ライフサイエンスコーパス: pregnenolone

1 zymatic products (i.e., isocaproaldehyde and pregnenolone).

2 omovanillic acid, dehydroepiandrosterone, or pregnenolone.

3 ng are 2 pg for these steroids and 10 pg for pregnenolone.

4 lar to those for cholesterol conversion into pregnenolone.

5 lasmic linker protein 170 in the presence of pregnenolone.

6 ic factor 1, P450scc converts cholesterol to pregnenolone.

7 y for progesterone hydroxylation relative to pregnenolone.

8 onsiderably lower levels of androsterone and pregnenolone.

9 progesterone and dehydroepiandrosterone from pregnenolone.

10 re analyzed for sulfating activities towards pregnenolone.

11 yosis, displayed low activity (1-10%) toward pregnenolone.

12 n reported to be highly selective to sulfate pregnenolone.

13 H) and 20R,22R-(OH)(2) cholesterol, yielding pregnenolone.

14 activity of coded SULT2B1a allozymes toward Pregnenolone.

15 HEA than toward the 17alpha-hydroxylation of pregnenolone.

16 450 11A1 reaction to produce the key steroid pregnenolone.

17 onversion of lysosome-derived cholesterol to pregnenolone.

18 oidogenic pathway, converting cholesterol to pregnenolone.

19 Both 3alpha,5alpha-THP and pregnenolone (0.5-1.0muM) substantially (~80%) inhibited

20 h different affinities for dexamethasone and pregnenolone 16 alpha-carbonitrile and may explain the m

21 tional inducer and glucocorticoid antagonist pregnenolone 16 alpha-carbonitrile at 100 microM blocks

22 The inability of pregnenolone 16 alpha-carbonitrile to fully compete with

23 of CYP3A1 mediated by high concentrations of pregnenolone 16 alpha-carbonitrile.

24 s induced on treatment with dexamethasone or pregnenolone-16 alpha-carbonitrile only if consensus II

25 In female rats, dexamethasone and pregnenolone-16 alpha-carbonitrile treatment elevated ri

26 examethasone or with rifampicin but not with pregnenolone-16 alpha-carbonitrile.

27 Treatment with PXR activator pregnenolone 16alpha-carbonitrile (PCN) down-regulated t

28 Here we report that the activation of PXR by pregnenolone 16alpha-carbonitrile (PCN) in AKR/J mice ca

29 targeting the PXR, we activated the PXR with pregnenolone 16alpha-carbonitrile (PCN) in wild-type mic

30 ound to be induced in response to PXR ligand pregnenolone 16alpha-carbonitrile (PCN) treatment in mou

31 ecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cy

32 rongly induced by PB and modestly induced by pregnenolone 16alpha-carbonitrile in the RR strain but n

33 induction by the prototypical CYP3A inducer pregnenolone 16alpha-carbonitrile was restricted to cons

34 Notably, PXR.1 is efficaciously activated by pregnenolone 16alpha-carbonitrile, a glucocorticoid rece

35 phenobarbital (PB), Aroclor 1254, isoniazid, pregnenolone 16alpha-carbonitrile, and clofibrate) or th

36 mg/kg/day) of nicardipine, clotrimazole, or pregnenolone 16alpha-carbonitrile, but not microsomes fr

37 ,5-dichloropyridyloxy)]benzene (TCPOBOP) and pregnenolone 16alpha-carbonitrile, respectively.

38 The dexamethasone- and pregnenolone 16alpha-carbonitrile-dependent induction of

39 yridyloxy)] (TCPOBOP) but not the PXR ligand pregnenolone 16alpha-carbonitrile.

