ライフサイエンスコーパス: prediagnostic

1 l of the prostate cancer cases (n = 21) with prediagnostic (2-3 years before diagnosis) and diagnosti

2 , n = 267), recent (1995-1999, n = 396), and prediagnostic (2000 and after, n = 770).

3 (tertiles or a priori-defined categories) of prediagnostic 25(OH)D were calculated using conditional

4 erm follow-up and clinicopathologic details, prediagnostic 5-ARI use was not associated with PCa-spec

5 Sensitivity analyses based on prediagnostic 5-ARI use, Gleason score, comorbidity, 5-A

6 ged 50-69 years at baseline, to test whether prediagnostic adiponectin concentrations are associated

7 Prediagnostic alcohol abstaining and heavy drinking were

8 The associations of lifetime and 1-y prediagnostic alcohol consumption with relevant prognost

9 randomly divided into training (292 CTs: 110 prediagnostic and 182 controls) and test subsets (128 CT

10 182 controls) and test subsets (128 CTs: 45 prediagnostic and 83 controls).

11 (RR) were estimated for associations between prediagnostic aspirin use and lymph node-positive status

12 Our findings indicate that recent prediagnostic aspirin use is protective against lymph no

13 Prediagnostic aspirin use was associated with lower 5-ye

14 Women with prediagnostic aspirin use were statistically significant

15 % confidence interval [CI], 88 to 100) had a prediagnostic B-cell clone; in 41 patients (91%; 95% CI,

16 ined up to 77 months before a CLL diagnosis, prediagnostic B-cell clones were present in 44 of 45 pat

17 ed the immunoglobulin gene repertoire of the prediagnostic B-cell clones.

18 emonstrates that serum RNAs can be promising prediagnostic biomarkers in an LC screening setting, fro

19 sample from participants for measurement of prediagnostic biomarkers, assuming that 1 measurement ad

20 assessed by molecular backtracking of paired prediagnostic blood and tumor samples.

21 Prediagnostic blood from these and 218 controls were scr

22 he authors examined the associations between prediagnostic blood levels of micronutrients and prostat

23 he median time between the collection of the prediagnostic blood sample and the subsequent CLL diagno

24 var, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collected on average 3 and

25 entified 170 individuals who had donated two prediagnostic blood samples before B-cell lymphoma diagn

26 studies that applied metabolomic analyses to prediagnostic blood samples from prospective epidemiolog

27 Here, we used prediagnostic blood samples from three studies to analyz

28 92 circulating inflammatory proteins in 648 prediagnostic blood samples from two prospective cohorts

29 phoma-free controls who had available stored prediagnostic blood samples.

30 Together with data from prediagnostic blood specimens showing positive associati

31 nal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated th

32 Compared with survivors with normal prediagnostic BMI (18.5-24.9 kg/m(2)), those who were ov

33 We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (re

34 udies have investigated associations between prediagnostic BMI change and CRC prognosis.

35 The associations of BMI at diagnosis and prediagnostic BMI change with relevant prognostic outcom

36 Compared with stable BMI, a strong prediagnostic BMI decrease of >5 was associated with poo

37 Higher prediagnostic BMI was associated with more advanced stag

38 Higher prediagnostic BMI was associated with statistically sign

39 ls to examine associations between baseline (prediagnostic) BMI and risk of second obesity-associated

40 er, studies have not prospectively evaluated prediagnostic body mass index (BMI) and survival.

41 rasting with marked autonomic involvement in prediagnostic body-first cases.

42 sible cancer symptoms may be associated with prediagnostic care and time to cancer diagnosis.

43 sociation of non-Hodgkin lymphoma (NHL) with prediagnostic carotenoid levels, a marker for a diet ric

44 t-retest reliability of saccadic measures in prediagnostic carriers of the HD gene expansion (PDHD) a

45 For prediagnostic cases below cutoff value for CA19-9, the c

46 brain-first and body-first subtypes in early prediagnostic cases with mild Lewy pathology.

47 arkedly for recent cases and disappeared for prediagnostic cases.

