ライフサイエンスコーパス: pre-mRNA splicing

1 nd have been implicated in the regulation of pre-mRNA splicing.

2 p40) is a nuclear protein that has a role in pre-mRNA splicing.

3 ngly, RTA induced m(6)A and enhanced its own pre-mRNA splicing.

4 vation of RBM39 by indisulam causes aberrant pre-mRNA splicing.

5 ceosome, the molecular machine that executes pre-mRNA splicing.

6 on by regulating tissue-specific alternative pre-mRNA splicing.

7 ts N-terminal region, and directly regulates pre-mRNA splicing.

8 ated in processes such as gene silencing and pre-mRNA splicing.

9 cular, branched RNAs (bRNAs) produced during pre-mRNA splicing.

10 and splice-site RNAs are likely to influence pre-mRNA splicing.

11 dipocyte gene expression include alternative pre-mRNA splicing.

12 Glut4 mRNA and decreased efficiency of Glut4 pre-mRNA splicing.

13 rge ribonucleoprotein complex that catalyzes pre-mRNA splicing.

14 athy and display numerous defects in cardiac pre-mRNA splicing.

15 he expression of a subset of human genes via pre-mRNA splicing.

16 o 45% of synonymous SNPs are likely to alter pre-mRNA splicing.

17 hat recently discovered snRNPs functioned in pre-mRNA splicing.

18 e binding of RNA polymerase to promoters and pre-mRNA splicing.

19 at greatly influences mRNA levels as well as pre-mRNA splicing.

20 us plays a crucial role at an early stage of pre-mRNA splicing.

21 Overexpression of CHK2 promoted pre-mRNA splicing.

22 ties of eight RNA helicases are required for pre-mRNA splicing.

23 Prp16-mediated spliceosome remodeling during pre-mRNA splicing.

24 n results in multiple competing pathways for pre-mRNA splicing.

25 ion is required for normal cotranscriptional pre-mRNA splicing.

26 ht highly conserved proteins is critical for pre-mRNA splicing.

27 uitin mark from ubH2B and co-transcriptional pre-mRNA splicing.

28 ing of pri-miRNAs in addition to its role in pre-mRNA splicing.

29 hether TRAMP may have any potential roles in pre-mRNA splicing.

30 mplex macromolecular machine responsible for pre-mRNA splicing.

31 viral regulator, at the level of alternative pre-mRNA splicing.

32 ions as a spliceosome assembly factor during pre-mRNA splicing.

33 xport of newly synthesized RNA and disrupted pre-mRNA splicing.

34 nserved heterotrimeric complex essential for pre-mRNA splicing.

35 A/RNA-binding protein with a nuclear role in pre-mRNA splicing.

36 el system for understanding the chemistry of pre-mRNA splicing.

37 2p is one of eight RNA helicases involved in pre-mRNA splicing.

38 n though haploinsufficiency of SmD3 supports pre-mRNA splicing.

39 ibonucleoproteins (snRNPs) which function in pre-mRNA splicing.

40 ated to involve dysregulation of alternative pre-mRNA splicing.

41 recruit spliceosomal components to initiate pre-mRNA splicing.

42 les in early embryo development by effecting pre-mRNA splicing.

43 cing are fundamental unanswered questions in pre-mRNA splicing.

44 differentiation is regulated by alternative pre-mRNA splicing.

45 nd utilize sudemycin compounds that modulate pre-mRNA splicing.

46 ed NS proteins via its role in governing MVC pre-mRNA splicing.

47 stood, but may act in both transcription and pre-mRNA splicing.

48 suggesting that it could play a key role in pre-mRNA splicing.

49 oupled functional role for these proteins in pre-mRNA splicing.

50 in muscle, likely independent of its role in pre-mRNA splicing.

51 1 (MBNL1) and hamper its normal function in pre-mRNA splicing.

52 matin in the regulation of premessenger RNA (pre-mRNA) splicing.

53 During pre-mRNA splicing, a central step in the expression and

54 mediated gene silencing independently of its pre-mRNA splicing activity and indicate that the dual ro

55 is study demonstrates two instances in which pre-mRNA splicing actually enhances the synthesis of pro

56 3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces

57 ish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcrip

58 he cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing.

