ライフサイエンスコーパス: preexisting

1 d Abeta peptide monomers can be catalyzed by preexisting Abeta fibrils.

2 Alone, Dip1 activates Arp2/3 complex without preexisting actin filaments to nucleate 'seed' filaments

3 Synergistic co-activation does not require preexisting actin filaments, explaining how Wsp1 contrib

4 eline biomarkers showed that the presence of preexisting activated T cells was more prominent than ex

5 8,9), we hypothesized that humans may harbor preexisting adaptive immune responses to the Cas9 orthol

6 uces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering ch

7 ng that this syndrome evolved by co-opting a preexisting age-dependent program.

8 research while endeavoring to maintain their preexisting agenda.

9 sensitization by assessing the influence of preexisting allergy on the outcome of helminth infection

10 especially relevant to cancer patients with preexisting allogeneic transplants or autoimmune disease

11 n transplant waiting lists are evaluated for preexisting alloimmunity to minimize episodes of acute a

12 Distinguishing preexisting and de novo immunity will be critical for ou

13 gene therapy and vaccines, selected to avoid preexisting and potentially fatal host immune responses

14 are multiple contributory factors including preexisting, and the posttransplant development of, card

15 Low preexisting anti-dengue virus (DENV) antibody levels are

16 Further, although high preexisting anti-DENV antibody titers protected against

17 Women with undetectable preexisting anti-GBS concentrations may benefit from a s

18 Preexisting anti-NA antibody titers were most predictive

19 These results suggest that preexisting antibodies against HIV-2, which mediate inte

20 Preexisting antibodies in controls recognized SARS-CoV-2

21 reactive H1 COBRA HA-based vaccines boosted preexisting antibodies induced by wild-type H1N1 virus i

22 anent loss of T-cell memory or if it affects preexisting antibodies to childhood vaccinations or infe

23 Therefore, this study investigated how preexisting antibodies to historical influenza viruses i

24 Preexisting antibody and high IgG avidity index (>50%) a

25 In addition, we show that high levels of preexisting antibody can have a negative effect on boost

26 Furthermore, the immunogens refocused preexisting antibody responses toward defined neutraliza

27 tion, and a previously unrealized decline in preexisting antibody responses was observed.

28 Preexisting antiviral antibodies decreased after transpl

29 led with a radical cascade that connects two preexisting aromatic cores via a formal C-H activation s

30 urgery in nondiabetic and diabetic mice with preexisting atherosclerosis.

31 onant conditions interacts strongly with the preexisting bands.

32 Hyperactivity occurred in neurons with preexisting baseline activity, whereas inactive neurons

33 we show that polarized users reinforce their preexisting beliefs by leveraging the activity of their

34 t information that is incongruent with their preexisting beliefs.

35 ls suggests that poor decision making due to preexisting biological factors can independently enhance

36 oss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained.

37 risk stratification models in women without preexisting breast cancer or ductal carcinoma in situ.

38 we have modeled a gel like structure with a preexisting bubble of 5 nm radius.

39 Preexisting Ca(2+)-handling abnormalities and activation

40 recipients who experienced cancer death had preexisting cancer.

41 This increased risk was largely driven by preexisting cancers in patients on dialysis and de novo

42 a subgroup analysis excluding patients with preexisting cancers.

43 n with loop extrusion activity is stopped by preexisting CAR-bound cohesins, generating positioned lo

44 We show enhanced efflux of preexisting carbon from intertidal sediments enriched wi

45 In pneumonectomy patients, preexisting cardiac comorbidity and low diffusion capaci

46 iopulmonary resuscitation, 125 (85.0%) had a preexisting cardiac condition, 75 (51.0%) were postcardi

47 zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiat

48 progenitor cells, cardiac SP cells fuse with preexisting cardiomyocytes to stimulate cardiomyocyte ce

49 on following injury through proliferation of preexisting cardiomyocytes(1,2) and that Meis1, a three

50 e presence (group A) or absence (group B) of preexisting cardiopulmonary disease.

