ライフサイエンスコーパス: potential target

1 The tumor microenvironment (TME) is a potential target.

2 try site as vital to viral translation and a potential target.

3 suggest that the BDNF-TrkB pathway may be a potential target.

4 ntifying the JAK-STAT signaling pathway as a potential target.

5 the lysine rich coiled-coil 1 (KRCC1), as a potential target.

6 d chemotherapy and provide TP53 mutations as potential targets.

7 including an increase in the surface area of potential targets.

8 and 17-beta-hydroxysteroid dehydrogenase as potential targets.

9 f entities connected to both drugs and their potential targets.

10 teNK cells and tumor cells revealed multiple potential targets.

11 ligands vWF, P-selectin or Mac-1, offering a potential target against NASH.

12 orders in clinical trials, as well as future potential targets and methods to broaden the applicabili

13 hanism underlying this process, and suggests potential targets and strategies for the treatment of EB

14 e viral hemagglutinin has been identified as potential target antigen for this new generation of vacc

15 low coronary artery plaque burden suggests a potential targeted approach for immune modulation to lim

16 d" segments were rotated and translated over potential "target" binding sites on F-actin where the co

17 drugs, including antibody-drug conjugates as potential targeted cancer therapies.

18 s recognize cognate HLA class I molecules on potential target cells, and recent studies imply that an

19 The information we gather on potential targets concerns small-molecule druggability (

20 e binding of Ca1-Cas2 to the protospacer and potential target DNAs respectively.

21 One potential target for alcohol-induced changes is the circ

22 ve behavior and therefore makes PGC-1alpha a potential target for anti-glioblastoma therapies.

23 t can stimulate tumour progression, and is a potential target for anticancer therapy.

24 ability, thus identifying ac4C addition as a potential target for antiviral drug development.

25 nto SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention.

26 nd identifies the TENT4-ZCCHC14 complex as a potential target for antiviral therapeutics.

27 tein CTLA-4 at T-cell surface, identifying a potential target for autoimmune and/or cancer therapy.

28 iated with high QUIN and low KYNA, is also a potential target for AV-101.

29 in these cells, and can thus be considered a potential target for cancer diagnosis and therapy.

30 These results render FASN as a potential target for cancer prevention studies.

31 p97 represents a potential target for cancer therapy and its malfunction

32 vulnerability in PERK and suggests PERK as a potential target for cancer therapy, specifically in the

33 in tumor suppression and may thus serve as a potential target for cancer therapy.

34 lation of KPNA2, thus pointing to KPNA2 as a potential target for cancer therapy.

35 aging and identify this phosphorylation as a potential target for cancer therapy.See related commenta

36 affecting skin transformation, opening a new potential target for cancer treatment and prevention.

37 uld be and, for a while, was considered as a potential target for cholesterol-lowering drugs (the rol

38 -leaf photosynthesis could be an unexploited potential target for crop improvement.

39 dentification of Nemo-like kinase (NLK) as a potential target for DBA therapy.

40 ession, indicating that Pdcd4 might be a new potential target for depressive disorder therapy.

41 , makes disruption of the P-connector site a potential target for developing antivirals against other

42 s of IAV, nonstructural protein 1 (NS1) is a potential target for developing antivirals.

43 a critical step in membrane biogenesis and a potential target for development of antimicrobial and an

44 lucagonlike peptide-1 receptor (GLP-1R) is a potential target for diagnosis, localization, and treatm

45 formation of CCF during senescence and is a potential target for drug-based interventions to inhibit

46 findings suggest that CBFA2T3 can serve as a potential target for enhancing AML responsiveness to ATR

47 Health behaviors are thought to be a potential target for frailty prevention, but the evidenc

48 rker for risk following PCI and represents a potential target for future therapies.

49 m and identify the DRD5-ARRB2-PP2A axis as a potential target for future therapy of inflammation-asso

50 CDK5 plays a critical role in GBM and is a potential target for GBM.

51 cal DA system in men vs. women, suggesting a potential target for gender-specific treatments.

52 As a corollary, we propose the AhR as a potential target for HDT in TB in adjunct to canonical c

53 factor (IRF)7, a driver of type I IFN, as a potential target for ICP0.

