ライフサイエンスコーパス: preimplantation

1 ks of genes that play important roles during preimplantation.

2 We assayed 712 genes for requirements during preimplantation.

3 72 pairs of SCS and NMP organs when measured preimplantation.

4 This study analyzed preimplantation, 3 and 24 months protocol biopsies and a

5 etter 10 years post-implantation compared to preimplantation (7.4 +/- 4.3 vs 14.0 +/- 3.2; P < 0.0001

6 Independent factors associated with preimplantation and 3-month HRQOL scores, and with the l

7 cessful TAVR or surgical AVR (SAVR) obtained preimplantation and at 7 days, 1 and 6 months, and 1, 2,

8 ecapitulated key morphogenetic events during preimplantation and early postimplantation development i

9 ntification of novel phenotypes during mouse preimplantation and facilitates functional annotation of

10 Extensive preimplantation and outcome data were collected on all p

11 artificial insemination (AI) at day (d) 18 (preimplantation) and d 34 (postimplantation) of gestatio

12 preservation, its various modes (continuous, preimplantation) and temperatures (hypo-, sub, or normot

13 Preimplantation aortic regurgitation >/=mild was associa

14 nzyme-catalyzed process, loss of 5hmC during preimplantation appears to be a DNA replication-dependen

15 The preimplantation arrest is mainly due to a maternal cytos

16 expression) than would be predicted by their preimplantation baseline scores (5.4; 95% CI, 4.1-6.7, c

17 with real-time polymerase chain reaction, in preimplantation biopsies (n=89) and first day posttransp

18 Preimplantation biopsies and related scores have been us

19 oxidative stress and metabolic evaluation on preimplantation biopsies.

20 Preimplantation biopsy analysis is associated with accep

21 cified protocol in France and Belgium, where preimplantation biopsy findings are generally not used f

22 ted from DCD donors over 70 years old, using preimplantation biopsy Remuzzi grading to inform implant

23 d kidneys from deceased donors with AKI with preimplantation biopsy showing <10% cortical necrosis an

24 ue of the Kidney Donor Profile Index policy, preimplantation biopsy, dual KT, machine perfusion and s

25 Embryonic stem (ES) cells derived from preimplantation blastocysts and induced pluripotent stem

26 However, the inner cell mass (ICM) of mouse preimplantation blastocysts and their in vitro counterpa

27 g through the emergence of epiblast cells in preimplantation blastocysts, and ceasing during human em

28 in 116 single blastomeres comprising entire preimplantation bovine embryos (n = 23) following in vit

29 acts the levels of H3K9me3, 5mC, and 5hmC in preimplantation bovine embryos.

30 During mammalian preimplantation, cells of the inner cell mass (ICM) adop

31 Although preimplantation clinical status was associated with outc

32 reprogramming and apoptotic status of bovine preimplantation cloned embryos.

33 Preimplantation coronary angiography with simultaneous t

34 duction or various methods of ART, including preimplantation culture, embryo transfer, in vitro ferti

35 associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been kn

36 al low protein diet exclusively during mouse preimplantation development (Emb-LPD) is sufficient to c

37 t genome-scale DNA methylation maps of human preimplantation development and embryonic stem cell deri

38 s directly involved in genome defense during preimplantation development and in PGCs at the time of g

39 GA), begins during the 2-cell stage in mouse preimplantation development and marks a vital transition

40 nic genome activation, as well as subsequent preimplantation development and term viability.

41 ally suppressed during oocyte maturation and preimplantation development and that endo-siRNAs, rather

42 highlights significant differences in human preimplantation development compared with mouse and prov

43 Preimplantation development culminates with the emergenc

44 However, the roles of PADI1 in preimplantation development have not been addressed.

45 iling the expression of microRNAs throughout preimplantation development identified several candidate

46 ion using methyl-beta-cyclodextrin inhibited preimplantation development in culture.

47 ed during oocyte growth and persists through preimplantation development in mice.

