ライフサイエンスコーパス: preexist

1 d Abeta peptide monomers can be catalyzed by preexisting Abeta fibrils.

2 Alone, Dip1 activates Arp2/3 complex without preexisting actin filaments to nucleate 'seed' filaments

3 Synergistic co-activation does not require preexisting actin filaments, explaining how Wsp1 contrib

4 eline biomarkers showed that the presence of preexisting activated T cells was more prominent than ex

5 8,9), we hypothesized that humans may harbor preexisting adaptive immune responses to the Cas9 orthol

6 uces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering ch

7 ng that this syndrome evolved by co-opting a preexisting age-dependent program.

8 research while endeavoring to maintain their preexisting agenda.

9 sensitization by assessing the influence of preexisting allergy on the outcome of helminth infection

10 especially relevant to cancer patients with preexisting allogeneic transplants or autoimmune disease

11 n transplant waiting lists are evaluated for preexisting alloimmunity to minimize episodes of acute a

12 Distinguishing preexisting and de novo immunity will be critical for ou

13 gene therapy and vaccines, selected to avoid preexisting and potentially fatal host immune responses

14 are multiple contributory factors including preexisting, and the posttransplant development of, card

15 Low preexisting anti-dengue virus (DENV) antibody levels are

16 Further, although high preexisting anti-DENV antibody titers protected against

17 Women with undetectable preexisting anti-GBS concentrations may benefit from a s

18 Preexisting anti-NA antibody titers were most predictive

19 These results suggest that preexisting antibodies against HIV-2, which mediate inte

20 Preexisting antibodies in controls recognized SARS-CoV-2

21 reactive H1 COBRA HA-based vaccines boosted preexisting antibodies induced by wild-type H1N1 virus i

22 anent loss of T-cell memory or if it affects preexisting antibodies to childhood vaccinations or infe

23 Preexisting antibody and high IgG avidity index (>50%) a

24 In addition, we show that high levels of preexisting antibody can have a negative effect on boost

25 Furthermore, the immunogens refocused preexisting antibody responses toward defined neutraliza

26 tion, and a previously unrealized decline in preexisting antibody responses was observed.

27 Preexisting antiviral antibodies decreased after transpl

28 led with a radical cascade that connects two preexisting aromatic cores via a formal C-H activation s

29 urgery in nondiabetic and diabetic mice with preexisting atherosclerosis.

30 onant conditions interacts strongly with the preexisting bands.

31 Hyperactivity occurred in neurons with preexisting baseline activity, whereas inactive neurons

32 we show that polarized users reinforce their preexisting beliefs by leveraging the activity of their

33 t information that is incongruent with their preexisting beliefs.

34 ls suggests that poor decision making due to preexisting biological factors can independently enhance

35 oss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained.

36 risk stratification models in women without preexisting breast cancer or ductal carcinoma in situ.

37 we have modeled a gel like structure with a preexisting bubble of 5 nm radius.

38 Preexisting Ca(2+)-handling abnormalities and activation

39 recipients who experienced cancer death had preexisting cancer.

40 This increased risk was largely driven by preexisting cancers in patients on dialysis and de novo

41 a subgroup analysis excluding patients with preexisting cancers.

42 n with loop extrusion activity is stopped by preexisting CAR-bound cohesins, generating positioned lo

43 We show enhanced efflux of preexisting carbon from intertidal sediments enriched wi

44 In pneumonectomy patients, preexisting cardiac comorbidity and low diffusion capaci

45 iopulmonary resuscitation, 125 (85.0%) had a preexisting cardiac condition, 75 (51.0%) were postcardi

46 zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiat

47 progenitor cells, cardiac SP cells fuse with preexisting cardiomyocytes to stimulate cardiomyocyte ce

48 on following injury through proliferation of preexisting cardiomyocytes(1,2) and that Meis1, a three

49 e presence (group A) or absence (group B) of preexisting cardiopulmonary disease.

