ライフサイエンスコーパス: presymptomatic

1 ients studied, including 3 patients who were presymptomatic.

2 symptomatic), 53 MAPT mutation carriers (34 presymptomatic, 19 symptomatic) and 183 non-carrier cont

3 symptomatic), 119 GRN mutation carriers (88 presymptomatic, 31 symptomatic), 53 MAPT mutation carrie

4 tein biochemistry in hippocampal tissue from presymptomatic 3xTg-AD and NonTg mice, we show that bloc

5 nels of hippocampal CA1 pyramidal neurons in presymptomatic 3xTg-AD mice.

6 itiative: 114 C9orf72 expansion carriers (74 presymptomatic, 40 symptomatic), 119 GRN mutation carrie

7 ecal ligation and excision were performed on presymptomatic 5- to 11-month-old triple-transgenic Alzh

8 ovide an ongoing opportunity to characterize presymptomatic abnormalities that predict progression to

9 versely, those who resisted infection showed presymptomatic activation of IL-17- and tumor necrosis f

10 subtle amounts or changes of Abeta burden in presymptomatic AD and during therapy.

11 ircRNA expression changes occurring early in presymptomatic AD and in autosomal dominant AD.

12 st that these pathways may be altered during presymptomatic AD and that CDH6 and HAGH may be new bloo

13 Here, we identified several presymptomatic AD markers by investigating brain proteom

14 en the increased RyR calcium release seen in presymptomatic AD mice and aberrant NO signaling which a

15 however, it is unknown if levels increase in presymptomatic AD.

16 homeostasis and network depression at early (presymptomatic) AD stages.

17 Presymptomatic ADAD mutation carriers showed significant

18 DED binding was highest in presymptomatic ADAD mutation carriers.

19 pression using shRNA in the dentate gyrus of presymptomatic adolescent hAPP mice was sufficient to pr

20 s of mutant (G93A) SOD1 transgenic mice at a presymptomatic age, which was similarly induced by in vi

21 tive allosteric modulator (PAM) beginning at presymptomatic ages improves motor and synaptic deficits

22 ng in vitro patch-clamp electrophysiology at presymptomatic ages P8-P12.

23 Strikingly, in two presymptomatic ALS mouse strains transgenic for mutant h

24 he first time, they include the diagnosis of presymptomatic Alzheimer disease, recognizing that the d

25 Astrocyte activation may occur in presymptomatic Alzheimer's disease (AD) because reactive

26 e should expect to see additional studies of presymptomatic Alzheimer's disease to join the ongoing p

27 that axonal injury may be an early event in presymptomatic Alzheimer's disease, causing an initial f

28 and will soon be tested in individuals with presymptomatic Alzheimer's disease.

29 tilized the facial nerve axotomy model and a presymptomatic amyotrophic lateral sclerosis (ALS) mouse

30 g data from 27 HCHWA-D mutation carriers (12 presymptomatic and 15 symptomatic) and 33 healthy contro

31 We included 106 presymptomatic and 54 symptomatic carriers of a pathogen

32 ld impact the current capability to diagnose presymptomatic and asymptomatic EBOV infections.

33 ification, and this approach can misdiagnose presymptomatic and asymptomatic individuals.

34 We evaluate the contribution of presymptomatic and asymptomatic transmission based on re

35 enting a resurgence depends on the extent of presymptomatic and asymptomatic transmission.

36 resolution, and the critical contribution of presymptomatic and asymptomatic transmission.

37 enzymes of glutamine/glutamate metabolism in presymptomatic and early symptomatic NPC1-deficient cere

38 and axonopathy would thus be the hallmark of presymptomatic and early-stage Parkinson disease, follow

39 al assessments; 10 were symptomatic, 10 were presymptomatic and on average 5.6 years younger than the

40 These data demonstrate that presymptomatic and progressive neurodegeneration in SCA1

41 8)F-fluorodeoxyglucose (FDG) respectively in presymptomatic and symptomatic ADAD participants (n = 21

42 we examined brain volume differences between presymptomatic and symptomatic FAD mutation carriers and

43 longitudinal NfL trajectories in people with presymptomatic and symptomatic genetic frontotemporal de

44 In this case-control study, we included presymptomatic and symptomatic HCHWA-D mutation carriers

45 ether haemodynamic measures are decreased in presymptomatic and symptomatic HCHWA-D mutation carriers

46 Data from presymptomatic and symptomatic individuals were compared

47 n number for individuals progressing through presymptomatic and symptomatic stages of at least 15.