48 of DNA methylation patterns during mammalian preimplantation development involves the concurrent main

49 me-wide DNA methylation reprogramming during preimplantation development is a dynamic balance between

50 are present in the blastocyst, each stage of preimplantation development is characterized by a differ

51 A major feature occurring during preimplantation development is the dramatic remodelling

52 tially packaged sperm and egg genomes during preimplantation development is unknown.

53 tivation of the FGF signaling pathway during preimplantation development of the mouse embryo is known

54 ttranslational modification is essential for preimplantation development of the mouse embryo.

55 ic primitive endoderm (PrE) formation during preimplantation development of the rabbit.

56 Melatonin was added during the preimplantation development period.

57 ucture of chromatin and its reprogramming in preimplantation development remain poorly understood.

58 vation, the full range of their functions in preimplantation development remains largely unknown.

59 -species comparison of open chromatin during preimplantation development reveals strong similarity in

60 le may be a more informative model for human preimplantation development than mice.

61 ingle-cell gene-expression analysis in human preimplantation development to instruct human stem cell

62 rnal LPD treatment during post-fertilization preimplantation development which may reflect the relati

63 evelopment to blastocyst, the final stage of preimplantation development, and promoted mitochondrial

64 of aneuploidy, digyny, progressive delays in preimplantation development, and severe degeneration bef

65 tage-specific expression in ICM cells during preimplantation development, and show that Mbd3 is requi

66 is a prolonged process that extends through preimplantation development, as characterized by slow co

67 e methylation acquired in the oocyte through preimplantation development, but become fully methylated

68 nal and zygotic Dgcr8 alleles did not impair preimplantation development, including the determination

69 Although it is essential for mammalian preimplantation development, its role remains unclear.

70 During germ cell and preimplantation development, mammalian cells undergo nea

71 he single-cell transcriptional data of mouse preimplantation development, our algorithm outperforms c

72 During preimplantation development, outside and inside cells re

73 duction of HDAC2 has no noticeable effect on preimplantation development, suggesting that individual

74 During mouse preimplantation development, the generation of the inner

75 During preimplantation development, the number of cellular MTOC

76 It has been suggested that during mouse preimplantation development, the zygotically expressed t

77 nt, maternal HDAC3 protein was stable during preimplantation development, thereby preventing an exami

78 powerful tool for the study of fertilization/preimplantation development, vertical viral gene transmi

79 tional regulation during human oogenesis and preimplantation development, we defined stage-specific t

80 aling dynamics and fate specification during preimplantation development, we generated a transgenic m

81 contents are required for fertilization and preimplantation development.

82 failed fertilization or embryo arrest during preimplantation development.

83 eres comprising a single embryo during human preimplantation development.

84 uct function in supporting fertilization and preimplantation development.

85 s, DNA methylation is globally erased during preimplantation development.

86 l roles during oogenesis, fertilization, and preimplantation development.

87 ole in maintaining energy homeostasis during preimplantation development.

88 ly disrupts oocyte chromatin methylation and preimplantation development.

89 nd the inner cell mass (ICM) lineages during preimplantation development.

90 Ctr9 and Rtf1, are required during mammalian preimplantation development.

91 tic reprogramming is required for successful preimplantation development.

92 file changes in open chromatin during bovine preimplantation development.

93 l genome in zygotes is gradually lost during preimplantation development.

94 developing intestinal epithelium and during preimplantation development.

95 ed proteins and multi-component complexes in preimplantation development.

96 e function and chromosome segregation during preimplantation development.

97 ividual HDACs have distinct functions during preimplantation development.

98 the acetylation state of histone H4K5 during preimplantation development.

99 ylases (HDAC) HDAC1, HDAC2, and HDAC3 during preimplantation development.

100 l roles during oogenesis, fertilization, and preimplantation development.

101 Zscan4 thus seems to be essential for preimplantation development.

102 ether PI3K is intrinsically activated during preimplantation development.

103 ocysts, but this was unable to improve their preimplantation development.

