ライフサイエンスコーパス: predisposition

1 mutations were calculated to assess genetic predisposition.

2 gest greater risk where there is an existing predisposition.

3 iant at the 5q22 locus, rs73227498, with PTC predisposition.

4 lop in patients with hereditary and familial predisposition.

5 e tailored to individual patterns of genetic predisposition.

6 or body mass index interacts with polygenic predisposition.

7 thout a known (or as-yet-identified) genetic predisposition.

8 ivity analyses that suggested shared genetic predisposition.

9 sues for mapping psychiatric disease genetic predisposition.

10 s lead to diseases that are marked by cancer predisposition.

11 e insufficiencies, lipodystrophy, and cancer predisposition.

12 ncer predisposition yet consistent in glioma predisposition.

13 tic disorder that is marked by strong cancer predisposition.

14 ted with congenital abnormalities and cancer predisposition.

15 emonstrate how this locus contributes to CAD predisposition.

16 en for Lynch syndrome (LS)-associated cancer predisposition.

17 frequently associated with germline genetic predisposition.

18 n specific patient groups and suggest shared predisposition.

19 nd understanding the genomic role in disease predisposition.

20 g independent lesions mediated by a germline predisposition.

21 elated precursors on a background of genetic predisposition.

22 identified genes CTR9, REST and TRIM28 in WT predisposition.

23 d endocrine systems and/or heightened tumour predisposition.

24 by anemia, congenital anomalies, and cancer predisposition.

25 between environmental factors and inherited predisposition.

26 o genes that may contribute to breast cancer predisposition.

27 iation and play an important role in disease predisposition.

28 ve clinical implications for genetic disease predispositions.

29 USA to retrospectively investigate mortality predispositions.

30 exposures to exciting causes than to reverse predispositions.

31 Genetic predisposition accelerates the trajectory.

32 Genetic predisposition accounts for 5 to 10% of cancer diagnoses

33 lves a variety of factors, including genetic predisposition, acute injury and chronic inflammation(2-

34 ta-cells to their own demise, and epigenetic predispositions affecting both immune and islet cells.

35 Genetic predisposition affects the penetrance of tumor-initiatin

36 rmline variants in these genes confer strong predisposition (albeit with incomplete penetrance).

37 n studying unconscious responses as the real predispositions, alignment between conscious and unconsc

38 of HLA-DRB1 with smoking history in disease predisposition, along with predicted patterns of peptide

39 atory and autoimmune mechanisms, and genetic predisposition also interplay in the disease association

40 Differences in the incidence of genetic predisposition and clinical presentation of sinusoidal o

41 s clear that the interaction between genetic predisposition and early life environmental exposures is

42 resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exp

43 be a result of the interplay between genetic predisposition and increased vulnerability to early envi

44 rally normal rat hearts, identify arrhythmia predisposition and investigate mechanisms underlying arr

45 numbers, which subsequently enhances tumour predisposition and progression.

46 human genetic variation might affect disease predisposition and progression.

47 nt establishes a formal link between genetic predisposition and skin inflammation observed in HS.

48 ehensive analysis for both hereditary cancer predisposition and somatic profiling.

49 ghts into the relationship between inherited predisposition and the regulatory chromatin landscape of

50 xhibited many MVA features, including cancer predisposition and various progeroid phenotypes, such as

51 caused by a combination of prenatal genetic predispositions and oncogenic events occurring after bir

52 clinical data, this study aimed to identify predispositions and protections in brachycephalic dogs a

53 ental defects, hematopoietic failure, cancer predisposition, and metabolic disorders.

54 n genes involved in liver disease and cancer predisposition are associated with NAFLD-HCC development

55 Poor metabolic control and host genetic predisposition are critical for diabetic kidney disease

56 Although early predispositions are connected to physiological developme

57 Although genetic predispositions are frequent in children (>1% to 5%), fe

58 Approximately 10% of cases exhibit familial predisposition, but causative genes are not known in mos

59 ental states of members of their own race, a predisposition called the own-race bias, which can be si

60 t matching instruction to individual genetic predispositions can enhance learning.

