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3 a hot spot for copy number variations, which predispose carriers to a range of neuropsychiatric pheno
4 l groups, yet whether personality traits may predispose individuals to a particular rank remains uncl
5 both inflammatory and immunosuppressive and predisposes mice to a defective immune response to a min
6 related long-lasting immunosuppressive state predisposes patients to a higher risk of postoperative c
8 otine dependence (ND) have disclosed too few predisposing variants to account for the high estimated
9 n the gene encoding complement factor H (FH) predisposes individuals to acquiring age-related macular
10 ses the latest on how the vaginal microbiota predisposes women to acquisition of STIs and discusses f
13 e investigated whether a high level of suPAR predisposed patients to acute kidney injury in multiple
16 Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorec
17 ice and humans, and genetic deletion of Dab2 predisposed macrophages to adopt a proinflammatory M1 ph
18 uggest that the deletions of CCL2 and CX3CR1 predispose mice to age- and light-mediated retinal damag
22 l exposure to diesel exhaust particles (DEP) predisposed offspring to allergic airway disease (AAD, m
27 xposure to dietary refined carbohydrates may predispose offspring to an obese phenotype, indicating a
28 s may elicit a strong inflammatory response, predisposing recipients to an increased risk of cancer a
31 bserved during infections, may significantly predispose recipients to antibody-mediated TRALI reactio
32 nsulin resistance, obesity, and diabetes may predispose offspring to ASD by mechanisms involving chro
35 , it is unclear whether genetic risk factors predispose individuals to autism as a result of modifica
37 oestrogen inhibits lung development and may predispose individuals to be vulnerable to lung disease
38 ts substantial alterations, which we suggest predisposes it to be more active at low temperature.
39 segment, caesarean scars may heal improperly predisposing it to be a site of improper implantation of
40 atory networks of related sets of genes have predisposed miRNAs to become ideal candidates for drug d
44 nd Escherichia coli in the intestinal lumen, predisposing patients to bloodstream invasion and sepsis
50 d to have a germline mutation in a gene that predisposes women to breast or ovarian cancer, using a p
51 We hypothesized that hyperoxic exposure, a predisposing factor to bronchopulmonary dysplasia, modul
54 em-cell-derived forebrain excitatory neurons predisposes neurons to calcium dysregulation and ultimat
64 ntravascular catheters, forming biofilms and predisposing patients to catheter-associated infection (
69 esting that the mutation identified here may predispose patients to cholestasis through a delocalizat
71 reduction (MNR) during fetal development may predispose offspring to chronic disease later in life.
74 that may be partly established at birth and predisposes them to chronic obstructive pulmonary diseas
78 hinning for at least ~300 years, potentially predisposing them to collapse under intensified anthropo
80 dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovari
81 germline genetic variation in Mendelian loci predisposes bearers to common cancers, the same loci may
83 mplex pathway to maintain DNA integrity also predispose patients to constitutional defects in growth
84 th a possible role of psychiatric disease in predisposing patients to critical illness and an increas
85 ium elongation defects in kidney tubules and predisposed animals to cyst development, either in genet
86 ADeltaE, suggesting that the DeltaE mutation predisposes torsinA to defects in the presence of second
88 ven a single moderate to severe TBI can also predispose individuals to develop a pathologically disti
89 Obesity and associated insulin resistance predispose individuals to develop chronic metabolic dise
92 oded by CDH1), inactivation of Cdh1 does not predispose mice to develop mammary tumors, implying that
93 posure to artificial sweeteners in utero may predispose offspring to develop obesity; however, to our
94 experienced an onset of depression; this may predispose them to develop not only MDD but also other a
95 in two independently generated mouse strains predisposed mice to develop obesity, metabolic inflammat
96 t (AT) is an early-life heritable trait that predisposes individuals to develop anxiety and depressiv
97 findings demonstrate that an APOE3 genotype predisposes mice to develop obesity and its metabolic co
98 that an increase of intracellular Hcy levels predisposes neurons to develop abnormal protein aggregat
99 about having a mutation in their blood that predisposes them to develop a malignancy, but which is s
102 lium to metaplastic columnar epithelium that predisposes individuals to developing esophageal adenoca
103 of MaSC-like properties by luminal cells and predisposes them to development of mammary tumours with
104 upts rhythmic cycling of Ly6C(hi) monocytes, predisposing mice to development of pathologies associat
105 anism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnor
106 indicating pre-existing circuit function can predispose animals to differential fearful responses to
109 cular degeneration (AMD), and AP dysfunction predisposes individuals to disorders such as paroxysmal
111 sage through the mitosis-G1 transition might predispose cells to diverge in gene expression states.
113 ion that behaves as a partial FH deficiency, predisposing individuals to diverse pathologies with dis
114 ssociated with hepatic metabolic dysfunction predisposing patients to drug-induced liver injury.
