ライフサイエンスコーパス: precursor protein

1 and the soluble fraction beta of the amyloid precursor protein).

2 n presenilin 1, presenilin 2, or the amyloid precursor protein.

3 phosphorylated tau 181, and soluble amyloid precursor protein.

4 secretase of the Alzheimer's disease amyloid precursor protein.

5 ration in neurons overexpressing human Abeta-precursor protein.

6 proteolytic activation of the dimerized BMP7 precursor protein.

7 reased proteolytic processing of the amyloid precursor protein.

8 related processes and degradation of amyloid precursor proteins.

9 ocessing peptidase for complex mitochondrial precursor proteins.

10 of plant life and are usually synthesized as precursor proteins.

11 ochondria requires the import of hundreds of precursor proteins.

12 es can lead to the accumulation of cytosolic precursor proteins.

13 0)/HSP90-mediated transport of mitochondrial precursor proteins.

14 were connected to APP (encoding amyloid beta precursor protein), a major player in Alzheimer's diseas

15 oxycycline (dox) to suppress further amyloid precursor protein/Abeta production, and at the same time

16 Amyloid precursor protein accumulates within the periphery of th

17 occurred prior to the appearance of amyloid precursor protein accumulation, an indicator of disrupte

18 embrane alpha-helical portion of the amyloid precursor protein after the latter values were adjusted

19 We analysed soluble amyloid precursor protein alpha (sAPPalpha) and beta (sAPPbeta),

20 Secreted amyloid precursor protein-alpha (sAPPalpha) has growth factor-li

21 LTP.SIGNIFICANCE STATEMENT Secreted amyloid precursor protein-alpha (sAPPalpha) is a neurotrophic an

22 ure amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha), analytes central to

23 nce of any changes in the amounts of amyloid precursor protein, amyloid-beta or synaptic proteins.

24 ore, we observed increased levels of amyloid precursor protein and amyloid beta in PITRM1-knockout ne

25 Amyloid precursor protein and endosomal-lysosomal dysfunction in

26 eased phosphorylation of full-length amyloid precursor protein and its associated neurotoxic cleavage

27 tides deriving from the pro-opiomelanocortin precursor protein and localized a specific area of the p

28 ase association with substrates like amyloid precursor protein and N-cadherin, but not with its shedd

29 atalyzes the proteolytic cleavage of amyloid precursor protein and Notch.

30 c mouse model carrying mutated human amyloid precursor protein and presenilin 1 (APP/PS1-Tg).

31 hods: Nine wild-type (WT) mice and 9 amyloid precursor protein and presenilin 1 double-transgenic (AP

32 s revealed the 3D structure of a macrocyclic precursor protein and provided important mechanistic ins

33 kines of the IL-1 family, are synthesized as precursor proteins and activated by the inflammasome via

34 play important roles in binding amyloid beta precursor proteins and modulating PS1 catalytic activity

35 ides are proteolytically derived from larger precursor proteins and subject to several additional ste

36 pase-3 cleavage site within the amyloid-beta precursor protein, and a caspase-3 cleavage of tau as th

37 GR signaling pathways, processing of amyloid precursor protein, and enzymes involved in Tau phosphory

38 a product of the proteolysis of the amyloid precursor protein APP, is related to Abeta42 by an addit

39 h and Indiana mutations of the human amyloid precursor protein (APP mice) and WT mice.

40 ells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellular mode

41 s disease, as they are produced from amyloid precursor protein (APP) along the endocytic pathway of l

42 ain region-specific up-regulation of amyloid precursor protein (APP) and Abeta (40 and 42) in astrocy

43 teraction between astrocyte-released amyloid precursor protein (APP) and death receptor-6 (DR6) on MN

44 eased Abeta production by modulating amyloid precursor protein (APP) and gamma-secretase levels in li

45 roduct of the ubiquitously expressed amyloid precursor protein (APP) and is able to self-associate in