50 , and had been on dialysis longer, with more preexisting cardiovascular disease, whereas DC-GF patien

51 hyroid function in patients with and without preexisting cardiovascular disease.

52 cker, had been on dialysis longer, with more preexisting cardiovascular disease.

53 ssociated with cumulative drug exposures and preexisting cardiovascular disorders.

54 ugh the vast majority of these patients have preexisting cardiovascular implantable electronic device

55 f Akt and ERK by decreasing extrinsic noise (preexisting cell-to-cell differences in kinase activity)

56 istent EBV epithelial infection depends upon preexisting cellular alterations and suggest the ability

57 er graft failure, earlier era of transplant, preexisting cerebrovascular disease and no previous mali

58 Preexisting cerebrovascular disease was a potentially mo

59 er graft failure, earlier era of transplant, preexisting cerebrovascular disease, and no previous mal

60 In adults, the absence of a preexisting chronic liver disease (CLD) is required to d

61 (48.6% versus 17.2%, respectively) and have preexisting CKD or CKD that developed during follow-up (

62 , and this remains true for individuals with preexisting CKD.

63 betes, but not among those with diabetes and preexisting CKD.

64 rating that recall responses are confined by preexisting clonal diversity.

65 s that EPAG may promote expansion of dormant preexisting clones with an aberrant karyotype.

66 ndary germinal centers (GCs) or by selecting preexisting clones without further affinity maturation.

67 f leukocytes, which supply growth factors to preexisting collateral arterioles enabling them to grow.

68 Advancing maternal age and preexisting comorbid conditions have contributed to the

69 to volume depletion, contrast exposure, and preexisting comorbid diseases.

70 ex, more recent admitting years, presence of preexisting comorbidities, and repeat ICU admission.

71 rrhythmic activity that was independent from preexisting comorbidities.

72 -19 and diabetes pathology and suggests that preexisting complications or pathologies in patients wit

73 d independently in different phyla utilizing preexisting components.

74 Severe disease centers on older persons with preexisting conditions and not infants or individuals wi

75 and short-term mortality rates adjusted for preexisting conditions but not in-hospital comorbidity m

76 djusted for demographics, primary diagnosis, preexisting conditions, and with vs without further adju

77 Medications, preexisting conditions, clinical measures on admission,

78 , which include protections for persons with preexisting conditions, have made health insurance more

79 e: 1 month to 17 years); 50% of patients had preexisting conditions.

80 ent strategy, especially in patients without preexisting conduction abnormalities.

81 vity in recent years also had relatively low preexisting connectivity in our earliest time period.

82 We excluded cases with preexisting corneal perforations before surgery.

83 Fourteen percent of patients had preexisting coronary artery disease (n=31), 33% arterial

84 fter adjusting for participating sites, age, preexisting coronary artery disease, diabetes mellitus,

85 eported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of

86 nscatheter aortic valve implantation without preexisting CSA.

87 of differences in treatment effect based on preexisting CVD status.

88 cardiac damage and strain in adults without preexisting CVD.

89 nancies include male preponderance, frequent preexisting cytopenia, additional somatic DDX41 mutation

90 from a pristine system and one starting with preexisting defects to demonstrate the potential for a p

91 to 97 y, and dental data were obtained from preexisting dental records.

92 subgroups, including patients with ADHD with preexisting depression or substance use disorder.

93 gates of these cells rapidly reversed severe preexisting diabetes in mice at a rate close to that of

94 Preexisting diabetes in pregnancy is complex and is asso

95 Studies including preexisting diabetes or nondiabetic women were excluded.

96 he COVID-19 pandemic is superimposing on the preexisting diabetes pandemic to create large and signif

97 he United States annually are complicated by preexisting diabetes.

98 lin is first-line therapy for all women with preexisting diabetes; injections and insulin pump therap

99 taract surgery VA, age <75 years, absence of preexisting diabetic macular edema (DME) or postvitrecto

100 Patients with preexisting diagnoses of coronary artery disease and arr

101 rom a history of drug use or instead reflect preexisting differences.

