ライフサイエンスコーパス: pre-existing

1 previr and voxilaprevir escape variants, and pre-existing A156T facilitated genotype 1 escape from cl

2 and 30 specific pathogen-free (SPF) cats for pre-existing AAV-binding antibodies against the 11 serot

3 term memory and how are they integrated with pre-existing abstracta are questions not discussed by Gi

4 tiary C-F bond, especially those remote from pre-existing activating groups.

5 No interference by pre-existing Ad26 immunity was identified.

6 icit excess APA production even in mice with pre-existing adaptive immunity against PEG.

7 eptors, but not by chemical sympathectomy of pre-existing adrenergic nerves.

8 ll function; however, their ability to treat pre-existing allergy remains unclear.

9 A pre-existing, allosteric equilibrium between closed (E*)

10 ei directly from an atomic seed (Fe), from a pre-existing amorphous nanocluster (Au) or by coalescenc

11 By contrast, the SRG Bdnf engages in both pre-existing and activity-inducible loops that form with

12 demonstrate how the relative contribution of pre-existing and de novo mutations varies across drug re

13 Such pre-existing and developing cardiovascular diseases pose

14 erform a high-resolution ex vivo analysis of pre-existing and induced SARS-CoV-2-specific CD8(+) T ce

15 , phenotype, functional capacity and fate of pre-existing and induced SARS-CoV-2-specific CD8(+) T ce

16 this study was to investigate the impact of pre-existing and new-onset DM on liver transplantation (

17 Specifically, we found that a pre-existing and persistent deficiency of active ACE2 le

18 infection with the immune pathways that are pre-existing and reactivated during secondary dengue.

19 ntecedents were divided into two categories: pre-existing and those related to the intensive care adm

20 re associated with early malarial anemia and pre-existing anemia is the main determinant for prolonge

21 Women with undetectable pre-existing anti-GBS concentrations may benefit from a

22 Among RT-PCR-confirmed infections in adults, pre-existing anti-NA antibody levels >=40 were associate

23 Future investigation of the impact of pre-existing anti-vector immune responses on protective

24 e Provector as well as AAV2, suggesting that pre-existing antibodies against AAV2 would not negate th

25 Here we quantify the pre-existing antibodies against SAgs in many human plasm

26 (NA) glycoproteins that abrogate binding of pre-existing antibodies in a process known as antigenic

27 lts provide a potential solution to overcome pre-existing antibodies to AAV-based gene therapy.

28 Many people had pre-existing antibodies to SpyTag:SpyCatcher but less to

29 Here we develop a procedure to validate pre-existing antibodies.

30 uppression and are not efficient in removing pre-existing antibodies.

31 ve immune regulatory checkpoints and unleash pre-existing antitumour immune responses.

32 Pre-existing anxiety disorders were associated with more

33 ible concussion patients, 155 (24%) reported pre-existing anxiety.

34 liposomes in the presence of high titers of pre-existing APA for at least 48 h in mice.

35 the DA, suggesting that Runx1 represses the pre-existing arterial programme in HE to allow progressi

36 aspartoacylase-deficient mice reverses their pre-existing ataxia and diminishes cerebellar and thalam

37 TP inhibitor anacetrapib among patients with pre-existing atherosclerotic vascular disease.

38 iterative, without substantial remodeling of pre-existing basal structures.

39 e fates of these lineages to the presence of pre-existing beneficial mutations, and we demonstrate ho

40 ained non-equivalence of newly formed versus pre-existing bonds after the first bond migration.

41 Pre-existing breaks are first blocked and DNA modificati

42 Women with pre-existing breast cancer were excluded.

43 lective return of BRG1 in cis, starting from pre-existing BRG1 sites that are free of Xist.

44 amber, with some contribution from a deeper, pre-existing brine reservoir.

45 We used pre-existing, but fragmentary, structures to model a com

46 is achieved through functional adaptions to pre-existing Ca(2+) channels.

47 These results demonstrate that pre-existing cardiac aging phenotypes can be reversed by

48 ge younger than 18 years, use of anesthesia, pre-existing cardiac or respiratory arrest, and respirat

49 k given their older age, smoking habits, and pre-existing cardio-pulmonary comorbidities.