54 d by NANOG is a central molecular axis and a potential target for immune-refractory tumor.

55 in B cell development and in CSR providing a potential target for immunodeficiency therapy.

56 suppressive functions of MDSCs and may be a potential target for immunomodulation in conjunction wit

57 OPPP enzymes therefore represent a potential target for increasing efficiency and yield in

58 m gametocyte surface protein, Pfs48/45, is a potential target for malaria transmission-blocking vacci

59 Steroids are consequently a potential target for malaria vector control.

60 ssential regulator of sperm head shaping and potential target for male contraception.

61 ase (CSE) catalyzes H(2)S synthesis and is a potential target for modulating H(2)S levels under patho

62 tive channels in axon regeneration and add a potential target for modulating nervous system repair.

63 ess stable multimerization domain provides a potential target for mucin depolymerization to remove mu

64 K a candidate for further investigation as a potential target for neuroblastoma therapy.

65 our findings suggest that DRG DNMT1 may be a potential target for neuropathic pain management.SIGNIFI

66 t in the pathophysiology of anxiety and is a potential target for new treatments of anxiety disorders

67 together, our results support Siglec-15 as a potential target for normalization cancer immunotherapy.

68 cum spp.) throughout the southern U.S. and a potential target for novel control methods that may requ

69 ting breast cancer early dissemination and a potential target for novel therapies targeting early met

70 esis by deubiquitinating TRIM25, providing a potential target for oncotherapy.

71 As such, they are a potential target for optimizing therapeutic strategies a

72 These results suggest IL-17RB can be a potential target for pancreatic cancer therapy.

73 t, highlighting the REGgamma-proteasome as a potential target for personalized HCC therapy.

74 -exposed epitopes suggest that NTHI1441 is a potential target for preventative and therapeutic interv

75 Therefore, Cx43 is a potential target for prevention of aberrant cardiomyocyt

76 ghlight adipocyte-endothelial crosstalk as a potential target for prevention of ectopic lipid deposit

77 A acquisitions, indicating this setting as a potential target for preventive strategies.

78 s, and highlight this neural population as a potential target for reducing avoidance in anxiety disor

79 Hence, MANF might be a potential target for regenerative therapy in diabetes.

80 tte syndrome, and evidence that pre-SMA is a potential target for repetitive transcranial magnetic st

81 IL-15 is a potential target for such a treatment because it is high

82 of the lncRNA MALAT1 and suggest MALAT1 as a potential target for the chemosensitization of GBM.

83 This transporter is a potential target for the development of antimalarial dru

84 n viral infections and represents SREBP as a potential target for the development of broad-spectrum a

85 ein translation and represents an attractive potential target for the development of new antibiotics.

86 great deal of interest in recent years as a potential target for the development of new therapeutics

87 lowering mechanism within POMC neurons is a potential target for the development of novel anti-diabe

88 ells and IBV in type II pneumocytes and as a potential target for the development of novel drugs to t

89 lso identifies plant defense resistance as a potential target for the improvement of biological contr

90 ntifies the UDP-Glc/P2Y14 receptor axis as a potential target for the prevention and/or attenuation o

91 M-1 may be a potent clinical biomarker and a potential target for the therapy in pancreatic cancer.

92 motes atherosclerosis, and provide Nck1 as a potential target for the treatment of atherosclerosis.

93 y, the present study also suggests mGluR1 as potential target for the treatment of autism spectrum di

94 in beta-cell destruction processes and as a potential target for the treatment of autoimmune T1D.

95 The miR-210-MLL4 axis is a potential target for the treatment of BA-associated hepa

96 in normal and disease states - and reveal a potential target for the treatment of chronic pain.

97 of tau spread in the brain, and therefore a potential target for the treatment of diseases that invo

98 y phenotype of Tiam1 KO mice, Tiam1 may be a potential target for the treatment of disorders involvin

99 MKP5 has been suggested as a potential target for the treatment of dystrophic muscle

100 Together, our results support FABP7 as a potential target for the treatment of HER2+ BCBM.

101 e encouraging preclinical data of Bcl-2 as a potential target for the treatment of hypodiploid B-ALL.