102 AE, here we demonstrate that when applied to preexisting disease, chronic mild hypoxia (CMH, 10% O(2)

103 uished newly diagnosed cases from those with preexisting disease.

104 r mild hypoxia can impact the progression of preexisting disease.

105 d for all participants, including those with preexisting diseases (apart from diabetes, for which exi

106 present the first functional evidence that a preexisting disturbance in the gut microbiome leads to i

107 sting DM, but only persisted at follow-up in preexisting DM in patients with HIV-1 infection.

108 as significant at enrollment in both new and preexisting DM, but only persisted at follow-up in preex

109 ciation in patients with HIV-1 infection and preexisting DM, despite TB therapy.

110 Preexisting donor-reactive memory T and B cells and pref

111 neral estimate of the size and dynamics of a preexisting, drug-resistant tumor cell population versus

112 The preexisting DSA ABMR had superior graft survival compare

113 At last follow-up, preexisting DSA had decreased or stabilized.

114 Persistence of preexisting DSAs or development of dnDSA after transplan

115 racellular signal transduction but rather to preexisting established heterogeneous states of promoter

116 n is accommodated by frictional slip on many preexisting faults.

117 In contrast, because Wsp1 requires preexisting filaments to activate, it has been assumed t

118 actin networks by stimulating branching from preexisting filaments.

119 er, when the lake expanded and reactivated a preexisting fracture that had been responsible for a dra

120 We identified factors before (e.g., frailty, preexisting functional impairments), during (e.g., durat

121 Higher minimum postarrest lactate and preexisting gastrointestinal conditions were independent

122 es the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized m

123 cquired genes to be coordinated with that of preexisting genes.

124 roposed to evolve mainly by orchestration of preexisting genes.

125 through phenotypic changes mediated by their preexisting genetic repertoire.

126 mental passages demonstrate that substantial preexisting genetic variation is not necessarily require

127 th intra-nuclear distance to the Airn locus, preexisting genome architecture, and the abundance of Ai

128 njection, number of intravitreal injections, preexisting glaucoma, and globe decompression before inj

129 t pronounced in children with no evidence of preexisting HAI and in those with detectable virus.

130 red to transplant candidates with or without preexisting HCV infection.

131 Adjusting for preexisting health and socioeconomic conditions attenuat

132 wer income communities have higher levels of preexisting health conditions and lower access to health

133 However, the preexisting healthcare infrastructure was already overwh

134 Although preexisting herd immunity in regions of past outbreaks m

135 Strikingly, our analysis indicates a preexisting heterozygous frameshift mutation at codon 61

136 Preexisting HF was defined by any HF encounter during th

137 those without HF at baseline, patients with preexisting HF were older, and more likely to be male an

138 Preexisting high antibody titers to dengue virus were as

139 thesis during infection and/or catabolism of preexisting host cell biomass, and the relative contribu

140 cells can be attributed entirely to robust, preexisting host cell heterogeneity in bacterial adhesio

141 omonas phage phi6), we studied the impact of preexisting host range mutations on another host range e

142 This study identifies dysbiosis as a preexisting, host-intrinsic regulator of tissue inflamma

143 , a circulating pattern observed among other preexisting human seasonal coronaviruses (sCoVs).

144 ether, these data demonstrate that there are preexisting humoral and cell-mediated adaptive immune re

145 n differences by testing the hypothesis that preexisting humoral and mucosal immunity may influence v

146 recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity.

147 Thus preexisting humoral or cellular memory alloresponses are

148 Vaccination boosted preexisting humoral responses in our HCMV+ cohort but di

149 lbumin (5.5% compared with 2.6%; p = 0.001), preexisting hypertension (4.3% compared with 1.5%; p = 0

150 This indicates that preexisting hypertension exacerbates the development of

151 lt women with live singleton births, without preexisting hypertension or diabetes, and with complete

152 related to critical illness severity and to preexisting hypoxemia.