50 Evidence is mounting that proliferation of pre-existing cardiomyocytes can be stimulated to repair

51 9 given their older age, smoking habits, and pre-existing cardiopulmonary comorbidities, in addition

52 ce (HR 0.61, 95% CI 0.49-0.75) or absence of pre-existing cardiovascular disease (0.80; 0.51-1.12; p(

53 Patients with pre-existing cardiovascular disease and/or traditional c

54 First, those with COVID-19 and pre-existing cardiovascular disease have an increased ri

55 Pre-existing cardiovascular disease seems to be linked w

56 E -5, 95%CI 2.48E -7-2.41E -5, compared with pre-existing carriage).

57 recruitment of experience-tuned neurons into pre-existing cell assemblies, and increased recruitment

58 Formation of a single new centriole from a pre-existing centriole is strictly controlled to maintai

59 e lesions; and hyperattenuated arteries) and pre-existing changes (atrophy, leucoaraiosis and old isc

60 bolic stress occurs through both de novo and pre-existing chromatin interactions which respond differ

61 Thus, distinct pre-existing chromatin states require specialized epigen

62 h gestation-induced worsening of subclinical pre-existing chronic cardiovascular dysfunction in early

63 Pre-existing chronic diseases might affect patient parti

64 the diagnosis of cancer in individuals with pre-existing chronic illnesses.

65 vity in a set of neural circuits, indicating pre-existing circuit function can predispose animals to

66 This study provides a framework of pre-existing circuit function that determines threat res

67 opathy and contributed to the progression of pre-existing CKD.

68 y; (2) UA crystal granulomas may form due to pre-existing CKD; and (3) proinflammatory granuloma-rela

69 Under increased shear flow, pre-existing clusters of cells disaggregate, orientate w

70 These APECs redirect pre-existing CMV immunity against tumor cells in vitro a

71 ase is higher in the elderly and people with pre-existing co-morbidities.

72 se is greater in the elderly and people with pre-existing co-morbidities.

73 Multiple predisposing factors (for example, pre-existing cognitive impairment) and precipitating fac

74 he femoral artery in C57BL/6 J mice enlarged pre-existing collateral arteries and increased numbers o

75 ients died within 3 months of treatment from pre-existing comorbidities.

76 in healthy women, while taking into account pre-existing comorbidity and potential confounders.

77 two patients withdrew [travel burden, severe pre-existing comorbidity], one was lost to follow-up, on

78 ling events that post-translationally modify pre-existing components of intercellular junctions.

79 ng attempts to determine new indications for pre-existing compounds and represents a major opportunit

80 ay from blank slate networks to selection of pre-existing compressed preplay sequences.

81 ased on various sociodemographic factors and pre-existing conditions for the US population, combining

82 openhagen, Denmark - which are linked by the pre-existing CopMich Collaborative - had to respond with

83 epidemiological aspects and implications of pre-existing cross-reactive immune memory to SARS-CoV-2,

84 lts are in accord with the observations that pre-existing cross-reactive T-cells correlate with prote

85 New antibacterial drugs without pre-existing cross-resistance are under-represented and

86 rveillance studies that depend on geography, pre-existing cross-resistance both within and across ant

87 methods that can rapidly terminate (<3 h) a pre-existing CRS-like toxicity and two unrelated methods

88 icenter cohort of 295 patients with LVAD and pre-existing CRT was studied.

89 in higher-risk, often elderly patients with pre-existing CV disease.

90 fter breast cancer diagnosis, independent of pre-existing CVD risk factors and cancer treatments.

91 demographics, smoking, cancer treatment, and pre-existing CVD risk factors.

92 From 1 center, patients were selected from a pre-existing database of patients undergoing cytoreducti

93 Open data allows researchers to explore pre-existing datasets in new ways.

94 chemogenetic manipulation, we revealed that pre-existing DGCs actively regulated microvascular blood

95 between LTMs and MNPs may be attributable to pre-existing differences.

96 specification involved the co-option of the pre-existing digit patterning mechanism and therefore un

97 was significant at enrolment in both new and pre-existing DM, but only persisted at follow-up in HIV-

98 nly persisted at follow-up in HIV-1-infected pre-existing DM.