115 t leads to dystonia: a background level that predisposes individuals to dystonia, a disease-related l
118 ess, intravenous drug use, and alcohol abuse predisposed patients to emm32.2 iGAS disease; however, n
120 as a specific heterochromatin landscape that predisposes it to erosion of X chromosome inactivation (
121 n of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma, a tum
123 of DNA replication through the (CGG)n repeat predisposes it to expansions during intergenerational tr
124 a demonstrate that loss of CFTR function may predispose patients to experience depression and that th
126 inflammatory responses that may progress, in predisposed individuals, to fibrosis and cirrhosis.
127 t triggers biased G-protein agonism and thus predisposes platelets to full activation by other stimul
128 se platelet aggregation, but it is enough to predispose platelets to fully respond to Gi-activating s
129 dies have nominated a number of processes in predisposing PCA to genomic rearrangements, including an
130 radation of wild-type BRCA2 protein, thereby predisposing them to genomic instability and perhaps to
131 ion that increases in frequency with age and predisposes individuals to haematological malignancy.
132 characteristics of prestimulus activity that predisposed participants to hallucinations: overall lowe
133 characteristics of prestimulus activity that predisposed participants to hallucinations: overall lowe
134 y affinity maturation suggests that LypW may predispose individuals to have a diminished capacity to
135 uggests that (1) genetics play a bigger role predisposing eczema to hay fever and eczema to asthma th
136 nd (7) too many vaccines given early in life predisposing children to health and developmental proble
137 may adversely influence myocardial function, predisposing individuals to heart failure later in life.
138 Genetic disorders of lymphocyte cytotoxicity predispose patients to hemophagocytic lymphohistiocytosi
139 srupts the generation of normal blood cells, predisposing patients to hemorrhage, anemia, and infecti
141 dyskinesia, in which mucociliary dysfunction predisposes subjects to high rates of nontuberculous myc
142 Males are less compliant, which in turn may predispose them to higher colonization and infection rat
143 er CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications
145 mimic the high-progesterone luteal phase and predispose women to human immunodeficiency type 1 (HIV-1
146 y contribute to abnormal blood lipid levels, predisposing individuals to human cardiometabolic disord
147 tial biomass allocation aboveground that (1) predispose plants to hydraulic constraints limiting phot
148 tified specific quantitative trait loci that predispose animals to hypertension-associated albuminuri
150 an vary 10-fold, with reduced nephron number predisposing individuals to hypertension, renal, and car
151 allosteric opening of the active site, thus predisposing PBP2a to inactivation by a second beta-lact
152 idence suggesting that early-life stress may predispose individuals to increased anxiety and depressi
153 uced left ventricular ejection fraction (EF) predisposes patients to inducible VT after ST-segment-el
155 function characterized by immune depression, predisposing patients to infections, and immune activati
156 variants of inflammasome components known to predispose individuals to inflammatory disorders have a
157 h fat and simple sugar content-is thought to predispose individuals to inflammatory skin diseases suc
158 xpression of E4 in stem-cell-derived neurons predisposes them to injury and promotes the release of p
159 growth, and even mild, episodic stresses can predispose plants to inoculum levels they would otherwis
160 ong evidence that >/= 1 yr of severe drought predisposes pinon to insect attacks and increases mortal
162 haracteristic of end-stage liver disease may predispose patients to intestinal MDRB colonization and
164 riboswitches have 3b.3n sequences that would predispose them to ion-induced folding, U4 snRNA are str
168 ns, independent of pathogen replication, may predispose hosts to life-threatening environmental stres
169 onstraints, mutations in which are likely to predispose individuals to life-threatening disease, as i
170 Neutrophils in particular are defective, predisposing patients to life-threatening bacterial infe
171 rotein modification system in CVB3 infection predisposed mice to long-term disease with deposition of
173 monocytes to chemokine-induced recruitment, predisposing macrophages to M1 polarization, decreased a
174 rospectively identify anatomic variants that predispose patients to major surgical complications; how
176 netheless, loss of E-cadherin alone does not predispose mice to mammary tumor development, indicating
177 the Brca1185stop and Brca15382stop mutations predisposed animals to mammary tumors, but Brca1185stop
178 phisms between low-copy repeats (LCRs) might predispose chromosomes to meiotic non-allelic homologous
180 age 25 years, 16 of 42 patients (38%) had a predisposing mutation to meningioma and 27 of 135 patien
181 uld increase MERS-CoV receptor abundance and predispose individuals to MERS morbidity and mortality,
182 mutations in the BAP1 tumor suppressor gene predispose individuals to mesothelioma and other cancers
183 rahepatic cholestasis of pregnancy (ICP) can predispose offspring to metabolic disease in adulthood,
188 Obesity is a major public health problem, predisposing subjects to metabolic syndrome, type 2 diab
189 Efforts to identify genetic aberrations that predispose tumors to metastasis have been mostly unsucce
190 s in a gene encoding a ribosomal protein can predispose individuals to microsatellite-stable colon ca
192 ed childhood genetic diseases and those that predispose individuals to more common complex diseases.