104 rol is a critical developmental milestone in preimplantation development.

105 sure proper embryo sheltering during in vivo preimplantation development.

106 es to overcome chromosome instability during preimplantation development.

107 neage restriction and cell commitment during preimplantation development.

108 , and differentiation are coordinated during preimplantation development.

109 os segregate three different lineages during preimplantation development: trophoblast, epiblast and h

110 lication is therefore a major cause of human preimplantation developmental arrest in vitro.

111 ally positioned to a play a critical role in preimplantation developmental events.

112 Procedural guidance includes preimplantation device selection, intraprocedural guidan

113 in preimplantation embryos suggest that the preimplantation DNMT1-dependent maintenance mechanism sp

114 slightly between FCRx samples and the paired preimplantation donor organ samples, but most of the fun

115 DNA methylation patterns in the preimplantation embryo are dependent on the oocyte-speci

116 ed methylation to maintain in the zygote and preimplantation embryo at a time when much of the remain

117 In conclusion, TSPO was found necessary for preimplantation embryo development and ACTH-stimulated s

118 ocannabinoid signaling is critical to normal preimplantation embryo development and migration of trop

119 Human preimplantation embryo development involves complex cell

120 cate that HPAT2, HPAT3 and HPAT5 function in preimplantation embryo development to modulate the acqui

121 epletion of maternal stores of Filia impairs preimplantation embryo development with a high incidence

122 tent to fertilize rhesus oocytes, leading to preimplantation embryo development, pregnancy, and the b

123 signaling is required for fertilization and preimplantation embryo development.

124 fects in several pregnancy events, including preimplantation embryo development.

125 ly provided Plag1 is needed for timely mouse preimplantation embryo development.

126 analysed global remethylation from the mouse preimplantation embryo into the early epiblast and extra

127 In conclusion, the preimplantation embryo possesses a functional WNT signal

128 pression changes in the germ line and in the preimplantation embryo would greatly enhance the underst

129 Each protein persists in cells of the preimplantation embryo, but the continuous cell-cell con

130 on of endogenous retroelements active in the preimplantation embryo.

131 derm (PrE) fate that occurs in the mammalian preimplantation embryo.

132 a mouse model of transient DNMT1 loss in the preimplantation embryo.

133 anonical WNT signaling in development of the preimplantation embryo.

134 ys essential for the continued growth of the preimplantation embryo.

135 enerated from the inner cell mass of a human preimplantation embryo.

136 y reprograms to a naive state resembling the preimplantation embryo.

137 acts in the ICM, which activates Oct4 in the preimplantation embryo.

138 sis is common in the blastomere stage of the preimplantation embryo.

139 expressed by pluripotent cells in the human preimplantation embryo.

140 hromosome status resembles that of the human preimplantation embryo.

141 lipid formation in cultured cells and during preimplantation embryogenesis.

142 nscriptome data of human, macaque, and mouse preimplantation embryogenesis.

143 Mammalian preimplantation embryonic development (PED) is thought t

144 ome activation and comparatively accelerated preimplantation embryonic development program observed i

145 transcripts frequently results in failure of preimplantation embryonic development, but their functio

146 y have any function during fertilization and preimplantation embryonic development.

147 ablation of geminin in the mouse results in preimplantation embryonic lethality because pluripotent

148 d spatial clustering are virtually absent in preimplantation embryos and are markedly reduced in fate

149 BRG1 depletion in preimplantation embryos and Cdx2-inducible embryonic ste

150 mitotic origin of segmental aneuploidies in preimplantation embryos and develop a risk stratificatio

151 and corresponding nascent RNA transcripts in preimplantation embryos and during spermatogenesis.

152 fication phenotypes, similar to FGF4-treated preimplantation embryos and Fgf4 KO embryos, respectivel

153 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from i

154 ngle-cell DNA methylome sequencing for human preimplantation embryos and found that tens of thousands

155 HDAC1 is likely a major deacetylase in preimplantation embryos and its expression inversely cor

156 mammalian genomes can be global, as seen in preimplantation embryos and primordial germ cells (PGCs)

157 enhances both the developmental potential of preimplantation embryos and the live birth rate, it migh

158 ses similar changes in downstream targets in preimplantation embryos and trophoblast stem cells.