102 regulator of epidermal homeostasis and as a potential target for the treatment of inflammatory skin

103 e conclude that cortactin represents a novel potential target for the treatment of multiple sclerosis

104 Investigation of TRPV4 as a potential target for the treatment of pulmonary edema as

105 d activated cell states, and suggest U1 as a potential target for their modulation.

106 receptor-like kinase-2 (ALK2) constitutes a potential target for therapeutic intervention given its

107 atory role of PLK4 in cytokinesis makes it a potential target for therapeutic intervention in appropr

108 he catalytical NOX2 domain, and p47phox is a potential target for therapeutic intervention.

109 immune response from sepsis and represents a potential target for therapeutic intervention.

110 ion of the serine/threonine kinase ALK2 as a potential target for therapeutic intervention.

111 rt-lived IgE(+) plasmablasts, and serve as a potential target for therapeutic intervention.

112 n of pancreatic cancer cells, representing a potential target for therapeutic intervention.See relate

113 ry for their own replication, highlighting a potential target for therapeutic interventions that coun

114 ing represents a mechanism for relapse and a potential target for therapeutic interventions to reduce

115 sts that cGAS-mediated immune signaling is a potential target for therapeutic interventions.

116 is highlight the importance of miR-424-3p as potential target for therapeutic treatment in prostate c

117 cted to be decreased in cancers, making it a potential target for therapeutics to limit the progressi

118 This suggests the TROY/RKIP interaction is a potential target for therapy of gliomas.

119 ates aberrant erythropoiesis in DBA and is a potential target for therapy.

120 Our findings support that NLRC3 serves as a potential target for treating adaptive immune responses

121 Our study also implicates LGR4 as a potential target for treating hair disorder in the futur

122 as an important neuroimmune modulator and a potential target for treating inflammatory pain.

123 ons in the adult brain, suggesting them as a potential target for treating negative emotional states

124 f the Golgi in cell physiology and provide a potential target for treating protein-trafficking disord

125 These results highlight PrL-PVT pathway as a potential target for treating psychopathologies associat

126 g endothelial cell health and secretion as a potential target for treating vascular disease-associate

127 Thus, YY1 might be a potential target for treatment of Mn toxicity and other

128 RIM25 as a regulator of ER homeostasis and a potential target for tumor therapy.

129 Moreover, we highlight P4HA2 as a potential target for uncoupling ECM signals that support

130 tigen, the neuraminidase, has reemerged as a potential target for universal vaccines.

131 These findings provide new insights and potential targets for a variety of fibrotic and malignan

132 r than the entire fibrotic areas, indicating potential targets for ablation therapy.

133 ted signatures and pathways that might offer potential targets for age-related diseases.

134 span mitochondrial complexes I-IV, providing potential targets for alleviating doxorubicin myotoxicit

135 ne editing may warrant further evaluation as potential targets for anti-metastatic treatment strategi

136 indings define HER2-CB(2)R heteromers as new potential targets for antitumor therapies and biomarkers

137 While these results established platelets as potential targets for antitumor therapy, their depletion

138 s to understand capsid assembly and identify potential targets for antiviral drug discovery.

139 ent of invasive MRSA infections and are thus potential targets for antivirulence therapies.

140 nants of cardiovascular health, and identify potential targets for behavioral interventions.

141 ors of important plant pathways and provides potential targets for breeding or biotechnological appli

142 ckdown and CRISPR-Cas9 knockout data reveals potential targets for cancer drugs and associated biomar

143 DK6, have attracted considerable interest as potential targets for cancer therapy.

144 1 to the list of BER factors, e.g. PARP1, as potential targets for cancer treatment.

145 est that these miRNAs play a role in and are potential targets for circumvention of acquired resistan

146 r knowledge of itch transmission and uncover potential targets for combating itch.

147 ar biology that drives GC as well as provide potential targets for defining novel therapeutic strateg

148 of the initiation of AR transactivation and potential targets for developing and refining treatments

149 latory loop in GIST tumorigenesis, which are potential targets for developing combination therapy to

150 ys and mechanisms that drive disease, and of potential targets for disease prevention, detection and

151 rs in CTC-neutrophil interactions, providing potential targets for disrupting formation of these dead

152 lecules have been increasingly recognized as potential targets for drug development efforts, which in

153 gnized as endogenous bioactive mediators and potential targets for drug development.