48 s in these subcortical structures during the presymptomatic and symptomatic stages of familial Alzhei

49 4), GRN (128) and MAPT (49) groups, and into presymptomatic and symptomatic stages.

50 he proportion of cases who were symptomatic, presymptomatic, and asymptomatic and (2) incidence of sy

51 Infection can be spread by asymptomatic, presymptomatic, and symptomatic carriers.

52 of the substantia nigra (SN) from wild-type, presymptomatic, and symptomatic Mecp2(+/-) mice.

53 tage but downregulate postsynaptic Chrna2 in presymptomatic animals.

54 n hippocampus CA1 and dentate gyrus of young presymptomatic APPPS1 mice (1 to 3 months) as compared t

55 The findings suggest that, even in the presymptomatic/asymptomatic phase of the infection, diff

56 ue characteristics for each infection at the presymptomatic/asymptomatic stage of infection and compa

57 , non-invasive imaging (including studies of presymptomatic, at-risk cases) and genetically modified

58 least the next 40 weeks, a range over which presymptomatic BACHD mice become symptomatic.

59 ese pathogenic autoantibodies could serve as presymptomatic biomarkers and therapeutic targets, there

60 ate stages, and major progress in validating presymptomatic biomarkers now makes secondary prevention

61 Here, considering the unmet need for presymptomatic biomarkers of sporadic Alzheimer's diseas

62 [730] vs 2119 [619] kcal/day; P < .01), and presymptomatic body mass index (calculated as weight in

63 Determining risk factors for such presymptomatic brain changes may assist in identifying c

64 dentifying white matter abnormalities in the presymptomatic C9orf72 carriers.

65 ion and thickness patterns in a cohort of 15 presymptomatic c9orf72 expansion carriers (age 43.7 +/-

66 Presymptomatic c9orf72 expansion carriers show regions o

67 Sixty-seven participants (38 presymptomatic C9orf72 mutation carriers (C9+) and 29 no

68 Thirty-eight presymptomatic C9orf72 mutation carriers (C9+, mean age

69 elling MRI-based cerebral blood flow between presymptomatic C9orf72, GRN or MAPT mutation carriers (n

70 tions (median 643 pg/mL, IQR (301-872)) than presymptomatic carriers (1003 pg/mL (624-1358), p<0.001)

71 (median 52 pg/mL [IQR 24-69]) compared with presymptomatic carriers (9 pg/mL [6-13]; p<0.0001) and n

72 Twenty-four were presymptomatic carriers (mean baseline EYO -9.6 years) w

73 Overall, for both presymptomatic carriers and healthy controls, gyrificati

74 ickness or volume and detects differences in presymptomatic carriers at an early age.

75 Nine presymptomatic carriers became symptomatic during follow

76 ver, we noted no changes in rCBF and flux in presymptomatic carriers compared with controls.

77 s in three genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing those

78 We included 59 symptomatic carriers and 149 presymptomatic carriers of a mutation in GRN, C9orf72, o

79 these results indicate that brain atrophy in presymptomatic carriers of common frontotemporal dementi

80 y, those areas with abnormal gyrification in presymptomatic carriers showed no concomitant cortical t

81 Compared with controls, presymptomatic carriers showed significantly lower lGI i

82 pared p-tau181 between symptomatic carriers, presymptomatic carriers, and non-carriers, adjusting for

83 otentiation-like plasticity were impaired in presymptomatic carriers, compared to healthy controls, m

84 terval intracortical inhibition, compared to presymptomatic carriers, was found.

85 lications for prognosis and the follow-up of presymptomatic carriers.

86 and testing that identifies asymptomatic and presymptomatic cases, in order to safely lift current re

87 A full understanding of these presymptomatic cellular properties may lead to more effe

88 These presymptomatic changes in hippocampal physiology in FAD

89 ty during treadmill running aiming to detect presymptomatic changes in motor patterning.

90 are also being used to identify the earliest presymptomatic changes.