61 e that matching the tutor song to individual predispositions can improve learning across genetic back

62 sorders, and to relate variations in them to predisposition, clinical course, treatment response, neu

63 LS is the most common inherited cancer predisposition condition and confers an elevated lifetim

64 reated with lumpectomy regardless of genetic predisposition; contralateral annual mammogram may be of

65 ividuals who had "special susceptibilities." Predispositions could lead to "affects, passions, and pe

66 L1 mutations in SDS, we define this leukemia predisposition disorder as a ribosomopathy that is cause

67 F2) is an autosomal dominant Mendelian tumor predisposition disorder caused by germline pathogenic va

68 is an autosomal-dominant, pleiotropic tumor-predisposition disorder caused by pathogenic germline va

69 term encompassing four overgrowth and cancer predisposition disorders associated with germline PTEN m

70 cally processed, and appeal to psychological predispositions distinctly from other recruitment narrat

71 rldwide, is a systemic disorder with genetic predisposition due to variations in lysyl oxidase-like 1

72 These changes may be due to genetic predisposition, environmental perturbations, medication

73 ogy is complex and involves a strong genetic predisposition, epidermal dysfunction, and T-cell driven

74 tic stem cells and their progeny, can act as predisposition events, facilitating mutant haematopoieti

75 In this "predisposition-excitation framework" (PEF) for the etiol

76 genes, indicating that further Wilms tumour predisposition factors await discovery.

77 r and dilation of acinar lumen are potential predisposition factors.

78 SVMR showed genetic predisposition for alcohol consumption to be associated

79 Our findings identify that a genetic predisposition for autism is associated with adverse lif

80 In this study we investigated if a genetic predisposition for autism is associated with childhood t

81 in LDL-C on average than those with genetic predisposition for average LDL-C.

82 A2 gene mutations have an underlying genetic predisposition for breast and ovarian cancers.

83 ovide an overview of key aspects of germline predisposition for cancer in this age group.

84 , this supports the possibility that genetic predisposition for complex disease is manifested through

85 posed that the naive state may have enhanced predisposition for differentiation along this extraembry

86 ification of myeloid neoplasms with germline predisposition for each of these and other genes was add

87 to predatory wasps leads to inheritance of a predisposition for ethanol-rich food for five generation

88 For example, individuals with genetic predisposition for higher LDL-C had a lesser decrease in

89 A genetic predisposition for HLH was not identified in any patient

90 ctive tissue disease (CTD) associated with a predisposition for intestinal inflammation, food allergy

91 the first study to show that greater genetic predisposition for MS is associated with higher global b

92 e repertoire before transplant, suggesting a predisposition for post-transplant rejection risk.

93 ository using a gold standard of known breed predispositions for certain diseases (i.e., mitral valve

94 Here, we investigate whether predispositions for uncertainty-guided information seeki

95 al mechanism remains unclear for the disease predisposition from environmental Cd exposure.

96 ssense variants in a single copy of a cancer predisposition gene and earlier age of cancer diagnosis.

97 (.) ELP1 was the most common medulloblastoma predisposition gene and increased the prevalence of gene

98 esumed loss-of-function variants in a cancer predisposition gene can retain function due to their dir

99 TMEM79 is a predisposition gene for Atopic dermatitis, suggesting de

100 distinct second hits in SMARCA4, a putative predisposition gene for neuroblastoma.

101 CI, 5.5 to 32.5), and having a breast cancer predisposition gene mutation (HR, 23.0; 95% CI, 7.3 to 7

102 er in models excluding survivors with cancer predisposition gene mutations, chest radiation 10 Gy or

103 These results reveal NTHL1 as a multi-tumor predisposition gene with a high lifetime risk for extrac

104 of a deleterious allele in a known germline predisposition gene, and variant persistence identified

105 ide evidence, for the first time in a cancer-predisposition gene, that certain presumed null variants

106 ting the role of KDM3B as a childhood cancer predisposition gene.