193 uncharacterized NK cell functional deficits predispose individuals to more significant or frequent h
194 tly with severe PACG, suggesting that it may predispose patients to more aggressive disease developme
199 association with NAFLD, genetic factors that predispose liver to NAFLD and molecular mechanisms by wh
201 a large degree of phenotypic plasticity that predisposes them to neoplastic transformation and acquis
204 t are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, in
208 ion is that most mutations in the genes that predispose us to obesity are neutral and have been drift
210 Maternal obesity and high-fat diet (HFD) predisposes offspring to obesity and metabolic diseases.
212 sistance in opportunistic pathogens that may predispose individuals to opportunistic infections.
213 Immunosuppression after measles is known to predispose people to opportunistic infections for a peri
214 CKD have unsuspected genomic disorders that predispose them to organ malformations and neurocognitiv
215 any one of the four antigenic types of DENV predispose populations to outbreaks, viral genetic deter
216 by aberrant mitochondrial metabolism, which predisposes cells to oxidative stress and apoptosis.
218 VPA does not cause injury on its own, but it predisposes patients to pancreatitis by inhibiting HDACs
223 ed in animal models of chronic pain that may predispose patients to persistent neuropathic pain after
224 enesis is needed to define determinants that predispose patients to PML, a goal whose urgency is heig
225 Moreover, maternal and paternal obesity predispose offspring to poor cognitive outcomes by epige
227 nomer-mediated transcriptional effects could predispose individuals to prolonged behavioral and metab
229 leasant information, as measured by the LPP, predispose children to psychiatric symptoms when exposed
235 uring the first 5 years after birth, thereby predisposing individuals to reduced lung function and in
236 arly immune response to HDM allergen, likely predisposing neonates to respiratory infection and alter
237 genetic susceptibility allele for psoriasis, predisposes patients to respond differently to the 2 mos
238 by abnormal intravitreal neovascularization predisposing patients to retinal detachment and blindnes
240 n females than in males, which theoretically predisposes them to SAS in large parts of their genome.
242 Seasonal and especially pandemic influenza predispose patients to secondary bacterial pneumonias, w
243 sed ATG7 levels and an autophagy defect that predisposes cells to secondary mutations, resulting in t
248 ganglia reward, circuitries in a manner that predisposes individuals to self-medicating behaviors lik
250 significant gut bacterial translocation and predisposes patients to serious infections with gut orig
253 ecifically, maternal stress during pregnancy predisposes offspring to sex-biased neurodevelopmental d
255 orms the end of the substrate binding cavity predisposes them to single amino acid substitutions that
257 ne proteins can affect receptor function and predispose individuals to specific autoinflammatory diso
258 hat neural-specific knockout of nucleostemin predisposes embryos to spontaneous DNA damage that leads
260 egy to screen for genes that upon repression predispose mice to squamous cell carcinomas (SCCs).
261 en chronically or repeatedly activated-might predispose individuals to stress-related psychopathology
262 rs generate an abundance of micronuclei that predispose chromosomes to subsequent catastrophic pulver
267 er of genetic alterations or conditions that predispose individuals to the development of ALL and tre
268 e or bacterial microbiota have been shown to predispose individuals to the development of opportunist
270 bulbar manifestations, or low lung volumes, predispose patients to the development of obstructive ev
271 urate levels observed in patients with gout predispose them to the formation of monosodium urate (MS
273 expansion but arrests differentiation, which predisposes mice to the development of liver tumors.
275 gus is a chronic precancerous condition that predisposes patients to the development of oesophageal a
276 of nonalcoholic fatty liver disease (NAFLD), predisposes patients to the risk of developing hepatocel
277 ational loss of the skin barrier protein FLG predisposes subjects to the development of atopic dermat
278 ty.SIGNIFICANCE STATEMENT High-trait anxiety predisposes sufferers to the development of anxiety and
279 esophagus to the left atrial posterior wall predisposes esophagus to thermal injury during catheter
281 , we hypothesised that certain genotypes may predispose individuals to these lesions and consequently
283 action within the adult Leydig cell lineage predisposes individuals to this late-onset degeneration
287 ersistence of intravascular aged neutrophils predisposed them to thrombo-inflammation and death.
291 and novel potent off-target sites, which can predispose patients to treatment failure and adverse eff
295 that germline ELP1 loss-of-function variants predispose individuals to tumour development in combinat
296 ng mice and humans are primed for apoptosis, predisposing them to undergo cell death in response to g
297 ctions for the control of hand movements and predispose them to undertake different, perhaps somewhat
299 s, can greatly impact adult behavior and may predispose individuals to various psychopathologies.
300 icates that prenatal cannabis exposure (PCE) predisposes offspring to various neuropsychiatric disord