ライフサイエンスコーパス: preadipocyte

1 allmark of OSA, on senescence in human white preadipocytes.

2 SIRT1 is a key regulator of proliferation in preadipocytes.

3 SIRT1 is knocked down stably in mouse 3T3-L1 preadipocytes.

4 nhanced adipogenic differentiation of 3T3-L1 preadipocytes.

5 e depletion on the differentiation of 3T3-L1 preadipocytes.

6 icantly impairs adipocyte differentiation in preadipocytes.

7 d inflammation in healthy adipose tissue and preadipocytes.

8 in brown adipocytes differentiated from the preadipocytes.

9 ogenic defect caused by DPP8/9 inhibition in preadipocytes.

10 rs for identifying thermogenically competent preadipocytes.

11 marcated by H3K27me3 in both brown and white preadipocytes.

12 cause of stronger basal expression levels in preadipocytes.

13 is required for mitotic clonal expansion of preadipocytes.

14 ctly mTORC2-sensitive AKT substrate in brown preadipocytes.

15 e in restraining the adipogenic potential of preadipocytes.

16 uring in vitro adipogenesis of 3T3-L1 murine preadipocytes.

17 promotion of fibrogenesis in fibroblasts and preadipocytes.

18 nducers of UCP1 expression in adipocytes and preadipocytes.

19 that RA inhibits differentiation of cultured preadipocytes.

20 ed no effect on adipogenesis in nonsenescent preadipocytes.

21 n and mouse MSCs, as well as in mouse 3T3-L1 preadipocytes.

22 mediators of stem cell commitment to produce preadipocytes.

23 pro-adipogenic function of AGEs in senescent preadipocytes.

24 on in regulating p21 expression in senescent preadipocytes.

25 sis during adipogenesis in lipin-1-deficient preadipocytes.

26 ct binding between RAGE and p53 in senescent preadipocytes.

27 ced adipogenesis in MSCs and in mouse 3T3-L1 preadipocytes.

28 e examined in explanted skin fibroblasts and preadipocytes.

29 sed in s.c. preadipocytes than in epididymal preadipocytes.

30 ox region of the C/EBPalpha gene promoter in preadipocytes.

31 dothelial precursor cells, immune cells, and preadipocytes.

32 and the defects in adipogenesis in Ezh2(-/-) preadipocytes.

33 sarcoma cells induce oncogenic properties in preadipocytes.

34 ally inhibited the differentiation of 3T3-L1 preadipocytes.

35 n adipogenesis in both mouse and human brown preadipocytes.

36 NT5A promoted the expression of IL6 in human preadipocytes.

37 t cells differentiated from human neck brown preadipocytes.

38 ithin subpopulations of white adipocytes and preadipocytes.

39 as a trigger of senescence-like phenotype in preadipocytes.

40 hr after inducing differentiation of 3T3-L1 preadipocytes.

41 fibroblasts and differentiating human SW872 preadipocytes.

42 l as in stromal vascular fraction and 3T3-L1 preadipocytes.

43 We observed that in unsynchronized 3T3-L1 preadipocytes, 25% of cells had higher GFP-NAMPT fluores

44 ctive inhibitor 1G244 blocks adipogenesis in preadipocyte 3T3-L1 and 3T3-F422A, while DPP4 and FAP in

45 riers of MDM2 DNA that can be transferred to preadipocytes, a major and ubiquitous cellular component

46 Ciliated preadipocytes abundantly populate perivascular compartme

47 man adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation.

48 Co-culture experiments found that preadipocytes activate Wnt signaling and decrease cleave

49 50% adipocytes (AD50) or approximately 100% preadipocytes (AD0) were suspended over wells containing

50 lated by the glucocorticoid receptor (GR) in preadipocytes, adipocytes, and adipose tissues and is re

51 Irs1 and Irs2 conditionally in 3T3-L1 murine preadipocytes/adipocytes to assess whether acute loss of

52 ouse embryonic fibroblasts (MEFs) and 3T3-L1 preadipocytes after forced manipulation of Txnip express

53 cts harboring AGPAT2 mutations and in 3T3-L1 preadipocytes after knockdown or overexpression of AGPAT

54 highly induced upon differentiation of human preadipocytes, along with SREBP-1.

