ライフサイエンスコーパス: pre-mRNA

1 ing of human alpha-globin pre-messenger RNA (pre-mRNA).

2 moves introns from messenger RNA precursors (pre-mRNA).

3 xpression of RBPs, which interact with sad-1 pre-mRNA.

4 etween U2 snRNP and branch point (BP) on the pre-mRNA.

5 sites (PA-sites) at the terminal exon on the pre-mRNA.

6 eventing the association of NOVA1 with hTERT pre-mRNA.

7 ractions of spliceosomal components with the pre-mRNA.

8 ice site, and the branchsite (BS) of nascent pre-mRNA.

9 otic mRNAs requires splicing of introns from pre-mRNA.

10 as a single promoter that generates a single pre-mRNA.

11 nRNPs and the U2 snRNA is base-paired to the pre-mRNA.

12 ecreased transcription and processing of Asc pre-mRNA.

13 n intronic and exonic sequences of regulated pre-mRNA.

14 ing the association of splicing factors with pre-mRNA.

15 by the direct binding of ADAR3 to the GRIA2 pre-mRNA.

16 leoprotein complex that removes introns from pre-mRNAs.

17 itutive and alternative splicing of selected pre-mRNAs.

18 ng to U1-70K to induce splicing of lipogenic pre-mRNAs.

19 ol II termination of lincRNAs as compared to pre-mRNAs.

20 2- and U12 spliceosomes occur within nuclear pre-mRNAs.

21 gly increase the levels of the corresponding pre-mRNAs.

22 and U7 snRNA in 3' end processing of histone pre-mRNAs.

23 s well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromole

24 ALYREF promotes histone pre-mRNA 3'-end processing by facilitating U7-snRNP recr

25 The mammalian pre-mRNA 3'-end-processing machinery consists of cleavag

26 snRNP may reside before its release from the pre-mRNA 5' splice site.

27 Alternative splicing (AS) of pre-mRNAs, a process that generates two or more transcri

28 CPF cleaves pre-mRNAs, adds a polyadenylate tail, and triggers trans

29 L1 variations, some of which induce aberrant pre-mRNA AIPL1 splicing leading to the production of alt

30 Pre-mRNA alternative splicing and alternative polyadenyl

31 Our results establish a role for pre-mRNA alternative splicing in beta-cell function acro

32 nal activity and have a particular impact on pre-mRNA alternative splicing patterns.

33 ve feedback loop, in which RBP binds its own pre-mRNA and causes alternative splicing to introduce a

34 ectly bridges the 5'-exon and intron 3'SS of pre-mRNA and promotes exon ligation, as shown by functio

35 ceptor via its ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-

36 tein, participates in the processing of this pre-mRNA and so controls capsid gene access via its role

37 established between the 5' splice site of a pre-mRNA and the 5' end of the U1 snRNA.

38 ated by a productive interaction between the pre-mRNA and the U1 snRNP, in which a short RNA duplex i

39 ognition of the duplex between the authentic pre-mRNA and U7 small nuclear RNA (snRNA).

40 enylated RNAs, including long noncoding RNA, pre-mRNAs and bacterial RNAs.

41 vage factors IA and IB, which bind substrate pre-mRNAs and CPF, likely facilitating assembly of an ac

42 spliceosome removes non-coding introns from pre-mRNAs and joins exons.

43 ence for exon 2 regions of intron-containing pre-mRNAs and poly(A) proximal sites.

44 f mRNAs, a concomitant increase of unspliced pre-mRNAs and the disappearance of the trans-splicing Y

45 confirmed the capture of pre-messenger RNA (pre-mRNA) and exposed distinctions in diversity and abun

46 sembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceos

47 ore or soon after exon definition in nascent pre-mRNA, and while m(6)A is not required for most splic

48 ciation and translocation of UPF1 on nascent pre-mRNAs, and cells depleted of UPF1 show defects in th

49 animal cells, replication-dependent histone pre-mRNAs are cleaved at the 3' end by U7 snRNP consisti

50 NAs) produced from back-splicing of exons of pre-mRNAs are widely expressed, but current understandin

51 scribed eukaryotic precursor messenger RNAs (pre-mRNAs) are processed at their 3' ends by the 1-megad

52 cking the binding of splicing factors to the pre-mRNA, are a promising therapeutic modality to treat