48 ses but made little difference for recent or prediagnostic cases.

49 1.5 (95% confidence interval: 1.2, 1.9) for prediagnostic cases.

50 Information on prediagnostic cigarette smoking, alcohol consumption, an

51 mined the association of VDR expression with prediagnostic circulating 25(OH)D and 1,25-dihydroxyvita

52 ncers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were as

53 e was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D]

54 Heavy smokers defined by prediagnostic circulating cotinine levels had a multivar

55 We investigated whether prediagnostic circulating hormone and sex hormone bindin

56 We investigated whether prediagnostic circulating hormone and sex hormone bindin

57 ve US cohorts, we also evaluated survival by prediagnostic circulating levels of cotinine, a metaboli

58 of this study was to simultaneously contrast prediagnostic clinical characteristics of individuals wi

59 able (IGHV) genes was determined in 35 of 45 prediagnostic clones (78%).

60 etric pancreas segmentation was performed on prediagnostic computed tomography scans (CTs) (median in

61 Prediagnostic concentrations of estradiol, estrone, and

62 dition, which often has a long and insidious prediagnostic course, might result in earlier identifica

63 Median (range) time between prediagnostic CTs of the test subset and PDAC diagnosis

64 udy offers an innovative approach to examine prediagnostic disease and cancer development in a large

65 ncrease in MS risk among women with elevated prediagnostic EBNA-1 IgG levels is consistent with previ

66 ions; however, findings may be attributed to prediagnostic effects of tumors or recall bias.

67 A range of prediagnostic features can be detected several years bef

68 ease diagnosis, the incidence of all studied prediagnostic features except neck pain or stiffness was

69 iation between first presentation of several prediagnostic features in primary care and a subsequent

70 ons of 6-sulfatoxymelatonin were measured in prediagnostic first-morning urine samples from 251 breas

71 to diagnosis (effect size for the 0-38 weeks prediagnostic group, 1.91; P, 8.3E-05).

72 We investigated the relationship between prediagnostic HDL-C and non-Hodgkin lymphoma (NHL) in th

73 of machine learning models trained to detect prediagnostic heart failure in primary care patients usi

74 These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated w

75 e observed both in tumor-bearing mice and in prediagnostic human samples.

76 All women reported on prediagnostic intake; a subsample of 4,881 reported on p

77 interest exists in the potential efficacy of prediagnostic interventions within the autism spectrum d

78 cant associations for cases with the longest prediagnostic lag (9 to 13 years).

79 Our study supports the existence of three prediagnostic LBD subtypes and highlights the sympatheti

80 n was used to study the associations between prediagnostic levels of high-sensitivity C-reactive prot

81 We evaluated the association between prediagnostic levels of IGF-I and insulin-like growth fa

82 To investigate whether prediagnostic levels of plasma folate are associated wit

83 In two large prospective cohorts, higher prediagnostic levels of plasma folate were not associate

84 In conclusion, higher prediagnostic levels of plasma leptin were associated wi

85 Prediagnostic levels of testosterone, androstenedione, d

86 The association between prediagnostic levels of urinary total NNAL and risk of l

87 an analysis of a third set consisting of 18 prediagnostic lung cancer sera collected as part of the

88 The authors retrieved several prediagnostic mammograms for breast cancer cases and for

89 s study, we investigated the associations of prediagnostic measures of N(epsilon)-(carboxymethyl)-lys

90 Activities of Daily Living Scale), potential prediagnostic motor (hypo- and bradykinesia, tremor, rig

91 e assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from n = 81/160 EAC and

92 Of the 21 individuals with documented prediagnostic NNRP, 43% (nine out of 21) were seropositi

93 m metabolite with significant performance in prediagnostic NSCLC and has additive performance with pr

94 ns, kappa/lambda free light chains (FLCs) in prediagnostic obtained up to 9.8 years before CLL diagno

95 dence for an independent association between prediagnostic omentin concentrations and colorectal canc

96 Codes were extracted for a range of possible prediagnostic or early symptoms, comprising motor featur

97 ate the progression to neoplasia from serial prediagnostic pancreatic imaging tests in high-risk indi