46 AD, requires the extra gene copy of amyloid precursor protein (APP) and is specifically mediated by

47 We determined that full-length amyloid precursor protein (APP) and its beta-C-terminal fragment

48 Amyloid precursor protein (APP) and its cleavage product amyloid

49 beta-Amyloid precursor protein (APP) and its cleaved products are str

50 Amyloid precursor protein (APP) and its extracellular domain, so

51 rated altered levels of amyloid-beta (Abeta) precursor protein (APP) and its metabolites in FXS and i

52 and gamma-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergistic effec

53 Amyloid-beta (Abeta) precursor protein (APP) and metabolites are usually asso

54 a-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate beta-amyloid (Abeta

55 (fAD) results from mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 and PSEN2)

56 s) expressing varying levels of amyloid beta precursor protein (APP) and presenilin 1 (PS1) with AD m

57 ExNef caused a redistribution of amyloid precursor protein (APP) and Tau to lipid rafts and incre

58 cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-b

59 to a change in the approximation of amyloid precursor protein (APP) and the beta-site APP cleaving e

60 turn enhances transcription of amyloid-beta precursor protein (APP) and thereby increases amyloid-be

61 er C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal flu

62 and animal models to edit endogenous amyloid precursor protein (APP) at the extreme C-terminus and re

63 biological function of amyloid beta (Abeta) precursor protein (APP) beyond its role in Alzheimer's d

64 Cleavage of amyloid precursor protein (APP) by BACE-1 (beta-site APP cleavin

65 a) peptide, derived from cleavage of amyloid precursor protein (APP) by beta- and gamma-secretases.

66 formed by sequential cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE) and gam

67 enerated by a sequential cleavage of amyloid precursor protein (APP) by beta-secretase 1 (BACE-1) fol

68 Cleavage of amyloid precursor protein (APP) by beta-secretase BACE1 initiate

69 ived from sequential cleavage of the amyloid precursor protein (APP) by beta-site APP cleaving enzyme

70 otoxic peptide excised from the amyloid-beta precursor protein (APP) by beta-site APP-cleaving enzyme

71 Processing of amyloid-beta (Abeta) precursor protein (APP) by gamma-secretase produces mult

72 formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma secretases

73 Processing of amyloid precursor protein (APP) by the beta-secretase BACE1 is t

74 Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CTFs) by g

75 Mutations in PSEN and the Amyloid Precursor Protein (APP) cause early-onset AD GSECs succe

76 imer's disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by gamma-secretase, inc

77 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the

78 beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the

79 AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) traffi

80 se, butyrylcholinesterase, beta-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE-1), and

81 se (AD) brain and the requirement of amyloid precursor protein (APP) for these effects.

82 approach is to destabilize the amyloid beta precursor protein (APP) from which Abeta is derived.

83 Mutations in amyloid beta precursor protein (APP) gene alter APP processing, eithe

84 ssense mutations in the amyloid beta (Abeta) precursor protein (APP) gene have been implicated in ear

85 dels that one extra copy of a normal amyloid precursor protein (APP) gene impairs lysosomal acidifica

86 as compared to rodent Abeta, the rat Amyloid Precursor Protein (App) gene was mutated to produce huma

87 thesis derives from mutations in the amyloid precursor protein (APP) gene.

88 The amyloid precursor protein (APP) harbors physiological roles at s

89 proteins.SIGNIFICANCE STATEMENT The amyloid precursor protein (App) has been intensively studied for

90 The amyloid precursor protein (APP) has long been appreciated for it

91 The function of the amyloid precursor protein (APP) in brain health remains unclear.

92 amyloid beta (Abeta) formation from amyloid precursor protein (APP) in vitro To determine whether lo

93 (BACE1) initiates processing of the amyloid precursor protein (APP) into Abeta peptides, which have

94 s responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone am

95 g body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal fragmen

96 omponent, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage.

97 Amyloid precursor protein (APP) is associated with both familial

98 Amyloid-beta precursor protein (APP) is central to the pathogenesis o

99 ted with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by beta-secretase to

100 reveal that the membrane-associated amyloid precursor protein (APP) is highly expressed in macrophag

101 umulation of metabolites of the amyloid-beta-precursor protein (APP) is neurotoxic.

