ライフサイエンスコーパス: prepulse inhibition

1 etamine-induced hyperactivity; disruption of prepulse inhibition).

2 d-amphetamine- and DOI-induced disruption of prepulse inhibition.

3 t mice show increased aggression and reduced prepulse inhibition.

4 tial working memory, social interaction, and prepulse inhibition.

5 revious findings, Fmr1KO mice have increased prepulse inhibition.

6 ects were tested on both P50 suppression and prepulse inhibition.

7 significantly affect startle habituation or prepulse inhibition.

8 startle response but exhibit a deficiency in prepulse inhibition.

9 A/2J mice, a strain with low basal levels of prepulse inhibition.

10 s, motor coordination, pain sensitivity, and prepulse inhibition.

11 vant to exploratory locomotion, startle, and prepulse inhibition.

12 erstimulus interval, stimulus intensity, and prepulse inhibition.

13 more evident in measures of right eye-blink prepulse inhibition.

14 ersonality disorder showed less asymmetry of prepulse inhibition.

15 hanced susceptibility to stress and impaired prepulse inhibition.

16 enic patients showing the expected deficient prepulse inhibition.

17 ng was examined operationally via the use of prepulse inhibition.

18 of neurotensin had no significant effect on prepulse inhibition.

19 midbrain dopamine neurons, and disruption in prepulse inhibition.

20 ited any impairment in startle reactivity or prepulse inhibition.

21 inhibitory interneurons in gap detection and prepulse inhibition.

22 pment of temporal processing, assessed using prepulse inhibition.

23 performance, spatial object recognition, and prepulse inhibition.

24 malities in sensory filtering as measured by prepulse inhibition.

25 nitude of the acoustic startle reflex or its prepulse inhibition.

26 social interaction, locomotor activity, and prepulse inhibition.

27 el and potent mechanism of sensory gating in prepulse inhibition.

28 altered forebrain development and decreased prepulse inhibition.

29 exhibited increased sociability and impaired prepulse inhibition.

30 Rab3A or synaptotagmin 1 only show decreased prepulse inhibition.

31 23), sensorimotor dexterity (2q24 and 2q32), prepulse inhibition (5p15), the California Verbal Learni

32 In contrast, gap-prepulse inhibition, a behavioral test for auditory temp

33 out mice had a sexually dimorphic deficit in prepulse inhibition, a gene dosage-dependent decrease in

34 the rotorod, but not to any abnormalities in prepulse inhibition, a measure of sensorimotor gating.

35 term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating.

36 o showed overgrooming as well as deficits of prepulse inhibition, a widely used endophenotype of schi

37 demonstrated consistent associations between prepulse inhibition abnormalities and clinical measures.

38 tory disruption is impairment in gap-induced prepulse inhibition, also known as gap detection.

39 iors, less depression-like conduct, impaired prepulse inhibition, amphetamine hypersensitivity, and i

40 alpha deficient mice displayed a decrease in prepulse inhibition, an increase in grooming behaviors,

41 ith impaired sensorimotor gating measured by prepulse inhibition--an established endophenotype of sch

42 ld-type hosts, SCZ glial mice showed reduced prepulse inhibition and abnormal behavior, including exc

43 ell-characterised neural mechanisms, such as prepulse inhibition and antisaccades, to substantially a

44 icits in translational inhibitory biomarkers-prepulse inhibition and antisaccades-that occur after sl

45 ecreased anxiety-related behavior, increased prepulse inhibition and delayed acquisition of rewarded

46 ormal cerebellar and hippocampal morphology, prepulse inhibition and fear conditioning.

47 he PDE4B(Y358C) mutation was observed in the prepulse inhibition and forced swim tests.

48 se and adaptability of the startle response (prepulse inhibition and habituation) have been observed

49 eased social interaction, and impairments in prepulse inhibition and latent inhibition.