98 The field of prediagnostic Parkinson's disease (PD) is fast moving wi

99 From 7 years before diagnosis onwards, prediagnostic Parkinson's disease cases more commonly ha

100 In conclusion, in patients with prediagnostic Parkinson's disease, impairments in instru

101 Prediagnostic PCP use, measured in the 5 years prior to

102 ogical description, and understanding of the prediagnostic, peridiagnostic and immediate postdiagnost

103 types of NSAIDs combined during the 10-year prediagnostic period than did controls (odds ratio (OR)

104 symptoms absent or not considered abnormal); prediagnostic phase (symptoms noticed but diagnosis not

105 20% ("passive"); early diagnosis during the prediagnostic phase at a rate of 10% per year ("enhanced

106 Advances in the understanding of this prediagnostic phase of Parkinson's disease (for which th

107 review, we outline current knowledge of the prediagnostic phase of PD, including an up-to-date revie

108 The prediagnostic phase of the disease offers a window of op

109 played minimal peripheral organ pathology in prediagnostic phases, contrasting with marked autonomic

110 We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and l

111 fied risk of prostate cancer associated with prediagnostic plasma antioxidants (P(interaction) > or =

112 ORs and 95% CIs for the association between prediagnostic plasma concentrations of sICAM-1 and cance

113 th early disease, we profiled metabolites in prediagnostic plasma from individuals with pancreatic ca

114 ession to evaluate pancreatic cancer risk by prediagnostic plasma leptin, adjusting for race/ethnicit

115 Mean prediagnostic plasma level of 25(OH)D was 24.6 ng/mL, an

116 ts with pancreatic cancer who had sufficient prediagnostic plasma levels of 25(OH)D.

117 To investigate whether prediagnostic plasma levels of IGFBP-1 are associated wi

118 We assessed the association of prediagnostic plasma metabolites (N = 420) with risk of

119 We investigated the association between prediagnostic plasma omentin concentrations and risk of

120 Prediagnostic plasma samples from patients (collected, o

121 Prediagnostic plasma samples were collected, and 484 pro

122 Neither prediagnostic plasma vitamin D levels nor VDR polymorphi

123 Prediagnostic PLCO serum samples were tested for GBV-C R

124 from diagnosis to assess the association of prediagnostic prescribed use of common psychiatric medic

125 The risk of ALS diagnosis associated with prediagnostic prescribed use of common psychiatric medic

126 Prediagnostic presentations of falls, psychiatric sympto

127 ermine associations between risk factors and prediagnostic presentations to primary care with subsequ

128 Analysis of 86 prediagnostic samples and 86 matched normal controls fro

129 Prediagnostic samples and samples from 2,623 matched con

130 HPV16 E6 seropositivity was present in prediagnostic samples for 34.8% of patients with orophar

131 aphy to measure blood SFA and MUFA levels in prediagnostic samples from 476 incident prostate cancer

132 Prediagnostic samples were analyzed for alpha-carotene,

133 In 30 of 90 patients, 110 prediagnostic samples were available from 2.2 to 15.3 ye

134 and/or structural variant in 91% (63/69) of prediagnostic samples with the mutational spectrum mirro

135 the CLL clonotype was already present in the prediagnostic samples.

136 a strong dose-response relationship between prediagnostic sCD30 concentration and NHL risk among 234

137 performed using an independent set of CARET prediagnostic sera from 108 patients with NSCLC and 216

138 l, and Ovarian (PLCO) risk model) assayed in prediagnostic sera from 552 lung cancer cases and 2,193

139 analysis identified 40 of the 48 proteins in prediagnostic sera from NSCLC samples, of which, 21 occu

140 plied to identify biomarker candidates using prediagnostic sera from the Beta-Carotene and Retinol Ef

141 very of novel antigens and for validation in prediagnostic sera of autoantibodies to antigens previou

142 ver been determined by laboratory testing on prediagnostic sera.

143 her additional antigens may be identified in prediagnostic sera.

144 h head and neck cancer risk when measured in prediagnostic sera.

