ライフサイエンスコーパス: preclude

1 egy fails when direct line-of-site access is precluded.

2 human cortex, in which invasive studies are precluded.

3 f a significant excess in other genes cannot preclude a limited role in disease, such genes have limi

4 diction, yet the available evidence does not preclude a possible causal role in depression.

5 isease, but concerns about reverse causality precluded a conclusion about the relationship of shorter

6 eurotransmitters, technical limitations have precluded a full metabolomic analysis of SV content.

7 lack of structural information has thus far precluded a mechanistic understanding of ligand and lipi

8 vast size of possible parameter design space precludes a brute force approach to screening all topogr

9 However, imprecision in study results precludes a definitive conclusion, and further research

10 oduced by postsynthesis particle irradiation precludes a priori prediction of the critical current an

11 y of these progenitors has remained unclear, precluding a full understanding of the differentiation t

12 4 structures are in the active conformation, precluding a good understanding of IRAK4's conformationa

13 teps and a dedicated laboratory environment, precluding a high throughput process.

14 /LF) ) are embryonic and perinatally lethal, precluding a more rigorous examination of the effect of

15 ding of their working mechanism is currently precluding a targeted design of Organic Electrochemical

16 , differentiation is an asynchronous process precluding a temporal understanding of regulatory events

17 area increase immediately upon illumination, precluding a thermal effect.

18 nonamyloidogenic pathway by alpha-secretase, precluding Abeta production.

19 periments, VHA(B) -eGFP localization in SDVs precluded accumulation of the acidotropic silica biomine

20 , but an incompletely characterised proteome precludes accurate understanding of both plastid functio

21 ofile and small incremental survival benefit precludes additional development in MPM.

22 ater may contain growth inhibitory compounds precluding algal use in phycoremediation.

23 These findings do not preclude an algorithmic solvability for a particular cla

24 e complexity of these materials has thus far precluded an in-depth understanding of the oxygenated su

25 This timing precludes an Atlantic trigger for Cordilleran Ice Sheet

26 patients with early-stage cancer are scarce, precluding an understanding of energy requirements.

27 The low incidence of SSIs in this cohort precluded analysis of associations between dysbiosis and

28 ack of specific p120-3 protein detection has precluded analysis of their relative abundance in tissue

29 ty of results from studies published to date preclude any definitive characterization of the relation

30 y with latitude-these also affect dispersal, precluding any clear expectation of how dispersal change

31 e cystic kidneys by macrophages and T cells, precluding any improvement of kidney function.

32 -pass sequencing of genomes at low coverage, precluding assembly) becomes more prevalent, this proble

33 the Drosophila gene on the fourth chromosome precluded assessment of Crk's full role in embryogenesis

34 ange of variation, but such calibrations are precluded because of lack of experimental relative perme

35 talytic core, sits atop the active site, and precludes binding of substrate succinyl-CoA.

36 urogranin facilitates LTD, but limits LTP by precluding binding of CaMKII with calmodulin.

37 The nature of the intervention precluded blinding, but data collection and analysis wer

38 LMWH or VKA use does not preclude breastfeeding.

39 on is usually assumed to be absent on Venus, precluded by a high surface temperature of ~450 degrees

40 er subjects into the 1,000-mg dose group was precluded by adverse skin events (rash).

41 Clinical development of KCP, however, is precluded by its size and complexity.

42 However, this is precluded by limitations of current cell-based systems f

43 zing or functional cure for HIV is currently precluded by resting CD4(+) T cells that harbor latent b

44 in the human structural connectome has been precluded by the inability of non-invasive neuroimaging

45 However, significant advances have been precluded by the lack of mechanistic explanations for th

46 lopment of NTSR1 agonists has, however, been precluded by their severe side effects.

47 ereby preventing normal coronary vasomotion, preclude bypass grafting and can provoke long-term forei

48 ations include its nonrandomized design that precludes causal inference, residual confounding, and pa

49 the absence of changes in sensitivity do not preclude changes in sensory encoding.

50 etween scaRNA and the endogenous DNA targets precludes cleavage, highlighting the evolution of scaRNA

51 nstraints limit device functionalities, thus precluding color center integrated photonic circuits.