55 lic profiling demonstrate that the Tbx15(Hi) preadipocyte and adipocyte subpopulations of cells are h

56 ell as stable shRNA knockdown (KD) in 3T3-L1 preadipocyte and C3H10T1/2 mesenchymal stem cells, promo

57 -1 (ICAM1)/CD54-expressing (CD54+) committed preadipocytes and a related adipogenic cell population m

58 Furthermore, preadipocytes and adipocytes from these subpopulations d

59 Notably, preadipocytes and adipocytes had higher formation rates

60 synthesis rates denote new cell formation of preadipocytes and adipocytes in each depot.

61 ls are highly glycolytic, whereas Tbx15(Low) preadipocytes and adipocytes in the same depot are more

62 esize the bulk of the fibrillar ECM, and the preadipocytes and adipocytes of the hypodermis.

63 IR-loci in risk-relevant cell types, namely preadipocytes and adipocytes.

64 pid metabolism using primary human and mouse preadipocytes and adipose-specific EZH2 knockout (KO) mi

65 ntaneous differentiation of 3T3-L1 and human preadipocytes and allowed NIH 3T3 fibroblasts to become

66 anti-adipogenic effect of 5-Aza-dC in 3T3-L1 preadipocytes and block the osteoblastogenic effect of 5

67 OLST also inhibits differentiation of 3T3-L1 preadipocytes and C2C12 myoblasts.

68 gated whether prostamide signaling occurs in preadipocytes and controls adipogenesis.

69 e that PKCdeltaI expression level is high in preadipocytes and decreasing PKCdeltaI accelerated termi

70 We observed rapid proliferation of preadipocytes and expansion of the dermal fat layer afte

71 FZ to activate PPARgamma, and we used 3T3-L1 preadipocytes and human multipotent mesenchymal stromal

72 ronment, leading to impaired p53 activity in preadipocytes and increased proliferation, migration, an

73 proteins that are expressed in one class of preadipocytes and is potentially involved in regulating

74 cts as dual modulators of gene expression in preadipocytes and is required for early stage differenti

75 Preadipocytes and macrophages in adipose tissue also res

76 ombined, these data reveal the importance of preadipocytes and mature adipocytes on MM progression an

77 We also found that preadipocytes and mature adipocytes secrete many molecul

78 iption factors that bind to them in cultured preadipocytes and mature adipocytes.

79 bx15 expression is restricted to a subset of preadipocytes and mature white adipocytes.

80 and differentiation assays employing 3T3-L1 preadipocytes and mouse bone marrow-derived mesenchymal

81 ic function of AGEs in replicative senescent preadipocytes and mouse embryonic fibroblasts, as well a

82 ion during adipogenesis in both mouse 3T3-L1 preadipocytes and mouse mesenchymal stem cells.

83 PGF2alphaEA is produced from anandamide in preadipocytes and much less so in differentiating adipoc

84 ic mixtures of contaminants in murine 3T3-L1 preadipocytes and polar bear adipose tissue-derived stem

85 -beta) and its selective ligand reprogrammed preadipocytes and precursor stem cells into brown adipos

86 effect of weight loss on differentiation of preadipocytes and secretory capacity of in vitro differe

87 inhibited fatty acid biosynthesis in 3T3-L1 preadipocytes and selective human breast cancer cell lin

88 ducing (DI) increased adipogenic capacity of preadipocytes and shifted their secretion toward lower i

89 m patients with MM indeed contains increased preadipocytes and significantly larger mature adipocytes

90 te transcriptomic and epigenomic profiles of preadipocytes and skeletal muscle satellite cells collec

91 ipocytes exhibited higher Hsp60 release than preadipocytes and SkMCs, which was further stimulated by