40 tment of wild-type mice with the PXR agonist pregnenolone-16alpha-carbonitrile (PCN) activated Akr1b7

41 sing isolated capillaries to the PXR ligands pregnenolone-16alpha-carbonitrile (PCN) and dexamethason

42 3a gene was induced using the mPXR activator pregnenolone-16alpha-carbonitrile (PCN) and was subseque

43 tment of animals with phenobarbital (PB) and pregnenolone-16alpha-carbonitrile (PCN) occurs via incre

44 ulation by the pregnane X receptor activator pregnenolone-16alpha-carbonitrile (PCN) or the Ah recept

45 Treatment of rats with pregnenolone-16alpha-carbonitrile (PCN), a ligand for th

46 control female, 19- and 20-day pregnant, and pregnenolone-16alpha-carbonitrile (PCN)-treated rats usi

47 old, asymptomatic hAPP mice over 7 days with pregnenolone-16alpha-carbonitrile to activate the nuclea

48 (3) and the catatoxic synthetic steroid PCN (pregnenolone-16alpha-carbonitrile).

49 50 inducers, including 3-methylcholanthrene, pregnenolone-16alpha-carbonitrile, and ciprofibrate.

50 In C57L mice given the PXR agonist, pregnenolone-16alpha-carbonitrile, or the herbal medicin

51 prototypic inducers such as dexamethasone or pregnenolone-16alpha-carbonitrile.

52 with deuterium-labeled substrates: 17-[(2)H]-pregnenolone; 17-[(2)H]-, 16alpha-[(2)H]-, 21,21,21-[(2)

53 and Preg, and P450 17A2 is more efficient in pregnenolone 17alpha-hydroxylation but does not catalyze

54 cytochrome P450scc (converts cholesterol to pregnenolone), 3beta-hydroxysteroid dehydrogenase (3beta

55 cytochrome P450scc (converts cholesterol to pregnenolone), 3beta-hydroxysteroid dehydrogenase (conve

56 at week 6 were associated with higher 17-OH-pregnenolone (7.78 vs 3.71 ng/mL, P = .0004) and lower t

57 iple species, streamlining the conversion of pregnenolone, a 3beta-hydroxy-5-ene and steroid hormone

58 The neurosteroid pregnenolone, a US Food and Drug Administration (FDA) ap

59 The limit of detection (LOD) of pregnenolone acetate in reactive-FAPAMS is 310 ng/mL, wh

60 progesterone on sperm release was specific; pregnenolone and 17alpha-OH-progesterone did not affect

61 determinations made after oral ingestion of pregnenolone and data from the literature suggest there

62 e identical for blocking DHEA formation from pregnenolone and for 17alpha-hydroxylation, suggestive o

63 ed T(H)2 CD4 T cells significantly decreased pregnenolone and IL13 mRNA and protein levels.

64 catalyzes the oxidations of progesterone and pregnenolone and is the major source of androgens.

65 of its carbon-carbon bond cleavage products, pregnenolone and isocaproaldehyde .

66 Pregnenolone and its metabolic derivatives have been sho

67 Pregnenolone and its metabolites suppressed the secretio

68 , whereas SULT2B1a preferentially sulfonates pregnenolone and only minimally sulfonates cholesterol.

69 talyses not only the 17alpha-hydroxlation of pregnenolone and progesterone and the C17,20-side chain

70 catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17alpha

71 Second, both hydroxylase substrates pregnenolone and progesterone hydrogen bond to Asn(202)

72 aboon CYP17 has apparent Km and V values for pregnenolone and progesterone of 0.9 micro m and 0.4 nmo

73 n by mediating four reactions: conversion of pregnenolone and progesterone to 17-hydroxypregnenolone

74 s 17alpha-hydroxylase activities, converting pregnenolone and progesterone to 17alpha-hydroxysteroids

75 hways; thus, Xenopus CYP17 rapidly converted pregnenolone and progesterone to dehydroepiandrosterone

76 me p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precur

77 ated by naturally occurring steroids such as pregnenolone and progesterone, and synthetic glucocortic

78 ntal data reveal novel nongenomic targets of pregnenolone and provide important leads to understand i

79 f hydroxysteroids dehydroepiandrosterone and pregnenolone and their main metabolites in human plasma

80 Progesterone, pregnenolone, and 17alpha-OH-pregnenolone were potent in

81 NAD+ as a cofactor and oxidizes cholesterol, pregnenolone, and dehydroepiandrosterone to their respec

82 aproxen, ibuprofen, geraniol, umbelliferone, pregnenolone, and estrone.