153 Preexisting IBD increases the risk of severe GI adverse

154 ving labeling of either newly synthesized or preexisting IGF2R, vIL-6 promoted accumulation of the fo

155 be impaired in nonresponders because of the preexisting immune environment.

156 We hypothesize that preexisting immune memory and innate immune interference

157 The vast majority of people already have preexisting immune responses to influenza viruses from o

158 to evaluate the relations between markers of preexisting immunity (ie, hemagglutination inhibition [H

159 emiological factors, limited protection from preexisting immunity against IDVs in cattle herds and co

160 However, the high prevalence of preexisting immunity against these viruses in general po

161 demiological factors, the ineffectiveness of preexisting immunity and cocirculation of a diverse vira

162 ibody responses with less MMID indicate that preexisting immunity factors other than anti-HA antibody

163 duction of novel coronaviruses may encounter preexisting immunity in humans.

164 Natural preexisting immunity is ineffective at clearing an HCMV

165 n between different variables, and impact of preexisting immunity on parasite slope half-life (t1/2)

166 The impact of preexisting immunity on the efficacy of artemisinin comb

167 rent antimalarial drugs, revealing impact of preexisting immunity on the efficacy of artemisinin comb

168 ble to infect BALB/c mice in the presence of preexisting immunity than rA4G RSV.

169 Higher levels of preexisting immunity to influenza A/H3N2 and B were stro

170 ess of H3N3 COBRA HA vaccines in a host with preexisting immunity to influenza.

171 pressure, reducing the protective effects of preexisting immunity to previously circulating H3N2 stra

172 While no preexisting immunity to the vector was observed, more th

173 , not all patients can be treated because of preexisting immunity to viral capsids.

174 Preexisting immunity to Zika virus (ZIKV) or dengue viru

175 underscore the importance of accounting for preexisting immunity when evaluating virologic and immun

176 years of circulation in humans, the role of preexisting immunity, and the evolutionary rates of the

177 stood and is likely influenced by the host's preexisting immunologic comorbidities.

178 ched for a neural crest G(0)-like state that preexisted in the primary tumor and remained present in

179 Because of preexisting inequalities in health and other resources,

180 Preexisting inflammation is a risk factor for TRALI and

181 ate that mild hypoxia promotes recovery from preexisting inflammatory demyelinating disease and sugge

182 carceration and treatment systems as well as preexisting interventions such as needle and syringe pro

183 ients (age 85+/-8 years, 47% male) without a preexisting intracardiac device or prior valve surgery w

184 vestigate whether treatment of patients with preexisting isoniazid-resistant disease with first-line

185 nd beta(2)GPI arises from the ability of its preexisting J-form to accumulate on the membranes, there

186 representations and integrate these with our preexisting knowledge about the world.

187 reported a significantly association between preexisting LA-DRVs and risk of virological failure wher

188 searched PubMed, Google, Google Scholar, and preexisting lists for formal economic studies of the pro

189 without Pi*MZ genotype among persons without preexisting liver disease.

190 nge infection, full protection was linked to preexisting local and systemic EHV-1-specific antibodies

191 y and mortality, especially in patients with preexisting lung diseases such as asthma.

192 larly recruited to tumors and integrate into preexisting lymphatics.

193 3% of patients with NFAT developed MACE, and preexisting MACE was unlikely to resolve (<0.1%).

194 icipants with a Fontan circulation without a preexisting major neurological disability were prospecti

195 The preexisting materials knowledge naturally folds in the B

196 ngs were similar in patients with or without preexisting medical comorbidities.

197 h resources should be directed to those with preexisting medical conditions, their social networks, a

198 ounger, predominantly male, patients without preexisting medical conditions.

199 ic synthesis of diacylphospholipids requires preexisting membrane-embedded enzymes.

200 ters facilitate new learning and help modify preexisting memories throughout the lifespan of an organ

201 esponses in humans by effectively recruiting preexisting memory B cells as well as naive B cells into

202 with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infect

203 We demonstrate a range of preexisting memory CD4(+) T cells that are cross-reactiv

204 ever, little is known about their effects on preexisting memory CD8+ T cell (TCD8) pools.