107 mline pathogenic variants in 9 breast cancer predisposition genes (ATM, BRCA1, BRCA2, CDH1, CHEK2, NF

108 ogenic variants in 8 known hereditary cancer predisposition genes (PALB2, MLH1, MSH6, CHEK2, SMARCE1,

109 of age achieved > 90% sensitivity for the 9 predisposition genes and > 98% sensitivity for BRCA1 and

110 ap between these 21 constitutionally mutated predisposition genes and 20 genes somatically mutated in

111 e sensitivity of NCCN criteria was 70% for 9 predisposition genes and 87% for BRCA1 and BRCA2, with a

112 e WT cohorts revealing an expanding array of predisposition genes and associated genetic conditions.

113 ified, there is strong evidence that further predisposition genes are likely to exist.

114 re likely to carry a pathogenic variant in 9 predisposition genes compared with women not meeting cri

115 cer carrying germline pathogenic variants in predisposition genes do not qualify for testing by NCCN

116 variant detection performance in 118 cancer-predisposition genes estimated as sensitivity, specifici

117 Our study aim was to identify new predisposition genes for Wilms tumour.

118 While several Wilms tumour predisposition genes have been identified, there is stro

119 enic germline variants in established cancer predisposition genes have been recently identified in 5%

120 The four new Wilms tumour predisposition genes identified-TRIM28, FBXW7, NYNRIN, a

121 to classify variant pathogenicity in cancer predisposition genes in two large-scale investigations i

122 eling and germline genetic testing of cancer predisposition genes should be offered to all men with b

123 patients with pathogenic variants in cancer-predisposition genes than the standard method (prostate

124 ogether with the other 17 known Wilms tumour predisposition genes, account for about 10% of Wilms tum

125 prevalence of germline alterations in cancer predisposition genes.

126 cer independent of mutations in known cancer predisposition genes.

127 decade elucidated multiple candidate cancer predisposition genes.

128 Even though genetic predisposition has proven to be an important element in

129 ly meaningful improvements, and that genetic predisposition impacts clinical responses to lifestyle c

130 ions have been known to contribute to cancer predisposition in a group of disorders known as the RASo

131 ions in tumorigenesis is evidenced by cancer predisposition in both carriers of germline loss-of-func

132 us characterize immune networks of asthmatic predisposition in children at the age of 2, prior to the

133 chanistic insight into the metabolic disease predisposition in individuals with FA.

134 Nevertheless, the genetic predisposition in many families with multi-incidence dis

135 ntion and treatment strategies for leukaemia predisposition in patients with Shwachman-Diamond syndro

136 besity over time are associated with genetic predisposition in the context of an obesogenic environme

137 these data suggest that aortic root aneurysm predisposition in this LDS mouse model depends both on d

138 s in association with an underlying germline predisposition in up to 15% of cases.

139 h ETV6-related thrombocytopenia and leukemia predisposition includes genetic counseling, treatment or

140 Obesity, tobacco smoking, and genetic predisposition increase the risk of developing GERD.

141 sms of how the microbiota contributes to the predisposition, initiation and perpetuation of immune-me

142 niches contribute to haematological disease predisposition, initiation, progression and response to

143 prediction model based on the PIRO concept (Predisposition, Injury, Response and Organ failure) for

144 It has been hypothesized that a part of this predisposition is caused by the inheritance of specific

145 ny rare entities, our knowledge of heritable predisposition is incomplete.