83 h cholesterol side-chain cleavage, producing pregnenolone, and hydroxylation of vitamin D3, producing

84 rticosterone, cortisol, deoxycorticosterone, pregnenolone, and progesterone in bovine adrenal zona gl

85 es the 17a-hydroxylation of progesterone and pregnenolone as well as the subsequent lyase cleavage of

86 allozymes, 11 showed reduced activity toward pregnenolone at 0.1 uM.

87 1b in the presence of the acceptor substrate pregnenolone at 2.3 A.

88 subcutaneous pellets releasing DHEA or 17-OH pregnenolone at a constant rate failed to rescue P450c17

89 ized as a rotamer that was also converted to pregnenolone at a similar rate.

90 cts of the endogenous ligands lipoxin A4 and pregnenolone at CB1Rs.

91 n the SULT2B1 isoforms, becomes ordered upon pregnenolone binding, covering the substrate binding poc

92 egnenolone-derivative MAP4343 (3beta-methoxy-pregnenolone) binds MAP-2 in vitro and increases its abi

93 sely, the SULT2B1a isoform avidly sulfonates pregnenolone but not cholesterol.

94 Pregnenolone but not lipoxin A4 displaced [(3)H]SR141716

95 The rat SULT2B1a isoform avidly sulfonates pregnenolone but poorly utilizes cholesterol as a substr

96 isms of the SULT2B1 gene on the sulfation of pregnenolone by SULT2B1a allozymes, 13 recombinant SULT2

97 is converted to the major steroid precursor pregnenolone by the CYP11A1 enzyme.

98 lesterol is more efficiently sulfonated than pregnenolone by the SULT2B1b isoform; on the other hand,

99 This bifunctional enzyme is responsible for pregnenolone C17 hydroxylation, followed by a 17,20-lyas

100 adducts of the bifunctional steroid "reduced pregnenolone" (containing two hydroxyl groups) and its d

101 me (SCC or CYP11A1) catalyzes cholesterol to pregnenolone conversion, although its mechanism of actio

102 Internal standards, pregnenolone-d4 sulfate and dehydroepiandrosterone-d2 (D

103 Notably, MAP4343, a pregnenolone derivative known to promote tubulin assembl

104 The synthetic pregnenolone-derivative MAP4343 (3beta-methoxy-pregnenol

105 We found that human glial cells produced pregnenolone, detectable by mass spectrometry and ELISA,

106 However, we observed processivity in pregnenolone/DHEA pulse-chase experiments.

107 e of the 17alpha-OH pregnenolone formed from pregnenolone did not dissociate from P450 17A1 before co

108 along with ACAT1/ACAT2 contribute to control pregnenolone ester content in different cell types and t

109 as the precursor for other steroid hormones, pregnenolone exerts its own effect as an anti-inflammato

110 the frontal cortex for allopregnanolone and pregnenolone following a swim stress and for allopregnan

111 absence of nonionic detergents, and assayed pregnenolone formation by HPLC-mass spectrometry of the

112 vity is present, i.e. some of the 17alpha-OH pregnenolone formed from pregnenolone did not dissociate

113 pression remission rates were greater in the pregnenolone group (61%) compared with the placebo group

114 in neurosteroid levels were observed in the pregnenolone group but not in the placebo group.

115 In the pregnenolone group, baseline-to-exit change in the HRSA

116 A decreased level of pregnenolone has been observed in neuroinflammatory dise

117 Pregnenolone has been reported to induce activation of c

118 The neurosteroid and major steroid precursor pregnenolone has therapeutical potential in various dise

119 f the neurosteroids pregnenolone sulfate and pregnenolone hemisuccinate, which potentiate NMDA recept

120 nist-stimulated conversion of cholesterol to pregnenolone (i.e., cytochrome P-450 cholesterol monooxy

121 or the intracellular catalytic production of pregnenolone, i.e. the genes and proteins for P450scc en

122 terone, testosterone, 5alpha,3alpha-THP, and pregnenolone in 1-2 ml of human cerebrospinal fluid (CSF

123 The levels of 5alpha, 3alpha-THP and pregnenolone in human CSF were higher than those of monk

124 of genetic polymorphism on the sulfation of pregnenolone in individuals with different SULT2B1 genot

125 Levels of pregnenolone in serum were reduced in parallel.

126 rial membranes, where it is metabolized into pregnenolone in steroidogenic cells.