159 Preimplantation embryos are formed, yet abnormalities in

160 is significantly higher in in vitro-produced preimplantation embryos as compared to in vivo-conceived

161 inally, we show that chromatin compaction in preimplantation embryos can partially proceed in the abs

162 Here, we show that mouse preimplantation embryos contain endogenous betaine; Bhmt

163 Mammalian preimplantation embryos develop in the oviduct as indivi

164 We previously showed that human preimplantation embryos encapsulate missegregated chromo

165 ylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of ce

166 f DNase I-hypersensitive site (DHS) of mouse preimplantation embryos from 1-cell to morula stage.

167 High quality preimplantation embryos from individual cows were pooled

168 nd mitochondrial DNA mutations in gametes or preimplantation embryos have now been developed and are

169 We further demonstrate L1 RNA in preimplantation embryos lacking the L1 transgene and L1

170 and support the notion that discarded human preimplantation embryos may be useful recipients for the

171 ablation of the geminin gene (Gmnn) in mouse preimplantation embryos resulted in apoptosis, suggestin

172 liMAB-seq analysis of preimplantation embryos reveals the oxidation of 5mC to

173 ments of non-DMD, but not DMD methylation in preimplantation embryos suggest that the preimplantation

174 unostaining of mitotic chromosome spreads of preimplantation embryos that the 5hmC associated with th

175 does not adversely affect the development of preimplantation embryos to blastocysts and uterine prepa

176 plex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulate

177 Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming

178 perm protection but also indirect effects on preimplantation embryos via oviduct expression of embryo

179 essential cytoplasmic complex in oocytes and preimplantation embryos with poorly understood function,

180 of the heterozygous MYBPC3 mutation in human preimplantation embryos with precise CRISPR-Cas9-based t

181 ion embryos as compared to in vivo-conceived preimplantation embryos(4).

182 In some developmental contexts (e.g., preimplantation embryos) DNA is hypomethylated but repet

183 gly, these genes are paternally expressed in preimplantation embryos, and ectopic removal of H3K27me3

184 ides a high-resolution view of aneuploidy in preimplantation embryos, and supports the conclusion tha

185 rs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and bi

186 ation and oxidative stress were increased in preimplantation embryos, fetuses, and newborns of Wester

187 that are present in oocytes, sperm and early preimplantation embryos, including atypical patterns of

188 two SEs was also seen at different stages in preimplantation embryos, revealing that methylation hete

189 factor in determining methylation status in preimplantation embryos, suggesting a need to reassess m

190 ethod that facilitates chromatin analysis of preimplantation embryos, that H3K9me3 is enriched at the

191 the first time, a knockdown screen in mouse preimplantation embryos.

192 ingle-cell RNA-sequencing of human and mouse preimplantation embryos.

193 preservation of human and animal oocytes and preimplantation embryos.

194 in naive pluripotent stem cells (PSCs) with preimplantation embryos.

195 be reset in primordial germ cells (PGCs) and preimplantation embryos.

196 pplementation on the transcriptome of bovine preimplantation embryos.

197 f the H3K27me3 decrease normally observed in preimplantation embryos.

198 ning the role of kinesin 5 in mouse eggs and preimplantation embryos.

199 essential role for CTCF in mouse oocytes and preimplantation embryos.

200 ne lipid rafts in mouse oocytes and cleaving preimplantation embryos.

201 at PI3K is constitutively activated in mouse preimplantation embryos.

202 th dividing and postmitotic cells, including preimplantation embryos.

203 ers are accessible in GV and MII oocytes and preimplantation embryos.

204 an also serve as an imprinting mark in mouse preimplantation embryos.

205 and H2A.Z are also accessible in oocytes and preimplantation embryos.

