diabet

164 tative allosteric activator site, which is a potential drug target for the treatment of type 2 diabet

165 These data define PTPMT1 as a potential drug target for the treatment of type II diabe

166 from inflammatory arthritis, making iRHOM2 a potential drug target for this condition.

167 ing of assembly, which is an as yet untapped potential drug target for this important class of pathog

168 PCR, GPR161, as an important regulator and a potential drug target for TNBC.

169 he hepatic RAR-FGF21 pathway may represent a potential drug target for treating metabolic disorders.

170 esses and has generated recent interest as a potential drug target for treating neurodegenerative dis

171 ed to investigate whether the AhR could be a potential drug target for treating patients with GBM who

172 A potential drug target for treatment of Chagas disease, s

173 years, ASBT has attracted much interest as a potential drug target for treatment of hypercholesterola

174 In humans, it is a potential drug target for treatment of primary hyperoxal

175 ymes in this pathway, only HisG represents a potential drug target for tuberculosis.

176 -induced tumorigenesis and suggests YAP as a potential drug target for UM patients carrying mutations

177 protein-coupled receptors, is emerging as a potential drug target for various disorders, including c

178 AH2-omega-3 epoxide-Srcin1 axis presents new potential drug targets for allergic diseases.

179 tion of genes, and for the identification of potential drug targets for antimicrobial treatment.

180 imply that these responses are attractive as potential drug targets for blocking the evolution of pat

181 Tankyrases constitute potential drug targets for cancer and myelin-degrading d

182 We identified potential drug targets for chloroquine combination thera

183 Glutamate receptors are important potential drug targets for cognitive enhancement and the

184 ate central nervous system and are important potential drug targets for cognitive enhancement and the

185 We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide ass

186 essential roles in viral propagation and are potential drug targets for curbing herpesvirus infection

187 nd present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.

188 Histone deacetylases are potential drug targets for diseases caused by protozoan

189 This study establishes the PLKs as potential drug targets for influenza and contributes to

190 -transduction regulators and have emerged as potential drug targets for inhibitor design.

191 st that the extracellular domains of APP are potential drug targets for interfering with beta-secreta

192 These proteases may constitute potential drug targets for intervention against malaria

193 tiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function

194 Because Hsp70s are emerging as potential drug targets for many diseases, fully mapping

195 Since many of these enzymes represent potential drug targets for metabolic diseases, efforts w

196 RISPR screening to identify MDM2 and MDM4 as potential drug targets for MRTs.

197 actinobacteria and highlights a new class of potential drug targets for mycobacterial diseases.

198 atory subunits KChIP1, KChIP2, and DPP10 are potential drug targets for neuropathic pain because they

199 Thus, these modulatory subunits could be potential drug targets for neuropathic pain.SIGNIFICANCE

200 ght into the role of ASIC1a and CP-AMPARs as potential drug targets for neuroprotection.

201 Our results suggest that LIMKs are potential drug targets for NF2 and tumors associated wit

202 genomics and proteomics are identifying many potential drug targets for novel therapeutic proteins, a

203 tribute to epileptic phenotypes and that are potential drug targets for precision medicine approaches

204 these reasons, cyclophilins have emerged as potential drug targets for several diseases.

205 aviour and may lead to the identification of potential drug targets for smoking prevention and/or ces

206 of blood pressure regulation and highlights potential drug targets for the prevention or treatment o

207 portant regulators of liver repopulation and potential drug targets for the promotion of liver repopu

208 verse cognitive functions and they represent potential drug targets for the treatment of a number of

209 ACATs have gained attention as potential drug targets for the treatment of diseases suc

210 , and miR-326 and miR-9 may be considered as potential drug targets for the treatment of disorders in

211 and reward, making them ideally situated as potential drug targets for the treatment of several brai

212 Combined, our results reveal new potential drug targets for the treatment of tauopathies

213 te axon death genes, thereby providing novel potential drug targets for therapeutic intervention to p

214 rious pathways affected, as well as provided potential drug targets for therapeutics.

215 tioxidant small molecules such as NtBuHA are potential drug targets for thioesterase deficiency disea

216 ical pathways that may provide insights into potential drug targets for treatment or prevention of CV

217 Elucidation of new biomarkers and potential drug targets from high-throughput profiling da

218 We identified 20 potential drug target genes in two genomewide-corrected

219 es in these parasites, and a number of novel potential drug targets have been identified.

220 ns that HBc makes prior to capsid formation (potential drug targets) have proved refractory to struct

221 Identifying potential drug targets, i.e. causal protein-coding genes

222 entifies Vaccinia-related kinase (VRK1) as a potential drug target in a tumour-specific mitotic netwo

223 minant of renal cyst enlargement and hence a potential drug target in ADPKD.

224 Our findings indicate that PTGER4 is a potential drug target in AI-resistant cancers.

225 ide 3-kinase beta (PI3Kbeta) is considered a potential drug target in arterial thrombosis, which is a

226 ptor 2, the androgen receptor (AR) is also a potential drug target in breast cancer treatment.

227 diagnostic/prognostic value and can act as a potential drug target in cervical cancer.

228 ling partner for Bcr-Abl and may represent a potential drug target in CML.

229 he central hub for viral RNA synthesis and a potential drug target in CoV infection.

230 ges of L. donovani and authenticate ASL as a potential drug target in Leishmania.

231 ed protein response in mammalian cells and a potential drug target in multiple human diseases.