53 nd to non-adenylate RNA classes (tRNA, rRNA, pre-mRNA) as well as the vast majority of species that l

54 pre-mRNAs assemble into dynamic ribonucleoparticles as t

55 the small RNA-binding Argonaute NRDE-3, the pre-mRNA associated factor NRDE-2, and the HP1-like prot

56 ly, intron-targeted ASOs reduce the level of pre-mRNA associated with chromatin to a greater extent t

57 CPF cleaves pre-mRNAs at a specific site and adds a poly(A) tail.

58 is analysis discovers novel modes of U2snRNA:pre-mRNA base-pairing conserved in yeast and provides in

59 Telescripting requires U1:pre-mRNA base-pairing, which can be disrupted by U1 anti

60 on many substrates, including pre-rRNAs and pre-mRNAs, binding specificity is apparently conferred b

61 say that mimics molecular recognition of tau pre-mRNA by a U1 small nuclear ribonucleoprotein (snRNP)

62 The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the form

63 ptophan residue in the loop was required for pre-mRNA capping in the step of the covalent enzyme-pRNA

64 he gene-start sequence for mRNA synthesis or pre-mRNA capping.

65 Notably, HOPS sequesters pre-mRNA cleavage factor components from actively transc

66 ecreased DDX1 interactions with Gle1 and the pre-mRNA cleavage stimulation factor CstF-64.

67 ere, we show that reconstitution of specific pre-mRNA cleavage with recombinant yeast proteins requir

68 -dependent histone precursor messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprote

69 enylation (polyA) sites near the 3' end of a pre-mRNA create multiple mRNA transcripts with different

70 We identified several m(6)A sites in RTA pre-mRNA crucial for splicing through interactions with

71 The retained intron pre-mRNAs display a number of characteristics, including

72 We identified the regulator of pre-mRNA-domain-containing (RPRD) proteins as reader pro

73 blockage of m(6)A inhibited splicing of the pre-mRNA encoding the replication transcription activato

74 mic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulators of peptidergic secretion w

75 inds G tracts within nascent precursor mRNA (pre-mRNA), especially within predicted G-quadruplex stru

76 These data support a model in which pre-mRNA evicts PRC2 during gene activation and provides

77 uires Slu7, which interacts dynamically with pre-mRNA first, and then interacts stably with the 3'-ex

78 ead small molecules that directly target tau pre-mRNA from sequence.

79 Spliceosomes assemble onto pre-mRNA guided by specific sequences (5' splice site, 3

80 ins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent eff

81 argeted ASOs achieve full activity after the pre-mRNA has undergone splicing, but before the mRNA is

82 and physical characteristics of mis-spliced pre-mRNAs highlighted conserved properties, including le

83 ircRNA and the protein encoded by its linear pre-mRNA host.

84 ments reveal that PTBP1 interacts with hTERT pre-mRNA in a NOVA1 dependent fashion.

85 d to rescue disease-relevant splicing of tau pre-mRNA in a variety of cellular systems, including pri

86 e compounds are shown to directly target tau pre-mRNA in cells, via chemical cross-linking and isolat

87 We captured the pre-mRNA in the active site of the endonuclease, the 73-

88 to correct splicing of survival motor neuron pre-mRNA in the cortex and striatum after intracerebrove

89 ous U7 snRNP, and accurately cleaves histone pre-mRNAs in a reconstituted in vitro processing reactio

90 regulator that supports splicing of selected pre-mRNAs in an intron-specific manner in Schizosaccharo

91 ckpoint to ensure proper splicing of certain pre-mRNAs in fission yeast.

92 We show that FTO binds preferentially to pre-mRNAs in intronic regions, in the proximity of alter

93 ing (SLTS) plays a part in the maturation of pre-mRNAs in select species across multiple phyla but is

94 ation regarding the regulatory properties of pre-mRNA, including the RNA secondary structure context.

95 The pre-mRNA increase is dependent on UPF3A and independent

96 Alternative splicing of pre-mRNA increases genetic diversity, and recent studies

97 Alternative splicing (AS) of pre-mRNAs increases transcriptome and proteome diversity

98 -kappaB subunit-dependent reduction in eEF2K pre-mRNA, indicating that NF-kappaB activation represses

99 This includes both the processing of pre-mRNAs into mature mRNAs ready for translation and RN

100 The splicing of pre-mRNAs into mature transcripts is remarkable for its

101 nd characterized for its role in splicing of pre-mRNAs involved in photomorphogenesis.