51 , and had been on dialysis longer, with more preexisting cardiovascular disease, whereas DC-GF patien

52 hyroid function in patients with and without preexisting cardiovascular disease.

53 cker, had been on dialysis longer, with more preexisting cardiovascular disease.

54 ssociated with cumulative drug exposures and preexisting cardiovascular disorders.

55 ugh the vast majority of these patients have preexisting cardiovascular implantable electronic device

56 f Akt and ERK by decreasing extrinsic noise (preexisting cell-to-cell differences in kinase activity)

57 istent EBV epithelial infection depends upon preexisting cellular alterations and suggest the ability

58 er graft failure, earlier era of transplant, preexisting cerebrovascular disease and no previous mali

59 Preexisting cerebrovascular disease was a potentially mo

60 er graft failure, earlier era of transplant, preexisting cerebrovascular disease, and no previous mal

61 In adults, the absence of a preexisting chronic liver disease (CLD) is required to d

62 (48.6% versus 17.2%, respectively) and have preexisting CKD or CKD that developed during follow-up (

63 , and this remains true for individuals with preexisting CKD.

64 betes, but not among those with diabetes and preexisting CKD.

65 rating that recall responses are confined by preexisting clonal diversity.

66 s that EPAG may promote expansion of dormant preexisting clones with an aberrant karyotype.

67 ndary germinal centers (GCs) or by selecting preexisting clones without further affinity maturation.

68 f leukocytes, which supply growth factors to preexisting collateral arterioles enabling them to grow.

69 Advancing maternal age and preexisting comorbid conditions have contributed to the

70 to volume depletion, contrast exposure, and preexisting comorbid diseases.

71 ex, more recent admitting years, presence of preexisting comorbidities, and repeat ICU admission.

72 rrhythmic activity that was independent from preexisting comorbidities.

73 -19 and diabetes pathology and suggests that preexisting complications or pathologies in patients wit

74 d independently in different phyla utilizing preexisting components.

75 Severe disease centers on older persons with preexisting conditions and not infants or individuals wi

76 and short-term mortality rates adjusted for preexisting conditions but not in-hospital comorbidity m

77 djusted for demographics, primary diagnosis, preexisting conditions, and with vs without further adju

78 Medications, preexisting conditions, clinical measures on admission,

79 , which include protections for persons with preexisting conditions, have made health insurance more

80 e: 1 month to 17 years); 50% of patients had preexisting conditions.

81 ent strategy, especially in patients without preexisting conduction abnormalities.

82 vity in recent years also had relatively low preexisting connectivity in our earliest time period.

83 We excluded cases with preexisting corneal perforations before surgery.

84 Fourteen percent of patients had preexisting coronary artery disease (n=31), 33% arterial

85 fter adjusting for participating sites, age, preexisting coronary artery disease, diabetes mellitus,

86 eported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of

87 nscatheter aortic valve implantation without preexisting CSA.

88 of differences in treatment effect based on preexisting CVD status.

89 cardiac damage and strain in adults without preexisting CVD.

90 nancies include male preponderance, frequent preexisting cytopenia, additional somatic DDX41 mutation

91 cs, as defined in this review, is the use of preexisting data sets to address questions in ecology.

92 from a pristine system and one starting with preexisting defects to demonstrate the potential for a p

93 to 97 y, and dental data were obtained from preexisting dental records.

94 subgroups, including patients with ADHD with preexisting depression or substance use disorder.

95 gates of these cells rapidly reversed severe preexisting diabetes in mice at a rate close to that of

96 Preexisting diabetes in pregnancy is complex and is asso

97 Studies including preexisting diabetes or nondiabetic women were excluded.

98 he COVID-19 pandemic is superimposing on the preexisting diabetes pandemic to create large and signif

99 he United States annually are complicated by preexisting diabetes.

100 lin is first-line therapy for all women with preexisting diabetes; injections and insulin pump therap

101 taract surgery VA, age <75 years, absence of preexisting diabetic macular edema (DME) or postvitrecto

102 Patients with preexisting diagnoses of coronary artery disease and arr

103 rom a history of drug use or instead reflect preexisting differences.

