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1 0-32 degrees C, SEAP production was strongly potentiated 3.3-fold by the addition of the TRPV1 agonis
4 c oligoadenylate (cOA) signalling molecules, potentiating a powerful immune response by activating do
5 4D to C3b was increased upon addition of the potentiating Ab and similarly, the decay-accelerating ac
6 , we show that IgG immune complexes strongly potentiate activation of primary human microglia by brea
7 evelopment (e.g., nacubactam and zidebactam) potentiate activity of beta-lactam antibiotics, to vario
10 eviction in multiple orthogonal readouts and potentiated activity of the carbapenem, meropenem, again
11 ed to multiple HSPGs without diminishing WNT-potentiating activity in cultured cells and intestinal o
12 ed with antibiotic, this low-level variation potentiates adaptation, with HGT populations flourishing
15 to exert its antidepressant-like effects by potentiating alpha-amino-3-hydroxy-5-methyl-4-isoxazolep
16 It is widely accepted that membrane voltage potentiates aminoglycoside activity, which is ascribed t
17 al similarity to known serotonergic agonists potentiates an endogenous serotonin signal to affect beh
18 to viral infection of bacteria and archaea, potentiating an immune response by binding and activatin
20 Using a type 1 diabetic animal model, TCS potentiates and accelerates the development of steatohep
21 blockade increases tumor immunogenicity and potentiates anti-tumor immunity, which has implications
25 ' signal with a SIRPalpha-CD45 RIPR molecule potentiates antibody-dependent cellular phagocytosis bey
26 atezolizumab to trastuzumab emtansine might potentiate anticancer immunity and enhance the HER2-targ
27 w avenue that could be used to accelerate or potentiate antidepressant responses by triggering neurop
29 es insight into an antibody combination that potentiates antiviral activity and is able to prevent EV
31 ellular plasticity, invasive properties, and potentiates apoptosis resulting in reduced tumor growth.
32 beta cell secretory responses from a glucose-potentiated arginine (GPA) test, insulin sensitivity fro
33 and insulin secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) c
37 zyme critical for translesion DNA synthesis, potentiates beta-catenin stability/activity by inducing
42 showed that L498W is an activating mutation potentiated by H499C and that H499C and H499Y enhance th
46 antagonist activity, which could further be potentiated by the introduction of an additional basic c
48 on resulting from loss of Apc expression was potentiated by the presence of oncogenic Kras (G12D) Kno
50 ne upstream of the G-protein activation that potentiates calcium responses, and another source downst
53 Inhibition of the genes hycA, dsrB, and bolA potentiated carbapenem efficacy in CRE E. coli, whereas
54 Finally, we show that MSL10 is unable to potentiate cell swelling-induced death when phosphomimet
55 cleotides with an apyrase treatment strongly potentiated cell death and progenitor proliferation indu
57 an immune tumor microenvironment that could potentiate checkpoint immunotherapy for glioblastoma.
60 demonstrated that a stressor (footshock) can potentiate cocaine seeking in male rats via glucocortico
63 to the PrL-PFC and both CORT- and restraint-potentiated cocaine seeking required PrL-PFC CB1R activa
66 cant hyperactivity itself, but significantly potentiated cocaine-induced hyperactivity on Days 4 to 7
67 sor-induced plasma levels, reproduced stress-potentiated cocaine-primed reinstatement in both sexes.
68 hese findings demonstrate that, while stress potentiates cocaine seeking via PrL-PFC CB1R in both sex
70 under ambient (i.e., produced in situ) and 'potentiated' conditions (i.e., H(2)O(2) production enhan
71 locked the memory enhancement as well as the potentiated corticosterone response, indicating the depe
75 wed that MMP activation is necessary for and potentiates cued reinstatement of cocaine seeking, and M
77 uman CCA cells (EGI-1 and TFK-1) selectively potentiated cytotoxicity of SN-38, 5-fluorouracil and mi
82 identified residues that disrupt the steroid potentiating effect at the rat GluN1 (G638; I642) and Gl
83 o elevate [Ca(2+)](c) was diminished and the potentiating effect on insulin secretion was completely
85 e form of 2',3'-cAMP and 3'-AMP mimicked the potentiating effects of IAA/DNP on exosome secretion.
