ライフサイエンスコーパス: precedent

1 te three different growth modes, one without precedent.

2 stry that is without chemical or biochemical precedent.

3 octahedral complexes of this type is without precedent.

4 chemical characterization, and experimental precedent.

5 zed membrane channel has little evolutionary precedent.

6 en-containing organic molecules has far less precedent.

7 ondary dialkyl amines, a process with little precedent.

8 intensive care unit has a strong historical precedent.

9 urrent concentrations and fluxes are without precedent.

10 ajectory is feasible and has some historical precedent.

11 zation of functional proteins is not without precedent.

12 oscopic data and correlation with literature precedent.

13 tereochemistry opposite to that predicted by precedent.

14 ds similar to those expected from literature precedent.

15 ed into manzamine A (1) following literature precedent.

16 etralin derivatives, for example, has little precedent.

17 ometry of the homomeric assembly, is without precedent.

18 proposed, well-defined examples are without precedent.

19 rium Bacillus subtilis as proof-of-principle precedent.

20 mbers of natural products with no structural precedent.

21 metabolism as well as those with no chemical precedent.

22 gical rafting event with no known historical precedent.

23 There is no significant precedent.

24 pression profiles consistent with literature precedent.

25 y standards for EE2 set a much needed global precedent.

26 y, enzymatic catalysis has provided the only precedents.

27 zing conformation consistent with literature precedents.

28 onsistent with the majority of computational precedents.

29 nto the spotlight with its clear mechanistic precedents.

30 the clinical implications have few historic precedents.

31 e largest accumulations that have historical precedents.

32 planar four-coordinate complexes is far less precedented.

33 f a MET kinase inhibitor precursor (versus a precedented 14% via Kumada coupling) and a streamlined o

34 ation of 10 to methyl ester 14 followed by a precedented [3+2] dipolar cycloaddition gave bicyclic is

35 with problems including fabrication of legal precedents(5) or untrue facts in news articles(6) and ev

36 eliminary mechanistic studies and literature precedents, a plausible mechanism is proposed.

37 e terephthalate implants in mice require the precedent adsorption of one particular host protein, fib

38 determined by NMR methods, and does not have precedent among known DNA quadruplexes.

39 The latter finding is essentially without precedent among the vast number of M-H(2) complexes know

40 nanomolar Ki values, an observation with few precedents among aminergic GPCRs.

41 cy and efficiency of these molecules has few precedents among protein-protein interface inhibitors, a

42 for acetylnitrene consistent with literature precedent and analogous experiments with the benzoylnitr

43 th steps is based on a mixture of literature precedent and computational experiments.

44 ite ionization states assigned by literature precedent and computational pK(a) prediction were unable

45 Historical precedent and developments in other research areas show

46 The present study serves as a precedent and fundamental step toward further improvemen

47 This pathway is without precedent and our data suggest it is independent of the

48 arrays and DNA-nanocrystal conjugates has no precedent and suggests the possibility of detecting an e

49 umber of different design elements-some well precedented and others less well known within the contex

50 tion, deviate from the expectations based on precedents and because kF greatly depends on viscosity.

51 CPM-220 sets multiple precedents and benchmarks on the pacs platform in both s

52 sed on these results, together with chemical precedents and the available biochemical data for nitrog

53 displacement themselves is without reported precedent, and could have implications for catalytic rea

54 nduced improvement in task performance has a precedent, and is consistent with the idea that regions

55 H bond functionalization seems to be without precedent, and no mechanism for the process was establis

56 ine (bOPV) has constituted an effort without precedents, and with astonishing results.

57 ch to the preparation of CbBI was based on a precedented (Ar-3' and Ar-5') but previously unknown Ar-

58 ehavior including dissipation patterns whose precedents are condensate vortex and defect disorder and

59 The precedents are for such sites to sense arsenite/antimoni

60 are those processes that ostensibly have no precedent at lower levels of scientific organization.

61 have been identified, potentially enabling a precedent-based approach to match known aggregators with

62 , their use on preparative scale has minimal precedent because they require multistep synthesis for t

63 y and heterologously expressed ENaC requires precedent binding to glycosylated extracellular loop(s).

64 aken the bonds in associated ligands is well precedented, but has rarely been utilized as a mechanism

65 informed consent and examines whether legal precedent can shed light on this debate.

66 essary(15,16) and closely related literature precedents cannot be relied on.

67 Furthermore, to address the lack of precedent collective papers, this Review also summarizes

68 econdary alkyl iodides proceeds via a rarely precedented concerted oxidative addition pathway.