52 Because wobble rules preclude compensation for loss of tRNA(Lys43-UUU) by the

53 f they had any medical conditions that would preclude completing the study or cause harm during the c

54 As limited data availability precluded complex model designs, the projection was divi

55 e usually only available days after surgery, precluding contemporaneous re-assessment of positive mar

56 partners (phenol esters and silyl amines) to preclude conventional reactivity that forms inert amide

57 baseline; an immunosuppressive TME may also preclude CR.

58 nce of malignant regional lymph nodes (MRLN) precludes curative oncologic resection or liver transpla

59 ce of malignant regional lymph nodes (MRLNs) precludes curative oncological resection or liver transp

60 nders accurate comparisons between tools and precludes data sharing and the development of common dow

61 y for mediating vesicle priming but also for precluding de-priming by preventing trans-SNARE complex

62 having endometrial stromal-specific defects precluding decidualization and successful pregnancy.

63 alanin receptor antagonists in prior studies precluded defining a causal role for LC-derived galanin

64 nd resulting post hoc nature of the analyses preclude definitive conclusions.

65 large secondary electron background that has precluded definitive measurements of the low-energy elec

66 cified criteria for statistical superiority, precluding definitive conclusions.

67 ts require careful control of temperature to preclude deleterious aggregate aging effects traced to c

68 ped hypertrophic cardiomyopathy cohorts have precluded detailed genotype-phenotype correlations.

69 d HLA antibodies, low IgG concentrations can preclude detectability of HLA antibodies in luminex sing

70 missed from pinch biopsy sampling, which may preclude detecting virus reservoirs for monitoring HIV c

71 from the LES to the ground state and thereby preclude detection of the CSS and the inverted region be

72 e place with wild-type (WT) DNA, which often precludes detection of low-level mutations.

73 ny others exist solely within a few samples, precluding detection by conventional recurrence-based st

74 ave highly similar transcriptional profiles, precluding detection by transcriptional profile.

75 ver, tamoxifen-independent Cre recombination precluded determination of disease halting or reversal i

76 However, the large but simple trial design precluded determination of the mechanisms involved.

77 temperature variations, which in many cases precludes determination of key diagnostic information.

78 rd PAGE denatures proteins prior to analysis precluding determinations of folding states or PTMs.

79 prone to trapping off-pathway artefacts and precludes determining the order of molecular events.

80 tivation of these porous molecular materials precludes diffraction studies, we turn to a related clas

81 e a membrane diffusion barrier that normally precludes diffusion of NF186 to nodes.

82 Analysis (FBA), which makes assumptions that preclude direct integration of metabolomics data into th

83 ever, differences in definitions and methods preclude direct pooling of original data on individual p

84 lly different from the left ventricle, which precludes direct extrapolation of our knowledge of left-

85 fuse vibrational envelope displayed by water precludes direct observation of how different hydrogen-b

86 n and content differs by country and region, precluding direct comparison of scores across different

87 locked 3' DNA ends, problematic lesions that preclude DNA synthesis.

88 ayed fashion in a genetic system designed to preclude downstream repair steps.

89 simertinib, including mutations in EGFR that preclude drug binding as well as EGFR-independent activa

90 a6beta4 receptors in recombinant systems has precluded drug discovery.

91 Herein, we discuss the factors that can preclude durable remissions following CAR T cell therapy

92 This precludes dynein-mediated removal of the RZZ from kineto

93 during this asymptomatic phase are limited, precluding early therapeutic intervention.

94 that reduces eEF2K polypeptide abundance to preclude eEF2 phosphorylation, thereby stimulating trans

95 ly distinguished in biological environments, precluding efforts to visualize multicellular processes.

96 lashes with incoming aminoacyl-tRNA, thereby precluding elongation.

97 which these underlying sociocultural factors preclude end-stage renal disease (ESRD) patients from in

98 difficulties in arginylated actin detection, precluding estimations of the abundance of arginylated a

99 suggesting that inhibitory pathways possibly preclude ETV1 from exerting its full oncogenic potential

100 Sporadic incidence precludes evaluation of antimicrobial efficacy.

101 Lower-than-anticipated participation precluded examination of the effect of the tool on the f

102 intrinsic SOC in monolayer graphene(4-7) has precluded experimental observation in this material.