86 iming injections is greater in females, CORT-potentiating effects vary with the estrous cycle, and wh
88 (2C) receptor (5-HT(2C)R) allosteric site to potentiate endogenous 5-HT tone may provide novel therap
89 d to improve drug uptake through microbubble potentiated enhancement of microvascular permeability.
92 venile mice during acute RSV infection could potentiate extracellular matrix remodeling, facilitating
96 support of this model, UTX loss-of-function potentiated FGFR3-dependent transcriptional effects and
97 However, it is unclear whether this Ab can potentiate FH mutant variants in addition to wild-type (
98 e-I IFNs affect plaque-residing macrophages, potentiate foam cell and extracellular trap formation, i
101 crementally increasing GPCR gene copy number potentiates Galpha coupling of the pharmacologically dar
103 Rgs16::GFP expression in PDA primary cells, potentiated gemcitabine and JQ1 cytotoxicity in cell cul
104 latory plasticity by inducing redundancy and potentiating genetic drift locally while conserving geno
105 tinostat (MS-275) enhances GLP-1R agonism to potentiate glucose-stimulated insulin secretion and decr
111 the activation of an E3-ligase, XIAP, which potentiates IL-17-induced NFkappaB activation and suppre
112 rs were identified; among these, compound 40 potentiates imipenem activity against an NDM-1-producing
113 ibition by Lu AF60097 is demonstrated by the potentiated imipramine binding and increased hippocampal
114 ow the novel KRAS-G12C inhibitor AMG 510 can potentiate immune rejection in combination with immune c
115 s, ligand combinations could synergistically potentiate immune responses by elevating cytokine and ch
116 this population of CSCs can be exploited to potentiate immunotherapy and reduce tumor recurrence and
118 L1/2 kinase activities and/or expression are potentiated in cell lines and patient samples following
120 hese data indicate that IgG immune complexes potentiate inflammation by human microglia, which may pl
121 d mechanism associated with aging that could potentiate inflammation induced by bacterial components.
124 (LHb) is hyperactive in depression, and thus potentiating inhibition of this structure makes an inter
126 at hyperpolarized membrane potential of, and potentiated inhibitory inputs to, VP neurons may play a
127 g sites determine whether a neurosteroid has potentiating, inhibitory, or competitive antagonist acti
131 damage response kinase ATR can significantly potentiate ionizing radiation-induced innate immune resp
134 trexate with the AMPK activator, phenformin, potentiates its anti-proliferative activity in cancer ce
135 hat glycation of aSyn by methylglyoxal (MGO) potentiates its oligomerization and toxicity, induces do
139 (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammato
143 pendent differences: beta4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all d
144 e plasminogen activator, previously shown to potentiate NMDAR activity, induces metabotropic signalin
146 and M4 and the GluN1 helix M3, and that PES potentiates NMDAR function by stabilizing the open-state
150 myloid pathology (reduced amyloid burden and potentiated non-amyloidogenic APP processing), and oxida
153 e tumor suppressive actions of PP2A, thereby potentiating oncogenic signaling and reducing drug sensi
155 ning probes with desirable imaging contrast; potentiate ONOO(-) as a biomarker and target for AKI ear
159 results suggest that bacterial polyphosphate potentiates pathogenicity by acting as an extracellular
161 ival immune cell function between PD and T2D-potentiated PD may account for the increased risk and se
162 ne density, synaptic plasticity (L-LTP), and potentiates perseverative/repetitive behavior in mice.
