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1 esolution picture of a non-mammalian protein prenyltransferase.
2 enzymes such as the isoprenoid synthases and prenyltransferases.
3 to a conserved P-loop motif in this class of prenyltransferases.
4 FTase and is conserved in all known protein prenyltransferases.
5 c substrate isopentenyl diphosphate in other prenyltransferases.
6 eral common features with flavonoid-specific prenyltransferases.
7 the structures accessed by bacterial indole prenyltransferases.
8 ither cis-prenyltransferases (CPTs) or trans-prenyltransferases.
9 logies with known flavonoid and isoflavonoid prenyltransferases.
10 l and functional similarity to other protein prenyltransferases.
13 ed in up to 30% of all human cancers, making prenyltransferases a viable target for chemotherapeutic
14 nylated stilbenoids suggested that these two prenyltransferase activities represent the first committ
16 t time, a membrane-bound stilbenoid-specific prenyltransferase activity from the microsomal fraction
17 K-ras knockdown by siRNA or inhibition of prenyltransferase activity resulted in radiation sensiti
18 nonradioactive assay can be used to measure prenyltransferase activity under either single or multip
20 each cDNA individually yielded no detectable prenyltransferase activity; however, coexpression of the
21 prene donor specificity of the N1-tryptophan prenyltransferase AcyF from the anacyclamide A8P pathway
22 na benthamiana We observed that one of these prenyltransferases, AhR4DT-1, catalyzes a key reaction i
23 prenyl diphosphate synthase, and an aromatic prenyltransferase allow formation of a highly unusual ar
24 pattern that phenocopied silencing FNTA, the prenyltransferase alpha subunit shared by farnesyltransf
25 ltransferase complex consisting of an orphan prenyltransferase alpha-subunit, PTAR1, and the catalyti
27 er consisting of the synthase AN1242 and the prenyltransferase AN11080, as well as identification of
30 les, other examples of which include protein prenyltransferases and cobalamin-independent methionine
31 ses substrate selectivity upon lanthipeptide prenyltransferases and narrows their substrate scope as
32 logues for the study of a variety of protein prenyltransferases and other enzymes that employ FPP or
33 f the malaria parasite and mammalian protein prenyltransferases and their cellular substrates is impo
35 to classify known protein substrates of CaaX prenyltransferases and to generate a list of hypothetica
36 proteins showed some similarity to existing prenyltransferases, and both contained a plastid-targeti
37 flavone synthases, cytochrome P450 enzymes, prenyltransferases, and uridine diphosphate glycosyltran
38 ted as prenyl acceptors in assays with three prenyltransferases, and we were able to detect turnover
39 nes are generally unlinked but that aromatic prenyltransferase (AP), which produces the substrate for
40 ray crystallographic analysis with a protein prenyltransferase are described, verifying this compound
44 rved bio-chemical activities, we expect that prenyltransferases are likely integrated with the sterol
46 erazine substrates, a phytoene synthase-like prenyltransferase as the catalyst of indole alkaloid dik
47 ene synthases has been identified in which a prenyltransferase assembles 5-carbon precursors to form
48 gGS can be switched from cyclase to aromatic prenyltransferase at basic pH to generate prenylindoles.
50 gnaling, did not alter insulin action on the prenyltransferases, but completely inhibited the insulin
51 blocked by perillyl alcohol, an inhibitor of prenyltransferases, but not by the geranylgeranyltransfe
52 n a similar range to that of other flavonoid prenyltransferases, but the apparent catalytic efficienc
63 catalytic subunit (DHDDS) of the enzyme cis-prenyltransferase (cis-PTase), involved in dolichol bios
66 identification of a previously unknown human prenyltransferase complex consisting of an orphan prenyl
69 nce in yeast and animals indicate that a cis-prenyltransferase (CPT) is required for dolichol synthes
73 These reactions are catalyzed by either cis-prenyltransferases (CPTs) or trans-prenyltransferases.
74 r with previously characterised TPTs and cis-prenyltransferases (CPTs), tomato plants can make all ci
78 mans, missense mutations to the protein UbiA prenyltransferase domain-containing 1 (UBIAD1) are respo
80 ng of the vitamin K(2) synthetic enzyme UbiA prenyltransferase domain-containing protein-1 (UBIAD1) m
83 ve been identified in the gene encoding UbiA prenyltransferase domain-containing protein-1 (UBIAD1),
86 geranylgeranyl diphosphate generated by the prenyltransferase domains remains on the enzyme for cycl
87 PaFS consists of a central octameric core of prenyltransferase domains, with the eight cyclase domain
88 for hFTase (up to 333-fold) over the related prenyltransferase enzyme geranylgeranyltransferase-I (GG
90 is showed that it groups with a new class of prenyltransferase enzymes that lack the typical (N/D)DXX
93 membrane association, reveals a regulator of prenyltransferase expression, and suggests that reductio
95 ng with the characterization of two aromatic prenyltransferases, FamD1 and FamD2, and a previously un
96 med subglutinols) involves the activity of a prenyltransferase family geranylgeranyl diphosphate synt
98 ns closely with that of the chain elongation prenyltransferase farnesyl diphosphate synthase rather t
99 t the relative importance of the two protein prenyltransferases, farnesyltransferase (FT) and geranyl
101 To explore the importance of the protein prenyltransferases for normal tissues, we used condition
102 ing mainly on terpenoid cyclases and related prenyltransferases for which X-ray crystal structures ha
103 We solved the X-ray crystal structure of the prenyltransferase found in domoic acid biosynthesis, Dab
107 ure and molecular details of a new family of prenyltransferases from marine algae that repurposes the
109 t insulin signaling from its receptor to the prenyltransferases FTase and GGTase I is mediated by the
111 a cluster of 10 additional genes including a prenyltransferase gene, ausN, located on a separate chro
115 thaliana mutants lacking functional protein prenyltransferase genes have also revealed roles for pre
116 only a few plant flavonoid and isoflavonoid prenyltransferase genes have been identified to date.