206 , which are known to stimulate the growth of preimplantation embryos.

207 s critical functions for spindle assembly in preimplantation embryos.

208 maternal Xist expression and maternal XCI in preimplantation embryos.

209 Indeed, when preimplantation endometrial stromal cells are exposed to

210 use embryonic stem cells (ESCs) resemble the preimplantation epiblast and efficiently contribute to c

211 how the naive state is inherently linked to preimplantation epiblast identity in the embryo.

212 , a pre-requisite for rapid progression from preimplantation epiblast to gastrulation in rodents.

213 e transcriptional circuitry operative in the preimplantation epiblast.

214 Mettl3 knockout preimplantation epiblasts and naive embryonic stem cells

215 Therefore, DMAP1 mediates distinct preimplantation epigenetic reprogramming processes: TIP6

216 of this compensation, we found that reduced preimplantation estrogen secretion from ovarian HB-EGF d

217 regulating on-site anandamide tone to direct preimplantation events that determine the fate of pregna

218 estions: are the cells that show such early, preimplantation expression of this AVE marker the real p

219 egnancy derived synthetic peptide, synthetic PreImplantation Factor (sPIF), crosses the blood-brain b

220 fore and during X chromosome inactivation in preimplantation female embryos(15).

221 To describe the first case of preimplantation genetic diagnosis (PGD) and in vitro fer

222 pplication, success rates and limitations of preimplantation genetic diagnosis (PGD) for haematologic

223 Currently, the methods available for preimplantation genetic diagnosis (PGD) of in vitro fert

224 ite markers is the current gold standard for preimplantation genetic diagnosis (PGD) of single-gene d

225 The technology of preimplantation genetic diagnosis and genetic testing in

226 genetic results from nephrology research and preimplantation genetic diagnosis for heritable kidney d

227 in genetic counseling, prenatal testing, and preimplantation genetic diagnosis in extended families a

228 ethod can be applied as a generic method for preimplantation genetic diagnosis on single cells biopsi

229 fate may be of practical importance, because preimplantation genetic diagnosis requires removal of bl

230 by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibil

231 for prenatal and presymptomatic testing and preimplantation genetic diagnosis.

232 mutations in human embryos by complementing preimplantation genetic diagnosis.

233 in vitro fertilization and subsequently used preimplantation genetic diagnosis; 3 months ago she deli

234 s using whole genome amplification (WGA) and preimplantation genetic haplotyping (PGH) of embryos.

235 The MALBAC-based preimplantation genomic screening in in vitro fertilizat

236 cytes are important for meiosis research and preimplantation genomic screening.

237 the ability to spontaneously assimilate into preimplantation host morula via diploid aggregation, uni

238 We report studies of preimplantation human embryo development that correlate

239 age-specific transcription factors in staged preimplantation human embryos from the zygote until the

240 ant insight into developmental patterning of preimplantation human embryos with potential consequence

241 ion promoted a stable acquisition of a human preimplantation ICM-like ground state via modulation of

242 60-p400 complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1(+/+) and Dnmt1(V)(/)(V) ba

243 mation capture (HiC) protocol(12,13), during preimplantation in the mouse.

244 PSC) lines could be reverted to stable human preimplantation inner cell mass (ICM)-like naive states

245 Preimplantation kidney biopsies from ECD (n = 41) and st

246 icroarrays in 34 graft biopsies collected at preimplantation (L1) and at 90 min postreperfusion (L2)

247 Geminin knockout mouse embryos are preimplantation lethal by the 32-cell stage, precluding

248 blation of the mouse Tead4 gene results in a preimplantation lethal phenotype, and TEAD4 is one of tw

249 blation of the single murine Sac1 results in preimplantation lethality in the mouse and that Sac1 ins

250 The preimplantation mammalian embryo is a paradigm of tissue

251 Naive pluripotency is manifest in the preimplantation mammalian embryo.

252 Intriguingly, the trophectoderm (TE) in preimplantation monkey blastocysts also expressed X-link

253 proaches, and small molecule analyses during preimplantation mouse development to probe the mechanism

254 at Xist RNA functions relatively late during preimplantation mouse development.