59 factors play widespread roles in alternative pre-mRNA splicing and are known to promote splice site r

60 kinase is known for its roles in regulating pre-mRNA splicing and beyond.

61 ic repeats/Cas9 and effecting alterations in pre-mRNA splicing and by manipulating expression levels

62 ) is a nuclear protein that is implicated in pre-mRNA splicing and cell cycle progression, but the po

63 glutelin mRNA metabolism, perhaps in nuclear pre-mRNA splicing and cytosolic localization to the cist

64 tion of the photoreceptor connecting cilium, pre-mRNA splicing and epigenetic modifiers.

65 mouse liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impair

66 site, and reinforces the notion that nuclear pre-mRNA splicing and group II intron splicing have a co

67 nstrate that H2A.Z is required for efficient pre-mRNA splicing and indicate a role for H2A.Z in coord

68 inducible RNA helicase RCF1 is essential for pre-mRNA splicing and is important for cold-responsive g

69 Pre-mRNA splicing and mRNA stability are fundamentally a

70 ents in cell physiology by the regulation of pre-mRNA splicing and mRNA translation.

71 inct activities at the levels of alternative pre-mRNA splicing and mRNA translation.

72 ely spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulato

73 gest two new nuclear roles for Ago-2: one in pre-mRNA splicing and one in transcriptional repression.

74 tiple mRNA isoforms, produced by alternative pre-mRNA splicing and other mechanisms, and that most al

75 s across eukaryotes, play important roles in pre-mRNA splicing and other post-transcriptional process

76 actions during the regulation of alternative pre-mRNA splicing and other processes.

77 e of protein-protein interactions to control pre-mRNA splicing and photomorphogenic responses.

78 , RRP6, with in vivo consequences of altered pre-mRNA splicing and poly(A) tail length control.

79 his mutation results in aberrant beta-globin pre-mRNA splicing and prevents synthesis of beta-globin

80 ons of SR (serine/arginine-rich) proteins in pre-mRNA splicing and processing are modulated by revers

81 ounds also potently improve FXTAS-associated pre-mRNA splicing and RAN translational defects, while n

82 ctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3' end processin

83 (eU1s) have the unique ability to reprogram pre-mRNA splicing and restore exon 7 inclusion in SMN1 c

84 DDX41 lesions caused altered pre-mRNA splicing and RNA processing.

85 However, a direct link between alternative pre-mRNA splicing and small RNA pathways has remained el

86 PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR).

87 inase 11 (CDK11)(p110) kinase, implicated in pre-mRNA splicing and transcription, was identified as a

88 gets; strongly suggesting that SRSF1 couples pre-mRNA splicing and translation.

89 ied and include effects on mRNA translation, pre-mRNA splicing, and micro-RNA silencing.

90 ular processes such as chromatin remodeling, pre-mRNA splicing, and signal transduction.

91 1 silencing can be uncoupled from defects in pre-mRNA splicing, and the RNAi and splicing machineries

92 beyond transcription initiation and regulate pre-mRNA splicing, and thereby mRNA isoform production,

93 ed the first evidence that TRAMP facilitates pre-mRNA splicing, and we interpreted this as a fail-saf

94 Transcription and pre-mRNA splicing are coupled to promote gene expression

95 Small molecule inhibitors of pre-mRNA splicing are important tools for identifying ne

96 Transcription and pre-mRNA splicing are key steps in the control of gene e

97 cription-splicing territories and changes to pre-mRNA splicing are observed.

98 whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood.

99 Mutations that perturb normal pre-mRNA splicing are significant contributors to human

100 ms that regulate alternative precursor mRNA (pre-mRNA) splicing are largely unknown.

101 Here we identify interference with pre-mRNA splicing as a mechanism to combat vemurafenib r

102 e DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs.

103 lues are commonly used to report alternative pre-mRNA splicing (AS) changes.

104 Aberrant alternative pre-mRNA splicing (AS) events have been associated with

105 Alternative pre-mRNA splicing (AS) is a critical regulatory mechanis

106 le of chromatin in regulation of alternative pre-mRNA splicing (AS).

107 gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, as illustrated by the identification

108 urther supported by genetic interactions and pre-mRNA splicing assays.