145 74 years of age at baseline to test whether prediagnostic serum 25(OH)D concentrations were associat

146 This study showed that prediagnostic serum 25(OH)D concentrations were not asso

147 adequate vitamin D status, as determined by prediagnostic serum 25(OH)D concentrations, was associat

148 Our findings suggest that higher prediagnostic serum 25(OH)D levels may be associated wit

149 Prediagnostic serum concentration of soluble CD30 (sCD30

150 We measured prediagnostic serum concentrations of DDT, its metabolit

151 an (PLCO) Cancer Screening Trial.We examined prediagnostic serum concentrations of diet-related metab

152 d with ER-negative breast cancer (144 cases).Prediagnostic serum concentrations of metabolites relate

153 We examined the associations between prediagnostic serum concentrations of sRAGE or N-(carbox

154 Prediagnostic serum DBP and 25(OH)D were studied in rela

155 ted adductomics to detect adduct features in prediagnostic serum from the EPIC Italy cohort.

156 y II Nutrition Cohort to investigate whether prediagnostic serum leptin was associated with pancreati

157 authors investigated the association between prediagnostic serum levels of oxidative stress indicator

158 Prediagnostic serum or plasma concentrations of selected

159 ctive cohort studies were able to contribute prediagnostic serum or plasma samples for hormone quanti

160 In conclusion, prediagnostic serum ROM levels were associated with incr

161 We measured TARC levels in prediagnostic serum samples and found strikingly increas

162 To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 contr

163 e a wide range of metabolites was applied to prediagnostic serum samples from CARET participants (cur

164 e study in whom serially collected (up to 6) prediagnostic serum samples obtained 2 to 9.8 years prio

165 77 469 participants, with serially collected prediagnostic serum samples.

166 Greater prediagnostic serum selenium concentrations were not ass

167 eactive protein, and sCD27] were measured in prediagnostic serum specimens from 297 incident NHL case

168 The presence of HGV RNA in prediagnostic serum was not associated with the risk of

169 uals at high risk of nonfamilial cancer, and prediagnostic signs and symptoms are vague and not limit

170 We assessed the association between prediagnostic smoking and second smoking-associated canc

171 We ascertained prediagnostic social characteristics from national regis

172 ncreatic ductal adenocarcinoma (PDAC) at the prediagnostic stage (3-36 months before clinical diagnos

173 trials being planned for individuals in the prediagnostic stage of HD propose to use delay of diseas

174 ical trials that may be sensitive during the prediagnostic stage.

175 be sensitive and specific biomarkers in the prediagnostic stages of Huntington disease (HD).

176 Prediagnostic statin use was a risk factor for BC death

177 Between December 1993 and August 1994, prediagnostic sTNFp55 concentrations (a marker of excess

178 actors for pancreatic cancer with detectable prediagnostic symptomatology can allow investigators to

179 To examine associations of prediagnostic systemic inflammation with at-diagnosis sa

180 arly detection of LC in smokers at different prediagnostic time intervals and histological subtypes.

181 Subsequently, we compared prediagnostic trajectories of daily functioning and othe

182 Prediagnostic urinary 15-F(2t)-IsoP and 15-F(2t)-IsoPM w

183 In this study, we quantified prediagnostic urinary levels of r-1,t-2,3,c-4-tetrahydro

184 ific and all-cause mortality associated with prediagnostic use of 5-ARIs.

185 demonstrated among patients with ALS who had prediagnostic use of anxiolytics (hazard ratio [HR], 1.5

186 ined the association between recent (1 year) prediagnostic use of aspirin (COX1/COX2 inhibitor), lymp

187 lity, and considering effect modification by prediagnostic use of statins.

188 Prediagnostic use of such medications was also associate

189 %; 86.7-93.7) for classification of CTs into prediagnostic versus normal.

190 ntrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreat

191 se-control study, accounting for substantial prediagnostic weight loss further highlighted the associ

192 Our results support that an increasing prediagnostic whole-blood level of cadmium is associated

193 iation between 12 trace elements measured in prediagnostic whole-blood samples and PDAC.