104 AE, here we demonstrate that when applied to preexisting disease, chronic mild hypoxia (CMH, 10% O(2)

105 uished newly diagnosed cases from those with preexisting disease.

106 r mild hypoxia can impact the progression of preexisting disease.

107 d for all participants, including those with preexisting diseases (apart from diabetes, for which exi

108 present the first functional evidence that a preexisting disturbance in the gut microbiome leads to i

109 sting DM, but only persisted at follow-up in preexisting DM in patients with HIV-1 infection.

110 as significant at enrollment in both new and preexisting DM, but only persisted at follow-up in preex

111 ciation in patients with HIV-1 infection and preexisting DM, despite TB therapy.

112 Preexisting donor-reactive memory T and B cells and pref

113 neral estimate of the size and dynamics of a preexisting, drug-resistant tumor cell population versus

114 The preexisting DSA ABMR had superior graft survival compare

115 At last follow-up, preexisting DSA had decreased or stabilized.

116 Persistence of preexisting DSAs or development of dnDSA after transplan

117 racellular signal transduction but rather to preexisting established heterogeneous states of promoter

118 n is accommodated by frictional slip on many preexisting faults.

119 In contrast, because Wsp1 requires preexisting filaments to activate, it has been assumed t

120 actin networks by stimulating branching from preexisting filaments.

121 er, when the lake expanded and reactivated a preexisting fracture that had been responsible for a dra

122 We identified factors before (e.g., frailty, preexisting functional impairments), during (e.g., durat

123 Higher minimum postarrest lactate and preexisting gastrointestinal conditions were independent

124 es the odor responses of developing, but not preexisting GCs in vivo in both awake and anesthetized m

125 cquired genes to be coordinated with that of preexisting genes.

126 roposed to evolve mainly by orchestration of preexisting genes.

127 through phenotypic changes mediated by their preexisting genetic repertoire.

128 mental passages demonstrate that substantial preexisting genetic variation is not necessarily require

129 th intra-nuclear distance to the Airn locus, preexisting genome architecture, and the abundance of Ai

130 njection, number of intravitreal injections, preexisting glaucoma, and globe decompression before inj

131 t pronounced in children with no evidence of preexisting HAI and in those with detectable virus.

132 red to transplant candidates with or without preexisting HCV infection.

133 Adjusting for preexisting health and socioeconomic conditions attenuat

134 wer income communities have higher levels of preexisting health conditions and lower access to health

135 However, the preexisting healthcare infrastructure was already overwh

136 Although preexisting herd immunity in regions of past outbreaks m

137 Strikingly, our analysis indicates a preexisting heterozygous frameshift mutation at codon 61

138 Preexisting HF was defined by any HF encounter during th

139 those without HF at baseline, patients with preexisting HF were older, and more likely to be male an

140 Preexisting high antibody titers to dengue virus were as

141 thesis during infection and/or catabolism of preexisting host cell biomass, and the relative contribu

142 cells can be attributed entirely to robust, preexisting host cell heterogeneity in bacterial adhesio

143 omonas phage phi6), we studied the impact of preexisting host range mutations on another host range e

144 This study identifies dysbiosis as a preexisting, host-intrinsic regulator of tissue inflamma

145 , a circulating pattern observed among other preexisting human seasonal coronaviruses (sCoVs).

146 ether, these data demonstrate that there are preexisting humoral and cell-mediated adaptive immune re

147 n differences by testing the hypothesis that preexisting humoral and mucosal immunity may influence v

148 recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity.

149 Thus preexisting humoral or cellular memory alloresponses are

150 Vaccination boosted preexisting humoral responses in our HCMV+ cohort but di

151 lbumin (5.5% compared with 2.6%; p = 0.001), preexisting hypertension (4.3% compared with 1.5%; p = 0

152 This indicates that preexisting hypertension exacerbates the development of

153 lt women with live singleton births, without preexisting hypertension or diabetes, and with complete

154 related to critical illness severity and to preexisting hypoxemia.