92 ted by the basal transcription factor Sp1 in preadipocytes and that the magnitude of down-regulation

93 ately up-regulated in adipocytes relative to preadipocytes and that TZD treatment induces PGC-1beta a

94 adipose tissue-derived epididymal BK(L1/L1) preadipocytes and their differentiation to lipid-filled

95 ptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 17

96 adipogenesis, is expressed at low levels in preadipocytes, and its levels increase dramatically and

97 Specifically, in human and 3T3-L1 preadipocytes, Ang(1-7)-Mas signaling promotes adipogene

98 Preadipocytes are fibroblastoid cells committed to becom

99 This was correlated with enhanced preadipocyte aromatase expression following incubation i

100 AR also binds to enhancers already active in preadipocytes as evidenced by an active chromatin state

101 Senescent human primary preadipocytes as well as human umbilical vein endothelia

102 Importantly, FABP4-null mouse preadipocytes as well as macrophages exhibited increased

103 Two sources of 3T3-L1 preadipocytes as well as OP9 preadipocytes were assessed

104 ipogenic differentiation in both MSCs and in preadipocytes at low nanomolar concentrations comparable

105 nduce adipogenic differentiation in MSCs and preadipocytes at low nanomolar concentrations.

106 at the zinc finger protein Evi1 increases in preadipocytes at the onset of differentiation prior to i

107 Conversely, loss of Evi1 in preadipocytes blocks the induction of PPARgamma2 and sup

108 PPARgamma, when introduced into preadipocytes, bound only to regions depleted of repress

109 showed that the expression of EST was low in preadipocytes but increased upon differentiation.

110 AS160/TBC1D4 is expressed at low levels in preadipocytes but is induced in differentiation and prov

111 tein receptor (VLDLR) is virtually absent in preadipocytes but is strongly induced during adipogenesi

112 s a potent antiadipogenic factor in cultured preadipocytes, but evidence for its involvement in physi

113 ion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages.

114 iments demonstrated that factors secreted by preadipocytes, but not mature adipocytes, confer an ATM-

115 Inhibiting DNA methylation in 3T3-L1 preadipocytes by 5-Aza-dC significantly inhibited adipog

116 The cell fate specification of subcutaneous preadipocytes by canonical Wnt signaling was evaluated.

117 eral GR-regulated adipogenic genes in 3T3-L1 preadipocytes by glucocorticoid, it was not required for

118 Conversely, DAPK2 inhibition in human preadipocytes by small interfering RNA decreased LC3-II

119 esenchymal stem cells (eMSCs) and the murine preadipocyte cell line 3T3-L1.

120 st cancer cells (T47D and Hs578T), and mouse preadipocyte cells (3T3-L1).

121 te and Simpson-Golabi-Behmel Syndrome (SGBS) preadipocyte cells and that the rs3780181-A risk allele

122 Fibroblastic preadipocyte cells are recruited to differentiate into n

123 In mouse NIH 3T3 L1 preadipocyte cells, TBMEHP inhibited rat hepatic microso

124 e to make predictions about how mouse 3T3-L1 preadipocytes choose between proliferation, differentiat

125 Abolishing preadipocyte cilia in mice severely impairs white adipos

126 In addition, CM from macrophage/preadipocyte cocultures exposed to sera from obese patie

127 cg1 expression by RNA interference in 3T3-L1 preadipocytes compromised LPL-dependent TG accumulation

128 Reprogramming of preadipocytes could represent an adaptation to weight lo

129 lso inhibits adipogenesis in a human primary preadipocyte culture system.

130 During adipogenesis, preadipocytes' cytoskeleton reorganizes in parallel with

131 educed lipid accumulation in maturing 3T3-L1 preadipocytes, demonstrating an inhibitory effect on lip

132 opening during adipogenesis of immortalized preadipocytes derived from mouse brown adipose tissue (B

133 idymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display

134 ies Zfp423 as a transcriptional regulator of preadipocyte determination.

