ライフサイエンスコーパス: premature death

1 logical disorders, metabolic abnormality and premature death.

2 ibrosis, apoptosis, cardiac dysfunction, and premature death.

3 nsistently associated with increased risk of premature death.

4 ibrosis, apoptosis, cardiac dysfunction, and premature death.

5 behavioral abnormalities, and prevention of premature death.

6 lead to a considerable change in the risk of premature death.

7 late-onset lymphoid cancer development, and premature death.

8 l lung disease, ulcerative skin lesions, and premature death.

9 ss to fibrosis and cirrhosis contributing to premature death.

10 nd adults and that, if untreated, results in premature death.

11 with no indications of cardiac pathology or premature death.

12 pread central nervous system dysfunction and premature death.

13 heart failure, reduced quality of life, and premature death.

14 ical degeneration that causes disability and premature death.

15 often results in advanced heart failure and premature death.

16 mia, T cell cytopenia, skin ulcerations, and premature death.

17 r risk factor for stroke, heart failure, and premature death.

18 quently culminate in right heart failure and premature death.

19 n leading to abnormal foetal development and premature death.

20 ociated with cardiovascular disease risk and premature death.

21 r risk factor for cardiovascular disease and premature death.

22 ations, severe cardiovascular pathology, and premature death.

23 progressive cognitive and motor decline, and premature death.

24 ing disease leading to severe disability and premature death.

25 sis that increase the risk of arrhythmia and premature death.

26 use progressive neurologic deterioration and premature death.

27 d cardiac ventricular hypertrophy leading to premature death.

28 e motor neuron loss leading to paralysis and premature death.

29 factor for ESRD, cardiovascular disease, and premature death.

30 istance, right ventricular (RV) failure, and premature death.

31 pread sickling and tissue damage, leading to premature death.

32 e dementia, movement disorders, seizures and premature death.

33 idney failure, cardiovascular morbidity, and premature death.

34 pathy that leads to hind limb spasticity and premature death.

35 n of morbidity and are at increased risk for premature death.

36 cardiomyopathy, myocardial infarctions, and premature death.

37 hy (DCM), a major cause of heart failure and premature death.

38 factor for cardiovascular disease (CVD) and premature death.

39 ve stress, symptoms of hemolytic anemia, and premature death.

40 , blindness, motor and cognitive decline and premature death.

41 a strong predictor of subsequent suicide and premature death.

42 tios for cardiomyopathy by family history of premature death.

43 hich can progress to heart failure and cause premature death.

44 ion, Purkinje cell death, lipid storage, and premature death.

45 emodelling, progression to heart failure and premature death.

46 l infarction, heart failure, and stroke, and premature death.

47 ncluding severe neurological impairments and premature death.

48 an adults have extraordinarily high rates of premature death.

49 n, impairment of mobility, and in some cases premature death.

50 Rap1b induced massive glomerulosclerosis and premature death.

51 vors (CCSs) are at high risk for illness and premature death.

52 t lead to muscle wasting and, in most cases, premature death.

53 en living in adverse contexts are at risk of premature death.

54 g neuropathy, failed muscle regeneration and premature death.

55 ized by progressive neuronal dysfunction and premature death.

56 s to loss of abdominal fat, infertility, and premature death.

57 ing,respiratory and cardiac impairments, and premature death.

58 rs may have greater risk for poor health and premature death.

59 s in neurons, severe locomotion defects, and premature death.

60 are generalized skeletal muscle weakness and premature death.

61 rupted skin and hair development, and caused premature death.

62 , blindness, motor and cognitive decline and premature death.

63 heart failure, reduced quality of life, and premature death.

64 e phenotype with impaired liver function and premature death.

65 is and fibrosis, dilated cardiomyopathy, and premature death.

66 tributed to myocyte loss, heart failure, and premature death.

67 O2 suggest that traffic pollution relates to premature death.

68 malities, compromised motor performance, and premature death.

69 eta and hs-CRP concentrations on the risk of premature death.

70 , motor and cognitive decline, seizures, and premature death.

71 antibiotic exposure may be a risk factor of premature death.

72 rated macrocephaly, spontaneous seizures and premature death.

73 a wheelchair, respiratory insufficiency and premature death.

74 ge to skeletal and cardiac muscle leading to premature death.

75 lications that collectively increase risk of premature death.

76 s that contribute to increased morbidity and premature death.

77 alters organ-to-body proportions, and causes premature death.

78 s, cognitive and motor decline, seizures and premature death.