102 ing sites within the primary sequence of the pre-mRNA is a predictor of 5' splice site usage, with th

103 The increase in pre-mRNA is delayed and due to enhanced transcription an

104 liced leader (SL)-mediated trans-splicing of pre-mRNAs is an obligatory step in gene expression, and

105 Polyadenylation of pre-mRNAs is one important step in their processing and

106 atalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a n

107 at generates two or more mRNAs from the same pre-mRNA, is largely controlled by splicing regulators,

108 factor NOVA2, which binds directly to L1CAM pre-mRNA, is necessary and sufficient for the skipping o

109 re alternative splicing of the 3' end of the pre-mRNA leads to the production of 3 validated ERR-beta

110 Moreover, missplicing of most targeted pre-mRNAs leads to the generation of nonsense-mediated d

111 of the Prp8 protein as signal conveyors for pre-mRNA maturation.

112 ratio by altering exon 5 inclusion in SmgGDS pre-mRNA (messenger RNA).

113 m(6)A near splice sites in nascent pre-mRNA modulates hnRNPG binding, which influences RNAP

114 Pre-mRNA molecules with two alternative 3ss can be bound

115 Most eukaryotic pre-mRNAs must undergo 3'-end cleavage and polyadenylati

116 Alternative splicing of pre-mRNA of Arabidopsis SR45, which encodes an SR-like s

117 alysis revealed that alternative splicing of pre-mRNAs of 558 genes, including the autophagy-related

118 Alternative splicing allows the pre-mRNAs of a gene to be spliced into various mRNAs, wh

119 by ensuring correct alternative splicing of pre-mRNAs of critical glycolytic genes such as GLUT1 and

120 ncRNAs) undergo the same maturation steps as pre-mRNAs of protein-coding genes (PCGs), but they are o

121 Pre-mRNAs of SR and SR-like proteins undergo extensive a

122 directionally from gene promoters to produce pre-mRNAs on the forward strand and promoter upstream tr

123 Alternative splicing of pre-mRNAs plays a pivotal role during the establishment

124 on of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and poly

125 In particular, the effect of auxin on pre-mRNA post-transcriptional regulation is mostly unkno

126 ation of the serotonin 2C receptor (5-HT2CR) pre-mRNA potentially leading to a reduction in 5-HT2CR f

127 Most pre-mRNAs proceed through 3' adenylation, uridine insert

128 BP) with established roles in transcription, pre-mRNA processing and DNA damage response.

129 ate U1's unique role as central regulator of pre-mRNA processing and transcription.

130 inks H2Bub during transcript elongation with pre-mRNA processing at CCA1 Furthermore, the presence of

131 rate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state outpu

132 Pre-mRNA processing events such as alternative splicing

133 At its functional core lies the essential pre-mRNA processing factor 8 (Prp8) protein.

134 indicated that CDK12 directly phosphorylates pre-mRNA processing factors, including those regulating

135 , interfere with host gene transcription and pre-mRNA processing genomewide and contributes to the sp

136 A critical role for alternative pre-mRNA processing in cell migration has emerged in axo

137 on microscopy and ability to support histone pre-mRNA processing in the presence of polyadenylation f

138 We reconstituted an active human histone pre-mRNA processing machinery using 13 recombinant prote

139 arries out reversible phosphorylation on the pre-mRNA processing machinery.

140 Pre-mRNA processing of these genes is critical and media

141 Pre-mRNA processing protein 40 (Prp40) is a nuclear prot

142 at a full understanding of such dysregulated pre-mRNA processing requires study of snRNAs, as well as

143 onal patterns of divergent transcription and pre-mRNA processing, including intron splicing and 3' cl

144 SR proteins function in nuclear pre-mRNA processing, mRNA export, and translation.

145 ent kinase for the parasite-specific mode of pre-mRNA processing.

146 functions in 3'-splice site selection during pre-mRNA processing.

147 of the viral capsid proteins via its role in pre-mRNA processing.

148 tor (CPSF30), a cellular protein involved in pre-mRNA processing.

149 he CKR9 kinase activity that is required for pre-mRNA processing.

150 tion occurs co-transcriptionally and impacts pre-mRNA processing; however, the mechanism of co-transc

151 /Mud2p functions in precursor messenger RNA (pre-mRNA) processing.