91 nsplantation provides modest benefit in both presymptomatic children and the murine model (Twitcher),

92 d a powerful imaging biomarker for the early presymptomatic classification and prediction of Alzheime

93 Sample sizes to power presymptomatic clinical trials based on rate of atrophy

94 stack mosaics, we characterized the earliest presymptomatic cortical LVPN morphologic and electrophys

95 EMMPRIN levels on splenic lymphocytes at the presymptomatic (day 7) phase, and prevented the developm

96 This was associated with a rapid, presymptomatic decline in mucosal interleukin-17A (IL-17

97 Presymptomatic delivery of scAAV9-SMN prevented SMA symp

98 While early, presymptomatic detection and chelation with conventional

99 Recent work using techniques for presymptomatic detection of disease in cognitively norma

100 ve prenatal testing also may enable accurate presymptomatic detection of maternal tumors and treatmen

101 We show that plasma DNA profiling allows for presymptomatic detection of tumors in pregnant women und

102 es a fundamental question of whether SMA has presymptomatic, developmental components to disease path

103 of bioinformatics tools for the purposes of presymptomatic diabetes risk prediction in the general p

104 Advancement in presymptomatic diagnosis and screening programs will be

105 g disease-causing genetic variation will aid presymptomatic diagnosis and treatment of such disorders

106 However, presymptomatic diagnosis is hampered by imperfect genoty

107 A means of presymptomatic diagnosis is urgently needed.

108 creening is warranted because it may lead to presymptomatic diagnosis of a cardiomyopathy that could

109 Rapid presymptomatic diagnosis of Bacillus anthracis at early

110 Proteomic biomarkers enable an early, presymptomatic diagnosis of disease, which makes them im

111 ntegrated public health program, can achieve presymptomatic diagnosis of SCID and other disorders wit

112 stages in its natural history (i.e., early, presymptomatic diagnosis), undertaking such efforts in t

113 organ dysfunction and damage, allowing for a presymptomatic diagnosis.

114 ches for oligomer detection and consequently presymptomatic diagnostic of PD.

115 otion that PRS-associated analytes represent presymptomatic disease alterations.

116 uld help to define biomarkers that can stage presymptomatic disease and track disease progression, wh

117 r neurochemical levels are altered by early, presymptomatic disease and whether they gauge disease pr

118 ated accumulation of infectious particles in presymptomatic disease is preceded by a progressive fall

119 We discovered that in presymptomatic disease microglial cells overexpress anti

120 e localized morphological variation of early presymptomatic disease progression.

121 ovides a unique model for studying the early presymptomatic disease stages.

122 tion in the striatum of R6/1 mice during the presymptomatic disease stages.

123 er of dendritic spines and axonal boutons in presymptomatic EAE mice.

124 of response to infection that correlate with presymptomatic, early, and late symptomatic stages of in

125 ymptomatic (AUC 0.93 [95% CI 0.85-0.98]) and presymptomatic (EYO >= -7 years) (AUC 0.86 [95% CI 0.72-

126 oncentration is increased in symptomatic and presymptomatic FAD suggests potential utility as an easi

127 Amyloid imaging studies of presymptomatic familial Alzheimer's disease have reveale

128 RI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia', by Jis

129 In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher edu

130 ple of subjects (n = 707) who have undergone presymptomatic gene testing.

131 lineate the cerebral blood flow signature of presymptomatic, genetic frontotemporal dementia using a

132 MAPT mutations (12.7, -33.3 to 90.4) or the presymptomatic groups.

133 treatments in patients at risk of CAA and in presymptomatic HCHWA-D.

134 tochondrial protein import first detected in presymptomatic HD mice.

135 ore, mitochondria from brain synaptosomes of presymptomatic HD model mice and from mutant Htt-express

136 of 8 biomarkers that can identify 80% of the presymptomatic HD sheep as transgenic, with 90% confiden

137 Ten other amino acids decreased in presymptomatic HD sheep, including branched chain amino

138 performed metabolic profiling of plasma from presymptomatic HD transgenic and control sheep.

139 Presymptomatic hematopoietic stem cell transplantation (

140 In contrast, in the initially presymptomatic hemisphere, putamen metabolic activity in

141 al hemisphere, focusing specifically on the "presymptomatic" hemisphere--ipsilateral to the initially

142 del of HD and could provide insight into the presymptomatic human disease.

143 bsence of corticospinal neurons also limited presymptomatic hyper-reflexia, a typical component of th

144 Presymptomatic immaturity in neonatal T-cell function is

145 afted into the lumbar spinal ventral horn in presymptomatic immunosuppressed SOD1(G93A) rats and to a

146 Plasma PHGDH exRNA exhibited presymptomatic increases in each of the 11 converters du

147 creening and longitudinal exRNA changes as a presymptomatic indication of sporadic AD.