135 d accumulation in 3T3-L1 cells and inhibited preadipocyte differentiation by down-regulation of the e

136 LCB reduced lipid accumulation during preadipocyte differentiation by down-regulation of the m

137 lation upregulates FGF10 levels and promotes preadipocyte differentiation into beige adipocytes.

138 We have developed a murine preadipocyte differentiation system for generating a nat

139 we demonstrate that CA selectively inhibits preadipocyte differentiation through 11beta-HSD1 inhibit

140 differentiation markers were analyzed during preadipocyte differentiation, and cell culture media wer

141 During 3T3-L1 and human preadipocyte differentiation, CCTalpha expression and PC

142 ctivation of Hh signaling blocks early brown-preadipocyte differentiation, inhibits BAT formation in

143 DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.

144 ould show that the total secretome inhibited preadipocyte differentiation.

145 ased modeling was applied to data from human preadipocyte differentiation.

146 vated during the early phase of mouse 3T3-L1 preadipocyte differentiation.

147 ipogenesis comes from cell culture models of preadipocyte differentiation.

148 Although adipose tissue contains numerous preadipocytes, differentiation into functionally compete

149 y phase of adipogenesis, piceatannol-treated preadipocytes displayed a delayed cell cycle entry into

150 Single-cell RNA-seq profiles of human preadipocytes during adipogenesis in vitro identifies at

151 TNMD expression increases in human preadipocytes during differentiation, whereas silencing

152 Remarkably, Ews null BATs and brown preadipocytes ectopically express myogenic genes.

153 ore, transfection of an miR-130 inhibitor in preadipocytes enhanced, whereas an miR-130 mimic blunted

154 sor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 ex

155 netheless, loss of GPAT3 in seipin-deficient preadipocytes exacerbated the failure of adipogenesis in

156 Remarkably, differentiating SIRT1-silenced preadipocytes exhibit enhanced mitotic clonal expansion

157 The FABP4-null preadipocytes exhibited a remarkably enhanced adipogenes

158 gulated during adipogenesis, and TDAG51(-/-) preadipocytes exhibited greater lipogenic potential.

159 wn about the molecular circuits that control preadipocyte expansion.

160 The soluble form of the preadipocyte factor (also known as pref-1) delta-like 1

161 SAH did not alter preadipocyte factor 1 (Dlk1) or peroxisome proliferator-

162 The high level of adipogenic inhibitor preadipocyte factor 1 (Pref-1) in IRS-1-null cells was m

163 The preadipocyte factor 1 (Pref-1) is involved in the prolif

164 The imprinted Delta-like homolog 1 (Dlk1)/preadipocyte factor 1 (Pref1) gene encodes a complex pro

165 Ews mutant brown preadipocytes fail to differentiate due to loss of Bmp7

166 Although preadipocyte fibroblasts expressed Thy1 mRNA and protein

167 acological manipulation restrains the 3T3-L1 preadipocytes from fully differentiating into mature adi

168 Furthermore, isolated human preadipocytes from gluteofemoral AT displayed a higher c

169 Preadipocytes from HDAC9 gene knock-out mice exhibited a

170 Here we generated clones of brown and white preadipocytes from human neck fat and characterized thei

171 We found that differentiating preadipocytes from LBW individuals showed reduced leptin

172 its production may be decreased in immature preadipocytes from LBW individuals.

173 on was derived from exon DNA microarrays and preadipocytes from obesity-resistant and -sensitive mice

174 Preadipocytes from these mice likewise exhibit impaired

175 Adipocyte renewal from preadipocytes has been shown to occur throughout life an

176 , which places DLK1 as a master regulator of preadipocyte homeostasis, suggesting that DLK1 manipulat

177 l knockdown of Irs1 and Irs2 but not Insr in preadipocytes impaired differentiation to adipocytes.