152 ponents of the replication-dependent histone pre-mRNA-processing complex.

153 with higher affinity to the splicing factor pre-mRNA-processing factor39-1 (PpPRP39-1) in the presen

154 y alternative splicing of full-length P2RX7A pre-mRNA, producing isoforms that delete or retain funct

155 Altered pre-mRNA recognition emerges as a molecular theme among

156 x5, that interferes with splicing of TMPRSS2 pre-mRNA, resulting in the expression of enzymatically i

157 TARBP2 binding to pre-mRNAs results in increased intron retention, subsequ

158 teins and SRSF3 are associated with unpaired pre-mRNA segments upstream of U2AF-repressed 3'ss.

159 immediately upstream of the introns contain pre-mRNA-specific splicing enhancers, the substitution o

160 We targeted hundreds to thousands of pre-mRNA splice junctions and obtained high-precision de

161 lues are commonly used to report alternative pre-mRNA splicing (AS) changes.

162 Aberrant alternative pre-mRNA splicing (AS) events have been associated with

163 he cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing.

164 ic repeats/Cas9 and effecting alterations in pre-mRNA splicing and by manipulating expression levels

165 tion of the photoreceptor connecting cilium, pre-mRNA splicing and epigenetic modifiers.

166 nstrate that H2A.Z is required for efficient pre-mRNA splicing and indicate a role for H2A.Z in coord

167 ely spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulato

168 s across eukaryotes, play important roles in pre-mRNA splicing and other post-transcriptional process

169 e of protein-protein interactions to control pre-mRNA splicing and photomorphogenic responses.

170 his mutation results in aberrant beta-globin pre-mRNA splicing and prevents synthesis of beta-globin

171 ons of SR (serine/arginine-rich) proteins in pre-mRNA splicing and processing are modulated by revers

172 (eU1s) have the unique ability to reprogram pre-mRNA splicing and restore exon 7 inclusion in SMN1 c

173 Transcription and pre-mRNA splicing are coupled to promote gene expression

174 Small molecule inhibitors of pre-mRNA splicing are important tools for identifying ne

175 Transcription and pre-mRNA splicing are key steps in the control of gene e

176 cription-splicing territories and changes to pre-mRNA splicing are observed.

177 Mutations that perturb normal pre-mRNA splicing are significant contributors to human

178 e DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs.

179 urther supported by genetic interactions and pre-mRNA splicing assays.

180 an essential role of m(6)A in regulating RTA pre-mRNA splicing but also suggest that KSHV has evolved

181 ce of the coordinated control of alternative pre-mRNA splicing by chromatin structure and transcripti

182 d specific RNA-target sequences and modulate pre-mRNA splicing by sterically blocking the binding of

183 that can change a protein sequence, abnormal pre-mRNA splicing can be devastating for the encoded pro

184 strate that antisense-mediated modulation of pre-mRNA splicing can increase endogenous expression of

185 leblind-like protein 1 (MBNL1), which causes pre-mRNA splicing defects.

186 describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle.

187 depletion caused a significant reduction in pre-mRNA splicing efficiency, as demonstrated through RN

188 tiviral vectors engineered to target several pre-mRNA splicing elements on the beta(IVS2-654)-globin

189 ript half-life but are not required for most pre-mRNA splicing events.

190 unclear how reduced expression of this core pre-mRNA splicing factor leads to craniofacial defects.

191 The transcription elongation and pre-mRNA splicing factor Tat-SF1 associates with the U2

192 Here, we identified an additional pre-mRNA splicing factor, WBP11, as a novel protein requ

193 essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly

194 Pre-mRNA splicing factors play a fundamental role in reg

195 dramatic translocation of Hnrnpa1 and other pre-mRNA splicing factors to the nucleus in a transcript

196 ecular theme among MDS-relevant mutations of pre-mRNA splicing factors.

197 urrent mis-sense mutations of genes encoding pre-mRNA splicing factors.

198 The termination of pre-mRNA splicing functions to discard suboptimal substr

199 In the mammalian nervous system, alternative pre-mRNA splicing generates functionally distinct isofor

200 Alternative pre-mRNA splicing has long been proposed to contribute g

201 Here we demonstrate that pre-mRNA splicing homeostasis is a biomarker and predict

202 ts with the photoreceptor phyB and regulates pre-mRNA splicing in Arabidopsis (Arabidopsis thaliana).