255 y and high-quality cell cycle progression in preimplantation mouse development.

256 tomeres compact to form polarized morulae in preimplantation mouse development.

257 ization may reflect the regulative nature of preimplantation mouse development.

258 In the preimplantation mouse embryo, TEAD4 is critical to estab

259 ombine to determine distinct lineages of the preimplantation mouse embryo.

260 gain of EED along with depletion of KDM6B in preimplantation mouse embryos abrogates CDX2 and GATA3 e

261 iating gene silencing on the X chromosome in preimplantation mouse embryos and in embryonic stem cell

262 sed on activation of the embryonic genome in preimplantation mouse embryos is the formation of a chro

263 (mESCs) are clonal populations derived from preimplantation mouse embryos that can be propagated in

264 We show that Usp36 depletion is lethal in preimplantation mouse embryos, where it blocks the trans

265 Perturbation of BMP signaling in preimplantation mouse embryos, whether by treatment with

266 lopment and is required for cell cleavage in preimplantation mouse embryos.

267 ding cells in the C. elegans germline and in preimplantation mouse embryos.

268 ta-2-spectrin co-localize with E-cadherin in preimplantation mouse embryos.

269 otent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established thro

270 Preimplantation necrosis (n = 7) was initially managed c

271 defers on-time implantation without altering preimplantation ovarian estrogen secretion.

272 e to dams prior to conception and during the preimplantation period can modulate gene expression in b

273 PR was decreased during decidualization and preimplantation period in Stat3(d/d) mice, and PR target

274 During the preimplantation period of pregnancy in eutherian mammals

275 pha accumulation in stromal cells during the preimplantation period.

276 nto adjacent tissue layers by the end of the preimplantation period.

277 ICD shock and the patient's preimplantation personality disposition were equally imp

278 d the association of shock and the patient's preimplantation personality with health status, using a

279 maternal Xist (Xm-Xist) is repressed during preimplantation phases to establish imprinted X-chromoso

280 of genetic discoveries on stigma, abortion, preimplantation procedures, and population screening for

281 THODS AND INTERMACS patients (n=3248) with a preimplantation profile of 1 (critical cardiogenic shock

282 d the apoptosis executor enzyme caspase-3 in preimplantation renal biopsies (PIB) as markers for dela

283 learning than would be predicted from their preimplantation scores.

284 e capacity of RNA-seq as a promising tool in preimplantation screening by showing that biopsies of an

285 n gonads at 12.5 dpc, these findings suggest preimplantation selection of embryos.

286 is revealed transient and early induction of preimplantation-specific genes in a Zscan4-dependent man

287 d H3K79 methylation in the zygote and in the preimplantation stage embryo is dispensable for mouse de

288 the frequency at which unspecified cells in preimplantation stage embryos express lineage markers pr

289 mitosis progresses gradually throughout the preimplantation stage in the mouse embryo, thus providin

290 lts illustrated the dynamic TE expression at preimplantation stages and revealed 146 TE-containing nc

291 d knowledge about the role of Notch in early preimplantation stages of mammalian development, or how

292 sults show that multiple signaling inputs at preimplantation stages specify the first embryonic linea

293 undant at the blastocyst stage but not other preimplantation stages, and BHMT activity is similarly d

294 ernally biased expressed genes (PBGs) in the preimplantation stages.

295 nce of histone H3 lysine 9 trimethylation in preimplantation stem cells.

296 genes at postreperfusion time compared with preimplantation time.

297 ion of different chemical agents or drugs in preimplantation tissues.

298 We have examined the preimplantation transcriptome of 112 kidney transplant r

299 yonic stem cells (ESCs) sporadically express preimplantation two-cell-stage (2C) transcripts, includi

300 The results demonstrate that the preimplantation uterus relies on Notch signaling to inhi