79 t with neurodegeneration, loss of vision and premature death.

80 motor and respiratory deficits, seizures and premature death.

81 ult in accelerated lung function decline and premature death.

82 rder (OUD) is associated with a high risk of premature death.

83 hy associated with diastolic dysfunction and premature death.

84 progressive muscle wasting and weakness and premature death.

85 tive impairment, autistic-like behavior, and premature death.

86 Heart failure is a major cause for premature death.

87 e and progressive course that often leads to premature death.

88 n of advanced disease rather than a cause of premature death.

89 ced ejection fraction, cardiac fibrosis, and premature death.

90 exceptional arterial and organ fragility and premature death.

91 PUFA intake in lowering the risk of CVD and premature death.

92 iseases causing irreversible lung damage and premature death.

93 hepatic steatosis, cardiac hypertrophy, and premature death.

94 nal shortening, hypertrophy, dilatation, and premature death.

95 e to lupus nephritis (LN) have high rates of premature death.

96 cerbated organ damage, ultimately leading to premature deaths.

97 It leads to millions of premature deaths.

98 c health response is needed to avert further premature deaths.

99 global population, cause 3.9 million annual premature deaths.

100 2.5) is a causal factor in over 5% of global premature deaths.

101 in treatment, monitor DST results, and avoid premature deaths.

102 ockade of embryogenesis, adult sterility and premature death 18-24 months post-treatment.

103 0.1-1.6 mug/m(3)), avoiding an estimated 290 premature deaths, 180 hospital admissions for respirator

104 A third scenario assumed a 40% reduction in premature deaths across all ages and causes.

105 ires cause poor air quality and thousands of premature deaths across densely populated regions in Equ

106 For premature deaths (age 30-69 years), the WHO triple-inter

107 c fatty liver disease (NAFLD) contributes to premature death along with obesity, diabetes, and cardio

108 Risk of premature death among patients with lifetime anorexia ne

109 e showed positive advantage on prevention of premature death among persons with OUD.

110 for the prevention of CVD complications and premature deaths among individuals with diabetes mellitu

111 h is needed to help decision makers to avoid premature deaths among patients already in hospitals and

112 Herein, we demonstrate premature death and acceleration of age-related patholog

113 Since 1990, premature death and disability caused by communicable, n

114 ic heart disease (RHD) is a leading cause of premature death and disability in low-income countries;

115 However, the magnitude of excess risk of premature death and incident complications remains incom

116 the impact of tobacco smoking on the risk of premature death and its contribution to the excess morta

117 Type 2 diabetes leads to premature death and reduced quality of life for 8% of Am

118 et syndrome, including spontaneous seizures, premature death and seizures triggered by hyperthermia.

119 th percentile), avoiding between 160 and 390 premature deaths and 460 hospitalizations and emergency

120 ulation) would accrue 81.8% of reductions in premature deaths and 87.1% of gains in terms of quality-

121 to be associated with avoidance of 8 million premature deaths and an estimated extended mean life spa

122 Tobacco taxation reduces smoking-related premature deaths and increases government revenues, but

123 al cost $58.7 billion), averting 4.5 million premature deaths and leading to a gain of 51.5 million h

124 al causes of death, resulting in 5.8 million premature deaths and millions more with disability.

125 and has the potential to avoid a few million premature deaths and related morbidity from CVD at low c

126 spastic paraplegia, developmental delay with premature death, and autism spectrum disorder with intel

127 nts (ie, informal care), lost earnings after premature death, and costs associated with individuals w

128 tulate the DS phenotype, including seizures, premature death, and impaired spatial memory performance

129 rder marked by growth retardation, diabetes, premature death, and severe lymphoid and myeloid hypopla

130 ing scenario costs, avert an additional 4.6% premature deaths, and add an additional 9.6% healthy lif

131 Reduced exposure to PM(2.5) avoids 300 premature deaths annually (95% CI: 60 to 580) valued at

132 o an estimated 16,889 (3,839-30,663, 95% CI) premature deaths annually combining the effects of NMVOC

133 dmissions from exposure to SO2, and up to 30 premature deaths annually due to ECA emission controls.

134 iencies account for an estimated one million premature deaths annually, and for some nations can redu

135 e workplace are responsible for over 370,000 premature deaths annually.

136 tor, accounting for an estimated 1.6 million premature deaths annually.

137 .1 ppb, respectively, resulting in 200 fewer premature deaths annually.