154 Resource) web server is designed to identify potential targets for drug repurposing based on sub-stru

155 t LMNA-based disease mechanisms and identify potential targets for drug therapy.

156 hts into the development of NSCLC and, thus, potential targets for early treatment.

157 tory drug-screening study identified several potential targets for follow-up studies to further evalu

158 urora kinase A and Bcl-2 family proteins are potential targets for FP-RMS.

159 of the frailty concept in clinical practice, potential targets for frailty prevention, and directions

160 ltogether, these results shed light on novel potential targets for future diagnosis, monitoring or de

161 pmental triggers for bolting and to identify potential targets for genome editing and breeding.

162 inhibiting CSE or modulating glycolysis are potential targets for host-directed TB control.

163 d malignancies, thereby implicating HERVs as potential targets for immunotherapeutic therapies.

164 trophil-driven carcinogenesis and identifies potential targets for immunotherapy of B cell malignanci

165 y of cytotoxic T cells (CTLs) could identify potential targets for immunotherapy.

166 nts with TS to generate new hypotheses about potential targets for improving tics and comorbidities.

167 form- or cell type-specific AKT signaling as potential targets for improving treatment of neuropsychi

168 mmunity; (ii) the suite of sorghum traits as potential targets for increasing productivity in contras

169 This knowledge will help to identify potential targets for intervention and improve risk pred

170 n atherosclerosis, new exciting concepts and potential targets for intervention are emerging.

171 lutamatergic activity at vHipp to D1-MSNs as potential targets for intervention during early exposure

172 ein interactions in mGluR5-GluN complexes as potential targets for intervention in schizophrenia.

173 ion between MTA2 and NF-kappaB would provide potential targets for intervention of tumor growth and m

174 d by astrocytic alterations, but also reveal potential targets for intervention.SIGNIFICANCE STATEMEN

175 These and other genes represent potential targets for manipulating MHC-I immunosurveilla

176 effects on AMF and provide new insights into potential targets for manipulation of AMF symbiosis for

177 Several markers linked to these QTLs are potential targets for MAS against Phytophthora crown rot

178 the high ADC marker genes CDH2 and PTPRZ1 as potential targets for meningioma therapy using live imag

179 sed to encode essential viroporins providing potential targets for modern drug discovery.

180 ddressing these knowledge gaps, and describe potential targets for modifying the microbiome to contro

181 replicative cycle renders cellular functions potential targets for novel antivirals.

182 lators of gene expression that could provide potential targets for novel gene therapy.

183 sults of recent molecular studies suggesting potential targets for novel therapeutics strategies.

184 rential signaling induced by CSS, suggesting potential targets for pharmaceutical intervention that m

185 ole in disease pathogenesis and thus provide potential targets for pharmacological correction.

186 -BNST dynorphin-related circuit may serve as potential targets for potential therapeutic mediation as

187 that control monocyte chemotaxis can unravel potential targets for preventive therapies in inflammato

188 e varied the value associated with different potential targets for reaching movements by controlling

189 vel of detail of CCR2 signaling and identify potential targets for regulation of CCR2 function.

190 We identified potential targets for repurposing of licensed medication

191 mer colonies remain unoccupied and hence are potential targets for restoration.

192 key neurocognitive processes that emerge as potential targets for specialized cognitive training int

193 enzymes, lytic transglycosylases (Ltgs) are potential targets for such new antibiotics.

194 d GABAergic deficits in the frontal lobe are potential targets for symptomatic drug treatment of fron

195 ctor Receptor 1 (VEGFR1) could be one of the potential targets for TCDD in both mouse and humans.

196 These results may provide potential targets for the construction of paratransgenic

197 ntenance of phenotypic variation and provide potential targets for the development of therapeutic str

198 These regulators serve as potential targets for the expression of sex differences

199 sults demonstrate that RSK1 and MSK2 are the potential targets for the treatment of colon cancer.