99 Human impacts interact with pre-existing environmental gradients to reorganize biodi

100 stallography and rapid kinetics supporting a pre-existing equilibrium between open (E) and closed (E*

101 hough one-quarter of MA was accounted for by pre-existing evidence of atrophy on OCT alone, the devel

102 ockade works by reinvigorating ("rebooting") pre-existing exhausted tumor-infiltrating ilymphocytes (

103 While serving the same purpose as the pre-existing Expectation-Maximisation algorithm, the new

104 bioinformatic analyses, in combination with pre-existing experimental evidence, suggest that the SAR

105 refractive surgery have been described, but pre-existing factors that predispose clinically normal c

106 ressing and pore-pressure accumulation along pre-existing faults in deep basement contribute to recen

107 aining active lesions all had some degree of pre-existing fibrosis and remained stable.

108 Ring-shaped protein particles bound to pre-existing filaments match the size of ASC dimer struc

109 n in a DENV-experienced individual can boost pre-existing flavivirus immunity and elicit protective r

110 hment can influence the OCT detectability of pre-existing foveal cystoid lesions.

111 n the metal contact transfer their energy to pre-existing free electrons in the semiconductor, withou

112 striction are rare, or if they incur loss of pre-existing function against other viruses.

113 ior-related plasticity, but does not disrupt pre-existing functional connectivity.

114 y to install the stereocentres remotely from pre-existing functional groups.

115 f tinkering by exaptation-the repurposing of pre-existing functions for new roles-in the diversificat

116 Our study shows that pre-existing genetic diversity plays a key role in shapi

117 plished through progressive modifications of pre-existing genetic networks composed of allelic varian

118 , antagonistic pleiotropy, the importance of pre-existing genetic variation in populations, the dange

119 of this study, maxillary anterior teeth with pre-existing gingival recession were more likely to have

120 glaucoma was 29% vs. 8% among those without pre-existing glaucoma at 8 years.

121 Eyes with pre-existing glaucoma demonstrated more IOP increases ov

122 lity of glaucoma surgery among patients with pre-existing glaucoma was 29% vs. 8% among those without

123 ignificant IOP elevations, whereas eyes with pre-existing glaucoma were at a higher risk.

124 Of the total, 29% of patients had pre-existing glaucoma.

125 ial placodal tissues, without the need for a pre-existing guidance cue.

126 We studied the association between pre-existing H. pylori serum IgG and serum pepsinogens l

127 nt, age, serum albumin, body mass index, and pre-existing hearing loss.

128 Patients with pre-existing heart failure (HF) are likely at higher ris

129 ion led to an acute liver injury overlapping pre-existing hepatic fibrosis.

130 These findings demonstrate that pre-existing hereditary genetics can impact progression

131 g at neighboring sites, while enhancers with pre-existing histone acetylation/accessibility confer a

132 POAG is associated with pre-existing HTN, suggesting that internal medicine/fami

133 We also report pre-existing human CD8+T cell immunity in the majority o

134 However, our knowledge of pre-existing humoral immunity against various AAV seroty

135 Pre-existing humoral immunity can impact immune response

136 re to the posterior hyaloid even in areas of pre-existing hyaloidal detachment.

137 We conclude that pre-existing hypertension aberrantly shifts nociceptive

138 mune infiltration and leads to enrichment of pre-existing ICB-resistant cancer clones.

139 eal Bevacizumab resulted in unmasking of the pre-existing ILM drape sign at 12 weeks.

140 n of the immune contexture, representing the pre-existing immune parameters associated with patient s

141 py is to induce a shift from an ineffective, pre-existing immune response to a long-lasting, therapy-

142 art the mechanisms of action of adjuvants on pre-existing immune responses.

143 ruses like influenza A involve activation of pre-existing immunity and generation of new responses.

144 These results indicate that prevalent pre-existing immunity in cats is not necessarily inhibit

145 c influenza strains to which there is little pre-existing immunity in the human population(10,11).

146 ational model that can capture the effect of pre-existing immunity on influenza vaccine responses.

147 n, it is antigenically slightly further from pre-existing immunity than the circulating strain.

148 However, pre-existing immunity to 10403S did not confer protectio

149 se and recent gains in vaccination coverage, pre-existing immunity to dengue virus is abundant in the

150 mon human pathogen, the human population has pre-existing immunity to HPIV-3, which may restrict the

151 infections, even though they likely possess pre-existing immunity to IAV.