109 ntified a small molecule that inhibits human pre-mRNA splicing at an intermediate stage during conver

110 cl-x are produced as a result of alternative pre-mRNA splicing: Bcl-x(L) (the long form) is anti-apop

111 an essential role of m(6)A in regulating RTA pre-mRNA splicing but also suggest that KSHV has evolved

112 os, demonstrating the involvement of Hoip in pre-mRNA splicing, but not in transcription, of muscle s

113 rtant roles in the regulation of alternative pre-mRNA splicing, but their role in other gene regulato

114 ce of the coordinated control of alternative pre-mRNA splicing by chromatin structure and transcripti

115 cate that the Psis in U2 snRNA contribute to pre-mRNA splicing by directly altering the binding/ATPas

116 ncing data identified a global regulation of pre-mRNA splicing by GnRH.

117 a new potential mechanism for regulation of pre-mRNA splicing by lysine methylation of a splicing fa

118 d specific RNA-target sequences and modulate pre-mRNA splicing by sterically blocking the binding of

119 that can change a protein sequence, abnormal pre-mRNA splicing can be devastating for the encoded pro

120 strate that antisense-mediated modulation of pre-mRNA splicing can increase endogenous expression of

121 nificantly expand our current concept of the pre-mRNA "splicing code" to include dynamic intragenic D

122 ic transcription initiation, nor alternative pre-mRNA splicing, contributed to the observed changes i

123 ytosine and CTCF mediate opposing effects on pre-mRNA splicing: CTCF promotes inclusion of weak upstr

124 t a number of different levels by regulating pre-mRNA splicing, deadenylation and mRNA stability.

125 om the Hoechst query improves DM1-associated pre-mRNA splicing defects in cell and mouse models of DM

126 leblind-like protein 1 (MBNL1), which causes pre-mRNA splicing defects.

127 Alternative pre-mRNA splicing determines the protein output of most

128 s caused by the dysregulation of alternative pre-mRNA splicing due to sequestration of muscleblind-li

129 describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle.

130 We hypothesized that the requirements for pre-mRNA splicing efficiency were likely to vary during

131 depletion caused a significant reduction in pre-mRNA splicing efficiency, as demonstrated through RN

132 tiviral vectors engineered to target several pre-mRNA splicing elements on the beta(IVS2-654)-globin

133 wn about how these splicing factors regulate pre-mRNA splicing events, comparatively little is known

134 low temperature effects on a large subset of pre-mRNA splicing events.

135 ript half-life but are not required for most pre-mRNA splicing events.

136 Alternative pre-mRNA splicing expands the complexity of the transcri

137 Yeast Prp28 is a DEAD-box pre-mRNA splicing factor implicated in displacing U1 snR

138 unclear how reduced expression of this core pre-mRNA splicing factor leads to craniofacial defects.

139 The pre-mRNA splicing factor PRPF8 is a crucial component of

140 One of these, the pre-mRNA splicing factor SF3B1, is also frequently mutat

141 The transcription elongation and pre-mRNA splicing factor Tat-SF1 associates with the U2

142 rgoes isoform switching mediated by ESRP1, a pre-mRNA splicing factor that regulates EMT.

143 The essential pre-mRNA splicing factor U2AF(65) is faced with the para

144 How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyr

145 Here, we identified an additional pre-mRNA splicing factor, WBP11, as a novel protein requ

146 Select pre-mRNA splicing factors have been implicated in RNAi i

147 essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly

148 Pre-mRNA splicing factors play a fundamental role in reg

149 Somatic mutations of pre-mRNA splicing factors recur among patients with myel

150 l genomic screening, we identify a set of 26 pre-mRNA splicing factors that are required for sister c

151 dramatic translocation of Hnrnpa1 and other pre-mRNA splicing factors to the nucleus in a transcript

152 ediated by 'hotspots' of the SF3B1 and U2AF1 pre-mRNA splicing factors.

153 urrent mis-sense mutations of genes encoding pre-mRNA splicing factors.

154 teractions with U2AF ligand motifs (ULMs) of pre-mRNA splicing factors.

155 ecular theme among MDS-relevant mutations of pre-mRNA splicing factors.