148 group of healthy, young, cognitively-intact presymptomatic individuals (average age 33.7 years) who

149 ther such biomarkers can be used to identify presymptomatic individuals (probably yes), provide a mea

150 tific reports document that asymptomatic and presymptomatic individuals contribute to the spread of C

151 ble, blood-based screening tests to identify presymptomatic individuals destined to develop Alzheimer

152 ner, providing a unique opportunity to study presymptomatic individuals who can be predicted to devel

153 ward it may be relevant to clinically follow presymptomatic individuals who carry a C9orf72 repeat ex

154 Presymptomatic individuals with the Huntingtin (HTT) CAG

155 roach that enables sensitive OA detection in presymptomatic individuals.

156 rtex and striatum and highest in striatum of presymptomatic individuals.

157 highlights transmission by asymptomatic and presymptomatic individuals.

158 CPAP oxygen signal increased risk of NEC in presymptomatic infants.

159 We assess how presymptomatic infection affects predictability of infec

160 icrobiological and immunological features of presymptomatic infection.

161 However, despite extensive cryptic (i.e., presymptomatic) infection and frequent long-range transm

162 Accounting for presymptomatic infectiousness(2), time-varying ascertain

163 Others maintain that early, presymptomatic intervention would be a more informative

164 Attention is increasingly focused on presymptomatic intervention, because Abeta mismetabolism

165 must move from post-symptomatic treatment to presymptomatic intervention.

166 (EAE) mouse model of MS, we have shown that presymptomatic lesions can be quantified using VCAM-MPIO

167 Presymptomatic lupus-prone MRL(lpr/lpr) mice exhibited a

168 ants from the GENFI study were included: 108 presymptomatic MAPT, GRN, and C9orf72 mutation carriers

169 ntly decreased in the occipital lobe in both presymptomatic (mean BOLD change 1.1% [SD 0.5], mean dif

170 LTP were not affected in slices from younger presymptomatic Mecp2 KO mice.

171 g and capture (STC) were impaired already in presymptomatic mice.

172 naturally occurring canine model of GLD that presymptomatic monotherapy with intrathecal AAV9 encodin

173 an modulate alpha-synuclein aggregation in a presymptomatic mouse model of Gaucher-related synucleino

174 perimposed the facial nerve axotomy model on presymptomatic mSOD1 mice and investigated gene expressi

175 Behavioral tests were performed by using presymptomatic mSOD1 mice.

176 Presymptomatic mSOD1(G93A) mouse facial MN (FMN) are mor

177 dentified clear axonal transport deficits in presymptomatic mutant mice.

178 s higher in both symptomatic (p < 0.001) and presymptomatic mutation carriers (p < 0.001).

179 nts (P = 0.04 and 0.05, respectively) and in presymptomatic mutation carriers (P = 0.04 and 0.01, res

180 mptomatic groups and controls, or any of the presymptomatic mutation carriers and controls.

181 Cerebral blood flow was lower in presymptomatic mutation carriers closer to and beyond th

182 althy at-risk first-degree relatives (either presymptomatic mutation carriers or non-carriers), and h

183 th mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that Huntington

184 d a cohort of 11 symptomatic individuals, 19 presymptomatic mutation carriers, and 20 asymptomatic no

185 uals of 3 large SCA17 pedigrees, including 4 presymptomatic mutation carriers, underwent cranial 3-di

186 and parietal lobe, in all SCA17 patients and presymptomatic mutation carriers.

187 screening of families identified many (often presymptomatic) mutation-positive subjects.

188 y and brainstem inputs are reduced in MNs of presymptomatic mutSOD1 mice.

189 tic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n =

190 pted functional connectivity are potentially presymptomatic neuroimaging biomarkers for cognitive dec

191 s in 27/29 (93.1%) samples and in 6/12 (50%) presymptomatic NHPs.

192 In the future, coupling presymptomatic OA detection with emergent clinical thera

193 Transplantation at a presymptomatic or early symptomatic stage of juvenile ML

194 plexes occur in late stages of HD but not in presymptomatic or early-stage HD patients.

195 h), symptomatic with only atypical symptoms, presymptomatic, or asymptomatic.

196 These findings suggest that presymptomatic oxidative stress yields abnormal adult br

197 magnetic resonance imaging readily captures presymptomatic pathological changes and disease propagat

198 ge of symptom onset, allows investigation of presymptomatic pathological processes that can identify

199 isease (ILBD), which is thought to represent presymptomatic PD.

200 the neurochemical mechanisms underlying this presymptomatic period are still unclear.