127 e drug abiraterone and the natural substrate pregnenolone, in the CYP17 active site together with mol

128 oduction from progesterone and for DHEA from pregnenolone, indicating a distributive character of the

129 Notably, titration of b5 to CYP17A1.pregnenolone induced a set of conformational states clos

130 tochondria where cholesterol is converted to pregnenolone, initiating steroidogenesis.

131 Pregnenolone is a key intermediate in the biosynthesis o

132 Pregnenolone is a steroid hormone precursor that is synt

133 he ability of adipocyte CYP11A1 in producing pregnenolone is demonstrated for the first time, renderi

134 of the male hormone dehydroepiandrosterone, pregnenolone is first hydroxylated by P450 CYP17A1 at th

135 Pregnenolone is formed via three sequential monooxygenat

136 M under chronic exposure conditions, whereas pregnenolone is ineffective.

137 Although pregnenolone is one of the most abundant neurosteroids i

138 n is stronger when the hydroxylase substrate pregnenolone is present in the CYP17A1 active site than

139 These data suggest that pregnenolone is synthesized by a mitochondrial cytochrom

140 Although pregnenolone is synthesized by CYP11A1 in peripheral ste

141 of steroidogenic tissues, the first steroid, pregnenolone, is synthesized in adrenal and gonadal tiss

142 xylase activity while in contrast 17alpha-OH-pregnenolone lyase activity was stimulated by b5.

143 The results suggest that pregnenolone may improve depressive symptoms in patients

144 dogenic organs, our recent study showed that pregnenolone must be synthesized by another mitochondria

145 on, participants were administered 400 mg of pregnenolone (n=16) or placebo (n=15) and underwent 3T f

146 For 17OH-pregnenolone, no such shift is observed, the favorable H

147 rrent report, the effect of the neurosteroid pregnenolone on depressive symptoms in BPD was examined.

148 amined the effects of 3alpha,5alpha-THP, and pregnenolone on TLR4 activation in both the periphery an

149 t measurably alter the binding of 17alpha-OH pregnenolone or 17alpha-OH progesterone, as judged by th

150 progesterone but not the immediate precursor pregnenolone or estrogen, another major mammalian steroi

151 rmal pregnant females with pellets releasing pregnenolone or progesterone did not cause fetal demise.

152 Precursors of DHEA such as pregnenolone or six of its major metabolites, had no sig

153 ma tumor cells in culture biosynthesize both pregnenolone (P) and D.

154 positive allosteric modulators (zuranolone, pregnenolone, PEA), psychedelics (psilocybin, 5-MeO-DMT)

155 Pregnenolone (PREG) and dehydroepiandrosterone (DHEA) ha

156 The neurosteroid pregnenolone (PREG) and its metabolites pregnenolone sul

157 ical hydroxylation of its primary substrate, pregnenolone (PREG) and then also orchestrates a remarka

158 Pregnenolone (PREG) can be converted to PREG esters (PE)

159 tion of the steroids progesterone (Prog) and pregnenolone (Preg) to glucocorticoids and androgens.

160 10 min of exposure to the steroids cortisol, pregnenolone, pregnenolone sulfate, or progesterone.

161 l cells, implying that CYP1B1 is not a major pregnenolone-producing enzyme in the periphery.

162 Recombinant His-tag StAR stimulated pregnenolone production in a dose- and time-dependent ma

163 nlike testicular and adrenal cortical cells, pregnenolone production in glial cells was not inhibited

164 ought to identify the CYP450 responsible for pregnenolone production in the human brain.

165 P1A1/CYP1B1 inhibitors significantly reduced pregnenolone production in the presence of 22(R)-hydroxy

166 dria-targeted CYP1B1 significantly increased pregnenolone production under basal conditions and in th

167 mine and deferiprone significantly inhibited pregnenolone production, indicating involvement of anoth

168 esulted in an approximately 50% reduction in pregnenolone production.