146 Germline predisposition is increasingly recognized in MDS present

147 /liver function, stroke, bleeding history or predisposition, labile international normalized ratio, e

148 /liver function, stroke, bleeding history or predisposition, Labile international normalized ratio, e

149 dence indicates that, in addition to genetic predisposition, lifestyle changes owing to modernization

150 Excess alcohol intake and inherited predisposition may increase risk of atrial fibrillation

151 Genetic predisposition might affect neurodevelopmental outcomes

152 this Primer, the epidemiology (including MB predisposition), molecular pathogenesis and integrative

153 hanism in human genetics, in which a disease predisposition mutation inactivates enhancer regenerativ

154 Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm di

155 y pathogenic (LP) assessment that suggests a predisposition of genetic risk.

156 sults contribute to our understanding of the predisposition of patients carrying FXII-Lys/Arg309 to a

157 a growing number of publications report the predisposition of patients with COVID-19 to develop thro

158 In addition, pregnancy can also modify the predisposition of rodent and human MECs to initiate onco

159 Our data show that the mechanism of such predisposition of stone formation could be largely due t

160 rus-induced wheezing, associated with atopic predisposition of the patient and high risk of subsequen

161 The identification of a heritable tumor predisposition often leads to changes in management and

162 little is known about the impact of genetic predisposition on the response to lifestyle coaching.

163 linical markers and 2) the effect of genetic predisposition on these clinical changes.

164 nmental factors are likely to impact disease predisposition, onset, progression, and severity, yet lo

165 ences in vulnerability to PTSD result from a predisposition or trauma exposure remains unclear.

166 allels enrichment of prostate cancer genetic predispositions over these transcription regulators' tum

167 development, differentiation, and malignancy predisposition pathways.

168 While aging and inherent genetic predisposition play major roles in the onset of AD, life

169 y which excess iron may mediate/increase HCC predisposition/progression are not known.

170 ctasia (A-T) that is characterized by cancer predisposition, radiosensitivity, neurodegeneration, ste

171 h multiple risk factors and a strong genetic predisposition rather than a condition with a single exp

172 ach of which has a marked increase in cancer predisposition relative to the general population.

173 dial destruction, remodelling and arrhythmic predisposition remain poorly understood.

174 Predisposition risk loci influence a tumor's epigenome,

175 ning UV exposure is complicated by a genetic predisposition shared with neuropsychological traits.

176 Sexual differences in genetic predisposition should be considered in future studies of

177 A genetic predisposition, smoking, obesity and hormonal factors ar

178 rs in the context of more pleiotropic cancer predispositions, such as DICER1, Li-Fraumeni and Bloom s

179 fibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the NF1 t

180 ofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the pr

181 Here, we describe a novel brain tumor predisposition syndrome that is caused by germline GPR16

182 for a familial thrombocytopenia and leukemia predisposition syndrome.

183 sis, ocular melanocytoma and the BAP1-tumour predisposition syndrome.

184 orm surveillance and treatment for leukaemia predisposition syndromes are scarce and recommendations

185 Tumour predisposition syndromes in which cancers arise at an ac

186 eckpoint defect and contribute to the cancer predisposition syndromes.

187 gene implicated in breast and ovarian cancer predisposition that has become a high priority target fo

188 on for negative internal states, or a common predisposition that is related to all substance consumpt

189 creasing power to detect patterns of disease predisposition that might benefit from a targeted pharma

190 f a short and transient time window of early predispositions that does not depend on visual experienc

191 of different species are born with a set of predispositions that influence their early orienting res

192 gene and increased the prevalence of genetic predisposition to 40% among paediatric patients with MB(

193 The study findings of genetic predisposition to A(H7N9) in the Chinese population may

194 thma) through programming of their NK cells; predisposition to AAD did not develop in DEP pups that l

195 eased risk of AF across a range of polygenic predisposition to AF and adds to inherited and clinical

196 ssociation between alcohol intake, polygenic predisposition to AF, and incident AF in the UK Biobank,

197 eptibility to viral and bacterial infection, predisposition to allergic airway inflammation, and deve

198 The predisposition to allergic sensitization was associated

199 ogic, and biochemical evidence suggests that predisposition to Alzheimer's disease (AD) may arise fro

200 of neuronal subtypes.SIGNIFICANCE STATEMENT Predisposition to anxiety disorders has both a neurodeve

201 rotein function and contribute to individual predisposition to apical periodontitis (AP).