103 fluctuations within an adaptive state should preclude exploration of new adaptive states when the env

104 This result precludes extensive deep subduction of most CO(2) and su

105 ddress this challenge as species differences preclude extrapolation from animals.

106 s addressed by modifications that sterically preclude formation of a putative metabolic intermediate

107 onally nonfunctional in these cells as it is precluded from binding its E-box by the PcG protein, CBX

108 to study dynamical phases of matter that are precluded from existence at equilibrium but can be stabi

109 dels, but the high human intrinsic clearance precluded further development and prompted further inves

110 dels, but the high human intrinsic clearance precluded further development and prompted further inves

111 the generation of homozygous mutant plants, precluding further functional studies.

112 rns of fluctuations of an optimum phenotype, precluding further progress in connecting theory with ob

113 ds to a multi-domain site on PUUV Gc and may preclude fusogenic rearrangements of the glycoprotein th

114 t a potential patient selection bias and may preclude generalizability of results to specific risk su

115 neck imposed by the requirement for isolates precluded genomic insights for the vast majority of micr

116 "Horizontal" docking precludes germline CDR1beta- and CDR2beta-MHC binding to

117 Whilst these findings do not preclude glutamatergic alterations in psychosis, methodo

118 This precludes handling of chlorosulfonyl isocyanate and sulf

119 occurs in the context of a food system that precludes healthy foods as the default choices.

120 typical transition-metal-oxide cathodes(5,6) preclude higher energy densities.

121 critical for Swi6 association with FACT that precludes histone turnover to promote gene silencing and

122 nificant within-host genetic diversity could preclude identification of transmission events.

123 detection was rare and not well replicated, precluding identification of novel tightly linked specie

124 ay, is highly sensitive, but cost restraints preclude implementation of these technologies in resourc

125 nduced Kv4.3 charge increase, which was also precluded in channels (p.S550A Kv4.3) in which the CaMKI

126 Although its pathogenicity precluded in vivo studies, the M. tuberculosis Tam also

127 ce diffraction-limited signals and therefore preclude information on the nanometer-scale distribution

128 ure is constrained by the DNA polymer, which precludes interactions between genes on different chromo

129 rns are not resolved, or if symmetry reasons preclude interpretation.

130 osuppression and its associated side effects preclude intestinal transplantation if motivated only by

131 erive seed virus from nasal secretions, thus precluding introduction of extraneous pathogens through

132 entional bias, but the lack of animal models precluded investigation at the single-unit level.

133 areas where grid limitations would otherwise preclude it.

134 expression on resting and activated T cells precludes it from being a bona fide exhaustion marker.

135 is goal, other sources of emissions may also preclude its attainment.

136 The latter is less stable, which has so far precluded its detailed investigation, despite many theor

137 s typically low or absent in SCLC, which has precluded its use as a predictive biomarker.

138 on for buffer exchange and data acquisition, precluding its wide adoption.

139 The CF(3) substituent is found to preclude kappa-N coordination, allowing for direct coord

140 e applications, and their limited solubility precludes large-scale processing into more useful morpho

141 Broad HSCT application is currently precluded largely due to morbidity and mortality associa

142 al limitations of short-read sequencing have precluded linking bacterial taxa to specific mobile gene

143 val in our cohort and should not necessarily preclude listing.

144 monly needed for actuation can be cytotoxic, precluding long-term experiments.

145 me and the rarity of CTCs in the bloodstream preclude longitudinal, in-depth studies of these cells u

146 ms from being explicitly tested, and thereby precludes meaningful predictions on the consequences of

147 erlying molecular mechanisms remain elusive, precluding mechanism-based therapies.

148 This precludes mechanistical studies in presence of PBN.

149 is a basic principle of neuronal coding that precludes memory interference in the hippocampus.

150 ods and missing data, limiting synthesis and precluding meta-analysis.