201 In summary, we identified a critical presymptomatic period during which UCH-L1-dependent enha

202 ase pathogenesis that defines the extensive, presymptomatic period for many prion strains.

203 A long preclinical and subsequent presymptomatic period pose a challenge for recognition,

204 In the presymptomatic period, higher GFAP concentrations were c

205 ined Mecp2(-/y) and wild-type (WT) mice from presymptomatic periods to end-stage disease.

206 iation of treatment for heart failure in the presymptomatic phase can mitigate the progression to mor

207 ion of the antisense oligonucleotides in the presymptomatic phase efficiently suppressed the mutant g

208 h brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

209 ing patients susceptible to arrhythmias in a presymptomatic phase, and thus implementing preventive t

210 mmation, myelin, and neuron markers from the presymptomatic phase.

211 vanced disease stages, during a much earlier presymptomatic phase.

212 d their associated biomarkers in the mild or presymptomatic phases of Alzheimer's disease are likely

213 disease (AD) research moves to intervene in presymptomatic phases of the disease, we must develop ou

214 naffected organs of CBA/Pdss2(kd/kd) mice at presymptomatic, phenotypic-onset, and end-stages of the

215 sected from SMN-deficient SMA mouse model at presymptomatic postnatal day 1 (P1), before detectable M

216 e to Fracture Risk Assessment Tool score for presymptomatic prediction of future osteoporotic fractur

217 Compared to non-carriers, presymptomatic presenilin 1 mutation carriers exhibited

218 evidence among our users for asymptomatic or presymptomatic presentation; show a variety of exposure,

219 Despite identical behavioral performance, presymptomatic PS1 mutation carriers exhibited increased

220 ined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers t

221 stimulation has convincingly demonstrated a presymptomatic reduction or absence of short interval in

222 Samples from these 24 presymptomatic residents had a median rRT-PCR cycle thre

223 on-based results support recommendations for presymptomatic screening of relatives of cardiomyopathy

224 Recommendations for presymptomatic screening of relatives of cardiomyopathy

225 ies; however, the extent of asymptomatic and presymptomatic severe acute respiratory syndrome coronav

226 bed in muscle and spinal cord was normal in presymptomatic SMA mice (postnatal day 1), but failed to

227 Axotomized presymptomatic SOD1 FMNs displayed a dynamic pro-surviva

228 propose that the increased susceptibility of presymptomatic SOD1 FMNs to axotomy-induced cell death a

229 and axotomized facial motor nuclei of WT and presymptomatic SOD1 mice for mRNA expression pattern ana

230 Presymptomatic SOD1 mice had a significant decrease in F

231 axotomy-induced gene expression response of presymptomatic SOD1 neuropil was compared with WT.

232 egeneration was markedly reduced compared to presymptomatic SOD1(G93A) mice and wild types.

233 ed by elevated nuclear PTEN in spinal MNs of presymptomatic SOD1(G93A) mice.

234 METHODS/PRINCIPAL FINDINGS: Presymptomatic SOD1(G93A) rats (60-65 days old) received

235 n of mutant SOD1 in only the motor cortex of presymptomatic SOD1(G93A) rats through targeted delivery

236 innate immunity and phagocytotic pathways in presymptomatic SOD1-G93A mice expressing IL-10 + M3 or I

237 ilent transmission from a combination of the presymptomatic stage and asymptomatic infections.

238 ysfunction and neurodegeneration even in the presymptomatic stage and may serve as markers for diseas

239 Identification of at-risk individuals at the presymptomatic stage has become a major research interes

240 e considerable systemic changes at an early, presymptomatic stage in SMA mice, revealing a significan

241 Detection and treatment at an early presymptomatic stage may have contributed to the favorab

242 in older adults who are unlikely to be in a presymptomatic stage of AD.

243 We observed a normal NMJ organization at a presymptomatic stage of ALS (120 d), but PSC detection o

244 Individuals in the presymptomatic stage of Alzheimer disease (AD) are incre

245 cies in the SMA mouse model occur during the presymptomatic stage of disease, suggesting a role in in

246 ve/reactive brain mechanisms attributed to a presymptomatic stage of obstructive sleep apnea.

247 e of neurodegeneration in SCA17, even in the presymptomatic stage of the disease.

248 ly disrupted in R6/2 mice at 9 weeks of age (presymptomatic stage).