138 l combustion is associated with four million premature deaths annually; contributes to forest degrada

139 One in three premature deaths are attributable to socioeconomic inequ

140 Premature deaths are generally more common among patient

141 t PM(2.5), avoiding 130,000 (90,000-160,000) premature deaths associated with PM(2.5) exposure.

142 early-onset spontaneous seizures leading to premature death at 2-3 weeks of age.

143 henotype with mental retardation, leading to premature death at age 36 years in one of them.

144 egy for the poorest populations that targets premature death at younger ages, addresses environmental

145 r quality improvements decreased the risk of premature death attributable to PM2.5 sulfate in NC by a

146 eme Court) could substantially decrease U.S. premature deaths attributable to coal-fired power plant

147 Although studies have provided estimates of premature deaths attributable to either heat or cold in

148 ne across Europe will increase the number of premature deaths attributable to ozone pollution each ye

149 ely equating to 3.9 million (95% CI 2.5-5.6) premature deaths averted annually.

150 aged 40-74 years, we estimated the number of premature deaths averted for all adults and by gender.

151 Number of premature deaths avoided and years of life saved were pr

152 sible for averting 180,000 (117,000-389,000) premature deaths between 1990 and 2012.

153 ent to induce progressive motor symptoms and premature death, but genetically lacks corticospinal neu

154 ron degeneration, severe muscle wasting, and premature death by 6 mo of age.

155 spholamban (PLB) triggers cardiomyopathy and premature death by altering regulation of sarco/endoplas

156 Adjusted odds ratios (AORs) of premature death by external causes in patients with TBI

157 this population and may also help to reduce premature death by providing a forum for mutual support

158 n lower-middle-income countries would reduce premature deaths by an estimated 4.2 million per year.

159 s on premature avertable mortality from NCDs-premature deaths caused by NCDs that could be prevented

160 Of an estimated 1.10 million premature deaths caused by PM2.5 pollution throughout Ch

161 nevitability of death (patients), preventing premature death (clinicians), and ensuring safety (regul

162 ted severe growth retardation, kyphosis, and premature death, closely resembling the phenotype of sys

163 us erythematosus (SLE) have a higher rate of premature death compared to the general population, sugg

164 T2 from the brain, resulting in epilepsy and premature death, confirming the importance of EAAT2 for

165 stigate the impact of smoking on the risk of premature death, controlling for confounders.

166 More premature deaths could be averted in southern states (60

167 Occurrence of premature death (death prior to scheduled euthanasia) wa

168 r National Statistics to study all 2 465 285 premature deaths (defined as those before age 75 years)

169 high-income countries, the biggest cause of premature death, defined as death before 70 years, is sm

170 d's adult population and is a major cause of premature death despite considerable advances in pharmac

171 val motor neuron (SMN) protein that leads to premature death due to loss of motor neurons and muscle

172 riven estimates of the burden of disease and premature death due to major risk factors.

173 ncer defenses), thereby limiting the risk of premature death due to metastatic cancers.

174 , leading to progressive muscle weakness and premature death due to respiratory and/or cardiac compli

175 degenerative disease can be fatal, including premature death due to respiratory dysfunction.

176 ombin (Serpinc1) or protein C (Proc) display premature death due to thrombosis-related coagulopathy,

177 ere we show, of the 1.08 (0.74-1.42) million premature deaths due to anthropogenic PM(2.5) exposure i

178 of cause-specific outcomes examined, risk of premature death during the first year after discharge wa

179 regions could avoid several hundred thousand premature deaths each year.

180 primary PM(2.5) emissions led to cross-state premature deaths equal to three times those associated w

181 they still account for tens of thousands of premature deaths every year.

182 The burden of premature death for men (2.04 million years of potential

183 ies could substantially reduce suffering and premature death from cancer before 2030, with even great

184 weakness, leading to loss of ambulation and premature death from cardiopulmonary failure.

185 ised as a cost-effective means of addressing premature death from cardiovascular disease.

186 th of President Franklin D Roosevelt and his premature death from hypertensive heart disease and stro

187 entral Asia, face particularly high rates of premature death from ischemic heart disease.

188 In contrast, a family history of premature death from other cardiac or noncardiac conditi

189 riated muscle wasting disorder that leads to premature death from respiratory and/or cardiac failure.

190 tion of striated muscle wasting resulting in premature death from respiratory and/or cardiac failure.