152 As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent

153 activity was increased when the individual's pre-existing immunity was specific to an HA protein anti

154 s: the distances between the vaccine strain, pre-existing immunity, and the challenge strain.

155 pecificity and cross-reactivity dependent on pre-existing immunity.

156 tem responds to infection in the presence of pre-existing immunity.

157 ating influenza strain and interference with pre-existing immunity.

158 e of rapid antigenic drift in order to evade pre-existing immunity.

159 Treg cells and the inflammatory environment pre-existing in the patients.

160 affinity maturation, was elicited alongside pre-existing influenza immunity, and when IGHV1-69 B cel

161 There was an inverse correlation between pre-existing influenza-specific salivary IgA concentrati

162 The paper confuses individual learning of pre-existing information with creative generation of new

163 ired resistance is the direct consequence of pre-existing intratumor heterogeneity and ongoing divers

164 rol is demonstrated by the requirement for a pre-existing intratumour adaptive immune response for ef

165 ave been used to create new metalloproteins, pre-existing knowledge of the tertiary and quaternary pr

166 Some have confirmed pre-existing knowledge, including the role of skin barri

167 n summary, we show that bLECs can arise from pre-existing LECs and that rapamycin can prevent the gro

168 on-slowly expanding/evolving lesion areas of pre-existing lesions predicted subsequent composite disa

169 ute focal inflammatory lesions or in chronic pre-existing lesions without signs of acute inflammation

170 l location, with photographic evidence of no pre-existing lesions.

171 Real-space refinement from pre-existing ligand coordinates of 150 macrocycles resul

172 numerical models, we investigate the role of pre-existing lithospheric heterogeneities in continental

173 The presence of pre-existing liver disease in patients with elevated LFT

174 ut the Pi*Z mutation (controls), all without pre-existing liver disease.

175 of mostly newly frozen leads that reduce any pre-existing low-level cloudiness, which in turn decreas

176 Risk factors for acquisition of TCD included pre-existing lung diseases, lower GI endoscopy and antib

177 Moreover, we show that pre-existing lymphatic dysfunction before TBI leads to i

178 e 4 years of follow-up or the progression of pre-existing MA at year 4 (P = 0.692).

179 y to HIV-1 Gag epitopes and the expansion of pre-existing measurable responses.

180 ore than a quarter of women had at least one pre-existing medical condition and multiple risk factors

181 ding by patient demographic characteristics, pre-existing medical conditions, influenza vaccination,

182 rane-bound enzymes, which themselves require pre-existing membranes for function.

183 lear differences between newly generated and pre-existing memory B cells, highlighting the challenges

184 a vaccination in humans primarily stimulates pre-existing memory B cells, which differentiate into a

185 from PE as an exclusive food source through pre-existing metabolic pathways.

186 factors, might facilitate the progression of pre-existing micrometastases and the initiation of new m

187 lin co-condensation preferentially occurs on pre-existing microtubules, the site of branching microtu

188 ed to efficiently nucleate microtubules from pre-existing microtubules.

189 igomers, or through the rapid coalescence of pre-existing monomeric IgG1 nuclei into a dead-end aggre

190 ynodonts, drove the functional divergence of pre-existing morphological regions.

191 daughter centriole grows from the side of a pre-existing mother.

192 y parallel analysis of newly transcribed and pre-existing mRNAs from the same cell.

193 Pre-existing Mtb infection creates an immunological envi

194 f HIV infection, and we investigated whether pre-existing Mtb infection impacts the susceptibility of

195 ide cellular and molecular insights into how pre-existing Mtb infection influences HIV-1 pathogenesis

196 However, the impact of pre-existing Mtb infection on subsequent HIV infection h

197 ons, we show that first TPX2 is deposited on pre-existing MTs, followed by binding of augmin/gamma-Tu

198 ferentially originate near the minus-ends of pre-existing MTs.

199 umors in five patients showed no evidence of pre-existing mutations in four of five patients, suggest

200 ed infection, we examined the association of pre-existing NA, hemagglutination inhibiting, and HA sta

201 rate analysis was performed on patients with pre-existing nAMD to assess the effect of BLF IOLs on nA

202 ndition that cannot be better explained by a pre-existing neurocognitive disorder.