151 ide cells the enzyme is maximally active and preclude minor populations present in subcellular compar

152 llenging because ribosomal proteins and rRNA preclude most spectroscopic measurements of protein ener

153 Substitutions at Thr-2 that precluded N (alpha)-acetylation inhibited the heterodime

154 = 49) because they underwent surgery, which precluded observation of the natural disease course.

155 levels of Loa loa microfilariae in the blood preclude onchocerciasis elimination through community-di

156 able to coassemble a large dataset does not preclude one from multiassembly; rather, having a fast,

157 isons because their conformational diversity precludes optimal superimposition of the atomic coordina

158 While the results do not preclude other possible advantages of the exceptional-po

159 e access to a developmental path or actively preclude others.

160 This limited approach has precluded our ability to isolate and genetically manipul

161 dological procedures used across the studies precluded our possibility to meta-analyse the evidence a

162 nown, however, and the paucity of field data precludes our ability to test collapse theories tied to

163 nd cellular functions are currently unknown, precluding our understanding of the aetiology of this di

164 and were free of conditions that might have precluded participation at baseline (first postdiagnosti

165 jects or exhibited a broadened profile which precluded peak identification.

166 hrough simple binding, under conditions that preclude phosphorylation.

167 Upon infection, DeltaN146 precludes phosphorylation of translation initiation fact

168 onservation of the C-termini between classes precludes pinpointing the analogous residues in Class 1

169 ut clinical and methodological heterogeneity precluded pooling.

170 ll poses unsolved fundamental questions that preclude predictive models for microbial transport and s

171 interacts with ATG5 on isolation membranes, precluding premature dynein recruitment and autophagosom

172 f insects emerged with low teneral reserves, precluding previtellogenic ovarian development.

173 entify prohibitive safety signals that would preclude proceeding to a larger pivotal study of LV unlo

174 Cost and tissue availability normally preclude processing samples across multiple technologies

175 ever, this conversion of cystine to cysteine precludes product inhibition of the importer, so cystine

176 O-GlcNAcylation at Ser-642 not only entirely precluded production of the N-terminal fragment of HDAC4

177 oximal hygiene whereas 54% of the prostheses precluded proper access.

178 (+) affinity of the cytoplasmic-facing sites precluded proper pump activation under physiological con

179 eline-directed care, mandated care in sepsis precludes providers from tailoring treatments to heterog

180 , respiratory motion during data acquisition precludes quantification of perfusion.

181 ectiveness had sparse data availability that precluded quantitative pooling.

182 other hand, depleting Xist, PRC1, or HNRNPK precludes re-emergence of S1/S2 structures, and loss of

183 sis reduced latent viral gene expression and precluded reactivation.

184 Precluding recent laxative users from CDI testing, as pr

185 plasmic TIR modules of TLR4 in a manner that precludes receptor dimerization; such dimerization is a

186 arget effects remain a major bottleneck that precludes safe and reliable applications in genome editi

187 hydrodynamic radius of RNP particles (86 nm) precludes simple diffusion through the mesh of cytoskele

188 landscape with no dominant truncal drivers, precluding simplistic approaches to therapeutic targetin

189 binding to syntaxin-1-SNAP-25 heterodimers, precluding SNARE complex formation; and binding to trans

190 bunit, because its monomer-like conformation precludes stabilizing contacts with the penultimate subu

191 were moderately correlated (r = 0.60), which precluded statistical significance for DFS in a joint mo

192 gand-binding domain (LBD) has for many years precluded structure-guided improvements.

193 conventional knockout (KO) is lethal, which precludes studying the consequences of its deletion in o

194 lar cytokine staining require cell fixation, precluding subsequent functional interrogation.

195 tempted to replicate closely a previous one, precluding substantial meta-analyses, such that the latt

196 its highly antigenic and multicopy var genes preclude such clear clustering in endemic regions.

197 A data-release mechanism that precludes such attacks is "secure against predicate sing

198 This signal is able to preclude surface localization of PM protein AQP3 in HEK2

199 Age should not preclude surveillance imaging.

200 requisite for mammalian cell motility, which precludes swimming.

201 , using the ubiquitin-binding receptor NBR1, precluding T cell recognition.

202 patients whose dysfunctional vascular cells preclude TEVG generation via other methods.