163 t selective inhibition of mGlu(2) or mGlu(3) potentiates PFC excitatory transmission and confers anti
164 These results reveal that SMC-derived Fn-EDA potentiates phenotypic switching in human and mouse aort
165 teins, as well as of Abeta(42) ExNef further potentiated phosphorylation of Tau and activation of inf
166 no-terminal kinase (JNK), which consequently potentiates Pi triggered lethal epithelial-mesenchymal t
168 I3K inhibitor to the BMP7v-based combination potentiates PIK3CA-mutant tumor drug response and reduce
169 MYC2 and MYC3 stability and accumulation and potentiates plant responses to JA such as root-growth in
170 on pathway initiates an early ADP secretion, potentiating platelet activation, and a secondary wave o
171 ated caspase-3 in vitro, and TrxR inhibition potentiated polysulfide-mediated suppression of caspase-
172 n stress responses, which likely interact to potentiate, produce, and impair treatment of, stress-rel
174 Intracellular invasion of P. gingivalis potentiated proliferation, migration, invasion, and meta
178 ing of Sanpodo, a transmembrane protein that potentiates receptor activity, plays a pivotal role in t
180 ffects varied across the estrous cycle; CORT-potentiated reinstatement was only observed during diest
182 n vivo Based on these findings, we propose a potentiating role for Pfn1 in promoting tumor cell aggre
183 bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by
184 gnals preferentially via Gs, can effectively potentiate secretion in islets from the KATP channel-def
185 e; we demonstrate that persistent DNA damage potentiates senescence and activates cytokine signaling.
186 factors (such as the BDNF Val66Met variant) potentiates sensitivity to stress and, by extension, vul
187 surveillance would have avoided 1044 scans, potentiating significant cost-saving for maternity servi
188 with reduced muscle glycogen stores seems to potentiate skeletal muscle protein abundance and gene ex
190 ted with PTSD in adults, with increased fear-potentiated startle (FPS) serving as a potential interme
191 heses, results showed an increase in anxiety-potentiated startle following active but not sham rTMS.
194 evidence from two different paradigms (fear-potentiated startle, affect-modulated startle) in two in
195 -targeted antioxidant, suggesting that mtROS potentiates STAT3 signaling in skeletal muscle in respon
197 (3)H]muscimol binding in the presence of the potentiating steroid allopregnanolone and the inhibitory
202 Both phorbol esters and tetanic stimulation potentiate synaptic strength, and lower the energy barri
203 eceptors through their agonist isoproterenol potentiated synaptic transmission in cerebellar slices f
204 in male mice that associative fear learning potentiates synaptic transmission and cue-specific activ
205 2 activity with two distinct small molecules potentiated taxane response in multiple in vivo models o
207 lular signal-regulated kinase 1/2 pathway to potentiate TGFbeta1-mediated epithelial-mesenchymal tran
208 translesion synthesis (TLS) machinery, could potentiate the action of cisplatin in non-small cell lun
209 enolytics might be an additional strategy to potentiate the antitumor effects of CDK4/6 inhibitors.
210 educing the T(reg) population in the TME can potentiate the antitumor immune response of checkpoint i
211 fies future research and strategies that can potentiate the application of free radical-incorporated
212 nd inhibit in vitro NHEJ, cellular NHEJ, and potentiate the cellular activity of radiomimetic agents
215 gical analyses to demonstrate that DX314 can potentiate the effects of all-trans-RA in healthy and di
216 on of bioactive oral compounds that mimic or potentiate the effects of exercise, so-called 'exercise
220 activation, suggesting that chemotherapy can potentiate the immunogenicity of immune-excluded HGSOC t
221 Moreover, we found that the tendency to potentiate the inhibitory inputs to the VP might exist i
222 irst order, need state-selective circuits to potentiate the mesolimbic dopamine system's response to
226 enzyme GAD67 also cooperate to decrease and potentiate the synaptic excitatory and inhibitory tone o
227 ts indicate that the silencing of CTLA-4 can potentiate the T cell priming capacity of the DC vaccine
228 e antibiotics both in vitro and in vivo, and potentiated the activity of different classes of antibio
230 hermore, the addition of Q-HCL significantly potentiated the antimicrobial effects of aBL in a mouse
231 ent inhibition of BRAF or PI3K significantly potentiated the antitumor activity of degrader 27, sugge
233 of PKC with phorbol-12-myristate-13-acetate potentiated the Ci-VSP-induced decline in Kv7.5 current