178 Overexpression of Tbx15 in 3T3-L1 preadipocytes impairs adipocyte differentiation and decr

179 ) from (2)H2O into the DNA of adipocytes and preadipocytes in 25 women with overweight or obesity.

180 piceatannol inhibits adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner at noncytotoxic

181 educed proliferation and viability of 3T3-L1 preadipocytes in a dose-dependent manner.

182 Parp1 knockout in preadipocytes in a mouse lineage-tracing genetic model i

183 re adipocytes compared with undifferentiated preadipocytes in both human and mouse subcutaneous adipo

184 pansion and differentiation of murine 3T3-L1 preadipocytes in the presence of SAH impaired both basal

185 pocytes was positively correlated to that of preadipocytes in the scABD and scFEM depots and was rela

186 e impaired adipogenic potential of senescent preadipocytes in vitro and ex vivo.

187 VEGF increased proliferation in brown preadipocytes in vitro by 70%, and blockade of VEGF sign

188 RNA-seq data sets: (1) human differentiating preadipocytes in vitro, (2) fresh mouse brain tissue, an

189 te differentiation from mouse-derived 3T3-L1 preadipocytes in vitro, and inhibits expression of genes

190 s is widely studied in differentiating 3T3L1 preadipocytes in vitro.

191 regulation known to promote adipogenesis in preadipocytes, in HSC transdifferentiation.

192 Conditioned medium (CM) from senescent human preadipocytes induced macrophage migration in vitro and

193 78 in mouse embryonic fibroblasts and 3T3-L1 preadipocytes induced to undergo differentiation into ad

194 er, siRNA-mediated Dies1 knockdown in 3T3-L1 preadipocytes inhibited adipogenic conversion.

195 Conversely, in LRP5 knockdown preadipocytes, insulin-induced phosphorylation of IRS1,

196 Irisin reportedly promotes the conversion of preadipocytes into "brown-like" adipocytes within subcut

197 ory pathway that controls differentiation of preadipocytes into beige adipocytes.

198 Differentiation of preadipocytes into mature adipocytes capable of efficien

199 e impaired adipogenic potential of senescent preadipocytes is a hallmark of adipose aging and aging-r

200 We propose that prostamide signaling in preadipocytes is a novel anandamide-derived antiadipogen

201 rvations show that expression of CRABP-II in preadipocytes is repressed by all three components of th

202 se embryonic fibroblasts, as well as primary preadipocytes isolated from aged mice.

203 Consistent with these findings, human preadipocytes isolated from subcutaneous white fat also

204 In vitro experiments were conducted with preadipocytes isolated from VAT and SAT biopsies.

205 dipsin secretion or insulin action, while in preadipocytes it impaired adipogenesis.

206 PDGFC) in the Simpson-Golabi-Behmel syndrome preadipocyte knockout lines confirmed their function in

207 ated 16 human Simpson-Golabi-Behmel syndrome preadipocyte knockout lines each with a single IR-gene k

208 rescue in the Simpson-Golabi-Behmel syndrome preadipocyte knockout lines.

209 embers of the KDM5 family in white and brown preadipocytes leads to deregulated gene expression and b

210 In cultured human white preadipocytes, leptin increased caveolin-1 expression, w

211 d multiple conditionally immortalized clonal preadipocyte lines from white adipose tissue of mice.

212 siRNA-based silencing of APCDD1 in 3T3-L1 preadipocytes markedly increased the expression of Wnt s

213 se tissue from COX-2-deficient mice, whereas preadipocyte marker expression was increased.