102 Amyloid-beta precursor protein (APP) is overshadowed by its degradati

103 Amyloid precursor protein (APP) is predominantly expressed in br

104 Amyloid precursor protein (APP) is processed along the amyloidog

105 arlier complications occurring while amyloid precursor protein (APP) is trafficking through the early

106 tical slices from male wild-type and amyloid precursor protein (APP) knock-out (KO) mice to assess th

107 ations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of longer amy

108 Proteolysis of the amyloid precursor protein (APP) liberates various fragments incl

109 presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), of which

110 etabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic

111 retase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (secreted APPbeta, C

112 g human genes such as those encoding amyloid precursor protein (APP) or presenilins (PSEN1 or PSEN2)

113 Amyloid precursor protein (App) plays a crucial role in Alzheime

114 vement of endosomes and lysosomes in amyloid precursor protein (APP) processing and clearance, and th

115 varepsilon3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally increased

116 nfolded protein response and altered amyloid precursor protein (APP) processing.

117 ry synaptic alterations by promoting amyloid precursor protein (APP) processing.

118 other mutations at this site of amyloid beta precursor protein (APP) reduced C99 generation and decre

119 Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis,

120 Abeta is derived from amyloid precursor protein (APP) through sequential proteolytic c

121 eta by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pathway, w

122 ompelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD) and

123 The proteolytic cleavage of beta-amyloid precursor protein (APP) to form the amyloid beta (Abeta)

124 associated with the cleavage of the amyloid precursor protein (APP) to produce the toxic amyloid-bet

125 a pathology and neuroinflammation in amyloid precursor protein (APP) transgenic mice are worsened by

126 ted neurons extracted from preplaque amyloid precursor protein (APP) transgenic rats were found to pr

127 a42) peptide generated from the amyloid-beta precursor protein (APP) via cleavages by beta- and gamma

128 es revealed that the dynamics of the amyloid precursor protein (APP) were significantly impaired.

129 scyllo-inositol, in cells expressing amyloid precursor protein (APP) with the Osaka (E693Delta) mutat

130 thology and astrogliosis in the male amyloid precursor protein (APP)(SWE) /presenilin 1 (PS1)(DeltaE9

131 The amyloid precursor protein (APP), a key player in Alzheimer's dis

132 t of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morphology wa

133 Abeta is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational

134 erol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationship relat

135 esulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofibrillary

136 to an interaction between DISC1 and amyloid precursor protein (APP), and to an association of a sing

137 has been considered because the amyloid-beta precursor protein (APP), APP metabolites, and key APP cl

138 icits as well as the upregulation of amyloid precursor protein (APP), BACE-1, a trending increase in

139 hrough sequential proteolysis of the amyloid precursor protein (APP), first by the action of beta-sec

140 otal-Tau, phosphorylated-Tau (pTau), amyloid precursor protein (APP), GFAP, Iba1, alphaII-spectrin, a

141 metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in the patho

142 linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (PS).

143 rived from proteolytic processing of amyloid precursor protein (APP), play a central role in AD patho

144 The amyloid precursor protein (APP), primarily known as the precurso

145 ls overexpress mutant forms of human amyloid precursor protein (APP), producing high levels of amyloi

146 Similarly to the amyloid precursor protein (APP), PrP(C) is proteolytically cleav

147 gregates of peptide fragments of the amyloid precursor protein (APP), typically 40 or 42 residues in

148 that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in DS and i

149 ese conditions may be constituted by amyloid precursor protein (APP), which plays a pivotal role in t

150 tein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggregates t

151 rily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the g

152 The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is req

153 as recently suggested that beta-site amyloid precursor protein (APP)-cleaving enzyme 2 (BACE2) functi

154 products of the amyloid-beta (Abeta) peptide precursor protein (APP).