69 On the basis of this precedent, conserved basic residues of human PMK have be

70 p inventory of atmospheric emissions of five precedent-controlled toxic heavy metals (HMs), including

71 episodes to 7.5% from 32% in the immediately precedent cyclosporine/prednisone-treated patients.

72 orical cohort of 65 consecutive, immediately precedent, demographically similar recipients treated wi

73 Approved agents may establish regulatory precedents, demonstrate successful trial strategies, and

74 Based on the precedent determinations, theoretical chemical oxygen de

75 the biosynthesis of nocardicin A, a rare but precedented editing event in the formation of non-riboso

76 Thiopurine exposure is an important precedent event for the development of malignancy or HLH

77 ants, it was previously found that a crucial precedent event was the spontaneous adsorption and denat

78 In an attempt to find precedent examples we determined there was negative inte

79 onalization of CO2 is a challenging goal and precedents exist for the generation of HCOOH, CO, CH3OH,

80 Precedent exists for a role of beta-catenin, a downstrea

81 No enzymological precedent exists for an UQ-protein thiolate charge-trans

82 as not been described previously, and little precedent exists for analogous potentiometric titration

83 Precedent exists for disqualifying athletes with heart d

84 bond cleavage reaction provides a plausible precedent for a direct reversal of caC to the unmodified

85 ter for the retromer complex, establishing a precedent for a mechanism by which sorting nexins expand

86 Moreover this study provides a likely precedent for a mechanism in disorders associated with m

87 ral determinant of paraspeckles, providing a precedent for a ncRNA as the foundation of a nuclear dom

88 vious studies with streptomycetes provided a precedent for a pathway that initiates with the condensa

89 on protein synthesis and growth, there is a precedent for a pol III product having oncogenic activit

90 cularly the warning label component, set the precedent for a rapid global proliferation of similar po

91 Although there is precedent for additional roles of Sod1 beyond protection

92 Because there is no precedent for an anticancer strategy that specifically t

93 Accordingly, this study provides precedent for an ensemble of carbonyl and isocyanide lig

94 These studies thus serve as a synthetic precedent for an Fe(V)=O species in the oxygen activatio

95 Although there is no historical precedent for an H5N1 avian strain causing widespread hu

96 We establish a precedent for applying mouse genetics to dissect viral e

97 st retromer, and they establish a functional precedent for CDC25 protein phosphatases that lies outsi

98 hromosomal homologous recombination (iHR), a precedent for CN-LOH.

99 ar phagocytes in nondiseased lungs provide a precedent for comparative studies in diseased lungs and

100 This observation provides a precedent for differential interactions between Hsp90-as

101 nctional peramine synthetase, establishing a precedent for distribution of perA orthologs beyond genu

102 Overall, the results set a precedent for doping/additives to impact organic electro

103 There is no precedent for eliciting highly mutated antibodies by vac

104 Homodinuclear catalysts have good precedent for epoxide and carbon dioxide/anhydride copol

105 They also establish a precedent for error rates that will be required in the n

106 Yet, there is no precedent for examining the pathways by which specific s

107 ependent processing of pro-ADAMTS9 creates a precedent for extracellular maturation of endogenously p

108 The results set an important precedent for extremely rapid, formally forbidden (Delta

109 Here we summarize the precedent for FDA approval of imaging agents using effec

110 Such reactivity is without precedent for Fe-S clusters.

111 Moreover, this study sets the precedent for future unbiased DNA-ligand simulations of

112 and establishment of infection, as well as a precedent for future viroporin-targeted drug discovery.

113 gamma coiled-coil in Ste5p binding may set a precedent for Gbetagamma-effector interactions in more c

114 This example provides a synthetic precedent for how O-O bond cleavage of high-spin Fe(III)

115 he metal centers may serve as a new chemical precedent for how related proteins manage Cu ions in liv

116 Because there is no precedent for immune receptor signaling in the ER, we in

117 ic young maternal descendants, and support a precedent for inherited mtDNA mutation in some persons w

118 r specialties, including oncology, provide a precedent for investigation of the use of a multidiscipl

119 WHO's mandate; claiming the FCTC would set a precedent for issues beyond tobacco; and presenting corp

120 Our results provide a precedent for large-scale dynamics in a substrate-bound

121 provides rare, precise chemical and kinetic precedent for metal particle nucleation, growth, and now

122 However, there is little precedent for offering active drug users complex treatme

123 Given the precedent for other picornaviruses which use terminal si

124 cilitate antiviral drug design and provide a precedent for other positive-strand RNA viruses.