117 iptomic and metabolomic analyses to discover prenyltransferase genes in elicitor-treated peanut hairy
118 s because of its modification by the related prenyltransferase, geranylgeranyl:protein transferase ty
121 , and the genes encoding stilbenoid-specific prenyltransferases have yet to be identified in any plan
122 dy provides a detailed characterization of a prenyltransferase in Malbranchea species, reveals two en
123 n summary, we have identified five candidate prenyltransferases in peanut and confirmed that two of t
124 iphosphate synthase belongs to a subgroup of prenyltransferases, including farnesyl diphosphate synth
130 formation that is critical for the design of prenyltransferase inhibitors as anti-cancer agents.
132 s further demonstrate the potential of using prenyltransferase inhibitors in combination with radioth
133 certain prenyl alcohol analogues can act as prenyltransferase inhibitors in situ, via a novel prodru
135 by blocking Ras processing using a panel of prenyltransferase inhibitors of differing specificity fo
136 radiation survival in all cells and because prenyltransferase inhibitors target molecules other than
137 their H- or K-ras genes after treatment with prenyltransferase inhibitors that prevent the posttransl
139 enylation, and the ability of peptidomimetic prenyltransferase inhibitors to block parasite different
140 P-1 secretion can be regulated by statins or prenyltransferase inhibitors via effects mediated by ERK
142 indicate the regions where specific protein prenyltransferase inhibitors with antifungal activity ca
143 ve prenylation in response to four different prenyltransferase inhibitors, and quantification of defe
146 from farnesyltransferase, another family of prenyltransferases involved in protein modification.
148 cks the conserved motifs of conventional cis-prenyltransferase is required for natural rubber biosynt
150 ansferase type-I (GGTase-I), one of two CaaX prenyltransferases, is an essential enzyme in eukaryotes
152 llographic structure of the "head-to-middle" prenyltransferase, isosesquilavandulyl diphosphate synth
153 similar to other flavonoid and isoflavonoid prenyltransferases; it has a predicted chloroplast trans
154 ning was used to identify orphan cyanobactin prenyltransferases, leading to the isolation of tolypami
157 Kinetic crystallography reveals that the prenyltransferase mechanism of UbiX resembles that of th
158 found to possess 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) and bacterial electron transpor
159 ve organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as sel
162 sma membrane location was blocked in vivo in prenyltransferase mutants and by mevinolin, which inhibi
167 , we confirmed the presence of an active cis-prenyltransferase (PfCPT) and that dolichol biosynthesis
168 both GGPP and FPP compete for the binding to prenyltransferases, PGGT-I and PFT will likely be bound
169 we also examined the localization of protein prenyltransferases (PPTases) and regulation of GSIS by P
170 id (prenylation), is carried out by the CaaX prenyltransferases, protein farnesyltransferase (FTase)
171 re bifunctional, containing C-terminal trans-prenyltransferase (PT) and N-terminal terpene synthase (
175 We found that in contrast to other protein prenyltransferases, RabGGTase is autoinhibited through N
176 In this assay, the PPi group produced in the prenyltransferase reaction is rapidly cleaved by inorgan
177 of diphosphate (PPi) dissociation during the prenyltransferase reaction under both single and multipl
178 FTase and GGTase-I (also called the CaaX prenyltransferases) recognize protein substrates with a
179 family of RiPPs-proceeds with lanthipeptide prenyltransferases recognizing the entirety of the pepti
180 filled the last gap in the toolbox of indole prenyltransferases regarding their prenylation positions
181 These structures reveal that all protein prenyltransferases share a common reaction mechanism and
182 ther delineate the sequence requirements for prenyltransferase specificity and functional roles for p
184 These results improve the definition of prenyltransferase substrate specificity, test the effica
187 recently been characterized, namely the cis-prenyltransferases (TbCPTs) and the small rubber particl
189 ophosphate synthase (UppS), an essential cis-prenyltransferase that is an attractive target for antib
191 ss is catalyzed by a class of enzymes called prenyltransferases that are being intensively studied du
192 me, an archetypal member of a superfamily of prenyltransferases that generates lipophilic aromatic co
193 cognition is markedly different from that of prenyltransferases that lipidate other RiPPs such as cya
195 P is not channeled intramolecularly from the prenyltransferase to the cyclase, but instead is channel
196 inhibit the consumption of DMADP and IDP by prenyltransferases to gain insight into the extent of en
198 for a sesterterpene pyrophosphate synthase, prenyltransferase, type II polyketide synthase, anthrani
199 ence, while a single highly conserved flavin prenyltransferase UbiX is found associated with UbiD enz
203 tagged and native Escherichia coli MiaA tRNA prenyltransferase, which uses dimethylallyl diphosphate
204 zation of the cognate enzyme TolF revealed a prenyltransferase with strict selectivity for forward O-
205 arison of the kinetic behavior of the parent prenyltransferases with that of the hybrid enzyme reveal