203 ossible utilization of terminator gRNAs that preclude the 3' to 5' progression of editing.

204 Moreover, GC lesions do not preclude the ability of rats to learn and perform the ta

205 e findings suggest that the nucleus does not preclude the banded subset from reaching an infection si

206 calmodulin buffer, it does not significantly preclude the calmodulin opening by calcium.

207 for full reconstruction of microvasculature preclude the clinical translation of the technique.

208 ath of infected animals, however, appears to preclude the clonal selection typically observed in huma

209 t do are typically destructive in nature and preclude the collection of longitudinal temporal data.

210 All these fundamental constraints preclude the continual reduction of pixel dimensions and

211 the complexities underlying human AF; these preclude the creation of a "perfect" animal model and ha

212 approaches utilize binary modifications that preclude the identification of key knockdowns for essent

213 for a coevolutionary hypothesis but fails to preclude the possibility of unilateral evolution.

214 n trigger collateral side effects that could preclude the practical implementation of anti-GEF therap

215 pathology, IFN-gamma neutralization did not preclude the precipitation of sHLH in TLR9-inflamed SIRP

216 This novel signal may preclude the proper trafficking of TMC1 to the PM in het

217 n vitro stimulation or culture that can both preclude the study of unmanipulated naive T cells and al

218 d that these "drive resistant alleles" (DRA) preclude the successful application of CGD for managing

219 istic understanding is disclosed, and we now preclude the suggested involvement of a primary radical

220 categories, and command-line arguments that preclude the use of accessory scripts.

221 and intricate post-translational biogenesis preclude the use of simple genetic tagging in their cell

222 arly but not late surgical allograft removal precluded the acquisition of T cell dysfunction.

223 None of these events precluded the administration of cisplatin at the planned

224 ols that are employed prior to analysis have precluded the application of this technique for small-vo

225 , pregnancy, and enrollment CD4 count, which precluded the assessment of rapid ART initiation specifi

226 r, the presence of dynein on an Mcp5 cluster precluded the attachment of mitochondria to the same clu

227 t to create machine learning algorithms that precluded the dangerous behavior caused by standard mach

228 ependent oncogenic transformation has so far precluded the development of rational targeted therapies

229 infection with myeloid-restricted ZIKV that precluded the generation of viremia and viral disseminat

230 g capabilities, computational power and cost precluded the incorporation of whole-tumor microvascular

231 ects and variability in carbon nanotubes has precluded the realization of very-large-scale integrated

232 emerged on the spatial alternation task that precluded the use of intramaze cues.

233 This issue has precluded the use of MTV for risk stratification in tria

234 n the relationship between RSV and SIRT1 has precluded the use of RSV as a therapeutic drug.

235 rance by existing glycans in the matrix that precluded the virus from being captured by the synthetic

236 singly, the nominal configuration of the DWs precludes the alternating current (ac) conduction under

237 Such a large sample requirement generally precludes the application samples in the nanogram to low

238 The sheer scale of oceans, however, precludes the characterization of marine feeding network

239 Ectopic 5hmC trapping precludes the chromatin association of master pluripoten

240 The immunological barrier currently precludes the clinical utilization of allogeneic stem ce

241 ne checkpoint immunotherapy (ICI), one which precludes the continuation of ICI.

242 nosheets, with quite distant cobalt centers, precludes the direct coupling between the electrocatalyt

243 This coupling precludes the direct usage of pseudo-alignment to other

244 and therapeutic antibody in solution, which precludes the effective identification of low abundance

245 e insulin-IGF-1 signalling (IIS) pathway and precludes the induction of stress response genes by acti

246 remodels the active site of CDK8 and thereby precludes the inhibition of ternary CDK8 complexes by ty

247 However, the diffraction limit precludes the low-power trapping of nanometre-scale obje

248 ploys a chemoselective C-acylation step that precludes the need for intermediate isolations, extracti

249 ich NHC (IMe(4)) to the phosphorus atom in 5 precludes the pai-electron density transfer from the NHV

250 y unbiased Smpd3(-/-) mouse, described here, precludes the proposed role of Smpd3 as a candidate gene

251 of bulk phagocyte populations; however, this precludes the resolution of heterogeneity between indivi

252 and stray light are then predominant, which precludes the use of conventional imaging methods.