203 Pre-mRNA splicing in eukaryotes requires three DEAD-box

204 tron recognition in the majority of cases of pre-mRNA splicing in eukaryotes.

205 ought to define the landscape of alternative pre-mRNA splicing in prostate cancers and the relationsh

206 n embryonic day 13-13.5 (E13-13.5) corrected pre-mRNA splicing in the juvenile Usher syndrome type 1c

207 rotein 13) regulates the budding pattern and pre-mRNA splicing in yeast cells; however, no Bud13p hom

208 detection of splice isoforms, including rare pre-mRNA splicing intermediates.

209 Pre-mRNA splicing is a fundamental process in mammalian

210 1-3 identified a large number of genes whose pre-mRNA splicing is altered under dark and light condit

211 Pre-mRNA splicing is an essential step of eukaryotic gen

212 Pre-mRNA splicing is an important step for gene expressi

213 In eukaryotic cells, pre-mRNA splicing is catalyzed by the spliceosome, a hig

214 patterns through the regulation of specific pre-mRNA splicing is essential for adequate plant develo

215 In eukaryotes, pre-mRNA splicing is governed by the activity of a large

216 Pre-mRNA splicing must occur with extremely high fidelit

217 hylation plays an essential role in accurate pre-mRNA splicing necessary for a range of developmental

218 Mutations that disrupt pre-mRNA splicing occur in >15% of CF cases.

219 SFPS regulates pre-mRNA splicing of a large number of genes, of which m

220 also form a complex and coordinately control pre-mRNA splicing of a subset of genes involved in light

221 r photobodies, and regulates light-dependent pre-mRNA splicing of a subset of genes.

222 ABA-responsive AtU2AF65b functions in the pre-mRNA splicing of FLC and ABI5 in shoot apex, whereby

223 ring as well as the transcript abundance and pre-mRNA splicing of flowering-related genes in the knoc

224 ssing PRMT5 activity, palbociclib alters the pre-mRNA splicing of MDM4, a negative regulator of p53,

225 nisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macr

226 mbryos by causing non-productive alternative pre-mRNA splicing of xol-1, the master sex-determination

227 s employ antisense oligonucleotides to alter pre-mRNA splicing or diminish target gene expression and

228 ressed genes identified dysregulation of the pre-mRNA splicing pathway, accompanied by perturbed auto

229 teraction among U2 snRNPs and affects global pre-mRNA splicing pattern and extensive gene expression.

230 NF-kappaB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing

231 tanding of human retinal development and the pre-mRNA splicing process, and help to identify new cand

232 We discuss different levels of pre-mRNA splicing regulation such as post-translational

233 However, the role of plant Sm proteins in pre-mRNA splicing remains largely unknown.

234 polysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop th

235 ious levels, the regulatory mechanism at the pre-mRNA splicing step remains unclear.

236 gen receptor (AR) activity, yet also control pre-mRNA splicing through less clear mechanisms.

237 organ system in utero preemptively corrects pre-mRNA splicing to abrogate the disease phenotype.

238 Our results connect changes in alternative pre-mRNA splicing to oncogenic alterations common in pro

239 SF3B1 mutations are associated with aberrant pre-mRNA splicing using cryptic 3' splice sites (3'SSs),

240 etary restriction, we find defects in global pre-mRNA splicing with age that are reduced by dietary r

241 3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces

242 ied and include effects on mRNA translation, pre-mRNA splicing, and micro-RNA silencing.

243 ular processes such as chromatin remodeling, pre-mRNA splicing, and signal transduction.

244 beyond transcription initiation and regulate pre-mRNA splicing, and thereby mRNA isoform production,

245 Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on pro

246 o SR proteins-SRSF3 and SRSF7, regulators of pre-mRNA splicing, nuclear export and translation-intera

247 transcription elongation, cotranscriptional pre-mRNA splicing, transcription termination, and conseq

248 Pat1 is a hub for mRNA metabolism, acting in pre-mRNA splicing, translation repression, and mRNA deca

249 water potential (psi(w)) stress suggested a pre-mRNA splicing-related function.

250 recruit spliceosomal components to initiate pre-mRNA splicing.

251 les in early embryo development by effecting pre-mRNA splicing.

