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1  can synergize with BMP antagonism to induce prechordal and axial mesoderm when expressed as an indep
2 zer Gsc represses CE as well: Gsc-expressing prechordal cells, which leave the organizer first, migra
3                                Therefore the prechordal head is mostly composed of neural crest-deriv
4 suggest that cephalic mesendoderm, including prechordal mesendoderm and anterior paraxial mesendoderm
5  diencephalic ventral midline, lie above the prechordal mesendoderm and express Fgf10Fgf10(+) progeni
6 plate is normal, suggesting that ablation of prechordal mesendoderm selectively inhibits otic inducti
7 r embryonic structures, including notochord, prechordal mesendoderm, floor plate and forebrain.
8 es, namely the lateral head mesoderm and the prechordal mesendoderm, gradually induce placode progeni
9 ants, which are more completely deficient in prechordal mesendoderm, otic induction is delayed by 1.5
10 , which develop with a partial deficiency of prechordal mesendoderm, otic induction is delayed by up
11 gence from the node of a group of cells, the prechordal mesendoderm.
12 ng, such as anterior definitive endoderm and prechordal mesendoderm.
13                                 Furthermore, prechordal mesendodermal and prospective ventral telence
14  anteroposterior (AP) positional identity of prechordal mesendodermal inductive signals to the overly
15 ndow denuded of definitive endoderm, beneath prechordal mesoderm and a variable sector of anterior no
16  different regions: active cell migration of prechordal mesoderm and convergent extension of chordame
17 tial for formation of the notochordal plate, prechordal mesoderm and foregut endoderm during gastrula
18  of chordin to conjugate explant cultures of prechordal mesoderm and neural tissue prevents the rostr
19  functions of Dkk1: induction of chordal and prechordal mesoderm and specification of heart tissue fr
20 nodal homologue, is expressed in the nascent prechordal mesoderm and we provide evidence that Nodal s
21                                  We identify prechordal mesoderm as the tissue that inhibits NC in th
22  notochord before establishing register with prechordal mesoderm at stage 7.
23                           Nearby somitic and prechordal mesoderm becomes recruited into these enlarge
24                 We report that notochord and prechordal mesoderm cells are intermingled and share exp
25                                     Further, prechordal mesoderm cells in which Fgfr3 expression is r
26          Here we demonstrate that in Xenopus prechordal mesoderm cells, diffusely distributed, cytopl
27 terior endoderm-derived TGFbetas may specify prechordal mesoderm character in chick axial mesoderm.
28 oderm as it extends, but is downregulated in prechordal mesoderm coincident with the onset of RDVM ce
29 protein (BMP) and Wnt antagonists located in prechordal mesoderm for head induction, but may be neces
30 onstrate that Shh and Bmp7 from the adjacent prechordal mesoderm govern hypothalamic neural fate, the
31         Anterior endoderm elicits aspects of prechordal mesoderm identity in extending axial mesoderm
32 , targeted electroporation of Fgfr3 siRNA to prechordal mesoderm in vivo results in premature Shh dow
33                               Removal of the prechordal mesoderm led to formation of a single retina
34                                  Exposure of prechordal mesoderm microcultures to Nodal-conditioned m
35  signaling also interferes with migration of prechordal mesoderm on fibronectin.
36 gnals from axial mesoderm (the notochord and prechordal mesoderm) specify the pharyngeal endoderm, co
37 yonic chick, Shh is expressed transiently in prechordal mesoderm, and is governed by unprocessed Noda
38                                   Removal of prechordal mesoderm, in contrast, caused deficits of ant
39 or plate fate reveals a role for the nascent prechordal mesoderm, indicating that more than one induc
40 enitors of several axial tissues (notochord, prechordal mesoderm, somites, gut endoderm), by characte
41 ein sonic hedgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in in
42 ebrates, Otx genes are also expressed in the prechordal mesoderm, where they may have a role in cell
43 eral axial structures, such as notochord and prechordal mesoderm, which are thought to induce various
44 rm that gives rise to the notochord, but not prechordal mesoderm, which gives rise to the prechordal
45 er: deep endoderm, which expressed cerberus; prechordal mesoderm, which showed overlapping but non-id
46 e rostralization of ventral midline cells by prechordal mesoderm.