191 We estimated the burden of premature death from SCD and compared it with other dise

192 program was predicted to annually prevent 90 premature deaths from AAA and to gain 577 quality-adjust

193 desh contributes to the largest reduction of premature deaths from ambient air pollution, preventing

194 % in India and Nepal, and result in ~300 000 premature deaths from chronic obstructive pulmonary dise

195 The majority of premature deaths from CRC in southern states and half th

196 0 (142000-172000) and 182000 (163000-197000) premature deaths from heating and cooking emissions, res

197 culosis, HIV, and malaria deaths; a third of premature deaths from non-communicable diseases (NCDs);

198 e hypertension is the leading risk factor of premature death globally.

199 d with about 38,000 PM2.5- and ozone-related premature deaths globally in 2015, including about 10 pe

200 ulting in stroke, device-exchange surgery or premature death) has been increasing dramatically, which

201 fuel cookstoves is a leading risk factor for premature death; however, the effect of fuel moisture co

202 childhood approximately doubled the rate of premature death (ie, before age 70 years).

203 a and neurodegenerative phenotype leading to premature death in 36% of the population.

204 R2 editing leads to early-onset epilepsy and premature death in a mouse model.

205 Acute loss of Sel1L leads to premature death in adult mice within 3 wk with profound

206 sed risk of developing diabetes, obesity and premature death in adult offspring.

207 ajor contributor to morbidity, mortality and premature death in cystic fibrosis.

208 ecognized site and mechanism contributing to premature death in individuals with leaky RYR2 mutations

209 e hypothyroidism leads to growth defects and premature death in mice, we assayed for changes in thyro

210 atrophy, loss of goblet and Paneth cells and premature death in mice.

211 nal calcification, renal tubular injury, and premature death in multiple animal models.

212 ls rapidly led to severe organ pathology and premature death in Noxa-deficient mice.

213 continue to cause unnecessary disability and premature death in older people.

214 pected death in epilepsy is a major cause of premature death in people with epilepsy.

215 dering these postmitotic cells vulnerable to premature death in retinal degenerative disorders.

216 hence, these cells are highly susceptible to premature death in retinal degenerative disorders.

217 t vodka is a major cause of the high risk of premature death in Russian adults.

218 We studied the mechanism of premature death in Scn1a heterozygous KO mice and condit

219 h parents and by AUD, drug abuse, crime, and premature death in stepparents.

220 death (SCD) are among the leading causes of premature death in the general population, the origins r

221 AV-Slc25a46 treatment was able to rescue the premature death in the mutant mice (Slc25a46-/-).

222 f prescription opioids is a leading cause of premature death in the United States.

223 ease and stroke remain the leading causes of premature death in the world; however, there is wide reg

224 ancer are important causes of disability and premature death in women, who are the primary cooks and

225 ioxide emissions caused the most cross-state premature deaths in 2005, but by 2018 primary PM(2.5) em

226 opogenic PM(2.5) was responsible for 107,000 premature deaths in 2011, at a cost to society of $886 b

227 tely 174,000 global PM2.5- and ozone-related premature deaths in 2040.

228 Contributory factors to premature deaths in a subset of people with intellectual

229 000 (306000-370000; 95% confidence interval) premature deaths in China are attributable to residentia

230 e and the USA is linked to more than 108,600 premature deaths in China.

231 ardiomyopathy increased 100-fold; given >/=2 premature deaths in first-degree relatives, the rate inc

232 the atmosphere and contribute to millions of premature deaths in humans each year.

233 Data are scarce on premature deaths in people with mental disorders in HIV-

234 China in 2007 is linked to more than 64,800 premature deaths in regions other than China, including

235 rosis followed by myocardial infarctions and premature deaths in response to high-fat, high-cholester

236 uding about 10 per cent of all ozone-related premature deaths in the 28 European Union member states.

237 Smoking accounted for a quarter of all premature deaths in this population, but quitting before

238 about contributory factors to avoidable and premature deaths in this population.

239 other than China, including more than 3,100 premature deaths in western Europe and the USA; on the o

240 Epilepsy may cause premature death indirectly through co-morbid conditions.

241 Understanding the causes of premature death is a prerequisite for improving long-ter

242 st burden of household air pollution-related premature deaths is in children with pneumonia exposed t

243 2 in adipocytes, mediated by aP2-Cre, led to premature death, lack of white fat, low blood pressure,

244 progressive cognitive and motor decline and premature death (late teens to 20s).

245 risk of cardiomyopathy by family history of premature death (<60 years) from cardiomyopathy.