155 n the extracellular E2 domain of the amyloid precursor protein (APP).

156 ffects the Alzheimer's disease gene, amyloid precursor protein (APP).

157 lypeptides that are derived from the Amyloid Precursor Protein (APP).

158 wn for oAbeta, also oTau can bind to amyloid precursor protein (APP).

159 ond strengths in the TM helix of the amyloid precursor protein (APP).

160 strikingly overlaps with that of the amyloid precursor protein (APP).

161 alpha-secretase cleavage of the Alzheimer's precursor protein (APP).

162 eneration of Abeta-peptides from the amyloid precursor protein (APP).

163 ism of the Alzheimer disease-related amyloid precursor protein (APP).

164 long Abeta peptides derived from the amyloid precursor protein (APP).

165 Using the amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mo

166 Here we discovered that, in amyloid precursor protein (APP)/presenilin-1 (PS1) mice (age 3-4

167 ular amyloidogenic proteins (amylin, amyloid precursor protein [APP], and amyloid-beta [Abeta]) and a

168 sion of the membrane-bound beta-site amyloid precursor protein-(APP) cleaving enzyme (BACE1) from the

169 n the Kunitz inhibitor domain of the amyloid precursor protein (APPI) that incorporated a new disulfi

170 e have previously shown that the fly amyloid precursor protein (APPL) is required for memory in the M

171 D) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1DeltaE9)

172 hat mutations in the gene coding for amyloid precursor protein are responsible for autosomal dominant

173 Approximately 70% of mitochondrial precursor proteins are imported from the cytosol via N-t

174 These precursor proteins are translocated into mitochondria by

175 This protein is generated from the composite precursor protein Atp25 upon internal cleavage by the ma

176 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeutic target in Alzh

177 used a mouse model expressing human amyloid precursor protein bearing two familial mutations and ask

178 roblastoma cells expressing the beta-amyloid precursor protein (betaAPP) harboring the familial doubl

179 d association of variants at amyloid-beta A4 precursor protein-binding family B member 2 (APBB2; chro

180 se (AD) are tied to mutations in the amyloid precursor protein, but the cellular mechanisms that caus

181 s of AD are tied to mutations in the amyloid precursor protein, but the cellular mechanisms that caus

182 is expressed in the form of a large Gag-Pol precursor protein by suppression of translational termin

183 at is generated by thrombin from the zymogen precursor protein C in a reaction greatly accelerated by

184 Intramembrane cleavage of the beta-amyloid precursor protein C99 substrate by gamma-secretase is im

185 om >100 substrates, including Notch, amyloid precursor protein, cadherins, growth factors, and chemok

186 nied by a decrease in BACE1-mediated amyloid precursor protein cleavage and amyloid-beta levels.

187 "endosomal traffic jam" that drives amyloid precursor protein cleavage to amyloid-beta in endosomes.

188 RNA (miR-188-3p) targeting beta-site amyloid precursor protein cleaving enzyme (BACE)-1, a key enzyme

189 nt to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA demethy

190 Mice were treated with a beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor.

191 beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is an aspart

192 gene driven by the BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) promoter, which inc

193 idogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and

194 Furthermore, increased beta-site amyloid precursor protein-cleaving (APP-cleaving) enzyme 1 (BACE

195 The beta-site amyloid precursor protein-cleaving enzyme (BACE1) is the rate-li

196 is an orally administered beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) inhibitor t

197 ADE levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), gamma-secr

198 beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is best know

199 ion of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on Alzheimer

200 bstrate of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)).

201 major target has been the beta-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), with many

202 The transcript encodes a precursor protein comprising a signal peptide and 5 repe

203 LDA is encoded within a 235-amino acid precursor protein containing multiple cleavage sites tha

204 s partially due to overexpression of amyloid precursor protein, encoded by APP, as a result of the lo

205 Although brain amyloid precursor protein expression and amyloid beta production

206 First, POMC mRNA and precursor protein expression in non-neuronal cells varie

207 a shorter FE65 isoform able to bind amyloid precursor protein family members (APP, APLP1, APLP2), de

208 e released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing

209 ats, such as increased deposition of amyloid precursor protein fragments associated with the appearan

210 tase complex that cleaves Abeta from amyloid precursor protein fragments.