125 , such as shellfish, with greater historical precedent for real or perceived public health risk may o

126 Wnt and RSPO ligands establishes a molecular precedent for regulation of mammalian stem cells by dist

127 ar RNA which potentially provides a specific precedent for RNA involvement in nuclear structure and c

128 Although the precedent for SR proteins acting as repressors is establ

129 There is precedent for such a change in the Nobel Peace Prize, wh

130 In an effort to obtain a synthetic precedent for such a core, bulk electrolysis at 900 mV (

131 There is also no precedent for such an arrangement from biochemical studi

132 est using the Antarctic Treaty as a positive precedent for such international cooperation.

133 esaturases and provides a two-step catalytic precedent for the "alternative oxidase" activity recentl

134 iron(IV) complex, thus providing a synthetic precedent for the analogous conversion of P to Q in the

135 t require deep sequencing and may serve as a precedent for the application of CRISPR/Cas9 to primary

136 The rearrangements observed afford chemical precedent for the biogenetic pathways in the literature

137 in heterozygotes provides important in vivo precedent for the capacity of cells to clear activated M

138 sphorylation by Hippo kinase, establishing a precedent for the control of NDR kinases, and hence grow

139 Our results provide a precedent for the control of organ size by morphogen ran

140 There is a single precedent for the first approach, but nothing has been r

141 The structure establishes a precedent for the formation of Fe(IV)-OH in a peroxidase

142 More broadly, our results provide a precedent for the functional interrogation of ATP-bindin

143 This work also sets a precedent for the future study of other N-oxidases invol

144 Collectively, these findings provide precedent for the idea that motor-driven transport can o

145 These findings provide a precedent for the involvement of mechanosensitive channe

146 This sets a synthetic precedent for the observed low-spin to high-spin convers

147 Precedent for the significant function of arginines in p

148 These results establish a precedent for the stereoselective synthesis of epoxy alc

149 This investigation sets a good precedent for the study of reservoirs, big data mining,

150 0-catalyzed N-oxygenations, because there is precedent for the use of H2O2 and organic peroxides in s

151 The results set a precedent for thermally resilient organic synapses to im

152 The only precedent for this approach is Oregon's state parity law

153 fication of [CuOOR](2+) complexes, the first precedent for this core in enzymes is provided, with imp

154 A precedent for this hypothesis has been established for m

155 There was no observational precedent for this level of rainfall.

156 To establish precedent for this mechanism, we engineered a catechol t

157 has firm, disproof-based chemical-mechanism precedent for two specific, balanced pseudoelementary ki

158 These findings may provide a precedent for understanding apparently sporadic neurodeg

159 Our study establishes a precedent for using transgenic Drosophila to study clini

160 Although this type of reactivity is well-precedented for most transition metals, gold constitutes

161 tory, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy.

162 effects for this enzyme and with established precedents for phosphomonoester hydrolysis.

163 These results provide synthetic precedents for proposed intermediates in the catalytic c

164 However, despite numerous precedents for RNA molecules acting as scaffolds for pro

165 vity patterns are consistent with literature precedents for similar complexes.

166 This commentary suggests (1) that there are precedents for Smaldino's "collaboration" in the history

167 ently reported one of the first experimental precedents for such a step.

168 oree," the Drosophila genome established the precedents for the current paradigm used by most genome

169 bust T1-weighted MRI enhancements, providing precedents for the detection of intracellular targets by

170 To provide precedents for the possible interactions of platinum DNA

171 lications, physical complications, and legal precedents for the use of pure THC or crude marijuana.

172 These data provide precedents for translational strategies that would allow

173 This study sets precedents for using malonyl-CoA analogs with carboxyate

174 Precedent from invertebrate development, and from verteb

175 mer properties is rarely studied despite the precedent from Nature that monomer order can create mate

176 isotope effect is also contrary to empirical precedents from chemical reactions suspected of tunnelin

177 On the basis of precedents from synthetic diiron complexes, a high-valen

178 sing oligonucleotide constructs derived from precedented G-quadruplexes and i-motif-forming bcl-2 P1

179 Clinical precedent has been previously established for the FDA-ap

180 dies and on drug research and development, a precedent has been set that allows patients to reshape t

181 Numerous legal precedents have laid the groundwork for end-of-life deci

182 OS was superior compared with the precedent HIT '91 trial.

183 f extensional and rotational motions without precedent in allosteric machines.

184 uses enzymes that catalyse reactions without precedent in biology.

185 tiary amine is a reaction without an obvious precedent in bioorganic chemistry.

