ライフサイエンスコーパス: precursor B-cell

1 of priming immunogens that induce rare bnAb-precursor B cells.

2 this process in mice carrying V3-glycan bNAb precursor B cells.

3 istration rescue anergic Env(+) (non-edited) precursor B cells.

4 the expression of naked IgL on a surface of precursor B cells.

5 e bnAb induction by activating bnAb germline precursor B cells.

6 e, replenishment must involve replication of precursor B cells.

7 ication artifacts and are unique to leukemic precursor B cells.

8 D86, but not CD80, on follicular, MZ, and MZ precursor B cells.

9 ice despite a significant loss of H3K9me2 in precursor B cells.

10 d recombination of Iglambda gene segments in precursor B cells.

11 n from B220+CD43+ progenitor B to B220+CD43- precursor B cells.

12 Ab induction is vaccine priming of rare bnAb-precursor B cells.

13 dine deaminase (AID; also known as AICDA) in precursor B-cells.

14 y and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL).

15 Ikaros (IKZF1) is a hallmark of BCR-ABL1(+) precursor B cell acute lymphoblastic leukemia (pre-B ALL

16 quencies in T-cell acute LL and hyperdiploid precursor B-cell acute LL.

17 The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) re

18 IKAROS function indicates poor prognosis in precursor B-cell acute lymphoblastic leukemia (B-ALL).

19 To test the suitability of targeting CD22 on precursor B-cell acute lymphoblastic leukemia (BCP-ALL),

20 BCR-ABL1(+) precursor B-cell acute lymphoblastic leukemia (BCR-ABL1(

21 d on xenografts from pediatric patients with precursor B-cell acute lymphoblastic leukemia (pre-B ALL

22 Similar results were obtained in human precursor B-cell acute lymphoblastic leukemia lines when

23 The majority of childhood leukemias are precursor B-cell acute lymphoblastic leukemias (pB-ALLs)

24 amics during CD19 CAR T-cell therapy against precursor B-cell acute lymphocytic leukemia (B-ALL).

25 As few ETV6-RUNX1 carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), th

26 the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is ch

27 ecently been established from a patient with precursor-B-cell acute lymphoblastic leukemia (ALL), whi

28 and TCF3-PBX1 (E2A-PBX1)-frequently found in precursor-B-cell acute lymphoblastic leukemia (preB-ALL)

29 In developing B cells, the IL-7R and precursor B cell Ag receptor (pre-BCR) synergize to indu

30 w cytometric assay to identify patients with precursor B-cell ALL (B-ALL) at very low risk (VLR) of r

31 -consolidation marrows in 2143 children with precursor B-cell ALL (B-ALL).

32 rmed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 15

33 In patients with precursor B-cell ALL and PGR, survival after relapse was

34 r patients with PGR in the large subgroup of precursor B-cell ALL, dexamethasone especially reduced t

35 every 2 weeks, four times, were evaluated in precursor B-cell-ALL (pcB-ALL) IR.

36 ined that LOH of 6q was demonstrated both in precursor-B cell ALLs (15 of 93; 16%) and in T cell ALLs

37 Tumorigenesis starts in precursor B cells and becomes full-blown tumour when the

38 Many of the cell fate decisions in precursor B cells and more mature B cells are controlled

39 caused no change in the cell cycle status of precursor B cells and only modest changes in cycling pro

40 up-regulation of CD86(high) expression on MZ precursor B cells and trafficking of MZ precursor B cell

41 in lentivirus vectors and used to transduce precursor B-cell and myeloid progenitor cell lines.

42 lete loss of marginal zone and marginal zone precursor B cells, and 'preferential' population expansi

43 on of plasmacytoid dendritic cells (DCs), MZ precursor B cells, and CD4 T cells in the spleens of BXD

44 ular mimicry in Graves' disease, where early precursor B cells are expanded by Y. enterocolitica pori

45 ified impaired Ig locus contraction in adult precursor B cells as a likely mechanism by which ID2-med

46 ferentiation into germinal center and memory precursor B cells as well as preplasmablasts that rapidl

47 Precursor B cells assemble a diverse repertoire of immun

48 competition of broadly neutralizing antibody precursor B cells at a physiological precursor frequency

49 ings expand the range of NF-kappaB action in precursor B cells beyond Igkappa to include the control

50 ntified on splenic marginal zone (MZ) and MZ precursor B cells, but not on the bulk of newly formed B

51 arily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopoly

52 n IFN receptor-intact BXD2 mouse spleens, MZ precursor B cells clustered at the T cell-B cell border.

53 Notably, the composition of the precursor B cell compartment did not change with age.

54 49F) and IL-7Ralpha(-/-) mice had comparable precursor B cell defects, indicating that signaling from

55 However, MZ precursor B cells demonstrated the highest expression of

56 rgy or deletion at the transitional stage of precursor B cell development.

57 ed in a blockage of the progenitor B-cell-to-precursor B-cell development in bone marrow (BM) and B-c

58 We studied precursor B-cell development, immunoglobulin and T-cell

59 All patients showed a block in the precursor B-cell development, low B- and T-cell numbers,

60 dependent on sufficient levels of IL-7 than precursor B cell differentiation because the number of B

61 pproximating human conditions of VRC01-class precursor B cell diversity, affinity, and frequency, tha

62 tion of AID off-target mutagenic activity in precursor B-cells does not promote B-ALL.