252 cing are fundamental unanswered questions in pre-mRNA splicing.

253 differentiation is regulated by alternative pre-mRNA splicing.

254 nd utilize sudemycin compounds that modulate pre-mRNA splicing.

255 ed NS proteins via its role in governing MVC pre-mRNA splicing.

256 stood, but may act in both transcription and pre-mRNA splicing.

257 suggesting that it could play a key role in pre-mRNA splicing.

258 oupled functional role for these proteins in pre-mRNA splicing.

259 in muscle, likely independent of its role in pre-mRNA splicing.

260 1 (MBNL1) and hamper its normal function in pre-mRNA splicing.

261 nd have been implicated in the regulation of pre-mRNA splicing.

262 p40) is a nuclear protein that has a role in pre-mRNA splicing.

263 ed NS proteins via its role in governing MVC pre-mRNA splicing.IMPORTANCE The Parvovirinae are small

264 Precursor mRNA (pre-mRNA) splicing is a fundamental link between gene ex

265 The control of precursor-messenger RNA (pre-mRNA) splicing is emerging as an important layer of

266 In eukaryotes, precursor mRNA (pre-mRNA) splicing removes non-coding intron sequences t

267 matin in the regulation of premessenger RNA (pre-mRNA) splicing.

268 Alternative pre-mRNA-splicing-induced post-transcriptional gene expr

269 f glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

270 lymerase to the 3' terminus, thus leading to pre-mRNA stabilization, or decay depending on the occurr

271 cruitment of splicing factors and consequent pre-mRNA structural remodeling, leading up to assembly o

272 Splicing assays with select pre-mRNA substrates demonstrate that loops immediately u

273 licing elements on the beta(IVS2-654)-globin pre-mRNA such as cryptic 3' splice site, aberrant 5' spl

274 lymerase II transcribes several kilobases of pre-mRNA, suggesting that metazoan splicing transpires d

275 creases TIM protein and tim mRNA but not tim pre-mRNA, supporting a posttranscriptional role.

276 One pre-mRNA that is alternatively spliced and linked to neu

277 ing activates a poison 5'-splice site in its pre-mRNA that leads to a frame shift and degradation by

278 ribed as part of a polygenic precursor mRNA (pre-mRNA) that is initiated within a several-kilobase-lo

279 Genome editing studies show that TTN pre-mRNA, the main RBM20-regulated transcript in the hea

280 We show that RBPs frequently bind their own pre-mRNAs, their exons respond prominently to NMD pathwa

281 ectly bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonuc

282 lice site (3'SS) of precursor messenger RNA (pre-mRNA) through non-Watson-Crick pairing with the 5'SS

283 nformation on how the proteins interact with pre-mRNA to mediate the reaction is scarce.

284 with both RNAPII and m(6)A-modified nascent pre-mRNA to modulate RNAPII occupancy and alternative sp

285 lymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit.

286 nscription elongation rates, (ii) binding to pre-mRNA to recruit splicing factors, and/or (iii) block

287 est event in the splicing cycle that commits pre-mRNAs to splicing.

288 predicts splice junctions from an arbitrary pre-mRNA transcript sequence, enabling precise predictio

289 rstanding of when and where in the life of a pre-mRNA transcript the modifications are made.

290 ear RNA surveillance system is active on all pre-mRNA transcripts and modulated by nutrient availabil

291 factors interact at cis regulatory sites on pre-mRNA transcripts.

292 In Trypanosoma brucei, mitochondrial pre-mRNAs undergo 3'-5' exonucleolytic processing, 3' ad

293 Here, we report that PACE4 pre-mRNA undergoes DNA methylation-sensitive alternative

294 In cells, PRC2 transfers from chromatin to pre-mRNA upon gene activation, and chromatin-associated

295 rom uridylation and decay thereby protecting pre-mRNA upon KPAF3 displacement by editing.

296 A translation or alter the maturation of the pre-mRNA via splicing correction.

297 codons introduced by mis-splicing of PgABCA2 pre-mRNA were prevalent in field-selected larvae from In

298 is assembled via sequential interactions of pre-mRNA with five small nuclear RNAs and many proteins.

299 to the mis-splicing of a distinct subset of pre-mRNAs with a widespread effect on gene expression, i

300 It associates with intron 24 of Apob pre-mRNA, with the 3'UTR of Uqcrb, and with the 5'UTR of