156 M39 associates with precursor messenger RNA (pre-mRNA) splicing factors, and inactivation of RBM39 by

157 The termination of pre-mRNA splicing functions to discard suboptimal substr

158 In the mammalian nervous system, alternative pre-mRNA splicing generates functionally distinct isofor

159 Evidence of altered pre-mRNA splicing has been detected in CLL cases with SF

160 Alternative pre-mRNA splicing has long been proposed to contribute g

161 he proteome expanding effects of alternative pre-mRNA splicing have had a profound impact on eukaryot

162 Here we demonstrate that pre-mRNA splicing homeostasis is a biomarker and predict

163 ed NS proteins via its role in governing MVC pre-mRNA splicing.IMPORTANCE The Parvovirinae are small

164 sequestration of splicing factors and alters pre-mRNA splicing in a range of downstream effector gene

165 ts with the photoreceptor phyB and regulates pre-mRNA splicing in Arabidopsis (Arabidopsis thaliana).

166 ne-rich RNA-binding protein AtGRP7 regulates pre-mRNA splicing in Arabidopsis.

167 Pre-mRNA splicing in eukaryotes requires three DEAD-box

168 tron recognition in the majority of cases of pre-mRNA splicing in eukaryotes.

169 large ribonucleoprotein complex that guides pre-mRNA splicing in eukaryotic cells.

170 uss the roles of RNA editing and alternative pre-mRNA splicing in generating CaV channel isoforms wit

171 display altered hematopoiesis and changes in pre-mRNA splicing in hematopoietic progenitor cells by w

172 U2AF(65) is essential for pre-mRNA splicing in most eukaryotes.

173 ought to define the landscape of alternative pre-mRNA splicing in prostate cancers and the relationsh

174 n ABA signalling, shows a dramatic defect in pre-mRNA splicing in rbm25 mutants.

175 regulatory protein 1 (ESRP1) on alternative pre-mRNA splicing in the corneal epithelial context.

176 n embryonic day 13-13.5 (E13-13.5) corrected pre-mRNA splicing in the juvenile Usher syndrome type 1c

177 ases to institute phosphorylation control of pre-mRNA splicing in the nucleus.

178 dentified 10 new compounds that both inhibit pre-mRNA splicing in vitro and modify splicing of endoge

179 CPAMD8 splice-site mutations caused aberrant pre-mRNA splicing in vivo or in vitro.

180 rotein 13) regulates the budding pattern and pre-mRNA splicing in yeast cells; however, no Bud13p hom

181 Our quantitative analysis of the kinetics of pre-mRNA splicing in yeast reveals that ribosomal protei

182 Alternative pre-mRNA-splicing-induced post-transcriptional gene expr

183 Yeast pre-mRNA splicing initiates via formation of a complex c

184 hibitor resistance mechanism and we identify pre-mRNA splicing interference as a potential therapeuti

185 detection of splice isoforms, including rare pre-mRNA splicing intermediates.

186 Pre-mRNA splicing involves two transesterification steps

187 Pre-mRNA splicing is a complex regulatory nexus modulate

188 Pre-mRNA splicing is a fundamental process in mammalian

189 1-3 identified a large number of genes whose pre-mRNA splicing is altered under dark and light condit

190 Eukaryotic pre-mRNA splicing is an essential step in gene expressio

191 Pre-mRNA splicing is an essential step of eukaryotic gen

192 Pre-mRNA splicing is an important step for gene expressi

193 In eukaryotic cells, pre-mRNA splicing is catalyzed by the spliceosome, a hig

194 Pre-mRNA splicing is catalyzed through the activity of t

195 Pre-mRNA splicing is coupled to transcription by RNA pol

196 ongation rate increases, and the kinetics of pre-mRNA splicing is delayed with respect to RNAPII elon

197 patterns through the regulation of specific pre-mRNA splicing is essential for adequate plant develo

198 In eukaryotes, pre-mRNA splicing is governed by the activity of a large

199 A role for Bud31 in pre-mRNA splicing is implicated by virtue of its associa

200 witching oligonucleotides (SSOs) to modulate pre-mRNA splicing is increasingly evident in a number of

201 Pre-mRNA splicing is regulated by developmental and envi

202 Pre-mRNA splicing is required for the accurate expressio

203 Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscr

204 Precursor mRNA (pre-mRNA) splicing is a fundamental link between gene ex

205 Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleopro

206 The control of precursor-messenger RNA (pre-mRNA) splicing is emerging as an important layer of

207 at these positions reduce the efficiency of pre-mRNA splicing, leading to growth-deficient phenotype

208 ll nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their funct

209 e produced when the precursor messenger RNA (pre-mRNA) splicing machinery "backsplices" and covalentl

210 These results suggest that alternative pre-mRNA splicing may be an important regulatory mechani

211 Our data demonstrate that pre-mRNA splicing may be regulated by chromatin structur

212 ical cancers harbouring U2AF1 mutations with pre-mRNA splicing modulators like sudemycins.