205 censed seasonal influenza vaccines can boost preexisting memory responses against the HA stem in huma

206 significantly expanded IFNgamma-expressing, preexisting memory-like CD44(+)CD4(+) T cells and NK cel

207 1.36) moved to the null after adjustment for preexisting mental health conditions (RR, 1.00; 95% CI,

208 sk factor for unsuppressed viral load, while preexisting mental health conditions may influence HIV a

209 ttraumatic stress disorder symptoms included preexisting mental health disorders (adjusted odds ratio

210 Family members with preexisting mental health disorders, recent experiences

211 ess, as well as characterize the impact of a preexisting mental illness diagnosis on postoperative ou

212 Three in 10 Medicare beneficiaries had a preexisting mental illness diagnosis, which was strongly

213 f this study was to define the prevalence of preexisting mental illness, as well as characterize the

214 ases as an early dissemination process using preexisting metastatic ability rather than an evolution

215 cell by the gamma-tubulin ring complex or by preexisting microtubules; it also occurs in vitro from p

216 tectomy and liver graft implantation using a preexisting midline incision.

217 n ancestor of land plants and evolved from a preexisting MYC function in charophycean algae.

218 Overall, our data suggest that preexisting nasal IgG4/7 antibodies neutralize EHV-1, pr

219 urons, both the SIRPT1 and J-domain resolved preexisting neurofilament bundles.

220 However, preexisting neutralizing antibodies against the AAV caps

221 One limitation of AAV gene delivery is preexisting neutralizing antibodies, which present a sig

222 sociated genetic marker detection, expanding preexisting notification and analysis systems for resist

223 indicate that nanoparticles not only act as preexisted nuclei to promote nucleation for cavitation,

224 humoral immunity has been a challenge given preexisting, often cross-reactive, immunity and in parti

225 lves the formation of new blood vessels from preexisting ones, and it is an essential step during cut

226 sis that low vitamin D levels can exacerbate preexisting ophthalmic conditions, such as diabetes.

227 lbar anesthesia, especially in patients with preexisting Optic Nerve damage.

228 However, resistance to PARP inhibitors may preexist or evolve during treatment in many cancer types

229 Preexisting or emergent cardiovascular disease in a pati

230 nical investigation, to address the issue of preexisting or new-onset of atrial fibrillation and pote

231 and assessed the decomposition and export of preexisting organic matter.

232 duced SOA had a similar composition with the preexisting oxygenated ambient OA.

233 bally, mainly in the elderly population with preexisting pathologies.

234 aggressive disease process or may represent preexisting patient characteristics that predispose to b

235 f these displays lies in the exploitation of preexisting perceptual biases which increase female inve

236 divided by the total number of patients with preexisting peritoneal or mesenteric disease.

237 minate into rod-shaped, walled cells without preexisting PG templates.

238 lls, involving a base-exchange reaction from preexisting phospholipids.

239 FG and 89 036 persons (median age 79.5) with preexisting POAG, persons with XFG had more office visit

240 g chemotherapy treatments and suggest that a preexisting population harboring chr12p amplification is

241 stribution of weak shocks may reaccelerate a preexisting population of relativistic particles, produc

242 existing resistance would lead to very large preexisting populations of resistant cells at the initia

243 e propose that co-option of ABA to control a preexisting PP2C-SnRK2-dependent desiccation-tolerance p

244 y and cancer progression that are beyond the preexisting proliferative control deficit.

245 Most new proteins evolve from preexisting proteins but the evolutionary path from ance

246 models adjusted for age, sex, comorbidities, preexisting psychiatric condition, and nonshockable init

247 ight the importance of HIV coinfection, high preexisting rates of drug-resistant TB, human migration,

248 talytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistan

249 of p100 (IkappaBdelta) are known to inhibit preexisting RelA:p50 through sequestration, here we repo

250 n (4.3% compared with 1.5%; p = 0.0041), and preexisting renal disease (9.1% compared with 3.0%; p <

251 A noncardiac diagnosis and preexisting renal insufficiency were associated with inc

252 Noncardiac diagnoses, preexisting renal insufficiency, longer time from onset

253 However, combining preexisting resistance with persister populations can ex

254 ry high mutation induction rates, while only preexisting resistance would lead to very large preexist

255 velopment, including persister evolution and preexisting resistance, solely based on the macroscopic

256 st tuberculosis and to which there is little preexisting resistance.