200 ivated transcription factors, LXRs represent potential targets for the treatment of hypercholesterole

201 integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmon

202 ism regulating reversal learning and provide potential targets for the treatment of neuropsychiatric

203 , the hepatocyte growth factor receptor, are potential targets for therapeutic antitumor Abs.

204 ZIKV-induced neurological complications and potential targets for therapeutic approaches.

205 This provides a launching pad to identify potential targets for therapeutic intervention and optim

206 1.2 duplication pathology, and may represent potential targets for therapeutic intervention in ASD.

207 They additionally suggest potential targets for therapeutic intervention in inflam

208 h EMT cells enhance metastasis, and provides potential targets for therapeutic intervention in this h

209 plexus mutated in primary prostate tumors as potential targets for therapeutic intervention.

210 trajectory and treatment response and reveal potential targets for therapeutic intervention.

211 These dysregulated pathways represent potential targets for therapeutic intervention.

212 invasion and can be further investigated as potential targets for therapeutic intervention.

213 es within the Abeta42 sequence that could be potential targets for therapeutic intervention.

214 genesis of neurologic diseases, and identify potential targets for therapeutic intervention.

215 These multiple molecular pathways are potential targets for therapeutic interventions in patie

216 t intestinal flow and bacterial motility are potential targets for therapeutically managing bacterial

217 standing of TB immunopathogenesis, providing potential targets for therapies and vaccines for TB cont

218 peutic resistance, tumor aggressiveness, and potential targets for therapy.

219 rces for regeneration and cancer, as well as potential targets for therapy.

220 oV-2 using predictive algorithms to identify potential targets for vaccine development.

221 is suppressor SH3GL2 identified SPANXB1 as a potential target gene.

222 studies have generated lists of thousands of potential target genes and competing models of HY5 trans

223 In-silico identification of potential target genes for disease is an essential aspec

224 the mechanism of Pax8-mediated activation of potential target genes in inner medullary collecting duc

225 nd CTSS, which were previously implicated as potential target genes of prostate cancer risk variants

226 and TNF signaling pathway, since they had 73 potential target genes regulated by 8 TF motifs with dec

227 We also identified potential target genes that may underlie the behavioral

228 oach to assign loci in non-coding regions to potential target genes, and apply it to reanalyse the re

229 tide (GIP), has garnered much attention as a potential target: however, whether it is beneficial to b

230 ulator of ferroptosis and implicates it as a potential target in cancer therapy.See related commentar

231 ondrial fatty acid oxidation may represent a potential target in combating negative effects of diabet

232 ss responses and implicate this pathway as a potential target in human heart failure.

233 etion approaches indicating that GM-CSF is a potential target in many inflammatory/autoimmune conditi

234 We identified prohibitin as a potential target in mediating the therapeutic effects of

235 PARG is a potential target in pancreatic cancer as a single-agent

236 CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PD

237 nce has received considerable attention as a potential target in preventing or treating multiple age-

238 dentifies the RNA-binding protein RBM39 as a potential target in spliceosome mutant AML that can be t

239 c immune microenvironment in the liver and a potential target in the management of liver metastatic d

240 ance, and tRNA thiolation pathway might be a potential target in the next generation rice breeding fo

241 amined whether S1P signaling may represent a potential target in the treatment of chemotherapy-induce

242 une-mediated diseases and identify GARP as a potential target in their therapy.

243 on, we found that 76% of drugs either miss a potential target isoform or target other isoforms with v

244 dy, we propose that SM/Cer and SMPD1 are new potential target molecules for therapeutic strategies to

245 Despite its therapeutic potential, targeting NF-kappaB using pharmacologic inhib

246 Here, we postulate that GPC3 is a potential target of antibody-drug conjugates (ADCs) for

247 gnaling has attracted limited attention as a potential target of anticancer therapy.

248 complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora

249 protein for Cap-dependent translation, as a potential target of CUL3.

250 ole in the ZIKV assembly pathway revealing a potential target of lipid based antiviral drug developme

251 These results support neuraminidase as a potential target of next-generation influenza virus vacc

252 One potential target of siR109944 is the F-Box domain and LR

253 us, our results provide new evidence for the potential targeting of macrophages in the treatment of o

254 he hexosamine biosynthesis enzymes represent potential targets of antifungal drugs.