203 Exclusion criteria included prematurity and pre-existing neurologic, genetic, metabolic, or intraocu

204 gs demonstrate the existence of a stable and pre-existing NGFR(hi) multitherapy-refractory melanoma s

205 c T cells and observe strong enrichment of a pre-existing NGFR(hi) population.

206 w skin, divorced from confounding effects of pre-existing niche signals in haired skin.

207 scular network which may originate from both pre-existing normal endothelium and cancer-derived cells

208 ed metallic glass was established to be from pre-existing nuclei as confirmed by Avrami exponents of

209 ance, specifically the transfer of parental, pre-existing nucleosomes with their associated post-tran

210 ] 19.45; 95% CI 4.89-77.30, P < 0.001) and a pre-existing ocular comorbidity (aOR 10.70; 95% CI 1.69-

211 acuity outcomes were better in eyes with no pre-existing ocular pathologies, but both groups showed

212 282 eyes, including 94 with pre-existing ocular pathologies, were analysed.

213 ntation in cataract patients with or without pre-existing ocular pathologies.

214 d H4 are asymmetrically inherited, such that pre-existing (old) histones are segregated towards the s

215 dress these requirements, in addition to the pre-existing older methods that may not have been optimi

216 over, newborn neurons are thought to replace pre-existing ones that die.

217 sis, the formation of new blood vessels from pre-existing ones, occurs in pathophysiological contexts

218 d vanillic acids) and increased over 25% the pre-existing ones.

219 and demonstrate that BBDI resistance can be pre-existing or acquired.

220 Pre-existing organ damage negatively influenced outcome.

221 Pre-existing organelles, such as the nuclear envelope, e

222 ral insufficiency fracture, complications of pre-existing osteonecrosis, and rapid joint destruction

223 ptide nanoplexes co-targeting MK2 and XPA to pre-existing p53-deficient tumors in a highly aggressive

224 ied serial dictator game, to explore whether pre-existing paranoia could be accounted by specific alt

225 Our results explain how pre-existing paranoia may be the result of an increased

226 We found that pre-existing paranoia was associated with greater uncert

227 ibuted to harmful effects of treatment or to pre-existing parental characteristics that confound the

228 pidly scavenged by the high concentration of pre-existing particles.

229 t the hypothesis that instead of following a pre-existing pattern, the cranial neural crest creates t

230 Here, we combine SLED with a pre-existing patterned polymer film to study SLED's fund

231 ed for ER recruitment, but the presence of a pre-existing permissible chromatin environment can also

232 of the steps in FuFA biosynthesis occurs on pre-existing phospholipid fatty acid chains, and we iden

233 idence that HIV-1 Gag can selectively target pre-existing PIP2-enriched domains of the plasma membran

234 Aubergine and Ago3 increase the abundance of pre-existing piRNAs, and the phased piRNA pathway, which

235 sclerosis upon FXa inhibition, the effect on pre-existing plaques has never been studied.

236 46%, p < 0.05), and promoted a regression of pre-existing plaques in the carotids (-24%, p < 0.001).

237 In addition, the vulnerability of pre-existing plaques was reduced by FXa inhibition as re

238 membranes producing compositions resembling pre-existing plasma-membrane domains.

239 tein synthesis, and this rescue depends on a pre-existing pool of proteins in the Golgi.

240 n of disease globally, as COVID-19 exploited pre-existing poor population health among Americans to s

241 reated by non-coding mutations interact with pre-existing potential splice sites that originally lack

242 Patients with prior cardiac surgery or pre-existing PPM were excluded.

243 d generation of transmissible propagons from pre-existing prion aggregates.

244 This may be attributed to a pre-existing proinflammatory state that is further prope

245 While this may reflect pre-existing propensities, drug use also clearly contrib

246 -expressing individuals for establishment of pre-existing protective memory T cell pools.

247 g experiments, we show that bLECs arise from pre-existing Prox1-positive LECs.

248 Evidence suggests, for example, that pre-existing pulmonary, cardiovascular, neurological and

249 gery (true-negative results), and 8 eyes had pre-existing PVD at the time of surgery (false-negative

250 plete PVD on OCT, 20 eyes were found to have pre-existing PVD at the time of surgery (true-positive r

251 d Naive Bayes algorithm that did not include pre-existing PVR as an input feature had an AUC of 0.81,

252 tive PVR was better for models that included pre-existing PVR as an input.