234 owed by the two-step carcinogenesis protocol potentiated the conversion of benign papillomas to carci
235 II, but not the orexigenic hormone ghrelin, potentiated the dopamine response similarly to that obse
236 s (DNL) using (2)H(2)O revealed that 5-PAHSA potentiated the effects of CE and stimulated triacylglyc
239 t with its antiviral effect, AMPK activation potentiated the expression of genes with antiviral prope
241 on VP(GABA) neurons, dynorphin surprisingly potentiated the inhibitory input on VP(vGluT2) neurons,
245 itive bacteria and is restricted to the gut, potentiated the RT-induced antitumor immune response and
246 PI3Kbeta knockout (EpsilonC-betaKO) in mice potentiated the sunitinib-induced reduction in subcutane
248 hort-circuit currents by ~3-fold and further potentiated the therapeutic effects of small-molecule co
249 the TRPM7 chanzyme (ion channel and enzyme) potentiated the thymic development of T(reg) cells in mi
250 clear factor of activated T cells (NFAT) and potentiated the transcription of peroxisome proliferator
252 ow that the dual-functioning inhibitor TH588 potentiates the accumulation of reactive oxygen species
253 in human macrophages and indicate that 5-HT potentiates the activity of a transcription factor (AhR)
256 r other chemotherapeutic compounds) strongly potentiates the anti-tumor effect due to repression of D
257 tly, we find that 5-HT2C receptor antagonism potentiates the antidepressant and anxiolytic effects of
259 ered, after which the DNA unwinding activity potentiates the downstream homologous recombination (HR)
261 An FDA-approved inhibitor of GTP synthesis potentiates the effects of radiation in flank and orthot
263 he penetrance of MYCN-induced neuroblastoma, potentiates the invasion and migration of transformed sy
264 Since the EPR:CR co-activation with hypoxia potentiates the pressor response and restricts blood flo
265 es increases membrane tensions in silico and potentiates the progression of invasive squamous cell ca
266 by dysfunctional proteostasis, dramatically potentiates the propensity of alphasyn to pathologically
267 enomenon by which ultraviolet (UV) radiation potentiates the toxicity of photodynamic PAHs (often lea
269 cus transport.Measurements and Main Results: Potentiating the activity of TMEM16A with ETX001 increas
270 s, peripheral CB1R blockade may allow safely potentiating the antiobesity and antidiabetic effects of
271 etic TLR4 ligands thus show great promise in potentiating the conjugate vaccine platform for applicat
272 g long-term persistence while simultaneously potentiating the effector response of CD8(+) T cells has
274 C could increase synovial macrophage counts, potentiating the macrophage- and IL-10-associated mechan
276 training followed by abstinence selectively potentiates their synapses on targets that encode aversi
280 tions, we designed oligonucleotides strongly potentiating TLR8 sensing of Resiquimod, which preserve
281 MSec also similarly inactivates cofilin, but potentiates TNT formation independent of the nucleolin-1
282 ly on plasmacytoid dendritic cells, where it potentiates toll-like receptor (TLR)-9 activation and IF
284 fic response includes proapoptotic genes and potentiates toxicity triggered by tumor necrosis factor
285 turn promotes PLCdelta1 activity and further potentiates TRPC4 via a positive feedback mechanism.
287 cleatum promotes cytokine secretion that may potentiate tumor growth and metastatic progression in pa
288 ons in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca(2+) channel via PKA, but t
289 ate the pathology of the BBB, its ability to potentiate viral replication, as well as current therapi
291 origenesis by increasing primary tumor size, potentiating visceral organ metastasis, suppressing AR,
292 mmediate, unexpected sensory event, which is potentiated when evoked during threat and inhibited duri
293 input to the aversion-related structures is potentiated, whereas the input to the reward-related str
294 nclude that HSPGs are RSPO co-receptors that potentiate WNT signaling in the presence and absence of
295 eptor for R-spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt.
296 o R-spondins (RSPOs) with high affinity, and potentiate Wnt-beta-catenin signaling, presumably by the
298 e previously demonstrated that RSPOs 2 and 3 potentiate WNT/beta-catenin signaling in cells lacking l
299 chanistically, the Pygo2-histone interaction potentiated Wnt/beta-catenin signaling, in part, by repr
300 ymphoid enhancer-binding factor 1 (LEF1) and potentiates Wnt signaling in T-ALL cells with low levels