202 The predisposition to approach face-like stimuli observed in

203 We observe neither unusual predisposition to atherosclerosis nor abnormal pro-infla

204 develop AUD and the biomarkers indicating a predisposition to AUD are still unclear.

205 ct individual stress responses and therefore predisposition to autoimmunity and cancer.

206 to variations in response to infections and predisposition to autoimmunity.

207 s contributing to low to moderate penetrance predisposition to BE/EAC.

208 The association between a genetic predisposition to breast cancer (using PRS) and MD and m

209 vestigated the association between a genetic predisposition to breast cancer and mammographic feature

210 provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform

211 Increased genetic predisposition to CAD was inversely associated with migr

212 Genetic testing for hereditary predisposition to cancer is warranted in UM patients wit

213 ting in failure to produce blood cells and a predisposition to cancer(3,4).

214 In addition, each syndrome shows a predisposition to cancer.

215 rs of anti-IDs in asymptomatic patients with predisposition to CD and demonstrated that anti-ID deple

216 el gene (NDUFB9) associated with the genetic predisposition to CD in African-Americans.

217 nt studies have suggested a possible genetic predisposition to CH.

218 Overall, we did not find a genetic predisposition to CHIP mutations in this twin study.

219 have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL).

220 rther exacerbated among persons with genetic predisposition to coronary artery disease.

221 to MI and its potential to mitigate genetic predisposition to coronary disease is unclear.

222 Our understanding of familial predisposition to CRC and cancer syndromes has increased

223 mmatory genes, which may lead to an enhanced predisposition to developing renal complications in pati

224 We investigated whether a genetic predisposition to developmental disorders was associated

225 of risk of SRCC in individuals with genetic predisposition to DGC.

226 weight management strategies, as individual predisposition to diet response varies.

227 ory sequences can result in birth defects or predisposition to disease.

228 Rare familial cases reveal a genetic predisposition to disease.

229 oinsufficiency causes a dominantly inherited predisposition to early onset autoimmune diseases relate

230 mong participants with the strongest genetic predisposition to elevated IOP, greater caffeine consump

231 aims of this study were to identify genetic predisposition to elite athletic performance by investig

232 ttention to the bodily self may exacerbate a predisposition to focusing on external rather than inter

233 mal-dominant familial platelet disorder with predisposition to hematologic malignancies (RUNX1-FPD, F

234 Genetic predisposition to higher BMI did not increase the risk o

235 We also assessed whether genetic predisposition to higher coffee consumption was related

236 Genetic predisposition to higher HDL-C levels was associated wit

237 Genetic predisposition to higher HDL-C, specifically to choleste

238 ssure (IOP) and glaucoma and whether genetic predisposition to higher IOP modified these associations

239 A genetic predisposition to higher waist-to-hip ratio adjusted for

240 of the patients were found to have a genetic predisposition to HLH.

241 95% CI, 1.03-1.08; P=5.4x10(-5)) for genetic predisposition to hyperthyroidism.

242 Second, most writers concluded that a predisposition to illness rather than the illness itself

243 isorders, eventually resulting in a state of predisposition to immune deficiency.

244 ion to AF and adds to inherited and clinical predisposition to increase AF susceptibility.

245 studies have provided evidence for a genetic predisposition to keloid formation, and a keloid risk al

246 ming by MO of offspring cardiac function and predisposition to later life cardiovascular disease in t

247 t 2D:4D and Delta2D:4D are associated with a predisposition to lung cancer and/or the more aggressive

248 une lymphoproliferative syndrome with marked predisposition to lymphoma.

249 stature, variable cognitive impairment, and predisposition to malignancies.