169 ngiotensin II (5 nM)-induced aldosterone and pregnenolone production.

170 P450 cofactor ferredoxin reductase inhibited pregnenolone production.

171 nly CYP1B1 knockdown significantly decreased pregnenolone production.

172 iated with psychiatric disorders and reduced pregnenolone production.

173 The pregnenolone, progesterone, and dehydroepiandrosterone c

174 rometry (LC-MS/MS), we examined 11 steroids: pregnenolone, progesterone, corticosterone, dehydroepian

175 by upstream CYP11A1-dependent intraturmoral pregnenolone/progesterone synthesis.

176 Here we report that pregnenolone promotes ubiquitination and degradation of

177 ase reactions, particularly with 17a-hydroxy pregnenolone, remains a challenge for the treatment of p

178 Wild-type MLN64 increased pregnenolone secretion in this system 2-fold.

179 The exploitation of pregnenolone steroid for benzoquinolines and terephthala

180 Androgenic and pregnenolone steroids were significantly associated with

181 trates while the human enzyme favors Delta5 (pregnenolone) substrates.

182 zyme converts cholesterol and campesterol to pregnenolone, suggesting that digoxin biosynthesis start

183 omers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate (2), and (3alpha,5beta)-3-hydroxypr

184 The ability of pregnenolone sulfate (a positive modulator) and epipregn

185 of NMDARs include an endogenous neurosteroid pregnenolone sulfate (PES), but the binding site of PES

186 pounds, such as cholesterol and neurosteroid pregnenolone sulfate (PES).

187 roid pregnenolone (PREG) and its metabolites pregnenolone sulfate (PregS) and allopregnanolone in ser

188 TRPM3 can be activated by the neurosteroid pregnenolone sulfate (PregS) and heat.

189 Pregnenolone sulfate (PREGS), one of the most abundantly

190 h models of the GABA-inhibitory neurosteroid pregnenolone sulfate (PREGS), suggesting common mechanis

191 ates serum levels of the neuroactive steroid pregnenolone sulfate (PregS).

192 nhibited by the endogenous sulfated steroids pregnenolone sulfate (PS) and dehydroepiandrosterone sul

193 o stimulation by the endogenous neurosteroid pregnenolone sulfate (PS) and heat, and altered response

194 ted by heat and chemical agonists, including pregnenolone sulfate (PS) and nifedipine (Nif).

195 Sulfated steroids like pregnenolone sulfate (PS) are found endogenously in the

196 Pregnenolone sulfate (PS) is a sulfated neurosteroid whi

197 Pregnenolone sulfate (PS) is an abundant neurosteroid th

198 Pregnenolone sulfate (PS) is an abundant neurosteroid th

199 Pregnenolone sulfate (PS) is an endogenous neurosteroid

200 The endogenous neurosteroid pregnenolone sulfate (PS) is known to enhance memory and

201 We examined the effects of the neurosteroid pregnenolone sulfate (PS) on GABA(A) receptor-mediated s

202 Here, we report that pregnenolone sulfate (PS) uses a unique mechanism for en

203 The effects of the neurosteroid pregnenolone sulfate (PS) were studied in 3- to 9-week-o

204 One of these neurosteroid, pregnenolone sulfate (PS), depends on six identified M1

205 Pregnenolone sulfate (PS), one of the most commonly occu

206 exceeds that of the canonical TRPM3 agonist, pregnenolone sulfate (PS).

207 The steroid pregnenolone sulfate activates the transcription factor

208 iously shown that the sulfated neurosteroids pregnenolone sulfate and 3alpha-hydroxy-5beta-pregnan-20

209 parent lack of state dependence suggest that pregnenolone sulfate and 3alpha5betaP inhibit the GABA(A

210 ivated by heat and chemical agonists such as pregnenolone sulfate and CIM0216.