155 Preexisting IBD increases the risk of severe GI adverse

156 ving labeling of either newly synthesized or preexisting IGF2R, vIL-6 promoted accumulation of the fo

157 be impaired in nonresponders because of the preexisting immune environment.

158 We hypothesize that preexisting immune memory and innate immune interference

159 The vast majority of people already have preexisting immune responses to influenza viruses from o

160 to evaluate the relations between markers of preexisting immunity (ie, hemagglutination inhibition [H

161 emiological factors, limited protection from preexisting immunity against IDVs in cattle herds and co

162 However, the high prevalence of preexisting immunity against these viruses in general po

163 demiological factors, the ineffectiveness of preexisting immunity and cocirculation of a diverse vira

164 ibody responses with less MMID indicate that preexisting immunity factors other than anti-HA antibody

165 duction of novel coronaviruses may encounter preexisting immunity in humans.

166 Natural preexisting immunity is ineffective at clearing an HCMV

167 n between different variables, and impact of preexisting immunity on parasite slope half-life (t1/2)

168 The impact of preexisting immunity on the efficacy of artemisinin comb

169 rent antimalarial drugs, revealing impact of preexisting immunity on the efficacy of artemisinin comb

170 ble to infect BALB/c mice in the presence of preexisting immunity than rA4G RSV.

171 Higher levels of preexisting immunity to influenza A/H3N2 and B were stro

172 ess of H3N3 COBRA HA vaccines in a host with preexisting immunity to influenza.

173 pressure, reducing the protective effects of preexisting immunity to previously circulating H3N2 stra

174 While no preexisting immunity to the vector was observed, more th

175 , not all patients can be treated because of preexisting immunity to viral capsids.

176 Preexisting immunity to Zika virus (ZIKV) or dengue viru

177 underscore the importance of accounting for preexisting immunity when evaluating virologic and immun

178 years of circulation in humans, the role of preexisting immunity, and the evolutionary rates of the

179 stood and is likely influenced by the host's preexisting immunologic comorbidities.

180 Because of preexisting inequalities in health and other resources,

181 Preexisting inflammation is a risk factor for TRALI and

182 ate that mild hypoxia promotes recovery from preexisting inflammatory demyelinating disease and sugge

183 carceration and treatment systems as well as preexisting interventions such as needle and syringe pro

184 ients (age 85+/-8 years, 47% male) without a preexisting intracardiac device or prior valve surgery w

185 vestigate whether treatment of patients with preexisting isoniazid-resistant disease with first-line

186 nd beta(2)GPI arises from the ability of its preexisting J-form to accumulate on the membranes, there

187 , vasopressor requirement, thrombocytopenia, preexisting kidney disease, failed ventilator liberation

188 representations and integrate these with our preexisting knowledge about the world.

189 Genomic discovery that is agnostic to preexisting knowledge has uncovered dozens of loci that

190 reported a significantly association between preexisting LA-DRVs and risk of virological failure wher

191 searched PubMed, Google, Google Scholar, and preexisting lists for formal economic studies of the pro

192 without Pi*MZ genotype among persons without preexisting liver disease.

193 nge infection, full protection was linked to preexisting local and systemic EHV-1-specific antibodies

194 y and mortality, especially in patients with preexisting lung diseases such as asthma.

195 larly recruited to tumors and integrate into preexisting lymphatics.

196 3% of patients with NFAT developed MACE, and preexisting MACE was unlikely to resolve (<0.1%).

197 icipants with a Fontan circulation without a preexisting major neurological disability were prospecti

198 The preexisting materials knowledge naturally folds in the B

199 ngs were similar in patients with or without preexisting medical comorbidities.

200 h resources should be directed to those with preexisting medical conditions, their social networks, a

201 ounger, predominantly male, patients without preexisting medical conditions.

202 ic synthesis of diacylphospholipids requires preexisting membrane-embedded enzymes.