213 We find that small-molecule pre-mRNA splicing modulators reduce BRAF3-9 production a

214 Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on pro

215 Pre-mRNA splicing must occur with extremely high fidelit

216 hylation plays an essential role in accurate pre-mRNA splicing necessary for a range of developmental

217 o SR proteins-SRSF3 and SRSF7, regulators of pre-mRNA splicing, nuclear export and translation-intera

218 Mutations that disrupt pre-mRNA splicing occur in >15% of CF cases.

219 Pre-mRNA splicing occurs in spliceosomes whose assembly

220 Pre-mRNA splicing occurs mainly co-transcriptionally, an

221 SFPS regulates pre-mRNA splicing of a large number of genes, of which m

222 sponse to DNA damage, this complex regulates pre-mRNA splicing of a number of genes involved in DNA d

223 also form a complex and coordinately control pre-mRNA splicing of a subset of genes involved in light

224 r photobodies, and regulates light-dependent pre-mRNA splicing of a subset of genes.

225 -acceptor mutation, c.101-1G>C, which alters pre-mRNA splicing of ARLBP2 in blood RNA, was identified

226 Prp19 complexes, which specifically impaired pre-mRNA splicing of early zygotic but not maternally en

227 ABA-responsive AtU2AF65b functions in the pre-mRNA splicing of FLC and ABI5 in shoot apex, whereby

228 ring as well as the transcript abundance and pre-mRNA splicing of flowering-related genes in the knoc

229 lated developmental processes by controlling pre-mRNA splicing of light signaling and circadian clock

230 ssing PRMT5 activity, palbociclib alters the pre-mRNA splicing of MDM4, a negative regulator of p53,

231 pathway that operationally links alternative pre-mRNA splicing of the hypoxia-inducible death protein

232 nisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macr

233 cleotide (ASO) was used to correct defective pre-mRNA splicing of transcripts from the USH1C gene wit

234 mbryos by causing non-productive alternative pre-mRNA splicing of xol-1, the master sex-determination

235 s employ antisense oligonucleotides to alter pre-mRNA splicing or diminish target gene expression and

236 The CTD mutations did not affect pre-mRNA splicing or snRNA levels.

237 ides a surprising link between a pleiotropic pre-mRNA splicing pathway and the precise control of suc

238 ressed genes identified dysregulation of the pre-mRNA splicing pathway, accompanied by perturbed auto

239 teraction among U2 snRNPs and affects global pre-mRNA splicing pattern and extensive gene expression.

240 ndition-sensitive changes in precursor mRNA (pre-mRNA) splicing pattern, we mapped the transcriptome

241 in Argonaute-2 (Ago-2) regulates alternative pre-mRNA splicing patterns of specific transcripts in th

242 in myotonic discharges, a shift toward adult pre-mRNA splicing patterns, reduced myofiber hypertrophy

243 gene expression through altering alternative pre-mRNA splicing patterns.

244 NF-kappaB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing

245 Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of g

246 These results demonstrate that coding and pre-mRNA splicing pressures co-evolve and that a modifie

247 In xenograft models, interference with pre-mRNA splicing prevents tumour formation and slows gr

248 Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transeste

249 tanding of human retinal development and the pre-mRNA splicing process, and help to identify new cand

250 ssential for regulation of transcription and pre-mRNA splicing prompted us to investigate how automet

251 Consequently, alternative pre-mRNA splicing provides an important RNA-based layer

252 ructed, characterized, and used in a nuclear pre-mRNA splicing reaction.

253 nce specificity of lariat formation with the pre-mRNA splicing reaction.