211 Sig-1R agonists such as pregnenolone sulfate and cocaine caused the dissociation

212 his study shows that the inhibitory steroids pregnenolone sulfate and dehydroepiandrosterone sulfate

213 loreclezole, had different IC(50) values for pregnenolone sulfate and lanthanum, and were insensitive

214 sure alters the actions of the neurosteroids pregnenolone sulfate and pregnenolone hemisuccinate, whi

215 oth compounds competed with progesterone and pregnenolone sulfate and significantly reduced CatSper a

216 bserve enantioselectivity for the actions of pregnenolone sulfate and steroid sulfate 3 indicates tha

217 tsynaptic neuron depolarization, and an anti-pregnenolone sulfate antibody scavenger blocked this eff

218 The neurosteroids alphaxalone and pregnenolone sulfate appropriately modulated GABAR curre

219 lopregnanolone and/or the inhibitory steroid pregnenolone sulfate closely matched predicted open prob

220 l CatSper currents, whereas the neurosteroid pregnenolone sulfate exerted similar effects as progeste

221 ectrophysiological techniques, we found that pregnenolone sulfate increases the frequency of AMPA-med

222 report here that the excitatory neurosteroid pregnenolone sulfate induces a long-lasting strengthenin

223 Pregnenolone sulfate inhibited GABA-evoked currents with

224 The mechanism of action of pregnenolone sulfate involved a short-term increase in t

225 Moreover, the actions of pregnenolone sulfate on type A gamma-aminobutyric acid a

226 modulation by 3alpha5alphaP but not that by pregnenolone sulfate or beta-estradiol.

227 These results indicate that (i) pregnenolone sulfate together with progesterone are the

228 nhanced responses to the neurosteroid ligand pregnenolone sulfate when co-expressed with wild-type TR

229 hermore, the GluN2A/B-selective potentiator (pregnenolone sulfate) and the GluN2C/D-selective potenti

230 either enhance (allopregnanolone) or reduce (pregnenolone sulfate) receptor function.

231 teric potentiation of NMDA receptor pores by pregnenolone sulfate, 24(S)-hydroxycholesterol, and doco

232 resence of the steroids allopregnanolone and pregnenolone sulfate, although the steroids interact wit

233 ymmetrical and symmetrical dimethylarginine, pregnenolone sulfate, and adenosine.

234 s steroids allopregnanolone (3alpha5alphaP), pregnenolone sulfate, and beta-estradiol in the absence

235 ulfated and unsulfated neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DH

236 Another class of neurosteroid, pregnenolone sulfate, engages a similar GluN2B pocket, b

237 sure to the steroids cortisol, pregnenolone, pregnenolone sulfate, or progesterone.

238 ne mediating the effects of the neurosteroid pregnenolone sulfate, or the allosteric regulatory site

239 vity for activation by the endogenous ligand pregnenolone sulfate, pointing to an allosteric interact

240 Neurosteroids, such as pregnenolone sulfate, were previously shown to modulate

241 c-Jun-specific short hairpin RNA attenuated pregnenolone sulfate-induced AP-1 activation.

242 We conclude that pregnenolone sulfate-induced TRPM3 channel activation ch

243 This finding indicates that a pregnenolone sulfate-like neurosteroid is a previously u

244 allopregnanolone and the inhibitory steroid pregnenolone sulfate.

245 t postulated for the inhibitory neurosteroid pregnenolone sulfate.

246 eady-state current of the inhibitory steroid pregnenolone sulfate.

247 fected the negative allosteric modulation by pregnenolone sulfate.

248 losteric interaction between PI(4,5)P(2) and pregnenolone sulfate.

249 osteric agonists, and the inhibitory steroid pregnenolone sulfate.

250 ue, previously shown to ablate inhibition by pregnenolone sulfate.

251 ally, testosterone antagonized the effect of pregnenolone sulfate.

252 that is unique to SULT2B1a has no effect on pregnenolone sulfotransferase activity.

253 is synthesized, whereas if exon 1A is used, pregnenolone sulfotransferase is produced.

254 ivated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216.

255 een paired stimuli or between ACSF and 1 mum pregnenolone sulphate (PREGS).

256 he circulation of phosphates, which elevated pregnenolone synthesis by 2-fold by increasing the stabi

257 siRNA knockdown did not significantly reduce pregnenolone synthesis in human adrenal cortical cells,

258 est that mitochondrial CYP1B1 is involved in pregnenolone synthesis in human glial cells.