246 announced its goal of reducing the number of premature deaths (<70 years) due to noncommunicable chro

247 ubertal nadir androgen condition resulted in premature death, maintenance of androgen levels extended

248 ate identification of people at high risk of premature death may assist in the targeting of preventiv

249 A wide spectrum of CV conditions, including premature death, might develop consecutively or in paral

250 ged 25-49 years, an estimated 111 000 excess premature deaths occurred in white individuals and 6600

251 To counter premature death of a virus-infected cell, poxviruses use

252 lethal, muscle degenerative disease causing premature death of affected children.

253 ve muscle weakness, paralysis and eventually premature death of afflicted individuals.

254 on inhibited IEC apoptosis and prevented the premature death of mice with IEC-specific RIPK1 knockout

255 leading to a severe skin barrier defect and premature death of newborn animals.

256 ay explores the consequences of the imagined premature death of Oswald Avery, who in 1944 provided ev

257 ia activates a brainstorm, which accelerates premature death of the heart and the brain.

258 tion followed by either clonal exhaustion or premature death of the T cell.

259 e-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering b

260 The Confidential Inquiry into premature deaths of people with intellectual disabilitie

261 lation (OR: 1.08; 95% CI: 1.05 to 1.10), and premature death (OR: 1.04; 95% CI: 1.02 to 1.06).

262 eads to cardiac conduction abnormalities and premature death owing to arrhythmia.

263 matter (PM) pollution is a leading cause of premature death, particularly in those with pre-existing

264 cent confidence interval 1.61-4.81) million premature deaths per year worldwide, predominantly in As

265 y toxic when inhaled, leading to millions of premature deaths per year(2,3).

266 olid fuels used for cooking cause ~4 million premature deaths per year.

267 sis and vascular calcification that leads to premature death, predominantly of myocardial infarction

268 (PM2.5) amount to approximately 22.5 million premature deaths prevented between 2000 and 2100.

269 ion in these mice, consequently leading to a premature death rate of 40% within 2 weeks of treatment,

270 al fibrosis, leading to kidney failure and a premature death rate of 67% by 9 weeks of age.

271 o migration drove 137.1 (95%CI: 93.2, 179.4) premature deaths related to air pollution, with rural-ur

272 Climate change yields annual premature deaths related to fine particulate matter and

273 We find that, of the 3.45 million premature deaths related to PM2.5 pollution in 2007 worl

274 extent to which these factors contribute to premature death resulting from CRC nationwide and by sta

275 We also calculated the proportion of premature death resulting from CRC that could potentiall

276 Overall, half the premature deaths resulting from CRC that occurred nation

277 d Health Organization 25x25 risk factors for premature death, smoking and body mass index (BMI) were

278 ment to slow or halt SCAs (many SCAs lead to premature death), the clinical care of patients with SCA

279 ques but profoundly reduced the incidence of premature deaths, the number of thrombi (7 in 249 plaque

280 odelling, decline of cardiac performance and premature death, thereby limiting the use of betaAR agon

281 idney disease among NCD targets for reducing premature death throughout the world.

282 ulted in a reduction of risk with respect to premature death to 20.6% compared with the control group

283 ing from progressive infantile paralysis and premature death (type I) to limited motor neuron loss an

284 health target, "Avoid in each country 40% of premature deaths (under-70 deaths that would be seen in

285 e change in the number and economic value of premature deaths using modeled changes in ozone levels r

286 the number needed to operate on to prevent 1 premature death were 667 and 1.5, respectively.

287 causes, the years of life lost (YLLs) due to premature death were calculated.

288 35.6% (95% CI 35.3-35.9) of premature deaths were attributable to socioeconomic ineq

289 severe developmental defects, cell death and premature death, which correlate with the constitutive a

290 require 2 major advancements: (1) minimizing premature death with a functioning graft in the patients

291 icular arrhythmias, fibrosis, apoptosis, and premature death within 4 weeks.

292 rons causes axonal and locomotor defects and premature death without apparent TDP-43 pathology.

293 Fatty liver causes premature death worldwide and requires long-term health

294 of the ten leading causes of disability and premature death worldwide are psychiatric conditions.

295 rtension is the leading preventable cause of premature death worldwide.

296 leading cause of cardiovascular disease and premature death worldwide.

297 olid fuels is associated with over 4 million premature deaths worldwide every year including half a m

298 g risk factor for cardiovascular disease and premature deaths worldwide.

299 40% fewer premature deaths would be important in all countries, bu

300 ion people, causing severe complications and premature death, yet the underlying molecular mechanisms