47 and bone morphogenetic protein 7 (BMP7) from prechordal mesoderm.
48 is expressed in the notochord but not in the prechordal mesoderm.
49 rangement during radial intercalation in the prechordal mesoderm.
50 se to Sonic Hedgehog (Shh) secreted from the prechordal mesoderm.
51 fects in epiboly and patterning of axial and prechordal mesoderm.
52 nterior endoderm may determine the extent of prechordal mesoderm.
53 ular events that govern the specification of prechordal mesoderm.
54 ick embryo, posterior notochord and anterior prechordal mesoderm.
55 s and a subset of the genes expressed by the prechordal mesoderm.
56 m defects in signaling between the embryonic prechordal plate (consisting of the dorsal foregut endod
57 y the anterior definitive endoderm (ADE) and prechordal plate (PCP) progenitors.
58 h causes an arrest in the development of the prechordal plate (PCP), a structure required for forebra
59 anterior neural ridge (ANR) and Shh from the prechordal plate (PrCP).
60 temporal expression in the anterior endoderm prechordal plate and anterior neural plate can be recapi
61 y expressed after removal of the presumptive prechordal plate and consistently, opl was correctly exp
62 ation anterior axial mesoderm cells form the prechordal plate and express goosecoid (gsc) in wild-typ
63  axes donor tissue contributes to notochord, prechordal plate and floor plate.
64 e-attached and secreted forms of oep rescues prechordal plate and forebrain development in mutant emb
65                                 We find that prechordal plate and notochord are strongly reduced in m
66 t the blastoderm margin and are required for prechordal plate and notochord formation.
67 sing ShhN, we detected low-level ShhN in the prechordal plate and notochord, consistent with the noti
68 nal tissue, however, leads to a loss of both prechordal plate and notochord.
69 uring the latter half of gastrulation in the prechordal plate and paraxial cephalic mesendoderm, tiss
70 ive interactions dependent on the underlying prechordal plate and signals from the midline of the neu
71 signaling mediates communication between the prechordal plate and the neurectoderm to provide cellula
72           Thus abnormal morphogenesis of the prechordal plate and the notochord is likely a consequen
73 ior axis of the zebrafish gastrula including prechordal plate and ventral diencephalic precursors.
74 ation, organizer cells involute and form the prechordal plate anteriorly and the notochord more poste
75                                    Thus, the prechordal plate appears as a mesendodermal pivot betwee
76 oncomitantly, cells normally fated to become prechordal plate are transformed into notochord progenit
77 fects in the morphology of the notochord and prechordal plate by the end of gastrulation.
78 ion in zebrafish embryos, we reveal that all prechordal plate cells show the same behavior and rely o
79                                         This prechordal plate defect preceded a reduction of HH pathw
80                           In oep mutants the prechordal plate does not form and gsc expression is not
81 end caudally in the ventral midline from the prechordal plate during development of the foregut pocke
82 oderm during late blastula stages and in the prechordal plate during late gastrulation.
83 eyed pinhead (oep) mutant embryos, where the prechordal plate fails to form.
84 axial signaling centers of the notochord and prechordal plate functions as a morphogen in dorsoventra
85 nsion defect, the expression of hedgehog and prechordal plate genes, and the formation of cyclopia in
86 ective anterior migration of the prospective prechordal plate in silberblick (slb)/wnt11 mutant embry
87 g to the loss of shield derivatives, such as prechordal plate in the anterior and notochord in the po
88 periments in chick embryos indicate that the prechordal plate is able to suppress Pax-6 expression.
89 gulated in nehe mutants at the time when the prechordal plate is normally specified.
90 rgely unaffected, suggesting that underlying prechordal plate is not required for anterior-posterior
91 ral plate mesoderm adjacent to the notochord-prechordal plate junction.
92 sors, which reside adjacent to the notochord-prechordal plate junction.