50 rs of early auditory information processing: prepulse inhibition and mismatch negativity (MMN) in SZ

51 The comparison subjects showed greater prepulse inhibition and prepulse facilitation during the

52 Reduced prepulse inhibition and repetitive motor behaviors are c

53 nvestigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely h

54 Screens such as prepulse inhibition and startle have been adapted for mi

55 gnosed with 90.8% accuracy using measures of prepulse inhibition and temporal sensitivity.

56 e a reduced acoustic startle reflex, altered prepulse inhibition, and characteristics of compensatory

57 aze, inhibitory avoidance, acoustic startle, prepulse inhibition, and hot plate assays.

58 diminished startle response, as measured by prepulse inhibition, and impaired social recognition.

59 evelopment decreased startle habituation and prepulse inhibition, and increased avoidance (particular

60 sures were startle responsivity, reactivity, prepulse inhibition, and startle habituation.

61 phenotypes, such as perseveration, disrupted prepulse inhibition, and strong withdrawal from social i

62 of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5-/- m

63 hether abnormal P50 suppression and abnormal prepulse inhibition are independent neurophysiological c

64 ) and Disc1-Q31L(+/-) offspring, and reduced prepulse inhibition at 16 but not 8 weeks of age.

65 Prepulse inhibition at the other interstimulus intervals

66 AICP did not affect basal locomotion or prepulse inhibition but facilitated MK-801-induced hyper

67 containing the human FMR1 gene had levels of prepulse inhibition comparable to WT mice, indicating no

68 iors, with male Val/Val mice exhibited lower prepulse inhibition compared with Met/Met mice, whereas

69 Deficient prepulse inhibition correlated significantly with 2 of t

70 Deficient prepulse inhibition correlated with both positive and ne

71 w rescue of key SCZ-related deficits, namely prepulse inhibition decrease, working memory impairment,

72 Mice expressing AAV-DN1 have prepulse inhibition deficits and impairments in working

73 edicated or unmedicated at admission, showed prepulse inhibition deficits compared with healthy subje

74 served as prepulses in published reports of prepulse inhibition deficits in schizophrenia.

75 Prepulse inhibition deficits in schizophrenic patients c

76 The pattern of prepulse inhibition deficits in schizophrenic patients r

77 hat the neurobiological substrate underlying prepulse inhibition deficits may be dysregulated during

78 should probably focus on the relationship of prepulse inhibition deficits to measures such as thought

79 s robust as that in previous reports linking prepulse inhibition deficits with other measures, such a

80 novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditio

81 patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genet

82 conditions, schizophrenia-linked deficits in prepulse inhibition detected with a relatively strong pr

83 that produce an enhanced sensitivity to the prepulse inhibition-disruptive effects of the DA agonist

84 d that abnormal P50 suppression and abnormal prepulse inhibition do not necessarily occur together.

85 the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light <--> dark

86 DCN induces hearing using a novel electrical prepulse inhibition (ePPI) of startle reflex behavior mo

87 In this study, gap prepulse inhibition (gap-PPI) of the acoustic startle re

88 Gap prepulse inhibition (gap-PPI), a translational experimen

89 s a measure of pre-attentive sensory gating, prepulse inhibition has been found to be altered in smal

90 in a novelty-induced open field, deficits in prepulse inhibition, hypersensitivity to amphetamine, an

91 nce reflects a common endophenotype and that prepulse inhibition identifies a separate endophenotype

92 amphetamine-induced hyperlocomotion, but not prepulse inhibition impairments, in a dose-dependent man

93 erlocomotion, restored amphetamine-disrupted prepulse inhibition, improved social behavior, and novel

94 Measuring P50 suppression and prepulse inhibition in a single session is feasible and

95 First, we observed a reduction of prepulse inhibition in A(2A)R knockout mice, similar to

96 ging and ameliorated a behavioral deficit in prepulse inhibition in adulthood in a DISC1 knockdown mo

97 lation also reduced swim test immobility and prepulse inhibition in P rats and increased locomotor st

98 Patients showed reduced P50 suppression and prepulse inhibition in relation to healthy comparison su

99 f prepulses should not contribute to reduced prepulse inhibition in schizophrenia patients versus con

100 cluding hyperlocomotor activity, deficits in prepulse inhibition, increased anxiety, impaired social

101 Prepulse inhibition is a type of sensorimotor gating tha

102 ld test, it restored d-amphetamine-disrupted prepulse inhibition, it induced cognitive improvements i

103 y, the effector mechanisms underlying neural prepulse inhibition itself were unaffected by antagonist

104 impaired neurovascular coupling; attenuated prepulse inhibition (males); and hyperkinetic behavior.

