ライフサイエンスコーパス: prephenate

1 catalyzes the rearrangement of chorismate to prephenate.

2 he pericyclic rearrangement of chorismate to prephenate.

3 nd catalyzes the conversion of chorismate to prephenate.

4 ntramolecular rearrangement of chorismate to prephenate.

5 H7PS substrates and the allosteric inhibitor prephenate.

6 ere, we show that BigE6 encodes a plastidial prephenate aminotransferase (PPA-AT), a key enzyme in th

7 -type bifunctional enzyme displaying Asp and prephenate aminotransferase activities (PAT).

8 itated discovery of the tomato gene encoding prephenate aminotransferase, which converts prephenate t

9 We present here the first identification of prephenate aminotransferases (PATs) in seven arogenate-c

10 lly informed biochemical characterization of prephenate aminotransferases (PPA-ATs) that belong to cl

11 easurable catalytic activity, yet bound both prephenate and a competitive inhibitor (S-DNBA) comparab

12 This is because both prephenate and arogenate have been reported to undergo d

13 nd ADT homologs indeed efficiently converted prephenate and arogenate into arogenate and Phe, respect

14 Feeding with shikimate also led to prephenate and phenylpyruvate accumulation and a partial

15 indicate that the PDH domain, in which NAD, prephenate and tyrosine binding sites were present, was

16 n specific recognition of dicarboxylic keto (prephenate) and amino (aspartate) acid substrates.

17 arogenate pathway at chorismate, instead of prephenate as previously thought, and the complete pathw

18 ic analyses showed an unprecedented role for prephenate as the carboxyl donor and the involvement of

19 ere, we have identified the organic compound prephenate as the oxygen donor for the three hydroxylati

20 Prephenate binding results in the tighter association be

21 ne binding to the regulatory site as well as prephenate binding to the dehydratase domain, both throu

22 al structure of the full-length protein with prephenate bound and the accompanying small angle x-ray

23 the enolpyruvyl side chain, and the other to prephenate by a facile Claisen rearrangement.

24 The isomerization of chorismate to prephenate by chorismate mutase in the biosynthetic path

25 tant roles in the catalysis of chorismate to prephenate by chorismate mutase.

26 the mechanism of catalysis of chorismate --> prephenate by the EcCM enzyme are discussed.

27 BacA is an unusual prephenate decarboxylase that avoids the typical aromati

28 contains distinct chorismate mutase (CM) and prephenate dehydratase (PDT) domains as well as a regula

29 two catalytic domains (chorismate mutase and prephenate dehydratase activities) as well as one R-doma

30 n fragment (residues 101-386) containing the prephenate dehydratase and regulatory domains, and (c) R

31 A specific prephenate dehydratase protein (PD1) was discovered to h

32 idial enzyme produces a functional cytosolic prephenate dehydratase that catalyzes the conversion of

33 P-protein, a bifunctional chorismate mutase/prephenate dehydratase that is feedback inhibited by Phe

34 the biosynthetic enzymes chorismate mutase, prephenate dehydratase, and prephenate dehydrogenase in

35 inotransferase, a bidomain chorismate mutase/prephenate dehydratase, imidazole acetol-phosphate amino

36 oute in which arogenate dehydratase (ADT) or prephenate dehydratase, respectively, plays a key role.

37 in of the Escherichia coli chorismate mutase-prephenate dehydratase.

38 mer that exhibits chorismate mutase (CM) and prephenate dehydrogenase (PDH) activities, both of which

39 orismate mutase, prephenate dehydratase, and prephenate dehydrogenase in cell extracts, so the inhibi

40 ved aspartate kinase-chorismate mutase-tyrA (prephenate dehydrogenase) (ACT) domain upstream of the k

41 riments with (18)O-shikimate, a precursor of prephenate, demonstrated the incorporation of (18)O atom

42 Prephenate-dependent hydroxylation reactions represent a

43 While Phe is synthesized from prephenate exclusively via a phenylpyruvate intermediate

44 Chorismate mutase converts chorismate into prephenate for aromatic amino acid biosynthesis.

45 PchB also produces prephenate from chorismate, most likely due to structura

46 r the Claisen rearrangement of chorismate to prephenate has been investigated by application of the c

47 f the Claisen rearrangement of chorismate to prephenate have been examined in water and methanol.

48 r the Claisen rearrangement of chorismate to prephenate in six different environments: water, wild-ty

49 ant PAT enzymes exhibit high activity toward prephenate, indicating that the corresponding genes enco

50 ferase is required for the transamination of prephenate into arogenate, but the identity of the genes

51 Prephenate is an intermediate in the aromatic amino acid

52 with the reactant chorismate or the product prephenate, no water molecule remained near the oxygen o

53 lues of 1140, 490, and 620 M(-1) S(-1), with prephenate not serving as a substrate unless excess reco

54 via the action of either arogenate (ADT) or prephenate (PDT) dehydratases; however, neither enzyme(s

55 that the relative rate of the chorismate --> prephenate reaction is overwhelmingly dependent on the e

56 the important features of the chorismate --> prephenate reaction using molecular dynamics (MD) and th

57 enate versus 38, 240, and 16 M(-1) S(-1) for prephenate, respectively.

58 uggest that, along with ADT, a gene encoding prephenate-specific PPA-AT was transferred from a Chloro

59 The binding of prephenate, the product of CM-catalyzed reaction, to the

60 For the full-length protein, prephenate, the product of the CM reaction, acts as an a

61 d that DAH7PS is allosterically inhibited by prephenate, the product of the CM-catalyzed reaction.

62 cilysin antibiotic pathway, BacABGF, convert prephenate to a tetrahydrotyrosine (H(4)Tyr) diastereome

63 prephenate aminotransferase, which converts prephenate to arogenate.

64 dehydratase that catalyzes the conversion of prephenate to phenylpyruvate, the intermediate step betw

65 rous phenolic compounds, is synthesized from prephenate via an arogenate and/or phenylpyruvate route

66 acid anticapsin from the primary metabolite prephenate, we have overproduced, purified, and characte

67 0), more efficiently utilized arogenate than prephenate, whereas the remaining three, ADT3 (At2g27820