253 is limited by AAV packaging capacity, which precludes the use of full-length base editors.

254 Furthermore, this co-dependence precludes the use of GDNF as a tool to study a putative

255 ion face high wait-list mortality, as injury precludes the use of most donor lungs.

256 rrently, AML treatment is initiated rapidly, precluding the ability to consider the mutational profil

257 P) African hominins is largely unknown, thus precluding the definition of boundaries of variability i

258 on and maintenance remain poorly understood, precluding the deliberate therapeutic targeting of senes

259 ect cell surface epitopes or mAb conjugates, precluding the evaluation of the phosphorylation status

260 nistration (typically intravenous infusion), precluding the feasible dosing of antibody combinations

261 n exclusively intramolecular fashion thereby precluding the formation of dimers and oligomers via int

262 anisms: (i) markedly reducing IN levels thus precluding the formation of IN complexes with viral RNA;

263 s added to the surface as an adatom, thereby precluding the need for reorganization of the underlying

264 gnificantly increasing hemoglobin levels and precluding the need for transfusions.

265 low achieved levels of mobility potentially precluding the occurrence or detection of adverse events

266 uristic peak assignments for simple spectra, precluding the possibility of obtaining detailed structu

267 While not precluding the possibility that other forms of learning

268 ated 34.3% EA, 97.1% CA, 0% ME, and 2.9% mE, precluding the use of Etest MEV with this species.

269 ntially driven by kinase promiscuity), which preclude their evaluation in nononcology indications.

270 peutics, however, exert host toxicities that preclude their use as antifungals.

271 Unfortunately, kidney toxicity has precluded their therapeutic application so far.

272 encountered in these compounds have largely precluded their widespread use(3).

273 ventional fluorescent dyes in the NIR, which precludes their application.

274 -mediated gene editing in memory CD8 T cells precludes their proliferation after Ag re-encounter in v

275 to bacterial cells in the absence of amyloid precludes their utility for identifying amyloid in biofi

276 yl moiety of isoaccepting glycyl tRNAs, thus precluding their participation in translation.

277 cable only for relatively simple geometries, precluding their use for the surfaces with complex geome

278 e of nanocrystals containing toxic elements, precluding their use in biological or environmentally se

279 fluenced by general anthropogenic activities preclude them as individual robust tracers.

280 previous transplant, our findings should not preclude this patient population from operative consider

281 nal standard was approximately one, and thus precludes this method as a universal normalization appro

282 specimens for detection of enteric pathogens precludes this specimen type from being recommended by n

283 derable interest, but their complexity often precludes tractable analytical expressions for messenger

284 on of uncharacterized protein regions, which preclude trafficking to the plasma membrane (PM) in hete

285 tation of the hydroxylation acceptor proline precludes tyrosine autophosphorylation and folding of DY

286 al splicing is due to biophysical constraint precluding U1/U2 spliceosome assembly, which stalls in A

287 ck of suitable respiratory model systems has precluded understanding of how herpesvirus virions overc

288 This discrepancy precludes understanding the factors that drove past (and

289 oviding an alternative clipping pathway that precludes unfolding and degradation; the UBL degron favo

290 oallelic expression of specific genes, which precludes uniparental development and underlies various

291 ilized by MgADPVO(4) eliminates this cavity, precluding uptake of glutathione derivatives.

292 studies were heterogeneous in methods, which precluded us from conducting a formal meta-analysis.

293 he absence of data on intact FGF23 (iFGF23), precluding us from discerning whether the current result

294 buffered saline placebo (ethical obligations precluded use of a non-translatable mRNA control) at ran

295 lack chromogenic or fluorogenic signatures, precluding use of spectroscopy-based detection.

296 sparseness of ground-based measurements has precluded verification of these ecosystems being a net a

297 However, a lack of lifespan studies has precluded verification of these theories.

298 alinity and abundant divalent cations should preclude vesicle formation.

299 enon has been considered maladaptive and may preclude vision restoration in the blind.

300 ctions, and posttransplant malignancies have precluded widespread ITx application.