253 These findings demonstrate that pre-existing, randomly distributed leader cells within p

254 ients with baseline normal conduction, while pre-existing RBBB greatly increases the risk for CHB.

255 whereas Cf-2 evolved <6Mya by co-opting the pre-existing Rcr3 in the Solanum genus.

256 us integrated approaches generally require a pre-existing regulatory network.

257 , risk factors for severe infection included pre-existing renal disease (odds ratio [OR], 7.4; 95% CI

258 Acute or pre-existing renal disease, supplemental oxygen upon hos

259 quired resistance to these drugs relative to pre-existing resistance.

260 significant resistance occurs only when the pre-existing resistant phenotypes are able to proliferat

261 is compensated for by a reduced dilution of pre-existing ribosomes and a reduction in cell volume, t

262 iogenite was derived from partial melting of pre-existing rocks and had crystallized in the interior

263 The effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinic

264 secondary structure tendencies with numerous pre-existing secondary structure propensity scales resul

265 t in which iNKT cells can rapidly respond to pre-existing self-molecules after stress-induced structu

266 rstanding of the underlying coupling between pre-existing shell morphology, de novo surface depositio

267 for which AR binding in low dox increased at pre-existing sites that included sites for prostate-spec

268 ns of SLF were recaptured on vines with high pre-existing SLF populations, indicating that SLF may ex

269 e tree planting in regions with considerable pre-existing SOC stocks will have the intended policy an

270 Whether and how pre-existing spacers in type II systems affect the acqui

271 tein complex, Augmin, recruits gamma-TuRC to pre-existing spindle MTs, amplifying their number, in an

272 the absence of an SSP, in the presence of a pre-existing SSP, and with implementation of an SSP afte

273 o demonstrate that, without the influence of pre-existing structures, 3D extension is preferentially

274 that most initiation events are proximal to pre-existing subduction zones.

275 er to seismic sensors, allows us to leverage pre-existing submarine telecommunication cables for seis

276 on phase or in drying-heating reactions from pre-existing sugars and heterocycles suggests that a wid

277 k for developing proteinopathies rather than pre-existing suppression of glymphatic influx.

278 depletion of a third gene product enhances a pre-existing synthetic lethal combination.

279 ble to do very targeted customization of the pre-existing system to address specific end-user require

280 n original systematic review and to identify pre-existing systematic reviews.

281 igh suspicion of malignancy because of known pre-existing systemic malignancy or the presence of an a

282 elements gradually become accessible within pre-existing TADs during early differentiation.

283 esses underlying the mechanisms of action of pre-existing technologies.

284 ell assemblies played sequentially on robust pre-existing temporal frameworks could support rapid for

285 agulable state, although both may exacerbate pre-existing thrombi.

286 n perform other tasks without disrupting its pre-existing timescale architecture, suggesting that str

287 lation of PEG liposomes in animals with high pre-existing titers of APA, without stimulating addition

288 uctions could reflect effects of drug use or pre-existing traits, we used positron emission tomograph

289 work of the cell and are often controlled by pre-existing transcription factors.

290 ther generalized for the cross-metathesis of pre-existing trisubstituted olefins in other relay-actua

291 ive conventional CD4+ (Tconv) cells, but not pre-existing tTregs, could differentiate into RORgamma+

292 ckpoint blockade relies on reinvigoration of pre-existing tumor-infiltrating lymphocytes or on recrui

293 pansion of T cell clones did not derive from pre-existing tumor-infiltrating T lymphocytes; instead,

294 These results demonstrate that pre-existing tumor-specific T cells may have limited rei

295 om foregut basal progenitor cells expressing pre-existing tumorigenic mutation(s) and genetic alterat

296 However, pre-existing vector immunity and a pro-inflammatory vacc

297 the formation of new blood vessels from the pre-existing vessels and it has a vital role in the surv

298 h GD, suggesting these markers may represent pre-existing vulnerability to GD.

299 ntroversial which domains specifically index pre-existing vulnerability, state-related or trait-relat

300 trait-related markers of depression but not pre-existing vulnerability.