255 of the Copine (Cpne) family of molecules as potential targets of Brn3 transcription factors in the r

256 ted thiol (RSH) modification, are additional potential targets of HNO.

257 jury response in younger mice, and highlight potential targets of kidney injury.

258 prioritization of risk factors that could be potential targets of medical treatment to improve popula

259 re termination codon (PTC) and are therefore potential targets of nonsense-mediated mRNA decay (NMD).

260 function, transforming these molecules into potential targets of the immune system, presumably trigg

261 Potential targets of these pathological processes could

262 urthermore, we suggest Gh and Sp lesions are potential targets of transcription-coupled repair.

263 specific high-throughput RNAseq to identify potential targets or interactive partners of CjNC110 in

264 These findings provide potential targets or strategies for novel EBV-related ca

265 to understand the biology, epidemiology, and potential target points of COVID-19.

266 ves is mainly limited by the large number of potential targets present and the matrix effects suffere

267 ested for any interactions of KimA and other potential target proteins in B. subtilis with c-di-AMP.

268 neuroprotective pathways were identified as potential targets regulated by miRNAs.

269 binders to the same protein, or to infer new potential target(s) for a compound of interest, based on

270 atory hot spots in some kinases and thus are potential target sites for type IV inhibitors.

271 ct ligand effects on TR and imply that other potential target sites in the thyroid hormone axis shoul

272 ng a strain-specific cassette containing all potential target sites.

273 r subpopulations based on AXL signaling as a potential targeting strategy.

274 itor and Purvalanol A, a CDK inhibitor, as a potential targeted therapy for AML patients with an MLL

275 r results suggest that TTCC blockers offer a potential targeted therapy in resistant BRAF(V600E)-muta

276 hese results identify GZMK(+) Taa cells as a potential target to address age-associated dysfunctions

277 ntenance of CSCs, indicates that HDAC11 is a potential target to combat NSCLC.

278 mediator of prostaglandin biosynthesis and a potential target to control pain.

279 ortant tissue for thermogenesis, making it a potential target to decrease the risks of obesity, type

280 This metabolic cue is a potential target to decrease VRE colonization and subseq

281 of ependymal cells to injury, representing a potential target to improve the contribution of the CC s

282 e, this study provides novel insights into a potential target to increase the S. mutans sensitivity t

283 to TMZ treatment, NF-kappaB can be used as a potential target to increase the treatment's outcomes.

284 r, these studies suggest that HACE1 can be a potential target to induce cell death in KSHV-infected c

285 crobiome is worth further investigation as a potential target to mitigate the deleterious impact of t

286 us, suggesting hippocampal neurogenesis as a potential target to normalize cognitive impairments in M

287 a-cell excitability and suggests NMDARs as a potential target to overcome leptin resistance.

288 h (MSI-H) tumors, suggesting glycolysis as a potential target to overcome the resistance of MSI-H tum

289 nation of insulinopenia and dehydration as a potential target to prevent euglycemic ketoacidosis asso

290 CD44 is a potential target to suppress PD-L1 function in TNBC.

291 cerebral endothelin B receptors (ETBR) as a potential target to treat acute cerebral ischemic stroke

292 n APAP-induced hepatotoxicity and to provide potential targets to develop novel therapeutic modalitie

293 This research highlights Ephs as potential targets to enhance efficacy of immune-based th

294 uggest that connexins in ependymal cells are potential targets to improve self-repair of the spinal c

295 ived G-3-P in mineral metabolism and outline potential targets to modulate FGF23 production during ki

296 vascularization (CNV) and may, therefore, be potential targets to modulate the disease course.

297 t control Nox5 and VSMC-derived EVs provides potential targets to modulate vascular remodeling and ca

298 egulation of progranulin levels and identify potential targets to treat FTLD and other neurodegenerat

299 The findings identify ZNF217 as a potential target toward which preexisting therapies, suc

300 alose, and chlorogenic acid accumulation are potential target traits for genetic improvement.