186 bservation of the oxidation of 2+ is without precedent in confirming a radical-substrate (R-S) dimeri

187 was made possible through the large body of precedent in copper(I) hydride catalysis and the well-ex

188 nts with scope and accuracy that have little precedent in economics.

189 This biosynthetic reaction, which has little precedent in enzymology or organic synthesis, expands th

190 An and AnAsAn linkages reported here have no precedent in f-block chemistry.

191 ale germline genome arrangements are without precedent in mammals.

192 r the thiopyrone moiety of 1 has no previous precedent in natural products chemistry.

193 pursuing synthetic macrocycles that have no precedent in nature.

194 arrangements involved, many of which have no precedent in organic or biological chemistry.

195 pecies with a cyclic [VO](2) core, which has precedent in small molecules but has not been previously

196 enters in iron-sulfide complexes have little precedent in synthetic chemistry despite a growing inter

197 charge transfer energy continuum is without precedent in synthetic fullerene-based dyads.

198 Such an exciplex emission, which has also no precedent in TCBD chemistry, results from intramolecular

199 quence guidance, these drugs have also set a precedent in terms of the substantial annual costs and i

200 b]indole structure in this manner has little precedent in the chemical literature.

201 Further, this study sets a precedent in the field of gene-engineering, possibly app

202 lly proposed for this transformation with no precedent in the field of zirconium catalysis.

203 respond, would likely be without geological precedent in the last half a billion years.

204 The flaps and hood have no structural precedent in the protein database, therefore representin

205 e beta band can disrupt the function finds a precedent in the syndrome of cortical myoclonus.

206 The latter step has precedent in the virginiamycin resistance protein virgin

207 ide intermediate via reactions that are well precedented in lipid peroxidation.

208 our-agnostic indications, also set important precedents in the field.

209 Moreover, recent precedents in the literature describing antiviral deriva

210 carboxylation of alkenes-reactions with rare precedents in the literature-by means of the electroredu

211 3)CHN(2) are outlined, based on the overseen precedents in the literature.

212 emonstrating a pace for improvements with no precedents in the solar energy arena.

213 The E6-enhanced cytolysis correlated with a precedent increase in reactive oxygen species (ROS) leve

214 d residues, and quantitative comparison with precedents indicates that the thioester exchange system

215 reading of DNA methylation is not known, but precedent is provided by the Xist RNA, which results in

216 This scarce literature precedent is surprising given the established use of sub

217 paration of each, based on the Callam-Lowary precedent, is described, whereby formation of the crucia

218 al autoantigenicity, elevation of clinically precedented joint cytokines, and variation in the respon

219 been well established; however, there is no precedented literature reported for pyridyl-type nucleop

220 in addition to (in the case of CF(3)(+)) the precedented loss of CF(2)O + HF.

221 is hypothesized here that modern biological precedents may exist for RNA-based structural templating

222 Although this is an attractive and precedented mechanism, a dissociative mechanism is equal

223 peptide-based catalysts is more diverse than precedent might suggest.

224 e aerobic oxidations with Fe and Cu are well precedented, Ni-based oxidations are frequently less com

225 These results create an important precedent of catalyst control in the catalytic aerobic o

226 With no precedent of circulation in North America, HAdV-14 has b

227 ous nature of this virus and the challenging precedent of correlating antiviral antibodies with disea

228 ns of the substrates, PEP and A5P, after the precedent of DAHPS.

229 Based on the precedent of the d-erythrose-4-phosphate (E4P) modeled i

230 closely linked on mouse chromosome 4 and the precedent of the related Runx2 gene, which emerged recen

231 Based upon the precedent of the subunit c in vacuolar-type ATPases, whi

232 of the PDC core, which is an example without precedent of thermally activated global dynamics.

233 The FDA decision sets an important precedent of using a petition process to delist chemical

234 nning by hominins than those required by the precedent Oldowan technology.

235 We review current guidelines and precedents on the issue of coverage, as well as their un

236 ene product (4) in a transformation that has precedent only in stoichiometric processes.

237 tly, phenotypes of new models either have no precedents or are arbitrarily attributed according to in

238 f drug therapy from patients enrolled in the PRECEDENT (Prospective Randomized Evaluation of Cardiac

239 y of critical care settings, with or without precedent psychiatric illness, and it may be exacerbated

240 at the terminal oxygen, ruling out a better precedented Pt-OH complex.

241 Mechanistic studies suggest a precedented radical pathway is operating in the electroc

242 o a centralized model derived from Old World precedents, recent archaeological research suggests a re

243 l, the unexpected diastereoselectivity of an precedented reduction provided the epi-oxetin framework.