105 ndings suggest that antipsychotic effects on prepulse inhibition may not be evident at a time when sc

106 Abnormal prepulse inhibition may serve as an objective transdiagn

107 ndently accounted for 60% of the variance in prepulse inhibition measures and contributed 35% of the

108 immobility in the forced swim test, reduced prepulse inhibition, mild motor coordination impairments

109 ate that BACE1(-/-) mice exhibit deficits in prepulse inhibition, novelty-induced hyperactivity, hype

110 The levels of both P50 suppression and prepulse inhibition obtained in the combined session wer

111 tor gating deficits, as measured by acoustic prepulse inhibition, occur in both male and female Celsr

112 ing was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle.

113 ehavioral phenotypes in open-field activity, prepulse inhibition of acoustic startle response and con

114 y of tests, including eyeblink conditioning, prepulse inhibition of acoustic startle response, and st

115 r the effects of amphetamine (2-10 mg/kg) on prepulse inhibition of acoustic startle responses.

116 of behavioral alterations and of deficits in prepulse inhibition of acoustic startle, a measure of se

117 ated acoustic startle responses, deficits in prepulse inhibition of acoustic startle, and motor hyper

118 were also observed in locomotor activity and prepulse inhibition of acoustic startle, behaviors that

119 ia assesses the neurophysiologic measures of prepulse inhibition of acoustic startle, P50 event-relat

120 osure had the largest effect on activity and prepulse inhibition of startle 1-week post-irradiation t

121 Prepulse inhibition of startle declined at a faster rate

122 ntitative MRI, and sensorimotor gating using prepulse inhibition of startle in a subset of 12 individ

123 ed sensorimotor gating as measured using the prepulse inhibition of startle response.

124 The prepulse inhibition of startle responses by a weaker pre

125 tory tasks such as frequency discrimination, prepulse inhibition of startle responses, or fear condit

126 Changes in prepulse inhibition of startle was tested after MK-801 (

127 cits in auditory-evoked response adaptation, prepulse inhibition of startle, and evoked gamma-activit

128 startle amplitudes and similar magnitudes of prepulse inhibition of startle, suggesting that CREBalph

129 weight, spontaneous locomotor activity, and prepulse inhibition of startle.

130 Recently prepulse inhibition of the acoustic startle reflex (ASR)

131 the PV neuron population, robustly impaired prepulse inhibition of the acoustic startle reflex (PPI)

132 uisition of contextual fear conditioning and prepulse inhibition of the acoustic startle reflex.

133 ine system increases locomotion and disrupts prepulse inhibition of the acoustic startle response (PP

134 Prepulse inhibition of the acoustic startle response (PP

135 Prepulse inhibition of the acoustic startle response (PP

136 ften studied in humans and rodents using the prepulse inhibition of the acoustic startle response (PP

137 typical antipsychotic clozapine and enhanced prepulse inhibition of the acoustic startle response in

138 Chemospecific ablation of THINs impairs prepulse inhibition of the acoustic startle response sug

139 ater sensitivity to a D2 agonist and smaller prepulse inhibition of the acoustic startle response tha

140 ylyl)methyl]propanamide dihydrochloride), on prepulse inhibition of the acoustic startle response.

141 ng a temporary-threshold shift model and gap-prepulse inhibition of the acoustic startle to assess ti

142 veloped tinnitus as indicated by gap-induced prepulse inhibition of the acoustic startle.