203 ters facilitate new learning and help modify preexisting memories throughout the lifespan of an organ

204 esponses in humans by effectively recruiting preexisting memory B cells as well as naive B cells into

205 with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infect

206 We demonstrate a range of preexisting memory CD4(+) T cells that are cross-reactiv

207 ever, little is known about their effects on preexisting memory CD8+ T cell (TCD8) pools.

208 censed seasonal influenza vaccines can boost preexisting memory responses against the HA stem in huma

209 significantly expanded IFNgamma-expressing, preexisting memory-like CD44(+)CD4(+) T cells and NK cel

210 1.36) moved to the null after adjustment for preexisting mental health conditions (RR, 1.00; 95% CI,

211 sk factor for unsuppressed viral load, while preexisting mental health conditions may influence HIV a

212 ttraumatic stress disorder symptoms included preexisting mental health disorders (adjusted odds ratio

213 Family members with preexisting mental health disorders, recent experiences

214 ess, as well as characterize the impact of a preexisting mental illness diagnosis on postoperative ou

215 Three in 10 Medicare beneficiaries had a preexisting mental illness diagnosis, which was strongly

216 f this study was to define the prevalence of preexisting mental illness, as well as characterize the

217 ases as an early dissemination process using preexisting metastatic ability rather than an evolution

218 cell by the gamma-tubulin ring complex or by preexisting microtubules; it also occurs in vitro from p

219 tectomy and liver graft implantation using a preexisting midline incision.

220 n ancestor of land plants and evolved from a preexisting MYC function in charophycean algae.

221 Overall, our data suggest that preexisting nasal IgG4/7 antibodies neutralize EHV-1, pr

222 urons, both the SIRPT1 and J-domain resolved preexisting neurofilament bundles.

223 However, preexisting neutralizing antibodies against the AAV caps

224 One limitation of AAV gene delivery is preexisting neutralizing antibodies, which present a sig

225 sociated genetic marker detection, expanding preexisting notification and analysis systems for resist

226 humoral immunity has been a challenge given preexisting, often cross-reactive, immunity and in parti

227 lves the formation of new blood vessels from preexisting ones, and it is an essential step during cut

228 sis that low vitamin D levels can exacerbate preexisting ophthalmic conditions, such as diabetes.

229 lbar anesthesia, especially in patients with preexisting Optic Nerve damage.

230 Preexisting or emergent cardiovascular disease in a pati

231 nical investigation, to address the issue of preexisting or new-onset of atrial fibrillation and pote

232 and assessed the decomposition and export of preexisting organic matter.

233 duced SOA had a similar composition with the preexisting oxygenated ambient OA.

234 bally, mainly in the elderly population with preexisting pathologies.

235 aggressive disease process or may represent preexisting patient characteristics that predispose to b

236 f these displays lies in the exploitation of preexisting perceptual biases which increase female inve

237 divided by the total number of patients with preexisting peritoneal or mesenteric disease.

238 minate into rod-shaped, walled cells without preexisting PG templates.

239 lls, involving a base-exchange reaction from preexisting phospholipids.

240 FG and 89 036 persons (median age 79.5) with preexisting POAG, persons with XFG had more office visit

241 g chemotherapy treatments and suggest that a preexisting population harboring chr12p amplification is

242 stribution of weak shocks may reaccelerate a preexisting population of relativistic particles, produc

243 existing resistance would lead to very large preexisting populations of resistant cells at the initia

244 e propose that co-option of ABA to control a preexisting PP2C-SnRK2-dependent desiccation-tolerance p

245 y and cancer progression that are beyond the preexisting proliferative control deficit.