214 EB cells proliferation and expression of the preadipocyte marker Pref-1 at the commitment stage.

215 ipocyte stem cell markers CD34 and Sca-1 and preadipocyte markers Gata2 and Pref-1, indicating an inc

216 Our findings are consistent with impaired preadipocyte maturation, contributing to an increased ri

217 We have developed a model of how preadipocytes may use the dynamic interplay of two trans

218 es on adipogenesis were determined in 3T3-L1 preadipocytes, mouse adipose-derived stromal-vascular fr

219 er in visceral as compared with subcutaneous preadipocytes, negatively correlating with their potenti

220 xpression was significantly downregulated in preadipocytes of both MFR males and females; however, at

221 th MFR males and females; however, at PND21, preadipocytes of MFR males showed upregulation in these

222 y, shRNA-mediated NKX1-2 knockdown in 3T3-L1 preadipocytes or EMSCs almost completely blocked adipocy

223 3T3-L1 preadipocytes overexpressing Tbx15 also have a 15% reduc

224 able within-individual periods in mature and preadipocytes ( P > 0.05).

225 thine (IBMX) to promote cell death in 3T3-L1 preadipocytes placed under differentiation conditions.

226 Here, we show that brown preadipocytes possess primary cilia and can respond to H

227 Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory organelle call

228 rmacological or genetic ablation of DEGS1 in preadipocytes prevented adipogenesis and decreased lipid

229 Deletion of Pagr1 in white and brown preadipocytes prevents the induction of C/EBPbeta and C/

230 silencing identified TBX5 as a regulator of preadipocyte proliferation and adipogenic differentiatio

231 nversely, overexpression of miR-33b impaired preadipocyte proliferation and reduced lipid droplet for

232 le progression and thereby strongly inhibits preadipocyte proliferation in vitro.

233 ion; however, the impact of DLK1 isoforms on preadipocyte proliferation remains to be determined.

234 ididymal white adipose tissue (eWAT) weight, preadipocyte proliferation, hepatic inflammation, fastin

235 d regulated by weight cycling; Lmo4 enhanced preadipocyte proliferation, in vitro adipogenesis, trans

236 exhibits a substantial repression effect on preadipocyte proliferation.

237 d assessed for triglyceride accumulation and preadipocyte proliferation.

238 Additionally, KO of dicer in cultured brown preadipocytes promoted a white adipocyte-like phenotype

239 s in p53-regulated adipogenesis of senescent preadipocytes, providing new insights into aging-depende

240 his may be explained by a marked increase in preadipocyte replication.

241 Rescue experiments suggest brown preadipocytes require the mTORC2/AKT/ACLY pathway to ind

242 onal knockdown of CHOP in polyamine-depleted preadipocytes restored PPARgamma and C/EBPalpha expressi

243 Wnt-10b infection of normal fibroblasts and preadipocytes resulted in blockade of adipogenesis and t

244 nin ubiquitination and degradation in murine preadipocytes, resulting in elevated beta-catenin levels

245 promotes MM growth, whereas co-culture with preadipocytes results in enhanced MM cell chemotaxis in

246 Isolated preadipocytes retained a depot-specific transcriptional

247 Preadipocytes secrete several WNT family proteins that a

248 e adult skeleton; both mature adipocytes and preadipocytes serve as endocrine cells that secrete a nu

249 In HB2 mouse brown preadipocytes, short hairpin RNA-mediated knockdown (KD)

250 GR-depleted preadipocytes show adipogenesis defects 1 week after ind

251 iation was extended to 3 weeks, GR-deficient preadipocytes showed levels of adipogenesis marker expre

252 ient primary or immortalized white and brown preadipocytes showed severely delayed adipogenesis 1 wee

253 ectively, confirmed that Sca1(+) cells had a preadipocyte signature and showed differential expressio

254 ymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes significantly increases their adipogenic d

255 find that adipogenesis is impaired in 3T3-L1 preadipocytes stably transfected with Siah2 shRNA and th

256 in vitro adipogenic conversion of committed preadipocytes, such as 3T3-L1, does not include BMP4 tre

257 tion, whereas HDAC9 overexpression in 3T3-L1 preadipocytes suppressed adipogenic differentiation, dem

258 15 is 260-fold more highly expressed in s.c. preadipocytes than in epididymal preadipocytes.

259 efine novel sets of gene signatures in human preadipocytes that could predict the thermogenic potenti

260 nversion of mesenchymal stem cells (MSCs) to preadipocytes that differentiate into adipocytes.