143 Prepulse inhibition of the acoustic startling reflex (PP

144 e normal comparison subjects were tested for prepulse inhibition of the eyeblink component of the sta

145 h as those reported in studies that measured prepulse inhibition of the human startle response and ha

146 potential was significantly correlated with prepulse inhibition of the P13 potential, the N40 potent

147 These results demonstrate the presence of prepulse inhibition of the P13 potential, the N40 potent

148 prepulse intensity and the background level, prepulse inhibition of the SR was reduced or absent whil

149 mice deficient in TIMP-2 (knockout) exhibit prepulse inhibition of the startle reflex, suggesting de

150 s of schizophrenia are demonstrated by using prepulse inhibition of the startle reflex.

151 min (PV)-positive GABAergic, neurons reduced prepulse inhibition of the startle response (PPI) and en

152 -HT)2A receptors are known to be involved in prepulse inhibition of the startle response (PPI), a mea

153 We show that fear conditioning and prepulse inhibition of the startle response are also dis

154 Furthermore, this activation increased prepulse inhibition of the startle response in females.

155 er, heterozygous mice display an increase in prepulse inhibition of the startle response, a manifesta

156 ial P50 response to repeated stimuli and the prepulse inhibition of the startle response.

157 schizophrenia patients: P50 suppression and prepulse inhibition of the startle response.

158 ficits in sensorimotor gating as assessed by prepulse inhibition of the startle response.

159 ivity in a novel environment and deficits in prepulse inhibition of the startle response.

160 motor gating impairments, as assessed by the prepulse inhibition of the startle.

161 Wwc1 mice show reduced prepulse inhibition only in females.

162 udy, we used elevated plus-maze, startle and prepulse inhibition, open field, and novel object recogn

163 differ from each other in startle magnitude, prepulse inhibition, or habituation.

164 rate deficits in inhibition when assessed on prepulse inhibition, P50 suppression, and antisaccade pa

165 Prepulse inhibition, P50 suppression, and antisaccade pa

166 were compared on a silent gap variant of the prepulse inhibition paradigm.

167 deficits in working memory, sociability, and prepulse inhibition, paralleled by locomotor hyperactivi

168 digm, while hearing status was assessed with prepulse inhibition (PPI) and auditory brainstem respons

169 hors introduce a real-time model of acoustic prepulse inhibition (PPI) and facilitation (PPF) in anim

170 -relevant abnormalities, including deficient prepulse inhibition (PPI) and increased grooming stereot

171 f IL-6 on day 12.5 of mouse pregnancy causes prepulse inhibition (PPI) and latent inhibition (LI) def

172 They were also tested for prepulse inhibition (PPI) and locomotor activity in the

173 Previous analyses of prepulse inhibition (PPI) and P50 gating measures in thi

174 CCK-1 receptors play a role in prepulse inhibition (PPI) by modulating mesolimbic dopam

175 gonists also reduce hyperactivity, attenuate prepulse inhibition (PPI) deficits and social withdrawal

176 We did not detect overt prepulse inhibition (PPI) deficits in female or male MIA

177 nd lead times (20-40 ms) and was replaced by prepulse inhibition (PPI) for higher values, especially

178 ring on startle reactivity, habituation, and prepulse inhibition (PPI) in male Lewis, Sprague-Dawley,

179 sure the acoustic startle response (ASR) and prepulse inhibition (PPI) in mice.

180 autism, these offspring display deficits in prepulse inhibition (PPI) in the acoustic startle respon

181 se in fear conditioning (FC), a reduction in prepulse inhibition (PPI) in the KO animal, along with a

182 Clozapine increased prepulse inhibition (PPI) in wild-type mice.

183 LSD also disrupts prepulse inhibition (PPI) in WT and BArr1-KOs, but not i

184 Prepulse Inhibition (PPI) is a measure of pre-attentiona

185 Prepulse inhibition (PPI) is an example of sensorimotor

186 Prepulse inhibition (PPI) is an operational measure of s

187 Prepulse inhibition (PPI) is an operational measure of s

188 Prepulse inhibition (PPI) is an operational measure of s

189 ty to dopamine agonist-induced disruption of prepulse inhibition (PPI) may be a useful model for the

190 Prepulse inhibition (PPI) occurs when a weak prestimulus

191 Prepulse inhibition (PPI) of acoustic startle has been u

192 , and deficits in spatial working memory and prepulse inhibition (PPI) of acoustic startle in Grin1 m

193 Prepulse inhibition (PPI) of acoustic startle is a genet

194 rally active causing a dramatic reduction in prepulse inhibition (PPI) of acoustic startle response.