246 Most new proteins evolve from preexisting proteins but the evolutionary path from ance

247 models adjusted for age, sex, comorbidities, preexisting psychiatric condition, and nonshockable init

248 ight the importance of HIV coinfection, high preexisting rates of drug-resistant TB, human migration,

249 talytic BTK uncovered here may contribute to preexisting reduced sensitivity or even primary resistan

250 of p100 (IkappaBdelta) are known to inhibit preexisting RelA:p50 through sequestration, here we repo

251 n (4.3% compared with 1.5%; p = 0.0041), and preexisting renal disease (9.1% compared with 3.0%; p <

252 A noncardiac diagnosis and preexisting renal insufficiency were associated with inc

253 Noncardiac diagnoses, preexisting renal insufficiency, longer time from onset

254 However, combining preexisting resistance with persister populations can ex

255 ry high mutation induction rates, while only preexisting resistance would lead to very large preexist

256 velopment, including persister evolution and preexisting resistance, solely based on the macroscopic

257 st tuberculosis and to which there is little preexisting resistance.

258 Under the assumption of only preexisting resistant cells or only persister evolution,

259 volume trajectories and yields an estimated preexisting resistant fraction varying from 10(-4) to 10

260 ever, in the subset of patients (34.7%) with preexisting retinal neurodysfunction, IT worsened in the

261 ppears useful in preventing the worsening of preexisting retinal neurodysfunction.

262 nifestation of chronic drug use and/or are a preexisting risk factor for addiction.

263 Preexisting severe prosthesis-patient mismatch was not a

264 ctivated and measured slow, aseismic slip on preexisting, shallow faults.

265 d not hear it, and who were not exposed to a preexisting sign language because there was none availab

266 All but 1 patient who died had preexisting, significant comorbidities.

267 ed States, the COVID-19 pandemic has exposed preexisting social and health disparities among several

268 (i) as chiefdoms developed, leaders drew on preexisting social and political conditions; (ii) while

269 us to construct components that encase other preexisting solid objects, allowing for multimaterial fa

270 erface, a Python framework designed to unify preexisting spike sorting technologies into a single cod

271 anic phototropic growth process depends on a preexisting structure that has been first grown under di

272 and resistance, especially in the absence of preexisting subclones, remains unclear.

273 Preexisting surgical valve prosthesis-patient mismatch w

274 Preexisting surgical valve prosthesis-patient mismatch w

275 Patients were stratified by presence of preexisting surgical valve prosthesis-patient mismatch.

276 increase has generally been attributed to a preexisting system of orthogonal natural cracks, whose s

277 Preexisting T cell immunity to severe acute respiratory

278 The functional state of the preexisting T cells in the tumor microenvironment is a k

279 to break down tumor defenses and recover the preexisting T-cell immunity required to respond to immun

280 fy ZNF217 as a potential target toward which preexisting therapies, such as the Akt inhibitor triciri

281 oning macular area where baseline OCT showed preexisting thinning.

282 differences in techniques or the reliance on preexisting tools.

283 We accounted for preexisting trends independent of ACO participation usin

284 e that radiation-induced DSBs cooperate with preexisting tumor suppressor losses to generate high-gra

285 monstrated the potentially curative value of preexisting tumor-primed T cells in cancer treatment.

286 The presence of preexisting type 1 or type 2 diabetes in pregnancy incre

287 NA throughout the transcriptome by analyzing preexisting ultra-deep RNA-Seq data for modification-ind

288 and cardiovascular disease, as well as high preexisting use of kidney testing in such patients) subs

289 The importance of preexisting versus acquired drug resistance in patients

290 on and vaccination result from activation of preexisting virus-specific memory B cells (MBCs).

291 udies have evaluated the association between preexisting vitamin D deficiency and incident tuberculos

292 ve patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of

293 o occur when postoperative triggers act on a preexisting vulnerable substrate, but the underlying cel

294 te decompensated heart failure patients with preexisting worsening renal function (WRF) and renal tub

295 s with acute decompensated heart failure and preexisting WRF to intensive volume removal with stepped

296 te decompensated heart failure patients with preexisting WRF, intensive volume removal resulted in a

297 Eight patients with preexisting xerostomia after (177)Lu-PSMA showed no wors

298 2745 enrollees (median age 80.5 years) with preexisting XFG and 89 036 persons (median age 79.5) wit

299 llow-up for persons with newly diagnosed and preexisting XFG vs those with POAG.

300 ation are associated with surgical trauma or preexisting zonulopathy.