254 to alterations in RNA polymerase elongation, pre-mRNA splicing regulation and chromatin accessibility

255 We discuss different levels of pre-mRNA splicing regulation such as post-translational

256 the evolutionarily conserved Nrl1 protein in pre-mRNA splicing regulation, R-loop suppression and in

257 Here, we identified SLU7, which encodes a pre-mRNA splicing regulator that is inhibited in hepatoc

258 RBFox2 is a well-characterized pre-mRNA splicing regulator, but we now encounter an une

259 water potential (psi(w)) stress suggested a pre-mRNA splicing-related function.

260 However, the role of plant Sm proteins in pre-mRNA splicing remains largely unknown.

261 In eukaryotes, precursor mRNA (pre-mRNA) splicing removes non-coding intron sequences t

262 n and nutrient deficiency-induced changes in pre-mRNA splicing represent parallel, but potentially in

263 polysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop th

264 tabolic processes, such as mRNA translation, pre-mRNA splicing, ribosome biogenesis, and double-stran

265 iptional regulators of RNA and can influence pre-mRNA splicing, RNA localization, and stability.

266 th cases, AON delivery fully restored CEP290 pre-mRNA splicing, significantly increased CEP290 protei

267 hypoxia-ischemia reciprocally altered Bcl-x pre-mRNA splicing, similar to the in vitro studies.

268 nts, suggesting that specific changes in the pre-mRNA splicing sites may be a mechanism by which MAP

269 ious levels, the regulatory mechanism at the pre-mRNA splicing step remains unclear.

270 leocytoplasmic transport, DNA damage repair, pre-mRNA splicing, stress granule dynamics, and others.

271 calized with SR33-YFP, a protein involved in pre-mRNA splicing, suggesting a possible role for GmHSP4

272 hibited GzmA-mediated cell death and rescued pre-mRNA splicing, suggesting that hnRNP A1 is an import

273 son as an approach to evaluate the impact on pre-mRNA splicing suggests that up to 45% of synonymous

274 ar-reaching effect of an exonic variation on pre-mRNA splicing that is mediated by structural changes

275 sembly, as well as the downstream effects on pre-mRNA splicing that result from a decrease in SMN.

276 During pre-mRNA splicing, the spliceosome is activated for cata

277 gen receptor (AR) activity, yet also control pre-mRNA splicing through less clear mechanisms.

278 organ system in utero preemptively corrects pre-mRNA splicing to abrogate the disease phenotype.

279 The Bcl-x pre-mRNA undergoes alternative pre-mRNA splicing to generate Bcl-x(L) or Bcl-x(S) matur

280 Our results connect changes in alternative pre-mRNA splicing to oncogenic alterations common in pro

281 Becker muscular dystrophy (BMD) by altering pre-mRNA splicing to restore an open reading frame, allo

282 transcription elongation, cotranscriptional pre-mRNA splicing, transcription termination, and conseq

283 Pat1 is a hub for mRNA metabolism, acting in pre-mRNA splicing, translation repression, and mRNA deca

284 SF3B1 mutations are associated with aberrant pre-mRNA splicing using cryptic 3' splice sites (3'SSs),

285 he highly conserved histone variant H2A.Z in pre-mRNA splicing using the intron-rich model yeast Schi

286 the first evidence that CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).

287 Dysregulation of IR pre-mRNA splicing was confirmed in a chemically induced

288 In particular, pre-mRNA splicing was reported to be associated with slo

289 e effect of the Glrb(spa) LINE1 insertion on pre-mRNA splicing was studied using a minigene approach.

290 is inhibits not only transcription, but also pre-mRNA splicing, we reasoned that constraints on splic

291 The spliceosome regulates pre-mRNA splicing, which is a critical process in normal

292 pathway for mRNAs during the second step of pre-mRNA splicing, which is a potential step to regulate

293 etary restriction, we find defects in global pre-mRNA splicing with age that are reduced by dietary r

294 ckout (KO) results in substantial changes in pre-mRNA splicing with prevalence of exon skipping event

295 The ability to control pre-mRNA splicing with small molecules could facilitate

296 ifferent approaches used to target and alter pre-mRNA splicing with SSOs.

297 nine domain-containing proteins and mediates pre-mRNA splicing with unclear function in neurons.

298 tiple mRNA isoforms derived from alternative pre-mRNA splicing, with each alternative exon controlled

299 y protein ICP27 causes partial inhibition of pre-mRNA splicing, with the resultant accumulation of bo

300 mall molecules that either inhibit or modify pre-mRNA splicing would be valuable for research and pot