195 tactile startle as well as the magnitude of prepulse inhibition (PPI) of both tactile and acoustic s

196 Prepulse inhibition (PPI) of startle is being explored b

197 In humans, prepulse inhibition (PPI) of startle is greater during a

198 Prepulse inhibition (PPI) of startle is impaired in schi

199 t deficient sensorimotor gating (measured by prepulse inhibition (PPI) of startle) and mismatch negat

200 ensory gating of auditory evoked potentials, prepulse inhibition (PPI) of startle, and startle amplit

201 vestigated whether individual differences in prepulse inhibition (PPI) of the acoustic startle reflex

202 examine core and shell function, we measured prepulse inhibition (PPI) of the acoustic startle reflex

203 Prepulse inhibition (PPI) of the acoustic startle reflex

204 ry spatial acuity was measured in mice using prepulse inhibition (PPI) of the acoustic startle reflex

205 Rats were tested for prepulse inhibition (PPI) of the acoustic startle respon

206 ulation of the dopamine (DA) system disrupts prepulse inhibition (PPI) of the acoustic startle respon

207 locomotor activity in a novel open field and prepulse inhibition (PPI) of the acoustic startle respon

208 In animals, LSD disrupts prepulse inhibition (PPI) of the acoustic startle respon

209 Translational biomarkers, such as prepulse inhibition (PPI) of the acoustic startle respon

210 Prepulse inhibition (PPI) of the acoustic startle respon

211 tive probe associated with this circuitry is prepulse inhibition (PPI) of the acoustic startle respon

212 d schizophrenia patients exhibit deficits in prepulse inhibition (PPI) of the acoustic startle respon

213 Sensorimotor gating was measured by prepulse inhibition (PPI) of the acoustic startle respon

214 e than Long Evans (LE) rats to disruption of prepulse inhibition (PPI) of the startle reflex by the d

215 Prepulse inhibition (PPI) of the startle reflex has been

216 Prepulse inhibition (PPI) of the startle reflex is a mea

217 Sensorimotor gating, measured by prepulse inhibition (PPI) of the startle reflex, is redu

218 deficient sensorimotor gating as measured by prepulse inhibition (PPI) of the startle response, exhib

219 important measure of sensorimotor gating is prepulse inhibition (PPI) of the startle response, impai

220 nformation, a process which is studied using prepulse inhibition (PPI) of the startle response.

221 ed into the nucleus accumbens of rats on the prepulse inhibition (PPI) of their acoustic startle refl

222 Prepulse inhibition (PPI) refers to a reduction in the s

223 ity, impaired working memory, and deficit in prepulse inhibition (PPI) that was ameliorated by diazep

224 After AAE treatment, prepulse inhibition (PPI) to tone prepulses (4-24 kHz, 7

225 nt is preceded by a stimulus; this is called prepulse inhibition (PPI) when the prestimulus is weak a

226 etion (Df1) that models 22q11DS have reduced prepulse inhibition (PPI), a behavioral abnormality and

227 yond the dopaminergic pathway and influences prepulse inhibition (PPI), a critical translational meas

228 Prepulse inhibition (PPI), a form of sensorimotor gating

229 f3b-null mice also have a profound defect in prepulse inhibition (PPI), a measure of sensorimotor gat

230 whether intra-Acb amylin signaling modulates prepulse inhibition (PPI), a measure of sensorimotor gat

231 Prepulse inhibition (PPI), a phenomenon in which a weak

232 Prepulse inhibition (PPI), an operational measure of sen

233 n amygdala systems that modulate startle and prepulse inhibition (PPI), an operational measure of sen