211 Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively examine

212 xpress the Swedish mutant human beta-amyloid precursor protein gene with G protein-coupled receptor k

213 sed by an extra copy of beta-amyloid-(Abeta)-precursor-protein gene.

214 neurons and in mice expressing human amyloid precursor protein (hAPP mice), a model for familial AD t

215 the axon of AD-related mutant human amyloid precursor protein (hAPP) transgenic (Tg) mouse neurons.

216 8 (Tg) transgenic mice express human amyloid precursor protein harboring the Swedish and Indiana fami

217 st and human Sde2 are translated as inactive precursor proteins harbouring the ubiquitin-fold domain

218 r, the structural characterization of intact precursor proteins has been limited.

219 sm by which such peptides emerge from linear precursor proteins has received increased attention; how

220 ed in anterograde trafficking of the amyloid precursor protein in neurons and in the secretion of tum

221 nduced neurons overexpressing mutant amyloid precursor protein in the background of APOE varepsilon3/

222 mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryptic defi

223 s JNK-interacting protein 1 and amyloid beta precursor protein in the brains and spinal cords of MKK7

224 dependent on protease cleavage of the gp160 precursor protein in the Golgi apparatus.

225 terative, autocatalytic alpha- N-methylating precursor proteins in the borosin family of ribosomally

226 hment of the GPI anchor to the C terminus of precursor proteins in the endoplasmic reticulum.

227 sAPPbeta (a soluble beta fragment of amyloid precursor protein) in cerebrospinal fluid (CSF) has been

228 Two protein translocases transport precursor proteins into or across the inner mitochondria

229 ng as synapse-to-nucleus messengers, amyloid precursor protein intracellular domain associated-1 prot

230 and golgi body recycling as well as prolamin precursor proteins involved in refolding of proteins.

231 eature of AD, and endocytosis of the amyloid precursor protein is an important step in its subsequent

232 lzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell types an

233 Here we demonstrate that amyloid precursor protein is involved in regulating the phenotyp

234 hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzy

235 "remapping." We tested remapping in amyloid precursor protein knockin (APP-KI) mice with impaired sp

236 primarily due to triplication of the amyloid precursor protein located on chromosome 21, the precise

237 ization of the resulting products from their precursor protein location.

238 Strikingly, genetic deficiency of the Medin precursor protein, MFG-E8, eliminates not only vascular

239 use model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Abeta.

240 The amyloid precursor protein modulates alpha2A-adrenergic receptor

241 Amyloid precursor protein mutations falling within the amyloid-b

242 d with the intracellular accumulation of the precursor protein of Abeta, APP, as a result of the sele

243 ures of the two genes encoding the different precursor proteins of Ms 9a-1 were determined.

244 Tat precursor proteins possess a conserved twin-arginine (RR

245 ransgenic mice expressing human amyloid-beta precursor protein, presenilin 1, and tau mutations, and

246 intracerebroventricular infusion in amyloid precursor protein/presenilin 1 (APP/PS1) double-transgen

247 of CLU on Abeta pathology using the amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of

248 r, and brain tissues in a late-stage amyloid precursor protein/presenilin-1 (APP/PS-1) human transgen

249 s was coupled with reduced levels of amyloid precursor protein processing and Abeta production, compa

250 the latter case, proteins related to amyloid precursor protein processing and secretion are S-nitrosa

251 ransport in regulating amyloidogenic amyloid precursor protein processing and support a model wherein

252 ese swellings contain high levels of amyloid precursor protein processing enzymes (BACE1 and presenil

253 activity without detectably altering amyloid precursor protein processing or extracellular Abeta/beta

254 protein levels and the related amyloid-beta precursor protein processing, amyloid-beta load and eIF4