250 tion interact to modulate gut microbiota and predisposition to metabolic syndrome in spontaneously hy

251 ow lifestyle might influence an individual's predisposition to neurodegenerative diseases.

252 The underlying cell types mediating predisposition to obesity remain largely obscure.

253 malities to intestinal cell fate changes and predisposition to oncogene-driven colon tumorigenesis.

254 concern with this approach is the potential predisposition to opportunistic infections that might ou

255 SNPs in active regulatory elements influence predisposition to ovarian cancer, we used motifbreakR to

256 of patients and family members with possible predisposition to pancreatic adenocarcinoma.

257 , it provides further evidence for a genetic predisposition to PB and may partly explain the heteroge

258 ries of fecal samples, we found that genetic predisposition to pB-ALL (Pax5 heterozygosity or ETV6-RU

259 ociation studies indicate a role for genetic predisposition to PD-ICB.

260 of samples from individuals with hereditary predisposition to PDAC, for which specimens collected fr

261 dies are consistent with a view of a genetic predisposition to platinum-based chemotherapy mediated o

262 We show that polygenic predisposition to PR interval duration is an endophenoty

263 We found that the predisposition to preferentially attend to changes in sp

264 Thus, genetic predisposition to proteome instability may be a determin

265 11-1.43), and in individuals with a familial predisposition to psychiatric disorders (MRR = 1.48, 95%

266 s explained by prior suicidality or familial predisposition to psychiatric disorders.

267 expression of EPB41L4A is a mechanism in the predisposition to PTC.

268 MVA-related pathologies later in life, with predisposition to sarcopenia correlating with mTORC1 hyp

269 carriers, we propose a hypothesis of genetic predisposition to severe lung injury in patients with co

270 e was an inverse association between genetic predisposition to smoking and prostate cancer in the Pro

271 Genetic predisposition to smoking initiation (ever smoking regul

272 Genetic predisposition to smoking initiation was associated with

273 Additionally, genetic predisposition to smoking was associated with statistica

274 h degree of pain sensitivity or with genetic predisposition to stress and/or affective disturbances.

275 ntified 61 loci that are newly implicated in predisposition to T2D.

276 Genetic predisposition to T2DM was associated with higher odds o

277 of T1D and the genetic variants that confer predisposition to the disease.

278 UNX2 on soft and stiff substrates suggests a predisposition to this cell fate.

279 However, the extent to which genetic predisposition to tumor formation can be faithfully capt

280 ionship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glyc

281 loci have been shown to influence individual predisposition to type 2 diabetes (T2D).

282 mutations in PALB2 and MLH1 with hereditary predisposition to UM.

283 The results suggest locus heterogeneity in predisposition to UM.

284 arizing factor, Kcnk3-mutated rats presented predisposition to vasoconstriction of pulmonary arteries

285 Therefore, the individual predisposition to weight gain over time can be assessed

286 investigation of Ig- and TR-related genetic predispositions to diseases.

287 Genetic predispositions to venous thromboembolism (VTE) are rela

288 ntigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and ot

289 A genetic predisposition toward loneliness was associated with car

290 ere is also compelling evidence of a genetic predisposition toward loneliness.

291 Impulsivity, a predisposition toward rapid unplanned reactions to stimu

292 dress whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J m

293 t of an infectious pathogen alone or genetic predisposition triggered by an infection.

294 earning accurately (96.8%) predicted genetic predisposition using 40 of 3983 amplicon sequence varian

295 f CMAH likely contributes to atherosclerosis predisposition via multiple intrinsic and extrinsic mech

296 Seventy-seven genes associated with cancer predisposition were analyzed; allele frequencies were co

297 s previously implicated in hereditary cancer predisposition were captured using the BROCA Agilent can

298 tle is known on the temporal course of early predispositions (whether they are stable or change in ti

299 ta suggest a link between individual patient predisposition with respect to age and comorbidity and i

300 i-Fraumeni Syndrome mutants in breast cancer predisposition yet consistent in glioma predisposition.