93 ation of the Ca(i)(2+) field by the emerging prechordal plate may permit the independent regulation o
94 ed that the notochord might suppress, or the prechordal plate might enhance, the cardiogenic fate.
95  using cell transplants, we demonstrate that prechordal plate migration is a true collective process,
96 anterior endomesoderm, respectively, and the prechordal plate of gastrula stage embryos.
97 the medial neural plate are regulated by the prechordal plate perhaps through the action of Sonic Hed
98 egion of the field, and demonstrate that the prechordal plate plays a primary signaling role in retin
99 is seen in the anterior midline endoderm and prechordal plate precursor.
100 ed the roles of Mil in anterior migration of prechordal plate progenitor cells and found that, in slb
101                          This indicates that prechordal plate progenitor cells can migrate effectivel
102 se results suggest that the net migration of prechordal plate progenitors is determined by different
103                                              Prechordal plate progenitors reside close to the blastod
104 l signaling at different times suggests that prechordal plate specification requires sustained Nodal
105  their response to injury, suggests that the prechordal plate supports and/or the notochord suppresse
106 g vertebrate gastrulation, cells forming the prechordal plate undergo directed migration as a cohesiv
107 orsal mesendoderm at gastrulation and in the prechordal plate until early somitogenesis.
108 l mesendoderm anterior to the notochord (the prechordal plate) has a central role in induction of the
109 nterior axis (formation of the head process, prechordal plate).
110 its mesendodermal derivatives, including the prechordal plate, an organizing center for rostral devel
111  loss of SHH expression and signaling by the prechordal plate, and a decrease in FGF8 expression and
112 g gastrula stages: in the germ ring, shield, prechordal plate, and notochord.
113  layer of the shield and later in notochord, prechordal plate, and overlying anterior neurectoderm.
114 uring gastrulation in the anterior endoderm, prechordal plate, and the prospective cephalic neural pl
115 sulting in cyclopia and defects in endoderm, prechordal plate, and ventral neuroectoderm formation.
116  the normal progenitors also reside near the prechordal plate, but anterior to the Nkx2.5-expressing
117 severe phenotype characterized by absence of prechordal plate, cardiac mesoderm, endoderm and ventral
118                                              Prechordal plate, early definitive endoderm, and anterio
119  However, a third head organizer tissue, the prechordal plate, fails to express markers of cell type
120 , axial mesendoderm migrates in a group, the prechordal plate, from the embryonic organizer to the an
121 ly the ventral brain primordium, and not the prechordal plate, is an important Hh source.
122 ls are clustered in a region adjacent to the prechordal plate, just anterior to the notochord tip.
123 lastula stage embryos either the presumptive prechordal plate, marked by goosecoid (gsc) expression,
124 es of the anterior primitive streak, such as prechordal plate, node, notochord and definitive endoder
125  essential to maintain the axial identity of prechordal plate, notochord, floor plate and hypochord p
126 ic structures present at the dorsal midline, prechordal plate, notochord, hypochord and floor plate s
127 affects directed anterior axial mesendoderm (prechordal plate, ppl) cell migration within the zebrafi
128 ependent midline domain, associated with the prechordal plate, regulates brain asymmetry but is dispe
129  responses to the inductive signals from the prechordal plate, Sonic Hedgehog, the anterior neural ri
130 tivation of the Hedgehog (HH) pathway in the prechordal plate, the head organizer.
131 ed morphogenetic movements that generate the prechordal plate, which is required for normal developme
132 ibutes to the Organizer, head mesenchyme and prechordal plate.
133 is restored upon contact with the endogenous prechordal plate.
134 prechordal mesoderm, which gives rise to the prechordal plate.
135  first detected at bud stage in the anterior prechordal plate.
136  of the ventral neuroectoderm, endoderm, and prechordal plate.
137                             We find that the prechordal region does not have neural inducing ability,
138        Here we have investigated whether the prechordal region possesses the lost functions of the or
139 n the initial determination of the anterior (prechordal) region of the embryo.
140 results have suggested that juxtaposition of prechordal (rostral) and epichordal (caudal) neuroepithe
141 ittle is known about how Shh is regulated in prechordal tissue.

 
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