255 may contribute to amyloidogenic amyloid-beta precursor protein processing, compromise trophic signall

256 Increased APP (amyloid precursor protein) processing causes beta-amyloid (Abeta

257 levels is not due to a change in mRNA of its precursor protein, proenkephalin, in susceptible mice bu

258 agment of Nogo-A is generated by the amyloid precursor protein protease BACE1 and presented on the me

259 we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche signal in t

260 -secretase, soluble Abeta42, soluble amyloid precursor protein (sAPP)beta, sAPPalpha, glial-derived n

261 ncluding those derived from the same amyloid precursor protein, such as Aeta or sAPPalpha, and autono

262 ransgenic mice expressing human beta-amyloid precursor protein Swedish (Tg-SwDI), a model of cerebrov

263 l signs, astrogliosis, deposition of amyloid precursor protein, synaptic loss and neuronal death were

264 ntified the protein interacting with amyloid precursor protein tail 1 (PAT1) as a potential partner o

265 Amyloid precursor protein/tetracycline transactivator mice under

266 mice expressing mutated forms of the amyloid precursor protein (Tg2576 mice).

267 ansgenic mice overexpressing mutated amyloid precursor protein (Tg2576), Abeta causes dysfunction in

268 pressing the Swedish mutation of the amyloid precursor protein (tg2576).

269 The Vgf gene encodes a secretory peptide precursor protein that has critical neuroendocrine funct

270 Dentin sialophosphoprotein (DSPP) is a precursor protein that is expressed by the connective ti

271 smembrane proteins, most notably the amyloid precursor protein that results in Abeta, a transmembrane

272 Such precursor proteins that could be processed into multiple

273 complex involved in the cleavage of amyloid precursor proteins that lead to the formation of amyloid

274 Proprotein convertases (PC) activate precursor proteins that play crucial roles in various ca

275 e both contribute to the removal of arrested precursor proteins that specifically accumulate in these

276 -terminal fragment (beta-CTF) from the Abeta precursor protein, the gamma-secretase complex produces

277 proteome from the cytoplasm by translocating precursor proteins through the translocase of the outer

278 s biological importance, the thyroid hormone precursor protein, thyroglobulin (Tg), has been experime

279 Hedgehog (Hh) autoprocessing converts Hh precursor protein to cholesterylated Hh ligand for downs

280 y lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.

281 ves the correct folding of the mutant capsid precursor protein to permit virion assembly.IMPORTANCE R

282 a) and has also been shown to cleave amyloid precursor protein to trigger its secretion.

283 s noted in untreated HSCs of postnatal Abeta precursor protein transgenic (APP tg) mice, Abeta deposi

284 Expression analysis of amyloid precursor protein transgenic mice also revealed high lev

285 RNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell lines.

286 Starting at 5 months of age, tet-off amyloid precursor protein transgenic mice were treated with doxy

287 In Alzheimer amyloid precursor protein-transgenic mice and SH-SY5Y cell model

288 expectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in decreased,

289 Abeta deposition becomes detectable in Abeta precursor protein-transgenic mice.

290 TOMM34 and 14-3-3 participated in cytosolic precursor protein transport mediated by the coordinated

291 The human systemic amyloid precursor protein transthyretin (TTR) is known to inhibi

292 he cavity of hexon-the cleaved N terminus of precursor protein VI (pVIn), the cleaved N terminus of p

293 cellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

294 eased the import competence of mitochondrial precursor proteins via an extramitochondrial coaggregati

295 protein VI (pVIn), the cleaved N terminus of precursor protein VII (pVIIn2), and mature protein VI.

296 related mutations in presenilin-1 or amyloid precursor protein vs. isogenic gene corrected controls.

297 ed by mutations in the gene encoding amyloid precursor protein, whose processing can result in format

298 ributes to the productive interaction of Tat precursor proteins with the TatBC receptor complex.

299 ading ultimately to accumulation of immature precursor proteins within mitochondria.

300 or proteolytic activation of a wide array of precursor proteins within the secretory pathway.