261 in cultures of primary human adipocytes and preadipocytes that lipopolysaccharide and trans-10,cis-1

262 lineage-committed mesenchymal stem cells and preadipocytes that pairs H3K4me3 with H3K9me3 to maintai

263 wild-type protein, and in stably transfected preadipocytes the mutant protein was associated with sma

264 In cultured preadipocytes, the levels of KDM5C histone demethylase i

265 Progression from brown preadipocytes to adipocytes engages two transcriptional

266 or-activated receptor gamma and promoted the preadipocytes to assume an oxidative beige/brown adipose

267 wing commitment, exposure of growth-arrested preadipocytes to differentiation inducers [insulin-like

268 The mechanisms by which EDCs direct preadipocytes to form adipocytes are poorly understood.

269 In summary, IUGR programs WAT preadipocytes to greater adipogenic potential in males.

270 n of mouse mesenchymal stem cells and 3T3-L1 preadipocytes to mature adipocytes and decreased inducti

271 Exposure of 3T3-L1 preadipocytes to noncytotoxic levels of arsenic, includi

272 Exposure of mouse 3T3-L1 or human preadipocytes to PGF2alphaEA/bimatoprost during early di

273 gest a role for VEGF in brown adipocytes and preadipocytes to promote survival, proliferation, and no

274 In undifferentiated 3T3-L1 preadipocytes, translocation of myc7-Glut4 was low regar

275 Here, we sought to understand whether preadipocytes use their cilia to sense and respond to ex

276 e UCP1 regulators, PREX1 and EDNRB, in brown preadipocytes using CRISPR-Cas9 markedly abolished the h

277 I HDACs in the nuclear compartment of 3T3-L1 preadipocytes using two experimental approaches.

278 ide fatty acid composition of isolated human preadipocytes was determined.

279 genome-wide histone methylation profiling in preadipocytes, we find that among gene loci encoding adi

280 al knockout mice and derived white and brown preadipocytes, we show that endogenous KLF4 and Krox20 a

281 Using 3T3L1 preadipocytes, we studied adipogenesis in vitro and show

282 urces of 3T3-L1 preadipocytes as well as OP9 preadipocytes were assessed for cell proliferation and t

283 pocyte lipid accumulation was inhibited when preadipocytes were co-cultured with CD45(+)Cd11b(+)Cd11c

284 ess the role of GPAT4 directly, neonatal BAT preadipocytes were differentiated to adipocytes.

285 3T3-L1 preadipocytes were grown and differentiated in medium co

286 To test this hypothesis, murine brown preadipocytes were induced to differentiate the fatty ac

287 from subcutaneous abdominal fat depots, and preadipocytes were isolated and cultured.

288 Murine 3T3-L1 preadipocytes were used to assess adipogenic induction.

289 onal precursors, mesenchymal stem cells, and preadipocytes, where it regulates lineage allocation, pr

290 Skp2 re-expression in Akt-deficient preadipocytes, which are impaired in adipogenesis, is su

291 accumulation in differentiating human white preadipocytes, which was prevented by caveolin-1 overexp

292 Brown preadipocyte whitening was partially reversed by express

293 een insulin and Wnt signaling pathways using preadipocytes with and without knockdown of the Wnt co-r

294 We generated preadipocytes with different levels of DLK1 and examined

295 e to glucocorticoid, and treatment of 3T3-L1 preadipocytes with glucocorticoid alone induced GR occup

296 Adipogenic potential of preadipocytes with knockdown or absence of TDAG51 was as

297 By developing a coculture method of preadipocytes with primary subcutaneous and visceral adi

298 dipogenesis is induced by treating confluent preadipocytes with the adipogenic cocktail, which activa

299 In contrast, in explanted subcutaneous preadipocytes, Wnt-3a repressed adipogenesis and promote

300 ith increased beta-catenin levels in shSiah2 preadipocytes, Wnt10b is elevated in Siah2(-/-) adipose