257 Under the assumption of only preexisting resistant cells or only persister evolution,

258 volume trajectories and yields an estimated preexisting resistant fraction varying from 10(-4) to 10

259 ever, in the subset of patients (34.7%) with preexisting retinal neurodysfunction, IT worsened in the

260 ppears useful in preventing the worsening of preexisting retinal neurodysfunction.

261 nifestation of chronic drug use and/or are a preexisting risk factor for addiction.

262 Preexisting severe prosthesis-patient mismatch was not a

263 ctivated and measured slow, aseismic slip on preexisting, shallow faults.

264 d not hear it, and who were not exposed to a preexisting sign language because there was none availab

265 All but 1 patient who died had preexisting, significant comorbidities.

266 ed States, the COVID-19 pandemic has exposed preexisting social and health disparities among several

267 (i) as chiefdoms developed, leaders drew on preexisting social and political conditions; (ii) while

268 us to construct components that encase other preexisting solid objects, allowing for multimaterial fa

269 erface, a Python framework designed to unify preexisting spike sorting technologies into a single cod

270 anic phototropic growth process depends on a preexisting structure that has been first grown under di

271 and resistance, especially in the absence of preexisting subclones, remains unclear.

272 Preexisting surgical valve prosthesis-patient mismatch w

273 Preexisting surgical valve prosthesis-patient mismatch w

274 Patients were stratified by presence of preexisting surgical valve prosthesis-patient mismatch.

275 increase has generally been attributed to a preexisting system of orthogonal natural cracks, whose s

276 Preexisting T cell immunity to severe acute respiratory

277 The functional state of the preexisting T cells in the tumor microenvironment is a k

278 to break down tumor defenses and recover the preexisting T-cell immunity required to respond to immun

279 oad, suggesting that methylation differences preexisted the trauma.

280 fy ZNF217 as a potential target toward which preexisting therapies, such as the Akt inhibitor triciri

281 oning macular area where baseline OCT showed preexisting thinning.

282 differences in techniques or the reliance on preexisting tools.

283 We accounted for preexisting trends independent of ACO participation usin

284 e that radiation-induced DSBs cooperate with preexisting tumor suppressor losses to generate high-gra

285 monstrated the potentially curative value of preexisting tumor-primed T cells in cancer treatment.

286 The presence of preexisting type 1 or type 2 diabetes in pregnancy incre

287 NA throughout the transcriptome by analyzing preexisting ultra-deep RNA-Seq data for modification-ind

288 and cardiovascular disease, as well as high preexisting use of kidney testing in such patients) subs

289 The importance of preexisting versus acquired drug resistance in patients

290 on and vaccination result from activation of preexisting virus-specific memory B cells (MBCs).

291 udies have evaluated the association between preexisting vitamin D deficiency and incident tuberculos

292 ve patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of

293 o occur when postoperative triggers act on a preexisting vulnerable substrate, but the underlying cel

294 te decompensated heart failure patients with preexisting worsening renal function (WRF) and renal tub

295 s with acute decompensated heart failure and preexisting WRF to intensive volume removal with stepped

296 te decompensated heart failure patients with preexisting WRF, intensive volume removal resulted in a

297 Eight patients with preexisting xerostomia after (177)Lu-PSMA showed no wors

298 2745 enrollees (median age 80.5 years) with preexisting XFG and 89 036 persons (median age 79.5) wit

299 llow-up for persons with newly diagnosed and preexisting XFG vs those with POAG.

300 ation are associated with surgical trauma or preexisting zonulopathy.