249 tation carriers over non-carriers during the presymptomatic stage, suggesting these symptoms result w

250 amus and bilateral caudate were evident at a presymptomatic stage, together with increased fractional

251 med expPABPN1 carriers at a symptomatic or a presymptomatic stage.

252 mpal interneurons occurred mostly during the presymptomatic stage.

253 eded to inform design of trials aimed at the presymptomatic stage.

254 we assessed whether oxidative stress during presymptomatic stages causes adult anomalies in rats wit

255 health screening for type 1 diabetes in its presymptomatic stages may reduce disease severity and bu

256 of subtle myelin disruption during the early presymptomatic stages of AD and may help to validate new

257 variation at the APP locus in the earliest, presymptomatic stages of AD.

258 -dependent trajectory of cortical atrophy in presymptomatic stages of AD.

259 a peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the te

260 associated with faster cognitive decline in presymptomatic stages of disease progression.

261 igated its influence on cognitive decline in presymptomatic stages of disease progression.

262 y performance relative to noncarriers in the presymptomatic stages of disease progression.

263 ion and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer's disease, w

264 ted with one another and are elevated at the presymptomatic stages of familial Alzheimer's disease.

265 there is limited evidence of its utility in presymptomatic stages of frontotemporal dementia.

266 ising non-invasive imaging biomarker for the presymptomatic stages of genetic frontotemporal dementia

267 ondrial stress was detected during the early presymptomatic stages of leaf senescence, which was acco

268 and epigenetic changes in the cerebellum at presymptomatic stages of NPC disease represent previousl

269 tamatergic corticostriatal synapses at early presymptomatic stages that have been postulated to set t

270 d a transmission model with asymptomatic and presymptomatic states, calibrated to data on disease ons

271 e onset of AD given that we observed them in presymptomatic subjects and that six of the validated ge

272 d AD patients or via secondary prevention in presymptomatic subjects bearing amyloid plaques.

273 ) on grey matter volume in a large cohort of presymptomatic subjects bearing frontotemporal dementia-

274 In addition, presymptomatic subjects carrying pathogenic PSEN1 gene m

275 tomatic patients diagnosed with sporadic AD, presymptomatic subjects carrying pathogenic PSEN1 mutati

276 Presymptomatic subjects had reduced CTh/CSA in more rest

277 Symptomatic and presymptomatic subjects were compared to age-matched con

278 ower grey matter volume (P = 0.002), even in presymptomatic subjects.

279 es and then recorded sleep/wake behaviour at presymptomatic, symptomatic and late stages of the disea

280 or AD, which suggests that NGRN may reflect presymptomatic synaptic dysfunction or loss.

281 of PKCzeta levels in cord blood T cells as a presymptomatic test to predict allergy risk in children,

282 g, and has formed the basis for prenatal and presymptomatic testing and preimplantation genetic diagn

283 Proteomic analysis of a vulnerable organ, presymptomatic testis, showed a preferential accumulatio

284 ing (CFC) in the hippocampus and amygdala of presymptomatic Tg2576 mice, a genetic model for Abeta ac

285 ximity to estimated clinical conversion from presymptomatic to symptomatic phase in C9+ individuals (

286 crucial determinants in the transition from presymptomatic to symptomatic prion disease.

287 e peaked in participants converting from the presymptomatic to the symptomatic stage and was associat

288 Presymptomatic total daily energy intake in patients, re

289 Re-evaluation of presymptomatic transgenic mice expressing A53T human alp

290 ion profiling of spinal cord astrocytes from presymptomatic transgenic mice expressing mutant superox

291 g such syndromes and providing timely (often presymptomatic) treatment to families in which such synd

292 ally depend on thoughtful design of rigorous presymptomatic trials.

293 etabolic staging in mothers of children with presymptomatic type 1 diabetes (3 [1-7]) compared with m

294 e 3 type 1 diabetes in the 280 children with presymptomatic type 1 diabetes was 24.9% ([95% CI, 18.5%

295 children with multiple islet autoantibodies (presymptomatic type 1 diabetes) were invited to particip

296 on at large to optimally identify those with presymptomatic type 1 diabetes, and introducing safe and

297 The primary outcome was presymptomatic type 1 diabetes, defined by 2 or more isl

298 % girls), 280 (0.31%; 95% CI, 0.27-0.35) had presymptomatic type 1 diabetes, including 196 (0.22%) wi

299 Presymptomatic valve operation was not associated with l

300 that this effect is dramatically enhanced in presymptomatic YAC128 HD and BACHD relative to wild-type