234 rlocomotion, increased stereotype, defective prepulse inhibition (PPI), and disability in nest buildi

235 ibition of startle by sensory stimuli, i.e., prepulse inhibition (PPI), and is disrupted in patients

236 function demonstrated consistent deficits in prepulse inhibition (PPI), as well as higher startle res

237 The mGlu5 KO mice showed reduced prepulse inhibition (PPI), long-term memory deficits, an

238 In prepulse inhibition (PPI), startle responses to sudden,

239 In prepulse inhibition (PPI), the startle response to a str

240 the hypothesis that PPD in rats would alter prepulse inhibition (PPI), which is an operational measu

241 on-startling stimulus, a phenomenon known as prepulse inhibition (PPI), which reflects sensory gating

242 ed alternation memory tasks, and deficits in prepulse inhibition (PPI).

243 the sensorimotor gating phenomenon known as prepulse inhibition (PPI).

244 sensorimotor gating deficits, as measured by prepulse inhibition (PPI).

245 n Sapap3-KOs using the translational measure prepulse inhibition (PPI); however, there was significan

246 automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex.

247 This phenomenon, termed "prepulse inhibition" (PPI), appears to function to reduc

248 oups differed significantly in the amount of prepulse inhibition produced by the 16-dB prepulse, with

249 15 mg/kg, partially reversed the deficits in prepulse inhibition produced by the mutation.

250 or the improvement or whether differences in prepulse inhibition reflect other factors, such as acuit

251 Prepulse inhibition reflects subcortical sensory integra

252 zotypal personality disorder all had reduced prepulse inhibition relative to comparison subjects, and

253 ophrenia-relevant behavioral tasks including prepulse inhibition, response to psychotomimetic drugs,

254 These open-field and prepulse inhibition results suggest that the mGAT1 KO mi

255 suggest a genetically transmitted deficit in prepulse inhibition (sensorimotor gating) in patients wi

256 Prepulse inhibition, sensory gating, antisaccade, spatia

257 testing in a carefully designed combined P50/prepulse inhibition session using stimulus characteristi

258 r disorder, no association was found between prepulse inhibition size and objectively rated motor sym

259 ion without delays, spontaneous alternation, prepulse inhibition, social interaction, anxiety-, stres

260 on the activity of the dentate gyrus, e.g., prepulse inhibition, startle habituation, latent inhibit

261 s displayed more climbing behavior and lower prepulse inhibition, suggesting an increase in central n

262 ry avoidance, increased startle responses in prepulse inhibition tasks, and increased MK-801-induced

263 eline startle responses in the course of the prepulse inhibition test, and lower hedonic responses in

264 ss sensitive to an amphetamine disruption of prepulse inhibition than WT mice but were more sensitive

265 underlie certain core deficits (startle and prepulse inhibition) that are observed in post-traumatic

266 atory activity in CLAMS testing, and altered prepulse inhibition to startle, an important biomarker o

267 ficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 senso

268 Prepulse inhibition was also investigated.

269 Prepulse inhibition was calculated as the percent reduct

270 Prepulse inhibition was impaired in both mice and humans

271 Prepulse inhibition was measured by using a series of pr

272 Prepulse inhibition was most prominent at the 120-msec i

273 Prepulse inhibition was not affected by darkness and did

274 Prepulse inhibition was not correlated significantly wit

275 At the 500-msec interstimulus interval, prepulse inhibition was significantly but negatively cor

276 hyperactivity; sensorimotor gating (startle prepulse inhibition) was unaffected.

277 Social memory, spatial working memory and prepulse inhibition were also impaired.

278 The magnitude of startle and prepulse inhibition were assessed in alternating periods

279 in previous experiments, P50 suppression and prepulse inhibition were not significantly correlated.

280 nstrated greater right versus left eye-blink prepulse inhibition, whereas the probands, their relativ

281 ceptor channel blocker produced a deficit in prepulse inhibition which was prevented by a GluN2C/2D p

282 Transgenic mice were deficient in prepulse inhibition, which was restored by clozapine but