232 c glutamate receptor subtype 5 (mGluR5) is a potential drug target in neurological and psychiatric di

233 Thus, FAP-alpha could be a potential drug target in neutrophilic inflammatory respo

234 these results indicate that CRL4(CDT2) is a potential drug target in ovarian cancers and that MLN492

235 yme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which ca

236 tumor cells to IR, implicating gadd45a as a potential drug target in radiotherapy management.

237 enzyme porphobilinogen synthase (PBGS) is a potential drug target in several human pathogens.

238 yl diphosphate biosynthetic pathway and is a potential drug target in some pathogenic bacteria.

239 -2 in these keratinocytes and may serve as a potential drug target in the chemoprevention of skin can

240 Our observations suggest that SR-A may be a potential drug target in the prevention of metastatic ca

241 tion for the hypothesis that toxopain-1 is a potential drug target in Toxoplasma gondii and also prov

242 power-grid network and the identification of potential drug targets in a signalling network of human

243 and identify myeloid-specific Src kinases as potential drug targets in CML.

244 identify NAD(P)(H)-binding proteins that are potential drug targets in Mycobacterium tuberculosis and

245 s/losses in specific clades, and identifying potential drug targets in nonmodel organisms.

246 These bifunctional proteins are potential drug targets in several human pathogens (e.g.

247 they could represent driver alterations and potential drug targets in subgroups of SCLC patients.

248 to solve structures of proteins that may be potential drug targets, in order to support drug discove

249 We identify new potential drug targets, including some on which existing

250 factorization (DNILMF) algorithm to predict potential drug-target interactions (DTI).

251 nal contact points of the ligand, to predict potential drug-target interactions with remarkable accur

252 amidase, a metal-dependent amidase that is a potential drug target involved in the mycothiol detoxifi

253 Evaluation of the BRPF family as a potential drug target is at an early stage although ther

254 One potential drug target is isocitrate dehydrogenase 1 (IDH

255 PqsBC, a potential drug target, is unique for its heterodimeric a

256 tion in most RNA viruses, and they represent potential drug targets, it is essential to chart the arc

257 of inhibiting these enzymes and as leads for potential drugs targeting JNKs.

258 erstanding disease aetiology and identifying potential drug targets, microbial GWAS are likely to fur

259 Methods to accurately predict potential drug target mutations in response to early-sta

260 are available to treat CoV infections; thus, potential drug targets need to be identified and charact

261 n stress response and cell survival and is a potential drug target of activators and inhibitors.

262 Accordingly, any potential drug targeting of this gene product must be st

263 the toxic Abeta peptides may also provide a potential drug target or targetable pathway for interven

264 al of five different RNA constructs: four as potential drug targets plus one control RNA construct.

265 in the biosynthesis of epinephrine and is a potential drug target, primarily for the control of hype

266 To identify virulence factors and potential drug targets, random transposon (Tn) mutants d

267 olubility screen and detailed results for 41 potential drug target recombinant proteins from infectio

268 ortunity for new insights into pathogenesis, potential drug targets, risk stratification, response to

269 dehydrogenase (IMPDH) has been proposed as a potential drug target, since it maintains the balance be

270 ity of remote memory and identifies AC1 as a potential drug target site to improve long-term remote m

271 s9, and small-molecule libraries to identify potential drug targets specific for these cancers.

272 is of functional specialization and identify potential drug targets specific to each neuron subtype,

273 tive strengths and weaknesses and describing potential drug targeting strategies to interfere with Hh

274 PCR) C-X-C chemokine receptor 3 (CXCR3) is a potential drug target that mediates signaling involved i

275 As the list includes a number of known and potential drug targets, the identification of NTP bindin

276 The catalase may be a potential drug target to aid in the prevention of period

277 if activity toward both A3F and A3G and is a potential drug target to inhibit Vif activity and block

278 altered, making serine 14 phosphorylation a potential drug target to interfere with TRPC6 channel ac

279 nel-mediated PNH, thus identifying them as a potential drug target to treat some of the DPN related s

280 found in human, suggesting that they may be potential drug targets to block encystation.

281 dicts disease progression and that comprises potential drug targets to eradicate dormant myeloma cell

282 ed in a myriad of contexts, from identifying potential drug targets to predicting the spread of epide

283 rom acute to persistent PTH, and we identify potential drug targets to prevent and treat persistent P

284 ther pathways localized in the apicoplast as potential drug targets to prevent malaria infection.

285 e of our society, and thus identification of potential drug targets to reduce age-associated disease

286 athways in GAS species narrows the choice of potential drug targets to the two indispensable downstre

287 affinity alpha(1D)-AR interaction sites, and potential drug targets to treat diseases associated with

288 ets of insulin signaling that could serve as potential drug targets to treat type 2 diabetes.

289 ation of disease states and the selection of potential drug targets, to patient selection and the con

290 Our findings uncover novel biology and potential drug targets underlying brain development and

291 Finally, by analyzing potential drug targets, we provide a genomics-based rati

292 bolic functions of P. gingivalis and suggest potential drug targets, we study systematically how the

293 es and functions, some of which are known or potential drug targets, were targeted for tagging with H

294 evidence about the association of known and potential drug targets with diseases.

295 erculosis and has recently been studied as a potential drug target, with inhibitors progressing to cl

296 roperties of a wide range of established and potential drug targets, with in-depth information for a

297 mic analysis of mutated glioma genes reveals potential drug targets, with several investigational dru

298 rotein and messenger RNA levels, and suggest potential drug targets within the kinase-substrate netwo

299 se antibiotics, prompting a re-evaluation of potential drug targets within the pathway.

300 lopment of small-molecule agonists acting at potential drug targets within this physiologically impor