63 The transcription factor E2A can promote precursor B cell expansion, promote G(1) cell cycle prog

64 se renin-expressing progenitors enriches the precursor B-cell gene programme and constrains lymphocyt

65 ies (bnAbs) in humans, but priming rare bnAb precursor B cells has been challenging.

66 How TSAbs arise from early precursor B cells has not been established.

67 rturbs B-cell development, as evidenced by B-precursor/B-cell hyperplasia, and corrupts the regulatio

68 unogens that primed responses from rare bnAb-precursor B cells in a mouse model and bound a range of

69 of the HCDR3-dominant bnAb BG18, primed bnAb-precursor B cells in eight of eight rhesus macaques to s

70 he nucleus of progenitor B (pro-B) and large precursor B cells in the bone marrow, an expression patt

71 69 and CD86 observed in RBP(+) marginal zone precursor B cells in the spleens of BXD2 mice compared w

72 continue to express markers associated with precursor B cells including RAG gene products.

73 Human-like TdT expression in mouse precursor B cells increased LC CDR3 length and diversity

74 pment, is required for entry of activated GC precursor B cells into the germinal center reaction; del

75 -ALL, overexpression of TET1 alone in normal precursor B cells is sufficient to transform the cells a

76 LBL (T-LBL) and six (8%) of 73 patients with precursor B-cell LBL (pB-LBL) suffered from relapse.

77 uption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA

78 Children younger than 6 years of age with precursor B-cell leukemia and no adverse genetic feature

79 with chemotherapy, whereas patients who have precursor B-cell leukemia without other adverse features

80 ed with a favorable outcome in patients with precursor B-cell leukemia.

81 Thus, precursor B-cell leukemias maintain evolution at the IgH

82 BG18-like HIV broadly neutralizing antibody-precursor B cells (<1-in-50 million) in non-human primat

83 nt patient with Epstein-Barr virus-negative, precursor B cell lymphoblastic lymphoma diagnosed 6 mont

84 Precursor B cell lymphoblastic lymphoma has not been pre

85 al of immunosuppression, and a biopsy showed precursor B cell lymphoblastic lymphoma.

86 HistoryAn 18-year-old man was diagnosed with precursor B-cell lymphoblastic leukemia and underwent tr

87 istory An 18-year-old man was diagnosed with precursor B-cell lymphoblastic leukemia and underwent tr

88 Leukemic precursor B cells may continue to undergo recombination

89 This translocation is mainly acquired in precursor B cells mediated by recombination-activating g

90 or (SDF)-1 is a chemoattractant for T cells, precursor B cells, monocytes, and neutrophils.

91 ned two HIV-1 envelope immunogens that bound precursor B cells of either a CD4 binding site or V3-gly

92 er(fl/fl)/Emicro-myc mice were of very early precursor B-cell origin, a stage of B-cell development p

93 4-year event-free survival (EFS) for the 71 precursor B-cell patients was 70.1% +/- 5.8%.

94 serve to distinguish between the presumed MZ precursor B cell population in the spleen and other IgD-

95 ontrol the progenitor B cell (pro-B cell) to precursor B cell (pre-B cell) transition have not been w

96 ates with GC sensitivity in a panel of human precursor B-cell (pre-B) acute lymphoblastic leukemia (A

97 ment of progenitor B cells (ProB cells) into precursor B cells (PreB cells) is dictated by immunoglob

98 Precursor B cell production from bone marrow in mice and

99 tive protein as determined by stimulation of precursor B-cell proliferation.

100 a tertiary structure capable of stimulating precursor B-cell proliferation.

101 e critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for r

102 difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pa

103 Activating precursor B cell receptors of HIV-1 broadly neutralizing

104 truncated/V(H)-less mouse H chain Dmu forms precursor B cell receptors with the surrogate L chain co

105 expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogenous c-Myc and caused

106 ibody feedback significantly influences rare precursor B cell responses.

107 ild-type and IL-33-deficient pro-B and large precursor B cells revealed a unique, IL-33-dependent tra

108 rate stages: First, activate the appropriate precursor B cells; second, shepherd affinity maturation

109 ms behind are still unknown, we studied five precursor B cell subsets (ProB, PreBI, PreBII large, Pre

110 Precursor B cell survival is more dependent on sufficien

111 bs are important vaccine leads because their precursor B cells targeted by an engineered priming immu

112 approximately 10 times fewer virus-specific precursor B cells than normal spleen cells, had no signi

113 sis revealed intragraft differentiation from precursor B cells to memory B cells in accepted allograf

114 and recruited broadly neutralizing antibody precursor B cells to the GC response more efficiently co

115 n MZ precursor B cells and trafficking of MZ precursor B cells to the T cell-B cell border to provide

116 gH) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued

117 ion or pneumovirus cross-neutralization from precursor B cells with low initial affinity for the RSV-

118 scaffold nanoparticles can elicit rare bnAb-precursor B cells with predefined binding specificities

119 to prime specific and exceedingly rare bnAb-precursor B cells within a humanlike repertoire.