244 eference to higher oligomers, in contrast to precedent reports.

245 ia C-OMe cleavage is striking, with isolated precedents requiring specialized, yet expensive, ligands

246 scillations in Escherichia coli are cited as precedent resonant length measurement using chemical pot

247 This result, in keeping with these precedents, reveals that the thermosome is also a negati

248 the strategy of starting with the clinically precedented selective NEP inhibitor, Candoxatrilat, and

249 by which this occurs is far from clear, the precedent set by the cases could have broad implications

250 This program draws from the very successful precedent set by the Integrating the Healthcare Enterpri

251 Precedents set by viral receptor proteins would suggest

252 ale patterns across a vast spatial domain is precedent setting within the air toxics community.

253 Commercial precedents show that certain types of lignin (lignosulph

254 We portray a context of naturally precedented SLR from geological evidence, for comparison

255 d spectral relationship between the first or precedent sound wave and subsequent echoes.

256 robenzoyl chloride (22) which gave 3 in four precedented steps.

257 Precedented structural variation of the phi, psi dihedra

258 ences on unmet needs for health care whereas precedent studies have been focused on individual charac

259 uire conditions without natural interglacial precedents, such as catastrophic ice-sheet collapse, or

260 Literature precedents suggest that these substrates may interact di

261 og contains a functional group that chemical precedent suggests could produce mechanism-based inactiv

262 n this extremely variable region would set a precedent supporting the hypothesis that, despite its di

263 Here we present similar precedent systems, how NSyL extends existing frameworks,

264 on-stereogenic silanes is significantly less precedented than the synthesis of asymmetric carbon cent

265 Climate change poses complex risks without precedent that challenge established planning and risk m

266 ntury failed to identify lymphatic valves, a precedent that currently persists, raising the question

267 HDV genome in avian cells and establish the precedent that in certain situations HDV replication can

268 Taken together with a precedent that inhibition of EP2 signaling is protective

269 USP thus establishes the precedent that invertebrate orphan receptors are viable

270 These observations establish precedent that members of two distinct receptor superfam

271 euronal mitochondria in vivo is an essential precedent that will allow future elucidation of the mech

272 In keeping with historical precedent, the designation of several new Brucella speci

273 lthough the basics of thiolase chemistry are precedented, the mechanism by which OleA accommodates tw

274 Based on current trajectories and historic precedents, the increase will be primarily driven by bio

275 hat fall outside of windows defined by prior precedent, thereby reducing Type II errors.

276 revealed a group of inhibitors without known precedent. This molecule was optimized to 77 nM, which p

277 d by four dodecyloxy groups, requires only a precedented three-step sequence.

278 a divergent strategy that builds on existing precedent to address this long-standing challenge.

279 for situations that have little experimental precedent to demonstrate the potential utility of the mo

280 immunohistochemical analysis and literature precedent to identify potential off-target tissues in hu

281 nal economy and offers a valuable historical precedent to modern globalization.

282 In this review, we discuss the precedents to their notable achievement and reflect and

283 the aflatoxin pathway and these biochemical precedents, total syntheses of a tetrahydroxy-o-carboxyb

284 tion via sigma(S) -RNA polymerase is without precedent, transcription with purified components was ex

285 This step is followed by the well-precedented transformations observed in peroxidation rea

286 ate alpha-helix mimetic was initiated from a precedented triaryl template and refined by screening th

287 spatially and temporally coincides with the precedent wave.

288 xide-catalyzed amide hydrolysis has chemical precedent, we are not aware of a prior example of analog

289 On the basis of this precedent, we have considered a mechanism for tetrachlor

290 approximately 7 MHz), as well as literature precedent, we propose that the alkyne forms another pi/s

291 While this mechanism has little synthetic precedent, we show here that Ni complexes of the redox-a

292 Based on this precedent, we synthesized a dihydrothiazepine library an

293 protein interaction and recruitment is well precedented, we were interested in exploring HDAC1 regul

294 Based on these precedents, we decided to study the reaction of NO with

295 ical space and in building upon experimental precedents, we have utilized computational tools to deli

296 Based on other precedents, we hypothesize that DNA methylation spreads

297 Thirty-five practices in Northwest PRECEDENT were randomized to perform direct pulp caps wi

298 to the feasibility of such a process, those precedents were never applied by others due to cumbersom

299 This creates a new precedent whereby features of the channel pore can be mo

300 This study, which completes a precedent work focused on protein oxidation, clearly dem