259 nd siRNA knockdown did not negatively affect pregnenolone synthesis in human glial cells.

260 His-tag StAR proteins stimulated pregnenolone synthesis to the same extent as wild-type S

261 and sterol biosynthesis pathways upstream of pregnenolone synthesis was coordinately downregulated in

262 gh the intermediacy of cAMP rapidly increase pregnenolone synthesis, and this rapid steroidogenic res

263 e, addition of hydroxycholesterols increased pregnenolone synthesis, suggesting desmolase activity th

264 d antioxidants had no significant effects on pregnenolone synthesis, suggesting it is not regulated b

265 orylation site at serine 57 had no effect on pregnenolone synthesis.

266 r, Tom22 knockdown by siRNA had no effect on pregnenolone synthesis.

267 es for an alternative pathway for glial cell pregnenolone synthesis: (1) regulation by reactive oxyge

268 oids (allopregnanolone, epiallopregnanolone, pregnenolone, testosterone, and dehydroepiandrosterone)

269 ive symptoms of schizophrenia with a dose of pregnenolone that elevates serum levels of the neuroacti

270 22 carbon-carbon bond of cholesterol to form pregnenolone, the first 21-carbon precursor of all stero

271 aves the side chain of cholesterol, yielding pregnenolone, the precursor of all steroid hormones.

272 er mitochondrial membrane to be converted to pregnenolone, the precursor of all steroid hormones.

273 catalyzes conversion of cholesterol (CH) to pregnenolone, the precursor to all steroid hormones.

274 n cleavage (P450scc) converts cholesterol to pregnenolone, the rate-limiting enzymatic reaction in ne

275 PD, depressed mood state, were randomized to pregnenolone (titrated to 500 mg/day) or placebo, as add

276 the two-step oxidations of progesterone and pregnenolone to androstenedione and dehydroepiandrostero

277 tein that converts dehydroepiandrosterone or pregnenolone to androstenedione or progesterone, respect

278 into mitochondria, where it is converted to pregnenolone to initiate steroidogenesis.

279 pe 2 (3betaHSD2) catalyzes the conversion of pregnenolone to progesterone and dehydroepiandrostenedio

280 osensors to improve the biotransformation of pregnenolone to progesterone in yeast and to regulate CR

281 xysteroid dehydrogenase (3beta-HSD, converts pregnenolone to progesterone), and the progesterone rece

282 3beta-hydroxysteroid dehydrogenase (converts pregnenolone to progesterone), and the progesterone rece

283 id synthesis by catalyzing the conversion of pregnenolone to progesterone, which is mediated by the i

284 droepiandrostenedione to androstenedione and pregnenolone to progesterone.

285 crotubule defects were partially restored by pregnenolone treatment.

286 urther, when the concentration of 17alpha-OH pregnenolone was held constant and the P450 concentratio

287 Although the anti-inflammatory property of pregnenolone was recognized several decades ago, its mec

288 Pregnenolone was well tolerated.

289 24S-Hydroxysterol and pregnenolone were also present in the retina, but at muc

290 Progesterone, pregnenolone, and 17alpha-OH-pregnenolone were potent inhibitors of Delta24-reduction

291 ia from PBR-negative cells failed to produce pregnenolone when supplied with exogenous cholesterol.

292 oidogenic pathway, converting cholesterol to pregnenolone, whereas CYP11B2 completes the final step i

293 olesterol but is also capable of sulfonating pregnenolone, whereas SULT2B1a preferentially sulfonates

294 preference for dehydroepiandrosterone versus pregnenolone with second-order rate constants (kcat/Km)

295 factor unequivocally as the nuclear receptor pregnenolone X receptor (PXR) and its human homologue, s

296 The pregnenolone X receptor (PXR), a new member of the nucle

297 t by inhibiting the activation of NRs, human pregnenolone X receptor and constitutive androstene rece

298 tor SXR/PXR (steroid and xenobiotic receptor/pregnenolone X receptor) has been shown both biochemical